Structural Damage Detection and Reliability Estimation using a Multidimensional Monitoring Approach

Many structural elements are exposed to load conditions that are difficult to model during the design stage, such as environmental uncertainties, random impacts and overloading amongst others, thus, increasing un programmed maintenance and reducing..

Rms-flux relation of Cyg X-1 with RXTE: dipping and nondipping cases

The rms (root mean square) variability is the parameter for understanding the emission temporal properties of X-ray binaries (XRBs) and active galactic nuclei (AGN). The rms-flux relation with Rossi X-ray Timing Explorer (RXTE) data for the dips and nondip of black hole Cyg X-1 has been investigated in this paper. Our results show that there exist the linear rms-flux relations in the frequency range 0.1-10 Hz for the dipping light curve. Moreover, this linear relation still remains during the nondip regime, but with the steeper slope than that of the dipping case in the low energy band. For the high energy band, the slopes of the dipping and nondipping cases are hardly constant within errors. The explanations of the results have been made by means of the ``Propagating Perturbation'' model of Lyubarskii (1997).Comment: 15 pages, 12 figures, Accepted for publication in Astrophysics & Space Scienc

Efficient exploration of availability models guided by failure distances

Recently, a method to bound the steady-state availability using the failure distance concept has been proposed. In this paper we refine that method by introducing state space exploration techniques. In the methods proposed here, the state space is incrementally generated based on the contributions to the steady-state availability band of the states in the frontier of the currently generated state space. Several state space exploration algorithms are evaluated in terms of bounds quality and memory and CPU time requirements. The more efficient seems to be a waved algorithm which expands transition groups. We compare our new methods with the method based on the failure distance concept without state exploration and a method proposed by Souza e Silva and Ochoa which uses state space exploration but does not use the failure distance concept. Using typical examples we show that the methods proposed here can be significantly more efficient than any of the previous methods.Postprint (published version

The influence of gene expression time delays on Gierer-Meinhardt pattern formation systems

There are numerous examples of morphogen gradients controlling long range signalling in developmental and cellular systems. The prospect of two such interacting morphogens instigating long range self-organisation in biological systems via a Turing bifurcation has been explored, postulated, or implicated in the context of numerous developmental processes. However, modelling investigations of cellular systems typically neglect the influence of gene expression on such dynamics, even though transcription and translation are observed to be important in morphogenetic systems. In particular, the influence of gene expression on a large class of Turing bifurcation models, namely those with pure kinetics such as the Gierer–Meinhardt system, is unexplored. Our investigations demonstrate that the behaviour of the Gierer–Meinhardt model profoundly changes on the inclusion of gene expression dynamics and is sensitive to the sub-cellular details of gene expression. Features such as concentration blow up, morphogen oscillations and radical sensitivities to the duration of gene expression are observed and, at best, severely restrict the possible parameter spaces for feasible biological behaviour. These results also indicate that the behaviour of Turing pattern formation systems on the inclusion of gene expression time delays may provide a means of distinguishing between possible forms of interaction kinetics. Finally, this study also emphasises that sub-cellular and gene expression dynamics should not be simply neglected in models of long range biological pattern formation via morphogens

Trisomy 21 activates the kynurenine pathway via increased dosage of interferon receptors

Altres ajuts: This work has also been supported by a "Marató TV3" grant (20141210 to J.F. and 044412 to R.B.).Trisomy 21 (T21) causes Down syndrome (DS), affecting immune and neurological function by ill-defined mechanisms. Here we report a large metabolomics study of plasma and cerebrospinal fluid, showing in independent cohorts that people with DS produce elevated levels of kynurenine and quinolinic acid, two tryptophan catabolites with potent immunosuppressive and neurotoxic properties, respectively. Immune cells of people with DS overexpress IDO1, the rate-limiting enzyme in the kynurenine pathway (KP) and a known interferon (IFN)-stimulated gene. Furthermore, the levels of IFN-inducible cytokines positively correlate with KP dysregulation. Using metabolic tracing assays, we show that overexpression of IFN receptors encoded on chromosome 21 contribute to enhanced IFN stimulation, thereby causing IDO1 overexpression and kynurenine overproduction in cells with T21. Finally, a mouse model of DS carrying triplication of IFN receptors exhibits KP dysregulation. Together, our results reveal a mechanism by which T21 could drive immunosuppression and neurotoxicity in DS

Oceanographic processes and products around the Iberian margin: a new multidisciplinary approach

Our understanding of the role of bottom currents and associated oceanographic processes (e.g, overflows, barotropic tidal currents) including intermittent processes (e.g, vertical eddies, deep sea storms, horizontal vortices, internal waves and tsunamis) is rapidly evolving. Many deep-water processes remain poorly understood due to limited direct observations, but may generate significant depositional and erosional features on both short-and long-term time scales. This paper describes these oceanographic processes and examines their potential role in the sedimentary features around the Iberian margin. The paper explores the implications of the processes studied, given their secondary role relative to other factors such as mass-transport and turbiditic processes. An integrated interpretation of these oceanographic processes requires an understanding of contourites, sea-floor features, their spatial and temporal evolution, and the near-bottom flows that form them. Given their complex, three-dimensional and temporally-variable nature, integration of these processes into sedimentary, oceanographic and climatological frameworks will require a multidisciplinary approach that includes Geology, Physical Oceanography, Paleoceanography and Benthic Biology. This approach will synthesize oceanographic data, seafloor morphology, sediments and seismic images to improve our knowledge of permanent and intermittent processes around Iberia, and evaluate their conceptual and regional role in the sedimentary evolution of the margin. © 2015, Instituto Geologico y Minero de Espana. All rights reservedEl conocimiento del papel de las corrientes de fondo y los procesos oceanográficos asociados (overflows, corrientes de marea barotrópicas, etc), incluyendo procesos intermitentes (eddies, tormentas profundas, ondas internas, tsunamis, etc), está evolucionando rápidamente. Muchos de estos procesos son poco conocidos, en parte debido a que las observaciones directas son limitadas, si bien pueden generar importantes rasgos deposicionales y/o erosivos a escalas temporales de corto o largo periodo. Este artículo describe dichos procesos oceanográficos y examina su influencia en la presencia de rasgos sedimentarios alrededor del margen Ibérico. El trabajo discute las implicaciones de dichos procesos y el papel secundario que juegan en relación a otros factores tales como los procesos de transporte gravitacionales en masa y los turbidíticos. Para un mejor conocimiento de la sedimentación marina profunda, y en concreto de los sistemas contorníticos, se requiere de una interpretación de estos procesos oceanográficos, cuál es su evolución espacial y temporal, cómo afectan a las corrientes de fondo y cómo se ven afectados por la topografía submarina. Sin embargo, dada su complejidad y su variable naturaleza tridimensional y temporal, es necesario que estos procesos se integren en un marco sedimentológico, oceanográfico y climatológico con un enfoque multidisciplinar que incluyan la Geología, la Oceanografía Física, la Paleoceanografía y la Biología bentónica. Esta integración requiere de una mayor compilación de datos oceanográficos, de un mejor conocimiento de la morfología del fondo marino, y de una mejor caracterización de los sedimentos en ambientes profundos. Todo ello permitirá mejorar nuestro conocimiento de los procesos permanentes e intermitentes alrededor de Iberia y evaluar su verdadero efecto en la evolución sedimentaria delos márgenes continentales que le rodeanPostprint0,000

Oceanographic processes and morphosedimentary products along the Iberian margins: A new multidisciplinary approach

Postprin

La Cueva de El Sidrón (Piloña Asturias)

Estado de las excavaciones y estudios en la Cueva de El Sidrón (PIloña, Asturias)

Representativeness of aerosol measurements: EARLINET-CALIPSO correlative study

The high variability of tropospheric aerosols, both in space and time, is the main cause of the high uncertainty about radiative forcing related to tropospheric aerosols and their interaction with clouds. Because of the lack of high resolution aerosol global vertical profiles, the vertical mixing has not been considered so far in studies of spatial and temporal variability. The CALIPSO mission provides the first opportunity to investigate the 4-D aerosol and cloud fields in detail. However, because of the CALIOP small footprint and the revisit time of 16 days, correlative ground-based lidar observations are necessary in order to investigate the representativeness of these satellite observations. EARLINET, the European Aerosol Research Lidar Network, started correlative measurements for CALIPSO in June 2006, right after the CALIPSO launch. An integrated study of CALIPSO and EARLINET correlative measurements opens new possibilities for spatial (both horizontal and vertical) and temporal representativeness investigation of polar-orbit satellite measurements also in terms of revisit time.Postprint (published version