185 research outputs found
Neutron spectroscopy with the Spherical Proportional Counter
A novel large volume spherical proportional counter, recently developed, is
used for neutron measurements. Gas mixtures of with and
pure are studied for thermal and fast neutron detection, providing a
new way for the neutron spectroscopy. The neutrons are detected via the
and reactions. Here we
provide studies of the optimum gas mixture, the gas pressure and the most
appropriate high voltage supply on the sensor of the detector in order to
achieve the maximum amplification and better resolution. The detector is tested
for thermal and fast neutrons detection with a and a
neutron source. The atmospheric neutrons are successfully
measured from thermal up to several MeV, well separated from the cosmic ray
background. A comparison of the spherical proportional counter with the current
available neutron counters is also given.Comment: 7 pages, 10 figure
New pixelized Micromegas detector with low discharge rate for the COMPASS experiment
New Micromegas (Micro-mesh gaseous detectors) are being developed in view of
the future physics projects planned by the COMPASS collaboration at CERN.
Several major upgrades compared to present detectors are being studied:
detectors standing five times higher luminosity with hadron beams, detection of
beam particles (flux up to a few hundred of kHz/mm^{2}, 10 times larger than
for the present Micromegas detectors) with pixelized read-out in the central
part, light and integrated electronics, and improved robustness. Two solutions
of reduction of discharge impact have been studied, with Micromegas detectors
using resistive layers and using an additional GEM foil. Performance of such
detectors has also been measured. A large size prototypes with nominal active
area and pixelized read-out has been produced and installed at COMPASS in 2010.
In 2011 prototypes featuring an additional GEM foil, as well as an resistive
prototype, are installed at COMPASS and preliminary results from those
detectors presented very good performance. We present here the project and
report on its status, in particular the performance of large size prototypes
with an additional GEM foil.Comment: 11 pages, 5 figures, proceedings to the Micro-Pattern Gaseous
Detectors conference (MPGD2011), 29-31 August 2011, Kobe, Japa
X-ray detection with Micromegas with background levels below 10 keVcms
Micromegas detectors are an optimum technological choice for the detection of
low energy x-rays. The low background techniques applied to these detectors
yielded remarkable background reductions over the years, being the CAST
experiment beneficiary of these developments. In this document we report on the
latest upgrades towards further background reductions and better understanding
of the detectors' response. The upgrades encompass the readout electronics, a
new detector design and the implementation of a more efficient cosmic muon veto
system. Background levels below 10keVcms have been
obtained at sea level for the first time, demonstrating the feasibility of the
expectations posed by IAXO, the next generation axion helioscope. Some results
obtained with a set of measurements conducted in the x-ray beam of the CAST
Detector Laboratory will be also presented and discussed
Development of a novel segmented mesh MicroMegas detector for neutron beam profiling
A novel MicroMegas detector based on microbulk technology with an embedded XY strip structure was developed, obtained by segmenting both the mesh and the anode in perpendicular directions. This results in a very low-mass device with good energy and spatial resolution capabilities. Such a detector is practically âtransparentâ to neutrons, being ideal for in-beam neutron measurements and can be used as a quasi-online neutron beam profiler at neutron time-of-flight facilities. A dedicated front end electronics and acquisition system has been developed and used. The first studies of this new detection system are presented and discussed
Uremic Toxins Inhibit Transport by Breast Cancer Resistance Protein and Multidrug Resistance Protein 4 at Clinically Relevant Concentrations
During chronic kidney disease (CKD), there is a progressive accumulation of toxic solutes due to inadequate renal clearance. Here, the interaction between uremic toxins and two important efflux pumps, viz. multidrug resistance protein 4 (MRP4) and breast cancer resistance protein (BCRP) was investigated. Membrane vesicles isolated from MRP4- or BCRP-overexpressing human embryonic kidney cells were used to study the impact of uremic toxins on substrate specific uptake. Furthermore, the concentrations of various uremic toxins were determined in plasma of CKD patients using high performance liquid chromatography and liquid chromatography/tandem mass spectrometry. Our results show that hippuric acid, indoxyl sulfate and kynurenic acid inhibit MRP4-mediated [3H]-methotrexate ([3H]-MTX) uptake (calculated Ki values: 2.5 mM, 1 mM, 25 ”M, respectively) and BCRP-mediated [3H]-estrone sulfate ([3H]-E1S) uptake (Ki values: 4 mM, 500 ”M and 50 ”M, respectively), whereas indole-3-acetic acid and phenylacetic acid reduce [3H]-MTX uptake by MRP4 only (Ki value: 2 mM and IC50 value: 7 mM, respectively). In contrast, p-cresol, p-toluenesulfonic acid, putrescine, oxalate and quinolinic acid did not alter transport mediated by MRP4 or BCRP. In addition, our results show that hippuric acid, indole-3-acetic acid, indoxyl sulfate, kynurenic acid and phenylacetic acid accumulate in plasma of end-stage CKD patients with mean concentrations of 160 ”M, 4 ”M, 129 ”M, 1 ”M and 18 ”M, respectively. Moreover, calculated Ki values are below the maximal plasma concentrations of the tested toxins. In conclusion, this study shows that several uremic toxins inhibit active transport by MRP4 and BCRP at clinically relevant concentrations
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Itâs not the size, itâs the relationship: from âsmall statesâ to asymmetry
Debate about the definition of âsmall stateâ has produced more fragmentation than consensus, even as the literature has demonstrated its subjectsâ roles in joining international organizations propagating norms, executing creative diplomacy, influencing allies, avoiding and joining conflicts, and building peace. However, work on small states has struggled to identify commonalities in these statesâ international relations, to cumulate knowledge, or to impact broader IR theory. This paper advocates a changed conceptual and definitional framework. Analysis of âsmall statesâ should pivot to examine the dynamics of the asymmetrical relationships in which these states are engaged. Instead of seeking an overall metric for size as the relevant variableâfalling victim in a different way Dahlâs âlump-of-power fallacy,â we can recognize the multifaceted, variegated nature of power, whether in war or peacetime
ANTARES: the first undersea neutrino telescope
The ANTARES Neutrino Telescope was completed in May 2008 and is the first
operational Neutrino Telescope in the Mediterranean Sea. The main purpose of
the detector is to perform neutrino astronomy and the apparatus also offers
facilities for marine and Earth sciences. This paper describes the design, the
construction and the installation of the telescope in the deep sea, offshore
from Toulon in France. An illustration of the detector performance is given
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