Coevolutionary architectures with straight line programs for solving the symbolic regression problem

This is an electronic version of the paper presented at the International Conference on Evolutionary Computation (ICEC), held in Valencia (Spain) on 2010To successfully apply evolutionary algorithms to the solution of increasingly complex problems we must develop effective techniques for evolving solutions in the form of interacting coadapted subcomponents. In this paper we present an architecture which involves cooperative coevolution of two subcomponents: a genetic program and an evolution strategy. As main difference with work previously done, our genetic program evolves straight line programs representing functional expressions, instead of tree structures. The evolution strategy searches for good values for the numerical terminal symbols used by those expressions. Experimentation has been performed over symbolic regression problem instances and the obtained results have been compared with those obtained by means of Genetic Programming strategies without coevolution. The results show that our coevolutionary architecture with straight line programs is capable to obtain better quality individuals than traditional genetic programming using the same amount of computational effort.This work is partially supported by spanish grants TIN2007-67466-C02-02, MTM2004-01167 and S2009/TIC-165

Una propuesta genérica de trabajo en grupo y su aplicación en una asignatura de fundamentos teóricos de la Informática

En la presente comunicación se describen las actividades que conforman una propuesta de trabajo en grupo, así como algunos mecanismos que ayudan en el proceso de evaluación. Asimismo, se presentan los resultados obtenidos tras llevar a cabo la propuesta en una asignatura de último curso de una Ingeniería Técnica Informática. Una de las motivaciones de los autores a la hora de diseñar la propuesta, fue la de establecer actividades de grupo cuya realización de forma individual fuese complicado. Además, también se ha tratado de proponer trabajos que no fuera posible realizarlos exclusivamente a base de recopilación de material de la web, junto con labores de “copy/paste”. Un proceso de evaluación periódica del trabajo que se va realizando, supone un buen complemento para que el conjunto de la propuesta tenga éxito y se alcancen los objetivos perseguidos

Stability of total folates/vitamin B9 in irradiated watercress and buckler sorrel during refrigerated storage

The suitability of post-packaging gamma radiation treatment for preserving total folates or vitamin B9 in watercress (Nasturtium officinale R. Br.) and buckler sorrel (Rumex induratus Boiss. & Reut.) during storage at 4 °C was evaluated. Comparable amounts of total folates were found in fresh, non-stored samples of both species. In watercress, the irradiation treatment of up to 5 kGy reduced the loss of total folates caused by 7 days of storage. In turn, the 12-day storage period did not affect the total folate content of buckler sorrel (while the 2 kGy dose decreased the initial levels), evidencing that packaging and refrigeration are enough for preservation. These results suggest that the suitability of post-packaging irradiation for preserving total folates may depend not only on the applied dose but also on the plant matrix under analysis. In addition, new data useful to complete food composition tables or databases is provided.The authors are grateful to the Foundation for Science and Technology ( FCT , Portugal) and FEDER under Programme PT2020 for financial support to CIMO ( UID/AGR/00690/2013 ), REQUIMTE/LAQV ( UID/QUI/50006/2013 – POCI/01/0145/FERDER/007265) and C2TN ( UID/Multi/04349/2013 ) and the Grant of J. Pinela (UID/AGR/00690/2013_DNAABN); and to the ALIMNOVA Research Group (Project UCM-252/2017).info:eu-repo/semantics/publishedVersio

Global optimality in k-means clustering

Abstract: We study the problem of finding an optimum clustering, a problem known to be NP-hard. Existing literature contains algorithms running in time proportional to the number of points raised to a power that depends on the dimensionality and on the number of clusters. Published validations of some of these algorithms are unfortunately incomplete; besides, the constant factors (with respect to the number of points) in their running time bounds have seen several published important improvements but are still huge, exponential on the dimension and on the number of clusters, making the corresponding algorithms fully impractical. We provide a new algorithm, with its corresponding complexity-theoretic analysis. It reduces both the exponent and the constant factor, to the extent that it becomes feasible for relevant particular cases. Additionally, it parallelizes extremely well, so that its implementation on current high-performance hardware is quite straightforward. Our proposal opens the door to potential improvements along a research line that had no practical significance so far; besides, a long but single-shot run of our algorithm allows one to identify absolutely optimum solutions for benchmark problems, whereby alternative heuristic proposals can evaluate the goodness of their solutions and the precise price paid for their faster running times

Procalcitonin to stop antibiotics after cardiovascular surgery in a pediatric intensive care unit-The PROSACAB study.

Introduction and objective: Children admitted to the pediatric intensive care unit after cardiovascular surgery usually require treatment with antibiotics due to suspicion of infection. The aim of this study was to assess the effectiveness of procalcitonin in decreasing the duration of antibiotic treatment in children after cardiovascular surgery. Methods: Prospective, interventional study carried out in a pediatric intensive care unit. Included patients under 18 years old admitted after cardiopulmonary bypass. Two groups were compared, depending on the implementation of the PCT-guided protocol to stop or de-escalate the antibiotic treatment (Group 1, 2011-2013 and group 2, 2014-2018). This new protocol was based on the decrease of the PCT value by 20% or 50% with respect to the maximum value of PCT. Primary endpoints were mortality, stewardship indication, duration of antibiotic treatment, and antibiotic-free days. Results: 886 patients were recruited. There were 226 suspicions of infection (25.5%), and they were confirmed in 38 cases (16.8%). The global rate of infections was 4.3%. 102 patients received broad-spectrum antibiotic (4.7±1.7 days in group 1, 3.9±1 days in group 2 with p = 0.160). The rate of de-escalation was higher in group 2 (30/62, 48.4%) than in group 1 (24/92, 26.1%) with p = 0.004. A reduction of 1.1 days of antibiotic treatment (group 1, 7.7±2.2 and group 2, 6.7±2.2, with p = 0.005) and 2 more antibiotic free-days free in PICU in group 2 were observed (p = 0.001), without adverse outcomes. Conclusions: Procalcitonin-guided protocol for stewardship after cardiac surgery seems to be safe and useful to decrease the antibiotic exposure. This protocol could help to reduce the duration of broad-spectrum antibiotics and the duration of antibiotics in total, without developing complications or adverse effects

Flow cytometry for fast screening and automated risk assessment in systemic light-chain amyloidosis

Early diagnosis and risk stratification are key to improve outcomes in light-chain (AL) amyloidosis. Here we used multidimensional-flow-cytometry (MFC) to characterize bone marrow (BM) plasma cells (PCs) from a series of 166 patients including newly-diagnosed AL amyloidosis (N = 94), MGUS (N = 20) and multiple myeloma (MM, N = 52) vs. healthy adults (N = 30). MFC detected clonality in virtually all AL amyloidosis (99%) patients. Furthermore, we developed an automated risk-stratification system based on BMPCs features, with independent prognostic impact on progression-free and overall survival of AL amyloidosis patients (hazard ratio: ≥ 2.9;P ≤ .03). Simultaneous assessment of the clonal PCs immunophenotypic protein expression profile and the BM cellular composition, mapped AL amyloidosis in the crossroad between MGUS and MM; however, lack of homogenously-positive CD56 expression, reduction of B-cell precursors and a predominantly-clonal PC compartment in the absence of an MM-like tumor PC expansion, emerged as hallmarks of AL amyloidosis (ROC-AUC = 0.74;P < .001), and might potentially be used as biomarkers for the identification of MGUS and MM patients, who are candidates for monitoring pre-symptomatic organ damage related to AL amyloidosis. Altogether, this study addressed the need for consensus on how to use flow cytometry in AL amyloidosis, and proposes a standardized MFC-based automated risk classification ready for implementation in clinical practice

Espacio y territorios: razón, pasión e imaginarios

En este caleidoscopio de acercamientos hacia lo espacial y territorial, las visiones se mueven desde aquellas románticas y existencialistas, pasando por aquellas objetivistas y positivistas, hasta las estructuralistas y postestructuralistas. Por el espacio y el territorio se interesan con enfoques diversos numerosas disciplinas, desde la psicología, la etología o la literatura, y las ciencias naturales como la biología o la ecología, hasta las ciencias sociales y políticas, como la geografía, la antropología, la economía y la sociología. Este interés multidisciplinario demuestra la importancia y la complejidad del tema espacial y territorial, y reclama la necesidad de su estudio y comprensión interdisciplinarios, como se intenta con esta publicación