Diet quality, food groups and nutrients associated with the gut microbiota in a nonwestern population

Diet plays an important role in shaping gut microbiota. However, much remains to be learned regarding this association. We analyzed dietary intake and gut microbiota in a community-dwelling cohort of 441 Colombians. Diet quality, intake of food groups and nutrient consumption were paired with microbial diversity and composition using linear regressions, Procrustes analyses and a random-forest machine-learning algorithm. Analyses were adjusted for potential confounders, including the five cities from where the participants originated, sex (male, female), age group (18-40 and 41-62 years), BMI (lean, overweight, obese) and socioeconomic status. Microbial diversity was higher in individuals with increased intake of nutrients obtained from plant-food sources, whereas the intake of food groups and nutrients correlated with microbiota structure. Random-forest regressions identified microbial communities associated with different diet components. Two remarkable results confirmed previous expectations regarding the link between diet and microbiota: communities composed of short-chain fatty acid (SCFA) producers were more prevalent in the microbiota of individuals consuming diets rich in fiber and plant-food sources, such as fruits, vegetables and beans. In contrast, an inflammatory microbiota composed of bile-tolerant and putrefactive microorganisms along with opportunistic pathogens thrived in individuals consuming diets enriched in animal-food sources and of low quality, i.e., enriched in ultraprocessed foods and depleted in dietary fiber. This study expands our understanding of the relationship between dietary intake and gut microbiota. We provide evidence that diet is strongly associated with the gut microbial community and highlight generalizable connections between them

Evaluation of a customer loyalty strategy with system dymamics

The customer loyalty programs are a tool of differentiation and high impact to create long term relationships with customers of a company, so as to achieve an improvement in the portfolio and collections, redu­ced costs of customer service, increased revenue from higher sales to the most profitable customers, cross selling, among many other benefits. Ac­cordingly, we present a system dynamic model to analyze the economic benefits, in terms of profitability, which would be to implement a customer loyalty strategy. To adjust and validate the proposed model, its implemen­tation is done in a real case of a marketer of agricultural products in the department of Valle del Cauca - Colombia. The simulation results show that indeed the model fulfills its purpose, and that the loyalty program achieved significant results in the finances of the organization.Los programas de fidelización de clientes son una herramienta de diferen­ciación y alto impacto para crear relaciones de largo plazo con los clientes de una empresa, de tal forma que se logre una mejora en cartera y recaudo, reducción de costos de atención a clientes, incremento en ingresos por mayores ventas a los clientes más rentables, ventas cruzadas, entre muchos otros beneficios. De acuerdo con esto, se presenta un modelo de dinámica de sistemas que permita analizar los beneficios económicos, en términos de rentabilidad, que se tendrían al implementar una estrategia de fideliza­ción de clientes. Para ajustar y validar el modelo propuesto, se aplica en un caso real de una empresa comercializadora de productos agrícolas de la región. Los resultados de la simulación muestran que efectivamente el modelo cumple con su objetivo, y que el programa de fidelización logra importantes resultados en las finanzas de la organización

Bridging gaps in the molecular phylogeny of the Lymnaeidae (Gastropoda: Pulmonata), vectors of Fascioliasis

<p>Abstract</p> <p>Background</p> <p>Lymnaeidae snails play a prominent role in the transmission of helminths, mainly trematodes of medical and veterinary importance (<it>e.g</it>., <it>Fasciola </it>liver flukes). As this family exhibits a great diversity in shell morphology but extremely homogeneous anatomical traits, the systematics of Lymnaeidae has long been controversial. Using the most complete dataset to date, we examined phylogenetic relationships among 50 taxa of this family using a supermatrix approach (concatenation of the 16 S, ITS-1 and ITS-2 genes, representing 5054 base pairs) involving both Maximum Likelihood and Bayesian Inference.</p> <p>Results</p> <p>Our phylogenetic analysis demonstrates the existence of three deep clades of Lymnaeidae representing the main geographic origin of species (America, Eurasia and the Indo-Pacific region). This phylogeny allowed us to discuss on potential biological invasions and map important characters, such as, the susceptibility to infection by <it>Fasciola hepatica </it>and <it>F. gigantica</it>, and the haploid number of chromosomes (n). We found that intermediate hosts of <it>F. gigantica </it>cluster within one deep clade, while intermediate hosts of <it>F. hepatica </it>are widely spread across the phylogeny. In addition, chromosome number seems to have evolved from n = 18 to n = 17 and n = 16.</p> <p>Conclusion</p> <p>Our study contributes to deepen our understanding of Lymnaeidae phylogeny by both sampling at worldwide scale and combining information from various genes (supermatrix approach). This phylogeny provides insights into the evolutionary relationships among genera and species and demonstrates that the nomenclature of most genera in the Lymnaeidae does not reflect evolutionary relationships. This study highlights the importance of performing basic studies in systematics to guide epidemiological control programs.</p

Heterogeneous Photocatalytic Degradation of Ibuprofen Over TiO2–Ag Supported on Activated Carbon from Waste Tire Rubber

In recent years it has been discovered that some common use medicines, such as ibuprofen and other nonsteroidal anti-inflammatory drugs, are found in water sources in concentrations that have the potential to affect aquatic organisms. On the other hand, waste used tires are a massive problem for the environment due to the leaching of toxic compounds to soils and water. Also, the exposition to environmental conditions can make them sources of vectors like mosquitoes. In this work, three activated carbon (AC) catalysts derived from waste tire rubber, titanium dioxide and silver were synthesized using the sol–gel method. Morphological characterizations such as SEM and TEM were performed in which, the agglomeration of titanium particles and silver crystals on the surface of the AC is evident. In the XRD analysis, the presence of elemental silver nanoparticles was detected. In the diffuse reflectance spectroscopy analysis, the decrease in the titanium band gap, as well as activity in the visible spectrum, was observed. The photocatalytic tests were performed at pH 3 and 7 in the presence of UV/Vis radiation. These tests show that there are differences between the catalyst in both, UV and visible regions. Adsorption is a major phenomenon for the removal of ibuprofen, followed by photolytic decomposition. In visible spectra, the catalysts show a good performance for the removal of ibuprofen

Evaluación de una estrategia de fidelización de clientes con dinámica de sistemas

The customer loyalty programs are a tool of differentiation and high impact to create long term relationships with customers of a company, so as to achieve an improvement in the portfolio and collections, redu­ced costs of customer service, increased revenue from higher sales to the most profitable customers, cross selling, among many other benefits. Ac­cordingly, we present a system dynamic model to analyze the economic benefits, in terms of profitability, which would be to implement a customer loyalty strategy. To adjust and validate the proposed model, its implemen­tation is done in a real case of a marketer of agricultural products in the department of Valle del Cauca - Colombia. The simulation results show that indeed the model fulfills its purpose, and that the loyalty program achieved significant results in the finances of the organization. Los programas de fidelización de clientes son una herramienta de diferen­ciación y alto impacto para crear relaciones de largo plazo con los clientes de una empresa, de tal forma que se logre una mejora en cartera y recaudo, reducción de costos de atención a clientes, incremento en ingresos por mayores ventas a los clientes más rentables, ventas cruzadas, entre muchos otros beneficios. De acuerdo con esto, se presenta un modelo de dinámica de sistemas que permita analizar los beneficios económicos, en términos de rentabilidad, que se tendrían al implementar una estrategia de fideliza­ción de clientes. Para ajustar y validar el modelo propuesto, se aplica en un caso real de una empresa comercializadora de productos agrícolas de la región. Los resultados de la simulación muestran que efectivamente el modelo cumple con su objetivo, y que el programa de fidelización logra importantes resultados en las finanzas de la organización.

Modelacion de sistemas de recomendacion aplicando redes neuronales artificiales

This paper develops and describes a model for characterizing customers and product recommender system in movie rental companies, so that, when applied consistently, allows to know the trends of users in a timely, accurate and reliable. To do this, we use the methodology of artificial neural networks and adaptive resonance theory, because its implicit flexibility to adapt to business needs increases the efficiency of transactions in the field of web applications. Use the database The Netflix Prize, and the validation and simulation was coded in MatLab ®.Este artículo desarrolla y describe un modelo para un sistema recomendador de productos en empresas de alquiler de películas. Al aplicarlo sistemáticamente, caracteriza los clientes y permite conocer sus tendencias de manera oportuna, veraz y fiable. Para ello se utiliza la metodología de redes neuronales artificiales y la teoría de la resonancia adaptativa, ya que la flexibilidad implícita de adaptarse a las necesidades corporativas incrementa la eficiencia de las transacciones en el ámbito de las aplicaciones web. Se usa la base de datos de contenidos de alquiler electrónico de películas vía web The Netflix Prize. La validación y simulación del modelo se codifica en MatLab

Dietary antioxidant intake is inversely associated with 2,3-dinor oxylipin metabolites, the major excreted oxylipins in overweight and obese subjects

Cardiometabolic disease risk factors, including obesity, insulin resistance, high blood pressure, and dyslipidemia, are associated with elevated oxidative stress biomarkers like oxylipins. Increased adiposity by itself induces various isomers of this oxidized lipid family, while dietary polyphenols show benefits in its regulation. Previously, we showed that specific co-abundant microorganisms characterized the gut microbiota of Colombians and associated differentially with diet, lifestyle, obesity, and cardiometabolic health status, which led us to hypothesize that urinary oxylipins would reflect the intensity of oxidative metabolism linked to gut microbiota dysbiosis. Thus, we selected a convenience sample of 105 participants (age: 40.2 ± 11.9 years, 47.6% women), grouped according to microbiota, cardiometabolic health status, and body mass index (BMI); and evaluated 33 urinary oxylipins by HPLC-QqQ-MS/MS (e.g., isoprostanes, prostaglandins, and metabolites), paired with anthropometry and blood chemistry information and dietary antioxidants estimated from a 24-h food recall. In general, oxylipins did not show differences among individuals who differed in gut microbiota. While the unmetabolized oxylipin levels were not associated with BMI, the total content of oxylipin metabolites was highest in obese and cardiometabolically abnormal subjects (e.g., insulin resistant), mainly by prostaglandin-D (2,3-dinor-11β-PGF) and 15-F-IsoPs (2,3-dinor-15-F-IsoP and 2,3-dinor-15-epi-15-F-IsoP) metabolites. The total polyphenol intake in this cohort was 1070 ± 627 mg/day. After adjusting for body weight, the polyphenol intake was significantly higher in lean than overweight and showed an inverse association with dinor-oxylipin levels in principal component analysis. These results suggest that the 2,3-dinor-oxylipins could be more specific biomarkers associated with BMI than their parent oxylipins and that are sensitive to be regulated by dietary antioxidants.The authors thank the volunteers who agreed to participate in this study, the Colombian Ministry of science, technology, and innovation (Minciencias; grant number 832-2018), and Grupo Empresarial Nutresa. They also thank the Ibero-American Programme for Science, Technology and Development (CYTED) – Action 112RT0460 CORNUCOPIA networ

Defining a research agenda for layperson prehospital hemorrhage control: A consensus statement

Importance: Trauma is the leading cause of death for US individuals younger than 45 years, and uncontrolled hemorrhage is a major cause of trauma mortality. The US military\u27s medical advancements in the field of prehospital hemorrhage control have reduced battlefield mortality by 44%. However, despite support from many national health care organizations, no integrated approach to research has been made regarding implementation, epidemiology, education, and logistics of prehospital hemorrhage control by layperson immediate responders in the civilian sector.Objective: To create a national research agenda to help guide future work for prehospital hemorrhage control by laypersons.Evidence review: The 2-day, in-person, National Stop the Bleed (STB) Research Consensus Conference was conducted on February 27 to 28, 2019, to identify and achieve consensus on research gaps. Participants included (1) subject matter experts, (2) professional society-designated leaders, (3) representatives from the federal government, and (4) representatives from private foundations. Before the conference, participants were provided a scoping review on layperson prehospital hemorrhage control. A 3-round modified Delphi consensus process was conducted to determine high-priority research questions. The top items, with median rating of 8 or more on a Likert scale of 1 to 9 points, were identified and became part of the national STB research agenda.Findings: Forty-five participants attended the conference. In round 1, participants submitted 487 research questions. After deduplication and sorting, 162 questions remained across 5 a priori-defined themes. Two subsequent rounds of rating generated consensus on 113 high-priority, 27 uncertain-priority, and 22 low-priority questions. The final prioritized research agenda included the top 24 questions, including 8 for epidemiology and effectiveness, 4 for materials, 9 for education, 2 for global health, and 1 for health policy.Conclusions and relevance: The National STB Research Consensus Conference identified and prioritized a national research agenda to support laypersons in reducing preventable deaths due to life-threatening hemorrhage. Investigators and funding agencies can use this agenda to guide their future work and funding priorities