143 research outputs found
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Examination of Build Height in Ultrasonic Consolidation for Foil Width Specimens Using Supports
Ultrasonic consolidation (UC) is a novel, solid-state, additive manufacturing
fabrication process. It consists of ultrasonic joining of thin metal foils and contour milling
to directly produce functional components in a variety of geometries. The bond between
layers forms when an ultrasonic horn creates a local oscillating stress field at the mating
surfaces. It is commonly theorized that the high frequency vibration under pressure
produces a metallurgical bond without melting the base material. The mechanism behind
the bond is believed to be due to interfacial motion and friction that disrupts surface
contaminants, arguably allowing direct metal to metal contact, and producing sufficient
stress to induce plastic flow and promote the growth of grains across the mating surfaces.
Ignored in this explanation is the role of substrate dimensions on the quality and strength
of the joining process. Researchers have previously examined the effective height
limitations of the build process, i.e., the limiting height to width ratio of one of the
component features being fabricated. This paper extends the experimental work on using
support materials to extend build height on specimens using two different candidate materials, tin bismuth, and a mixture of sugar, corn syrup, and water, referred to as
âcandyâ. Tin bismuth and candy the represent the extremes of a tradeoff between
convenience and stiffness that a support material must possess.Mechanical Engineerin
GENETIC POLYMORPHISM OF REVERSE TRANSCRIPTASE AND PROTEASE ASSOCIATED WITH THE ANTIRETROVIRAL (ARV) INEFFICIENCY IN PEOPLE LIVING WITH HUMAN IMMUNODEFICIENCY VIRUS TYPE-2 (HIV-2) IN ABIDJAN, CĂTE DâIVOIRE
Objectives: To analyse the genetic polymorphism of reverse transcriptase and protease genes in patients living with HIV-2, to search for possible mutations preventing the effectiveness of antiretroviral drugs (ARVs).
Methods: RNA Viral was extracted after lysis of the virus particles and purified on filter columns (Qiagen). After their extraction, DNA fragments were amplified by the method of reverse transcription/polymerase chain reaction (RT/PCR) on one hand and by the PCR method enchase on the other hand. The study of genetic polymorphisms in reverse transcriptase and protease was performed after sequencing of amplicons.
Results: A significant polymorphism was observed in positions involved in resistance to antiretrovirals. The most frequent was mutations M 46 I, M 36 I/V, V82I, L 89 I on protease and Y 181 I, Y 188 L, G 190A on reverse transcriptase.
Conclusion: Polymorphic mutations were observed in the genes of the protease and reverse transcriptase and could be involved in the HIV-2 resistance to antiretrovirals (ARVs). It would be desirable to do the quantification of DNA provirus of HIV-2 in the other for a durable therapeutic monitoring of patients having HIV-2
Parenting gifted and talented children: What are the key child behaviour and parenting issues?
Objective: The literature on gifted and talented children is limited. Little is known about the types and nature of difficulties experienced by gifted and talented children, and even less known about parenting issues related to parenting a gifted and talented child. The aim of the present study was to describe children's behavioural and emotional adjustment, and the factors that contribute to children's difficulties, as well as to examine the styles of discipline used by parents of gifted and talented children and their level of confidence in managing specific parenting tasks
Factors Determining Nestedness in Complex Networks
Understanding the causes and effects of network structural features is a key task in deciphering complex systems. In this context, the property of network nestedness has aroused a fair amount of interest as regards ecological networks. Indeed, Bastolla et al. introduced a simple measure of network nestedness which opened the door to analytical understanding, allowing them to conclude that biodiversity is strongly enhanced in highly nested mutualistic networks. Here, we suggest a slightly refined version of such a measure of nestedness and study how it is influenced by the most basic structural properties of networks, such as degree distribution and degree-degree correlations (i.e. assortativity). We find that most of the empirically found nestedness stems from heterogeneity in the degree distribution. Once such an influence has been discounted â as a second factor â we find that nestedness is strongly correlated with disassortativity and hence â as random networks have been recently found to be naturally disassortative â they also tend to be naturally nested just as the result of chance.This work was supported by Junta de Andalucia projects FQM-01505 and P09-FQM4682, and by Spanish MEC-FEDER project FIS2009-08451. S.J. is grateful for financial support from the European Commision under the Marie Curie Intra-European Fellowship Programme PIEF-GA-2010-276454
Marine Carotenoids: Biological Functions and Commercial Applications
Carotenoids are the most common pigments in nature and are synthesized by all photosynthetic organisms and fungi. Carotenoids are considered key molecules for life. Light capture, photosynthesis photoprotection, excess light dissipation and quenching of singlet oxygen are among key biological functions of carotenoids relevant for life on earth. Biological properties of carotenoids allow for a wide range of commercial applications. Indeed, recent interest in the carotenoids has been mainly for their nutraceutical properties. A large number of scientific studies have confirmed the benefits of carotenoids to health and their use for this purpose is growing rapidly. In addition, carotenoids have traditionally been used in food and animal feed for their color properties. Carotenoids are also known to improve consumer perception of quality; an example is the addition of carotenoids to fish feed to impart color to farmed salmon
The Reform of âToo-Big-To-Failâ Bank: A New Regulatory Model for the Institutional Separation of âCasinoâ from âUtilityâ Banking
Produtividade e qualidade nutricional de cultivares de feijão em diferentes adubaçÔes
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