Preocupación por la apariencia física en usuarios de empresas multideportivas de México

Las escalas de Ansiedad Físico-Social (SPAS-7 y de Dismorfia Muscular (Complejo de Adonis) son herramientas sensibles para evaluar la preocupación por la apariencia física. El objetivo es analizar la asociación entre la dismorfia muscular y la ansiedad físico-social e identificar las diferencias por sexo en usuarios de empresas de servicios deportivos integrados del noroeste de México. Mediante un muestreo aleatorio simple se eligieron 429 (231 hombres y 198 mujeres). A todos ellos se les aplicaron los cuestionarios SPAS-7 y Complejo Adonis en el centro deportivo correspondiente. Se encontraron diferencias estadísticamente significativas que muestran que las mujeres registran mayores niveles de ansiedad que los hombres (Media = 12.5 ± 5 DS y Media = 14.5 ± 6 DS; p < .000); no obstante, las mujeres obesas presentan mayores puntuaciones con respecto al resto (Media = 18.8 ± DS; p < .000). También se comprobó a través de un modelo de regresión que los años de práctica física, la frecuencia a la semana y la duración de la sesión de entrenamiento predicen la ansiedad físico-social y el Complejo Adonis. Además se evidenció que existe una asociación significativa entre los niveles de dismorfia muscular y de ansiedad.Social Physique Anxiety (SPAS -7) and muscle dysmorphia (Adonis Complex) scales are sensitive tools to assess concern about physical appearance. The aim of this work is to analyse the association between muscle dysmorphia and social physique anxiety and identify the differences by gender in users of integrated sports complexes in north-west Mexico. Using simple random sampling, 429 (231 men and 198 women) were selected. SPAS-7 and Adonis Complex questionnaires were given in the relevant sports centre. Significant differences were4 found which showed that women reported higher levels of anxiety than men (M = 12.5 ± 5 SD and M = 14.5 ± 6 SD, p = .000); however, obese women reported much higher levels in relation to the others (M = 18.8 ± SD p < .000). It was also proved, using a regression model, that the number of years doing sports, the number of times a week and the duration of the training session predict social physique anxiety and the Adonis Complex. In addition, a significant association between muscle dysmorphia and anxiety levels was confirmed.As escalas de Ansiedade Físico-social (SPAS-7 e Dismorfia Muscular (Complexo de Adonis) são ferramentas sensíveis para avaliar a preocupação com a aparência física. O objectivo é analisar a associação entre a dismorfia muscular e a ansiedade físico-social e identificar as diferenças por sexo em utentes de empresas de serviços desportivos integrados do noroeste do México. A amostra aleatória simples foi composta por 429 participantes (231 homens e 198 mulheres). A todos eles se aplicaram os questionários SPAS-7 e Complexo Adonis no centro desportivo correspondente. Verificaramse diferenças estatisticamente significativas que mostram que as mulheres registaram maiores níveis de ansiedade que os homens (Média = 12.5 ± 5 dp e Média = 14.5 ± 6 dp; p < .000); não obstante, as mulheres obesas apresentam maiores pontuações nos restantes indicadores (Media = 18.8 ± 8 dp; p < .000). Também se comprovou através de um modelo de regressão que os anos de prática física, a frequência semanal e a duração da sessão de treino predizem a ansiedade físico-social e o Complexo de Adonis. Adicionalmente, evidenciou-se que existe uma associação significativa entre os níveis de dismorfia muscular e de ansiedade

Síntesis de derivados del glutamato integrantes de nuevos interruptores moleculares para el control fotoinducido de células nerviosas

Este TFG busca el desarrollo de interruptores moleculares basados en el sistema MAG (maleimida-azobenceno-glutamato), que posibilita el control del canal iónico en los receptores neuronales a glutamato mediante fotoexcitación inducida. El sistema estudiado presenta tres fragmentos con actividad complementaria: (1) un fragmento reactivo maleimida-cisteína, que enlaza a la proteína cerca del canal iónico, (2) el glutamato, como agonista del receptor del canal iónico y (3) una unidad de azobenzeno fotoisomerizable que permite o impide al agonista alcanzar el receptor, dependiendo de la forma isomérica. El trabajo desarrolla una ruta sintética para el sistema, partiendo del producto comercial acido L-piroglutámico.Aquest TFG cerca el desenvolupament d'interruptors moleculars basats en el sistema MAG (maleimida-azobenzè-glutamat), que possibilita el control del canal iònic en els receptors neuronals a glutamat mitjançant fotoexcitació induïda. El sistema estudiat presenta tres fragments amb activitat complementaria: (1) un fragment reactiu maleimida-cisteïna, que enllaça a la proteïna prop del canal iònic; (2) el glutamat, com agonista del receptor del canal iònic i (3) una unitat de azobenzè fotoisomeritzable que permet o impedeix al agonista arribar al receptor, depenent de la forma isomèrica. El treball desenvolupa una ruta sintètica per al sistema, partint del producte comercial àcid L-piroglutàmic

Experimental and Computational Studies on the Performance of Solar Trackers Under Vortex Shedding, Torsional Divergence, and Flutter

[Abstract] The current development of renewable energies has originated a number of new structural typologies that are the physical support of the energy production systems. Photovoltaic energy is a very mature source and it is obtained using rows of panels implemented in a longitudinal grillage. Many studies have been carried out in the past with an aim to improve the capacity to obtain electrical power, but another important issue is the need to guarantee the performance of these industrial facilities under the phenomena induced by the turbulent wind flow, taking into account the fact that they are usually built in wide open spaces. This paper describes an extensive research carried out on two configurations of solar trackers by experimental and computational methods. The former was composed of a number of tests of reduced models of segments of the solar trackers, which were carried out in an aerodynamic wind tunnel. The latter consisted of a series of structural analyses worked out through a finite element model of the full panel subjected to aerodynamic and aeroelastic loads. Several angles of attack of the wind flow and a wide range of wind speeds were included in the study. This approach allowed to clearly evaluate the structural and dynamic performance of both the configurations of solar trackers under the most important wind-induced phenomena such as vortex shedding, torsional divergence, and flutter. The paper relates the phases of the study and informs about the more relevant numerical results obtained in the experiments and the computer analysis

Clip-off Chemistry : Synthesis by Programmed Disassembly of Reticular Materials

Bond breaking is an essential process in chemical transformations and the ability of researchers to strategically dictate which bonds in a given system will be broken translates to greater synthetic control. Here, we report extending the concept of selective bond breaking to reticular materials in a new synthetic approach that we call Clip-off Chemistry. We show that bond-breaking in these structures can be controlled at the molecular level; is periodic, quantitative, and selective; is effective in reactions performed in either solid or liquid phases; and can occur in a single-crystal-to-single-crystal fashion involving the entire bulk precursor sample. We validate Clip-off Chemistry by synthesizing two topologically distinct 3D metal-organic frameworks (MOFs) from two reported 3D MOFs, and a metal-organic macrocycle from metal-organic polyhedra (MOP). Clip-off Chemistry opens the door to the programmed disassembly of reticular materials and thus to the design and synthesis of new molecules and materials. Clip-off Chemistry, a new approach to synthesizing molecules and materials based on the programmed de-reticulation and controlled etching at the molecular level in reticular materials, is introduced. Using this strategy, we have transformed two 3D metal-organic frameworks (MOFs) into two topologically distinct 3D MOFs, and one metal-organic polyhedra into a metal-organic macrocycle

Clonal chromosomal mosaicism and loss of chromosome Y in elderly men increase vulnerability for SARS-CoV-2

The pandemic caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2, COVID-19) had an estimated overall case fatality ratio of 1.38% (pre-vaccination), being 53% higher in males and increasing exponentially with age. Among 9578 individuals diagnosed with COVID-19 in the SCOURGE study, we found 133 cases (1.42%) with detectable clonal mosaicism for chromosome alterations (mCA) and 226 males (5.08%) with acquired loss of chromosome Y (LOY). Individuals with clonal mosaic events (mCA and/or LOY) showed a 54% increase in the risk of COVID-19 lethality. LOY is associated with transcriptomic biomarkers of immune dysfunction, pro-coagulation activity and cardiovascular risk. Interferon-induced genes involved in the initial immune response to SARS-CoV-2 are also down-regulated in LOY. Thus, mCA and LOY underlie at least part of the sex-biased severity and mortality of COVID-19 in aging patients. Given its potential therapeutic and prognostic relevance, evaluation of clonal mosaicism should be implemented as biomarker of COVID-19 severity in elderly people. Among 9578 individuals diagnosed with COVID-19 in the SCOURGE study, individuals with clonal mosaic events (clonal mosaicism for chromosome alterations and/or loss of chromosome Y) showed an increased risk of COVID-19 lethality

Hyperoxemia and excess oxygen use in early acute respiratory distress syndrome : Insights from the LUNG SAFE study

Publisher Copyright: © 2020 The Author(s). Copyright: Copyright 2020 Elsevier B.V., All rights reserved.Background: Concerns exist regarding the prevalence and impact of unnecessary oxygen use in patients with acute respiratory distress syndrome (ARDS). We examined this issue in patients with ARDS enrolled in the Large observational study to UNderstand the Global impact of Severe Acute respiratory FailurE (LUNG SAFE) study. Methods: In this secondary analysis of the LUNG SAFE study, we wished to determine the prevalence and the outcomes associated with hyperoxemia on day 1, sustained hyperoxemia, and excessive oxygen use in patients with early ARDS. Patients who fulfilled criteria of ARDS on day 1 and day 2 of acute hypoxemic respiratory failure were categorized based on the presence of hyperoxemia (PaO2 > 100 mmHg) on day 1, sustained (i.e., present on day 1 and day 2) hyperoxemia, or excessive oxygen use (FIO2 ≥ 0.60 during hyperoxemia). Results: Of 2005 patients that met the inclusion criteria, 131 (6.5%) were hypoxemic (PaO2 < 55 mmHg), 607 (30%) had hyperoxemia on day 1, and 250 (12%) had sustained hyperoxemia. Excess FIO2 use occurred in 400 (66%) out of 607 patients with hyperoxemia. Excess FIO2 use decreased from day 1 to day 2 of ARDS, with most hyperoxemic patients on day 2 receiving relatively low FIO2. Multivariate analyses found no independent relationship between day 1 hyperoxemia, sustained hyperoxemia, or excess FIO2 use and adverse clinical outcomes. Mortality was 42% in patients with excess FIO2 use, compared to 39% in a propensity-matched sample of normoxemic (PaO2 55-100 mmHg) patients (P = 0.47). Conclusions: Hyperoxemia and excess oxygen use are both prevalent in early ARDS but are most often non-sustained. No relationship was found between hyperoxemia or excessive oxygen use and patient outcome in this cohort. Trial registration: LUNG-SAFE is registered with ClinicalTrials.gov, NCT02010073publishersversionPeer reviewe

CIBERER: Spanish national network for research on rare diseases: A highly productive collaborative initiative

13 páginas,1 figura, 3 tablas, 1 apéndice. Se extraen los autores pertenecientes a The CIBERER network que trabajan en Centros del CSIC del Appendix ACIBER (Center for Biomedical Network Research; Centro de Investigación Biomédica En Red) is a public national consortium created in 2006 under the umbrella of the Spanish National Institute of Health Carlos III (ISCIII). This innovative research structure comprises 11 different specific areas dedicated to the main public health priorities in the National Health System. CIBERER, the thematic area of CIBER focused on rare diseases (RDs) currently consists of 75 research groups belonging to universities, research centers, and hospitals of the entire country. CIBERER's mission is to be a center prioritizing and favoring collaboration and cooperation between biomedical and clinical research groups, with special emphasis on the aspects of genetic, molecular, biochemical, and cellular research of RDs. This research is the basis for providing new tools for the diagnosis and therapy of low-prevalence diseases, in line with the International Rare Diseases Research Consortium (IRDiRC) objectives, thus favoring translational research between the scientific environment of the laboratory and the clinical setting of health centers. In this article, we intend to review CIBERER's 15-year journey and summarize the main results obtained in terms of internationalization, scientific production, contributions toward the discovery of new therapies and novel genes associated to diseases, cooperation with patients' associations and many other topics related to RD research.This study has been funded by Instituto de Salud Carlos III (ISCIII) and Spanish Ministry of Science and InnovationPeer reviewe

Stereoselective Synthesis of Conformationally Restricted Cyclohexanyl Nucleoside Analogues

En les darreres dècades, l'ús d'anàlegs de nucleòsids (ANs) ha despertat un gran interès de recerca per a la teràpia antiviral i anticancerigen. La conformació i el plegament de la unitat de sucre dels nucleòsids tenen un paper crític en la modulació de la seva activitat biològica. En aquest context, s'han dissenyat i sintetitzat nous anàlegs de carbanucleòsids (ACNs) restringits conformacionalment per imitar el comportament conformacional de l'anell de furanosa natural. Els nucleòsids ciclohexenílics són un tipus prometedor de compostos antivirals, en què la substitució de l'àtom d'oxigen de l'anell de furanosa per un doble enllaç indueix una flexibilitat anular, similar a la dels nucleòsids naturals. Recentment, s'ha descrit que ambdós enantiòmers del ciclohexenil G (DCG i LCG) mostren una potent i selectiva activitat antivirus. Tenint en compte la interessant activitat anti-HSV del ciclohexenil G, es va proposar una nova sèrie d'ANs biciclo[4.1.0]heptà al nostre grup de recerca, en què el doble enllaç va ser substituït per un ciclopropà fusionat. La present tesi doctoral està enfocada a la síntesi enantioselectiva d'una nova sèrie d'ANs carbocíclis de sis membres basats en l'esquelet del ciclohexenil G que conté la unitat de biciclo[4.1.0]heptà. Concretament, es descriu l'assoliment dels objectius següents: - En primer lloc, s'han optimitzat dues estratègies sintètiques desenvolupades en el nostre grup de recerca per preparar la cetona clau 36, que és l'intermedi comú per a la preparació dels ANs biciclo[4.1.0]heptà. La cetona 36 s'ha obtingut en una seqüencia de 6 passos robusta, reproduïble i eficaç a escala de multi-gram amb un rendiment total del 49% a partir de l'1-ciclohexadiona. -En segon lloc, ja que els ANs 5-hidroximetilbiciclo[4.1.0]heptà, BCH-(A, G, T i U), prèviament obtinguts al grup de recerca, no mostraven activitat antiviral significativa, es va decidir de completar la família de 5-hidroximetilbiciclo[4.1.0]heptà, on es va sintetitzar l'anàleg de citosina que es va obtenir amb un rendiment total del 4% en 17 etapes. Tot i això, no va presentar activitat antiviral ni citotoxicitat. Tota aquesta família de ANs han estat avaluades en assajos enzimàtics per determinar l'afinitat amb la timidina quinasa (TK) vírica. El compost basat en timidina BCH-T té una interessantíssima afinitat cap a HSV-TK (EC50 = 1.6 ± 0.1 µg / ml), que coincideix amb el nostre model computacional realitzat per a la primera etapa de fosforilació per aquests productes. -En tercer lloc, s'ha preparat una nova família d'ANs 5-hidroximetil-4-hidroxibiciclo[4.1.0]heptan-2-il. En particular, els ANs de timina i guanina s'han obtingut en 17 i 18 passos i amb un rendiment global del 18% i 10%, respectivament. L'epímer-C4 de la timina i l'alquè de la timina 4,5-é s'han sintetitzat en 19 etapes i un rendiment total del 6% i del 3%, respectivament. Aquests quatre ANs han estat avaluats per determinar la seva activitat antiviral, encara que cap d'ells mostra cap activitat significativa. -Finalment, també s'ha obtingut una nova família d'ACNs 1,2,3-triazole-biciclo[4.1.0]heptà. Aquest enfocament ha permès la preparació de quatre compostos 1,2,3-triazol-ACNs (4-substituït) via CuAAc amb un rendiment global del 19-16% en 15 etapes. A més, es va obtenir un compost 4,5-substituït mitjançant una reacció de cicloaddició i un 12% de rendiment en 14 etapes. S'ha avaluat l'activitat biològica d'aquests anàlegs contra diversos virus, tot i que només el propilbenzen-1,2,3-triazolo-ACNs 151 mostra una activitat considerable contra el virus Coxsackie B4 (EC50 = 13.5-9.4 µg / mL).En las últimas décadas, el uso de análogos de nucleósidos (ANs) ha generado un amplio interés de investigación para la terapia antiviral y anticancerígena. La conformación y el plegamiento de la unidad de azúcar de los nucleósidos juegan un papel crítico en la modulación de su actividad biológica. En este contexto, se han diseñado y sintetizado nuevos análogos de carbanucleósidos (ACNs) restringidos conformacionalmente para imitar el comportamiento conformacional del anillo de furanosa. Los nucleósidos de ciclohexenilo son un tipo prometedor de compuestos antivirales, donde el reemplazo del átomo de oxígeno del anillo de furanosa por un doble enlace induce flexibilidad anular, similar a la de los nucleósidos regulares. Recientemente, se ha descrito que ambos enantiómeros de ciclohexenilo G (DCG y LCG) muestran una actividad potente y selectiva contra el virus del herpes (HSV). Teniendo en cuenta la interesante actividad anti-HSV del ciclohexenilo G, en nuestro grupo de investigación se propuso una nueva serie de ANs biciclo[4.1.0]heptano en el que el doble enlace fue reemplazado por un ciclopropano fusionado. La presente Tesis doctoral se centra en la síntesis enantioselectiva de una nueva serie de ANs carbocíclicos de seis miembros basados en el esqueleto del ciclohexenilo G conteniendo la estructura de biciclo[4.1.0]heptano a partir de un intermedio clave común. Específicamente, se describe el logro de los siguientes objetivos: - En primer lugar, se han optimizado dos estrategias sintéticas desarrolladas en nuestro grupo de investigación para preparar la cetona clave 36, que es el intermedio común para la preparación de los ANs biciclo[4.1.0]heptano. La cetona 36 se ha obtenido en un secuencia robusta, reproducible y eficiente de 6 pasos en una escala de multi-gramo con un rendimiento general del 49% a partir de 1,4-ciclohexadiona. -En segundo lugar, dado que los análogos 5'-hidroximetilbiciclo[4.1.0]heptano BCH-(A, G, T y U), obtenidos previamente en el grupo de investigación, no mostraron actividad antiviral significativa, se decidió completar la familia 5'-hidroximetilbiciclo [4.1.0]heptanilo sintetizando el análogo de citosina que ha sido obtenido con un rendimiento global del 4% en 17 pasos. Sin embargo, no mostró actividad antiviral o citotoxicidad. Toda esta familia de AN se ha evaluado en ensayos enzimáticos para determinar la afinidad de la timidina quinasa (TK) vírica. El compuesto a base de timidina BCH-T tiene una gran afinidad interesante hacia HSV-TK (EC50 = 1.6 ± 0.1 µg/mL) que es consistente con nuestro modelo computacional realizado para la primera etapa de fosforilación para estos compuestos. -En tercer lugar, se ha preparado una nueva familia de ANs 5'-hidroximetil-4'-hidroxibiciclo[4.1.0]heptan-2'-ilo. En particular, se obtuvieron los ANs de timina y guanina en 17 y 18 pasos y un rendimiento general de 18% y 10%, respectivamente. El epimero-C4 de timina y el alqueno de timina 4',5'-eno se han sintetizado en 19 pasos y con un rendimiento general de 6% y 3%, respectivamente. Estos cuatro AN han sido seleccionados para evaluar su actividad antiviral, aunque ninguno de ellos muestra actividad significativa. -Finalmente, también se ha obtenido una nueva familia de ACNs 1,2,3-triazol-biciclo[4.1.0]heptanilo. Este enfoque ha permitido la preparación de cuatro 1,2,3-triazolo-ACNs (4-sustituido) a través de CuAAc con un rendimiento global del 19-16% en 15 pasos. Además, también se ha sintetizado un compuesto de triazol (4,5-sustituido) mediante una reacción de cicloadición y 12% de rendimiento en 14 etapas. Se ha evaluado la actividad biológica de estos análogos contra varios virus, aunque solo el propilbenceno-1,2,3-triazolo-ACN 151 muestra una actividad considerable contra el virus Coxsackie B4 (EC50 = 13.5-9.4 µg/mL).In the last decades, the use of nucleoside analogues (NAs) has garnered extensive research interest for antiviral and anticancer therapy. The conformation and puckering of the sugar moiety of nucleosides play a critical role in modulating their biological activity. In this context, new conformationally restricted carbanucleosides analogues (CNAs) have been designed and synthesised in order to mimic the conformational behaviour of the natural furanose ring. Cyclohexenyl nucleosides are a promising type of antiviral compounds, wherein replacement of the oxygen atom of the furanose ring by a double bond induces annular flexibility, similar to that of regular nucleosides. Recently, it has been described that both enantiomers of cyclohexenyl G (DCG and LCG) display potent and selective anti-herpes virus activity. Considering the interesting anti-HSV activity of cyclohexenyl G, new series of enantiopure bicyclo[4.1.0]heptanyl NAs were proposed in our research group, in which the double bond was replaced by a fused cyclopropane. The present Ph.D Thesis is focused on the enantioselective synthesis of a novel series of six-membered carbocyclic NAs based on the skeleton of cyclohexenyl G containing bicyclo[4.1.0]heptane structure from a common key intermediate. Specifically, it is described the achievement of the following objectives: - Firstly, two synthetic strategies developed in our research group have been optimized in order to prepare the key ketone 36, which is the common intermediate for the preparation of bicyclo[4.1.0]heptane NAs. Ketone 36 has been obtained in a robust, reproducible, and efficient 6-steps approach on a multigram scale in 49% overall yield from commercially available 1,4-cyclohexadione. -Secondly, since the 5'-hydroxymethylbicyclo[4.1.0]heptane analogues BCH-(A, G, T and U) NAs, previously obtained in the research group, did not show significant antiviral activity, in order to complete the 5'-hydroxymethylbicyclo[4.1.0]heptanyl family, the cytosine analogue has been synthesised in 4% overall yield in 17 steps. However, it does not show antiviral activity or cytotoxicity. All of this family of NAs have been evaluated in enzymatic assays in order to determine the virus-TK affinity. The thymidine-based compound BCH-T has an interesting great affinity towards HSV-TK (EC50 = 1.6 ± 0.1 µg/mL) which is consistent with our computational model performed for the first stage of phosphorylation. -Thirdly, a novel family of 5'-hydroxymethyl-4'-hydroxybicyclo[4.1.0]heptan-2'-yl NAs has been prepared. In particular, thymine and guanine NAs have been obtained in 17 and 18 steps and 18% and 10% overall yield, respectively. The thymine C4-epimer and the thymine alk-4,5-ene have been synthesised in 19 steps and 6% and 3% overall yield, respectively. These four NAs have been screened for antiviral activity, although none of them show significant activity. -Finally, a new family of 1,2,3-triazolo-bicyclo[4.1.0]heptanyl CNAs has also been obtained. This approach has allowed the preparation of the four 4-substituted-1,2,3-triazolo-CNAS via CuAAc in 19-16% overall yield in 15 steps. Furthermore, the 4,5-substituted-1,2,3-triazolo-CNAS has been synthesised via cycloaddition and 12% yield in 14 steps. The biological activity of these analogues against several viruses has been evaluated, although only the propylbenzene-1,2,3-triazolo-CNAs 151 shows a considerable activity against Coxsackie B4 virus (EC50 = 13.5-9.4 µg/mL)

Preocupación por la apariencia física en usuarios de empresas multideportivas de México

Las escalas de Ansiedad Físico-Social (SPAS-7 y de Dismorfia Muscular (Complejo de Adonis) son herramientas sensibles para evaluar la preocupación por la apariencia física. El objetivo es analizar la asociación entre la dismorfia muscular y la ansiedad físico-social e identificar las diferencias por sexo en usuarios de empresas de servicios deportivos integrados del noroeste de México. Mediante un muestreo aleatorio simple se eligieron 429 (231 hombres y 198 mujeres). A todos ellos se les aplicaron los cuestionarios SPAS-7 y Complejo Adonis en el centro deportivo correspondiente. Se encontraron diferencias estadísticamente significativas que muestran que las mujeres registran mayores niveles de ansiedad que los hombres (Media = 12.5 ± 5 DS y Media = 14.5 ± 6 DS; p < .000); no obstante, las mujeres obesas presentan mayores puntuaciones con respecto al resto (Media = 18.8 ± DS; p < .000). También se comprobó a través de un modelo de regresión que los años de práctica física, la frecuencia a la semana y la duración de la sesión de entrenamiento predicen la ansiedad físico-social y el Complejo Adonis. Además se evidenció que existe una asociación significativa entre los niveles de dismorfia muscular y de ansiedad.Social Physique Anxiety (SPAS -7) and muscle dysmorphia (Adonis Complex) scales are sensitive tools to assess concern about physical appearance. The aim of this work is to analyse the association between muscle dysmorphia and social physique anxiety and identify the differences by gender in users of integrated sports complexes in north-west Mexico. Using simple random sampling, 429 (231 men and 198 women) were selected. SPAS-7 and Adonis Complex questionnaires were given in the relevant sports centre. Significant differences were4 found which showed that women reported higher levels of anxiety than men (M = 12.5 ± 5 SD and M = 14.5 ± 6 SD, p = .000); however, obese women reported much higher levels in relation to the others (M = 18.8 ± SD p < .000). It was also proved, using a regression model, that the number of years doing sports, the number of times a week and the duration of the training session predict social physique anxiety and the Adonis Complex. In addition, a significant association between muscle dysmorphia and anxiety levels was confirmed.As escalas de Ansiedade Físico-social (SPAS-7 e Dismorfia Muscular (Complexo de Adonis) são ferramentas sensíveis para avaliar a preocupação com a aparência física. O objectivo é analisar a associação entre a dismorfia muscular e a ansiedade físico-social e identificar as diferenças por sexo em utentes de empresas de serviços desportivos integrados do noroeste do México. A amostra aleatória simples foi composta por 429 participantes (231 homens e 198 mulheres). A todos eles se aplicaram os questionários SPAS-7 e Complexo Adonis no centro desportivo correspondente. Verificaramse diferenças estatisticamente significativas que mostram que as mulheres registaram maiores níveis de ansiedade que os homens (Média = 12.5 ± 5 dp e Média = 14.5 ± 6 dp; p < .000); não obstante, as mulheres obesas apresentam maiores pontuações nos restantes indicadores (Media = 18.8 ± 8 dp; p < .000). Também se comprovou através de um modelo de regressão que os anos de prática física, a frequência semanal e a duração da sessão de treino predizem a ansiedade físico-social e o Complexo de Adonis. Adicionalmente, evidenciou-se que existe uma associação significativa entre os níveis de dismorfia muscular e de ansiedade