The Effect of Caffeine on Motor Task Performance

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Current Meter Observations in the Old Bahama Channel

Current meter observations were made at 50, 250, and 435 m in 495 m of water at the center of the Old Bahama Channel between November 1990 and November 1991. The mean speed at those depths was 2.6, 50, and 26 cm s-1 toward the Straits of Florida. A maximum speed of 193 cm s-1 was found at the 250-m level. There was evidence of a speed maximum between 50 and 250 m. Large internal diurnal tidal currents were observed that produced high shears in the water column under some conditions. Transport calculated from the single mooring using simple assumptions varied from -2.4 to +6.6 Sv with a mean of +1.9 Sv toward the Straits of Florida. These values, while based on limited data, are very significant compared to the mean flow in the Straits of Florida. Thus flow through the Old Bahama Channel may be an important component of heat and salt transport in the straits

A realistic assessment of methods for extracting gene/protein interactions from free text

Background: The automated extraction of gene and/or protein interactions from the literature is one of the most important targets of biomedical text mining research. In this paper we present a realistic evaluation of gene/protein interaction mining relevant to potential non-specialist users. Hence we have specifically avoided methods that are complex to install or require reimplementation, and we coupled our chosen extraction methods with a state-of-the-art biomedical named entity tagger. Results: Our results show: that performance across different evaluation corpora is extremely variable; that the use of tagged (as opposed to gold standard) gene and protein names has a significant impact on performance, with a drop in F-score of over 20 percentage points being commonplace; and that a simple keyword-based benchmark algorithm when coupled with a named entity tagger outperforms two of the tools most widely used to extract gene/protein interactions. Conclusion: In terms of availability, ease of use and performance, the potential non-specialist user community interested in automatically extracting gene and/or protein interactions from free text is poorly served by current tools and systems. The public release of extraction tools that are easy to install and use, and that achieve state-of-art levels of performance should be treated as a high priority by the biomedical text mining community

Toward Regional Characterizations of the Oceanic Internal Wavefield

Many major oceanographic internal wave observational programs of the last 4 decades are reanalyzed in order to characterize variability of the deep ocean internal wavefield. The observations are discussed in the context of the universal spectral model proposed by Garrett and Munk. The Garrett and Munk model is a good description of wintertime conditions at Site-D on the continental rise north of the Gulf Stream. Elsewhere and at other times, significant deviations in terms of amplitude, separability of the 2-D vertical wavenumber - frequency spectrum, and departure from the model's functional form are noted. Subtle geographic patterns are apparent in deviations from the high frequency and high vertical wavenumber power laws of the Garrett and Munk spectrum. Moreover, such deviations tend to co-vary: whiter frequency spectra are partnered with redder vertical wavenumber spectra. Attempts are made to interpret the variability in terms of the interplay between generation, propagation and nonlinearity using a statistical radiative balance equation. This process frames major questions for future research with the insight that such integrative studies could constrain both observationally and theoretically based interpretations

Characterizing, modelling and understanding the climate variability of the deep water formation in the North-Western Mediterranean Sea

Observing, modelling and understanding the climate-scale variability of the deep water formation (DWF) in the North-Western Mediterranean Sea remains today very challenging. In this study, we first characterize the interannual variability of this phenomenon by a thorough reanalysis of observations in order to establish reference time series. These quantitative indicators include 31 observed years for the yearly maximum mixed layer depth over the period 1980–2013 and a detailed multi-indicator description of the period 2007–2013. Then a 1980–2013 hindcast simulation is performed with a fully-coupled regional climate system model including the high-resolution representation of the regional atmosphere, ocean, land-surface and rivers. The simulation reproduces quantitatively well the mean behaviour and the large interannual variability of the DWF phenomenon. The model shows convection deeper than 1000 m in 2/3 of the modelled winters, a mean DWF rate equal to 0.35 Sv with maximum values of 1.7 (resp. 1.6) Sv in 2013 (resp. 2005). Using the model results, the winter-integrated buoyancy loss over the Gulf of Lions is identified as the primary driving factor of the DWF interannual variability and explains, alone, around 50 % of its variance. It is itself explained by the occurrence of few stormy days during winter. At daily scale, the Atlantic ridge weather regime is identified as favourable to strong buoyancy losses and therefore DWF, whereas the positive phase of the North Atlantic oscillation is unfavourable. The driving role of the vertical stratification in autumn, a measure of the water column inhibition to mixing, has also been analyzed. Combining both driving factors allows to explain more than 70 % of the interannual variance of the phenomenon and in particular the occurrence of the five strongest convective years of the model (1981, 1999, 2005, 2009, 2013). The model simulates qualitatively well the trends in the deep waters (warming, saltening, increase in the dense water volume, increase in the bottom water density) despite an underestimation of the salinity and density trends. These deep trends come from a heat and salt accumulation during the 1980s and the 1990s in the surface and intermediate layers of the Gulf of Lions before being transferred stepwise towards the deep layers when very convective years occur in 1999 and later. The salinity increase in the near Atlantic Ocean surface layers seems to be the external forcing that finally leads to these deep trends. In the future, our results may allow to better understand the behaviour of the DWF phenomenon in Mediterranean Sea simulations in hindcast, forecast, reanalysis or future climate change scenario modes. The robustness of the obtained results must be however confirmed in multi-model studies

Coronary artery dominance and the risk of adverse clinical events following percutaneous coronary intervention: insights from the prospective, randomised TWENTE trial

Aims: To investigate the prognostic value of coronary dominance for various adverse clinical events following the implantation of drug-eluting stents. Methods and results: We assessed two-year follow-up data of 1,387 patients from the randomised TWENTE trial. Based on the origin of the posterior descending coronary artery, coronary circulation was categorised into left and non-left dominance (i.e., right and balanced). Target vessel-related myocardial infarction (MI) was defined according to the updated Academic Research Consortium (ARC) definition (2x upper reference limit of creatine kinase [CK], confirmed by CK-MB elevation), and periprocedural MI (PMI) as MI ≤48 hours following PCI. One hundred and thirty-six patients (9.8%) had left and 1,251 (90.2%) non-left dominance. Target lesions were more frequently located in dominant arteries (p<0.005). Left dominance was associated with more severe calcifications (p=0.006) and more bifurcation lesions (p=0.031). Non-left dominance tended to be less frequent in men (p=0.09). Left coronary dominance was associated with more target vessel-related MI (14 [10.3%] vs. 62 [5.0%], p=0.009). Left dominance independently predicted PMI (adjusted HR 2.19, 95% CI: 1.15-4.15, p=0.017), while no difference in other clinical endpoints was observed between dominance groups. Conclusions: In the population of the TWENTE trial, we observed a higher incidence of periprocedural myocardial infarction in patients who had left coronary dominance. - See more at: http://www.pcronline.com/eurointervention/ahead_of_print/201402-11/#sthash.p3Zkzx7X.dp

Kinematic signatures of nuclear discs and bar-driven secular evolution in nearby galaxies of the MUSE TIMER project

The central regions of disc galaxies hold clues to the processes that dominate their formation and evolution. To exploit this, the TIMER project has obtained high signal-to-noise and spatial resolution integral-field spectroscopy data of the inner few kpc of 21 nearby massive barred galaxies, which allows studies of the stellar kinematics in their central regions with unprecedented spatial resolution. We confirm theoretical predictions of the effects of bars on stellar kinematics and identify box/peanuts through kinematic signatures in mildly and moderately inclined galaxies, finding a lower limit to the fraction of massive barred galaxies with box/peanuts at ∼62%. Further, we provide kinematic evidence of the connection between barlenses, box/peanuts, and bars. We establish the presence of nuclear discs in 19 galaxies and show that their kinematics are characterised by near-circular orbits with low pressure support and that they are fully consistent with the bar-driven secular evolution picture for their formation. In fact, we show that these nuclear discs have, in the region where they dominate, larger rotational support than the underlying main galaxy disc. In addition, we define a kinematic radius for the nuclear discs and show that it relates to bar radius, ellipticity and strength, and bar-to-total ratio. Comparing our results with photometric studies of galaxy bulges, we find that careful, state-of-the-art galaxy image decompositions are generally able to discern nuclear discs from classical bulges if the images employed have high enough physical spatial resolution. In fact, we show that nuclear discs are typically identified in such image decompositions as photometric bulges with (near-)exponential profiles. However, we find that the presence of composite bulges (galaxies hosting both a classical bulge and a nuclear disc) can often be unnoticed in studies based on photometry alone and suggest a more stringent threshold to the Sérsic index to identify galaxies with pure classical bulges

Inside-out formation of nuclear discs and the absence of old central spheroids in barred galaxies of the TIMER survey

The centres of disc galaxies host a variety of structures built via both internal and external processes. In this study, we constrain the formation and evolution of these central structures, in particular, nuclear rings and nuclear discs, by deriving maps of mean stellar ages, metallicities, and [α/Fe] abundances. We use observations obtained with the MUSE integral-field spectrograph for the TIMER sample of 21 massive barred galaxies. Our results indicate that nuclear discs and nuclear rings are part of the same physical component, with nuclear rings constituting the outer edge of nuclear discs. All nuclear discs in the sample are clearly distinguished based on their stellar population properties. As expected in the picture of bar-driven secular evolution, nuclear discs are younger, more metal-rich, and exhibit lower [α/Fe] enhancements, as compared to their immediate surroundings. Moreover, nuclear discs exhibit well-defined radial gradients, with ages and metallicities decreasing, and [α/Fe] abundances increasing with radius out to the nuclear ring. Often, these gradients show no breaks from the edge of the nuclear disc up through the centre, suggesting that these structures extend to the very centres of galaxies. We argue that continuous (stellar) nuclear discs may form from a series of bar-built (initially gas-rich) nuclear rings that expand in their radius as the bar evolves. In this picture, nuclear rings are simply the (often) star-forming outer edge of nuclear discs. Finally, by combining our results with those taken from a accompanying kinematic study, we do not find evidence for the presence of large, dispersion-dominated components in the centres of these galaxies. This could be a result of quiet merger histories, despite the large galaxy masses, or, perhaps, due to high angular momentum and strong feedback processes preventing the formation of these kinematically hot components