Combining deficit irrigation and nutrient amendment enhances the water productivity of tomato (Solanum lycopersicum L.) in the tropics

Water availability for irrigation farming is one of the greatest challenges associated with the increasing spatio-temporal effects of climate change and variability on tomato production, especially in tropical regions. This study was conducted to demonstrate the combined effect of irrigation and nutrient management as a water-saving strategy to maximize nutrient and water productivity in tomato production. The research was conducted in a screen house at the CSIR-Crops Research Institute (CSIR-CRI), Kumasi, Ghana using the split-plot design in the 2020 and 2021 cropping seasons. The main plot consisted of a single full irrigation at 100% recommended crop water requirement and two deficit irrigation levels (75 and 50% of the crop water requirement). The subplots consisted of two nutrient amendments (inorganic fertilizer and organic compost) and a control (without any nutrient amendment). Data from the research was used to parameterize the DSSAT CCROPGRO model to simulate the interactive effect of irrigation and nutrient management on the yield of tomatoes. Plant height and stem girth did not have a specific influence on tomato yield, but the number of branches had a positive effect on tomato yield. The combined use of inorganic fertilizer and full irrigation was found to improve tomato yield up to 7691.4 and 9009.9 kg/ha whereas treatment with no fertilizer application at 50% deficit irrigation recorded the lowest tomato yield of 1423.9 and 1739.2 kg/ha in 2020 and 2021, respectively. For the two deficit irrigations (50 and 75% ETc), organic compost produced the highest tomato yield. Deficit irrigation recorded higher crop water productivity (CWP) compared to full irrigation. At 50% deficit irrigation, organic compost recorded the highest CWP of 4.54 kg/m3 in 2020 while inorganic fertilizer recorded the highest CWP of 5.52 kg/m3 in 2021. No fertilizer at full irrigation recorded the lowest CWP of 1.37 and 1.67 kg/m3 in 2020 and 2021, respectively. This study has revealed that deficit irrigation with organic compost has the same effect on yield and water productivity as full irrigation with inorganic fertilizer. The strong agreement observed between the measured and simulated yields under the different irrigation and nutrient management shows that the DSSAT CROPGRO tomato model can be used to simulate tomato fruit yield under future climate scenarios. However, the general overestimation of the measured tomato yield shows the limitations of the model to simulate the real-world complexity of cropping systems under controlled conditions. This calls for more research into crop system modeling in controlled environment agriculture

High prevalence of integrase mutation L74I in West African HIV-1 subtypes prior to integrase inhibitor treatment.

OBJECTIVES: HIV-1 integrase inhibitors are recommended as first-line therapy by WHO, though efficacy and resistance data for non-B subtypes are limited. Two recent trials have identified the integrase L74I mutation to be associated with integrase inhibitor treatment failure in HIV-1 non-B subtypes. We sought to define the prevalence of integrase resistance mutations, including L74I, in West Africa. METHODS: We studied a Nigerian cohort of recipients prior to and during receipt of second-line PI-based therapy, who were integrase inhibitor-naive. Illumina next-generation sequencing with target enrichment was used on stored plasma samples. Drug resistance was interpreted using the Stanford Resistance Database and the IAS-USA 2019 mutation lists. RESULTS: Of 115 individuals, 59.1% harboured CRF02_AG HIV-1 and 40.9% harboured subtype G HIV-1. Four participants had major IAS-USA integrase resistance-associated mutations detected at low levels (2%-5% frequency). Two had Q148K minority variants and two had R263K (one of whom also had L74I). L74I was detected in plasma samples at over 2% frequency in 40% (46/115). Twelve (26.1%) had low-level minority variants of between 2% and 20% of the viral population sampled. The remaining 34 (73.9%) had L74I present at >20% frequency. L74I was more common among those with subtype G infection (55.3%, 26/47) than those with CRF02_AG infection (29.4%, 20/68) (P = 0.005). CONCLUSIONS: HIV-1 subtypes circulating in West Africa appear to have very low prevalence of major integrase mutations, but significant prevalence of L74I. A combination of in vitro and clinical studies is warranted to understand the potential implications.K.E.B. is supported by Wellcome Trust award number 170461. N.N. is supported by NIH R01 AI147331-01. R.K.G. is supported by a Wellcome Trust Senior Fellowship in Clinical Science (WT108082AIA). This study was supported by the President’s Emergency Plan for AIDS Relief (PEPFAR) through the Centers for Disease Control and Prevention (CDC) under the terms of U2G GH002099-01 and PA GH17-1753 (ACHIEVE)

Genomic history of the seventh pandemic of cholera in Africa.

The seventh cholera pandemic has heavily affected Africa, although the origin and continental spread of the disease remain undefined. We used genomic data from 1070 Vibrio cholerae O1 isolates, across 45 African countries and over a 49-year period, to show that past epidemics were attributable to a single expanded lineage. This lineage was introduced at least 11 times since 1970, into two main regions, West Africa and East/Southern Africa, causing epidemics that lasted up to 28 years. The last five introductions into Africa, all from Asia, involved multidrug-resistant sublineages that replaced antibiotic-susceptible sublineages after 2000. This phylogenetic framework describes the periodicity of lineage introduction and the stable routes of cholera spread, which should inform the rational design of control measures for cholera in Africa

Effect of remote ischaemic conditioning on clinical outcomes in patients with acute myocardial infarction (CONDI-2/ERIC-PPCI): a single-blind randomised controlled trial.

BACKGROUND: Remote ischaemic conditioning with transient ischaemia and reperfusion applied to the arm has been shown to reduce myocardial infarct size in patients with ST-elevation myocardial infarction (STEMI) undergoing primary percutaneous coronary intervention (PPCI). We investigated whether remote ischaemic conditioning could reduce the incidence of cardiac death and hospitalisation for heart failure at 12 months. METHODS: We did an international investigator-initiated, prospective, single-blind, randomised controlled trial (CONDI-2/ERIC-PPCI) at 33 centres across the UK, Denmark, Spain, and Serbia. Patients (age >18 years) with suspected STEMI and who were eligible for PPCI were randomly allocated (1:1, stratified by centre with a permuted block method) to receive standard treatment (including a sham simulated remote ischaemic conditioning intervention at UK sites only) or remote ischaemic conditioning treatment (intermittent ischaemia and reperfusion applied to the arm through four cycles of 5-min inflation and 5-min deflation of an automated cuff device) before PPCI. Investigators responsible for data collection and outcome assessment were masked to treatment allocation. The primary combined endpoint was cardiac death or hospitalisation for heart failure at 12 months in the intention-to-treat population. This trial is registered with ClinicalTrials.gov (NCT02342522) and is completed. FINDINGS: Between Nov 6, 2013, and March 31, 2018, 5401 patients were randomly allocated to either the control group (n=2701) or the remote ischaemic conditioning group (n=2700). After exclusion of patients upon hospital arrival or loss to follow-up, 2569 patients in the control group and 2546 in the intervention group were included in the intention-to-treat analysis. At 12 months post-PPCI, the Kaplan-Meier-estimated frequencies of cardiac death or hospitalisation for heart failure (the primary endpoint) were 220 (8·6%) patients in the control group and 239 (9·4%) in the remote ischaemic conditioning group (hazard ratio 1·10 [95% CI 0·91-1·32], p=0·32 for intervention versus control). No important unexpected adverse events or side effects of remote ischaemic conditioning were observed. INTERPRETATION: Remote ischaemic conditioning does not improve clinical outcomes (cardiac death or hospitalisation for heart failure) at 12 months in patients with STEMI undergoing PPCI. FUNDING: British Heart Foundation, University College London Hospitals/University College London Biomedical Research Centre, Danish Innovation Foundation, Novo Nordisk Foundation, TrygFonden

The Ghana Community-Based Rehabilitation Program for People With Disabilities: What Happened at the End of Donor Support?

In this case study the authors examined the functioning of the community-based rehabilitation (CBR) program for people with disabilities in 3 pilot districts after the conclusion of donor support in Ghana. Questionnaire and interview data from 42 people with disabilities, 8 local supervisors, and 3 social workers about program structures, support for people with disabilities, and challenges were analyzed using descriptive statistics and qualitative procedures, involving the use of Leximancer software. The authors found that some CBR structures remained in the communities. Diminished support for disabled peoples' organizations from communities and local government agencies were key challenges. The problem of volunteer local supervisors wanting to be paid ignited the evidence versus ideology debate around sustainability of CBR programs

Study of Local Construction and Technique: Adequacy of an Existing Nubian Vaulted Building with the "Bioclimatic" Concept Including the Performance of Its Envelope in Sahelian Climate of Ouagadougou

This study permitted to evaluate the adequacy of an existing Nubian vaulted building with the "bioclimatic" concept including the performance of its envelope. In that purpose, we needed to analyze its architectural concept and to measure parameters such as the temperature of the internal and external surfaces of all the façades (walls, roof and floor) of the study building. The measurement campaign took place over three (03) days in the month of January 2018 with a one-hour step for temperatures. Out of eleven (11) bioclimatic principles identified, six (06) were respected in the design of the building. In addition, we obtained thermal amplitudes of the interior surfaces lower than 1.5°C for the walls and 5°C for the roof, a decrement factor lower than 12% for the walls and 17% for the roof and a thermal time lag of 6 to 8 hours on in average for the walls and 4 to 6 hours in average for the roof. Finally, after evaluation of the thermal loads, with the Nubian vault building a reduction of a bit more than one third (1/3) of the thermal loads is achieved comparatively to a building of the same size made of cinder blocks for the walls and aluminum roofing sheet. However, this comfort offered by the Nubian vault can be improved with more bioclimatic provisions which we have recommended

High seroprevalence of hepatitis B virus and hepatitis C virus among human immunodeficiency virus carriers in blood donors of Burkina Faso: a need for their screening before HARRT therapy.

info:eu-repo/semantics/publishe