Birational self-maps and piecewise algebraic geometry

Let X be a smooth projective complex variety, of dimension 3, whose Hodge numbers h^{3,0}(X), h^{1,0}(X) both vanish. Let f: X--> X be a birational map that induces an isomorphism on (dense) open subvarieties U,V of X. Then we show that the complex reduced varieties (X \ U), (X \ V) are piecewise isomorphic

Periodic behaviour of coronal mass ejections, eruptive events, and solar activity proxies during solar cycles 23 and 24

We report on the parallel analysis of the periodic behaviour of coronal mass ejections (CMEs) based on 21 years [1996 -- 2016] of observations with the SOHO/LASCO--C2 coronagraph, solar flares, prominences, and several proxies of solar activity. We consider values of the rates globally and whenever possible, distinguish solar hemispheres and solar cycles 23 and 24. Periodicities are investigated using both frequency (periodogram) and time-frequency (wavelet) analysis. We find that these different processes, in addition to following the $\approx$11-year Solar Cycle, exhibit diverse statistically significant oscillations with properties common to all solar, coronal, and heliospheric processes: variable periodicity, intermittence, asymmetric development in the northern and southern solar hemispheres, and largest amplitudes during the maximum phase of solar cycles, being more pronounced during solar cycle 23 than the weaker cycle 24. However, our analysis reveals an extremely complex and diverse situation. For instance, there exists very limited commonality for periods of less than one year. The few exceptions are the periods of 3.1--3.2 months found in the global occurrence rates of CMEs and in the sunspot area (SSA) and those of 5.9--6.1 months found in the northern hemisphere. Mid-range periods of $\approx$1 and $\approx$2 years are more wide spread among the studied processes, but exhibit a very distinct behaviour with the first one being present only in the northern hemisphere and the second one only in the southern hemisphere. These periodic behaviours likely results from the complexity of the underlying physical processes, prominently the emergence of magnetic flux.Comment: 33 pages, 15 figures, 2 table

L’Après-11 septembre ou l’étiologie d’un monde qui change. Unicité sémantique et pluralité référentielle

À l’aide d’une analyse de contenu de la presse nationale française sur une longue période (2001-2006), les auteurs mettent en exergue la production et les conditions de circulation de l’expression Après-11 septembre. Ce chrononyme, dénommant une période historique semi-ouverte, est marqué par la pluralité de ses usages référentiels. Cette multiplicité de significations touche autant les attributs conférés à la période considérée que les pratiques sociales qu’elle est censée générer.Using a content analysis of the French national press over a long period (2001-2006), the authors emphasize the production and traffic conditions of the expression Après-11 septembre. This chrononyme, referring a semi-open historical period, is marked by its multiple references uses. These different meanings affect as much attributes given to the period than social practices it is supposed to generate.Fondamentando su trabajo sobre el analísis del contenido de la prensa nacional francesa sobre un periodo largo (2001-2006), los autores ponen de relieve la producción y las condiciones de circulación de la expresión Après-11 septembre. Éste cronónimo denominando un periodo histórico semiabierto, está marcado por una pluralidad de los usos referenciales. Ésta multiplicidad de significaciones abarca tanto los atributos conferidos al periodo analizado que las prácticas sociales que se le atribuyen

Etude d'évaluation du risque de mobilité des métaux dans l'agrosystème contaminé de Pierrelaye-Bessancourt : prospections du site, fonctionnement des sols et tests de lixiviation.

Ce sont les mécanismes de fixation et de libération des métaux dans ces sols pollués qui ont été approchés. Dans ce sens, l'étude se veut un outil d'aide à la décision pour les aménagements futurs du territoire. 1- Les de structures polygonales reconnues par géophysique conditionnent les modes et lieux d'infiltration des eaux. 2- L'irrigation a conduit à la déstabilisation des argiles des sols qui de ce fait ne jouent plus le rôle de rétention. Toutes les phases porteuses de métaux sont plus ou moins directement liées aux anciennes conditions d'hydromorphie (irrigation). L'arrêt de l'irrigation va déstabiliser progressivement ces complexes porteurs et libérer métaux retenus. 3- Des antibiotiques ont été mis en évidence dans les sols. Ils sont susceptibles d'agir sur les microorganismes des sols, et de ce fait présenter des risques environnementaux. 4- Les tests de lixiviation (lessivage/mobilisation) montrent la sensibilité des métaux à l'acidification du milieu et à l'oxydation de la matière organique. En raison de l'arrêt de l'irrigation il y aura accélération de la migration des métaux. 5- Les options de réaménagement sont discutées sous le regard sols/paysages : (1) en cas de boisement, l'acidification entraînera leur évacuation ; (2) les sols en place génèrent des poussières (dispersion dans l'environnement et inhalation humaine) ; (3) La dispersion incontrôlée des terres lors de terrassements est certainement un risque majeur

ABiMed: An intelligent and visual clinical decision support system for medication reviews and polypharmacy management

Background: Polypharmacy, i.e. taking five drugs or more, is both a public health and an economic issue. Medication reviews are structured interviews of the patient by the community pharmacist, aiming at optimizing the drug treatment and deprescribing useless, redundant or dangerous drugs. However, they remain difficult to perform and time-consuming. Several clinical decision support systems were developed for helping clinicians to manage polypharmacy. However, most were limited to the implementation of clinical practice guidelines. In this work, our objective is to design an innovative clinical decision support system for medication reviews and polypharmacy management, named ABiMed. Methods: ABiMed associates several approaches: guidelines implementation, but the automatic extraction of patient data from the GP's electronic health record and its transfer to the pharmacist, and the visual presentation of contextualized drug knowledge using visual analytics. We performed an ergonomic assessment and qualitative evaluations involving pharmacists and GPs during focus groups and workshops. Results: We describe the proposed architecture, which allows a collaborative multi-user usage. We present the various screens of ABiMed for entering or verifying patient data, for accessing drug knowledge (posology, adverse effects, interactions), for viewing STOPP/START rules and for suggesting modification to the treatment. Qualitative evaluations showed that health professionals were highly interested by our approach, associating the automatic guidelines execution with the visual presentation of drug knowledge. Conclusions: The association of guidelines implementation with visual presentation of knowledge is a promising approach for managing polypharmacy. Future works will focus on the improvement and the evaluation of ABiMed.Comment: 10 pages, 7 figure

Routine molecular profiling of cancer: results of a one-year nationwide program of the French Cooperative Thoracic Intergroup (IFCT) for advanced non-small cell lung cancer (NSCLC) patients.

International audienceBackground: The molecular profiling of patients with advanced non-small-cell lung cancer (NSCLC) for known oncogenic drivers is recommended during routine care. Nationally, however, the feasibility and effects on outcomes of this policy are unknown. We aimed to assess the characteristics, molecular profiles, and clinical outcomes of patients who were screened during a 1-year period by a nationwide programme funded by the French National Cancer Institute. Methods This study included patients with advanced NSCLC, who were routinely screened for EGFR mutations, ALK rearrangements, as well as HER2 (ERBB2), KRAS, BRAF, and PIK3CA mutations by 28 certified regional genetics centres in France. Patients were assessed consecutively during a 1-year period from April, 2012, to April, 2013. We measured the frequency of molecular alterations in the six routinely screened genes, the turnaround time in obtaining molecular results, and patients' clinical outcomes. This study is registered with ClinicalTrials.gov, number NCT01700582. Findings 18 679 molecular analyses of 17 664 patients with NSCLC were done (of patients with known data, median age was 64·5 years [range 18–98], 65% were men, 81% were smokers or former smokers, and 76% had adenocarcinoma). The median interval between the initiation of analysis and provision of the written report was 11 days (IQR 7–16). A genetic alteration was recorded in about 50% of the analyses; EGFR mutations were reported in 1947 (11%) of 17 706 analyses for which data were available, HER2 mutations in 98 (1%) of 11 723, KRAS mutations in 4894 (29%) of 17 001, BRAF mutations in 262 (2%) of 13 906, and PIK3CA mutations in 252 (2%) of 10 678; ALK rearrangements were reported in 388 (5%) of 8134 analyses. The median duration of follow-up at the time of analysis was 24·9 months (95% CI 24·8–25·0). The presence of a genetic alteration affected first-line treatment for 4176 (51%) of 8147 patients and was associated with a significant improvement in the proportion of patients achieving an overall response in first-line treatment (37% [95% CI 34·7–38·2] for presence of a genetic alteration vs 33% [29·5–35·6] for absence of a genetic alteration; p=0·03) and in second-line treatment (17% [15·0–18·8] vs 9% [6·7–11·9]; p<0·0001). Presence of a genetic alteration was also associated with improved first-line progression-free survival (10·0 months [95% CI 9·2–10·7] vs 7·1 months [6·1–7·9]; p<0·0001) and overall survival (16·5 months [15·0–18·3] vs 11·8 months [10·1–13·5]; p<0·0001) compared with absence of a genetic alteration. Interpretation Routine nationwide molecular profiling of patients with advanced NSCLC is feasible. The frequency of genetic alterations, acceptable turnaround times in obtaining analysis results, and the clinical advantage provided by detection of a genetic alteration suggest that this policy provides a clinical benefit

Erratum: The solar orbiter radio and plasma waves (RPW) instrument (Astronomy and Astrophysics (2020) 642 (A12) DOI: 10.1051/0004-6361/201936214)

The erratum concerns Fig. 9 entitled "Antenna radio-electrical properties" for which some of the parameters are not correct. The new figure with new parameters is provided in Fig. 1 of this corrigendum. Fig. 1. Corrected Antenna radio-electrical properties. (Figure Presented)

Brexucabtagene autoleucel in relapsed or refractory mantle cell lymphoma, intention-to-treat use in the DESCAR-T registry

Not available