Costs of delivering human papillomavirus vaccination to schoolgirls in Mwanza Region, Tanzania.

BACKGROUND: Cervical cancer is the leading cause of female cancer-related deaths in Tanzania. Vaccination against human papillomavirus (HPV) offers a new opportunity to control this disease. This study aimed to estimate the costs of a school-based HPV vaccination project in three districts in Mwanza Region (NCT ID: NCT01173900), Tanzania and to model incremental scaled-up costs of a regional vaccination program. METHODS: We first conducted a top-down cost analysis of the vaccination project, comparing observed costs of age-based (girls born in 1998) and class-based (class 6) vaccine delivery in a total of 134 primary schools. Based on the observed project costs, we then modeled incremental costs of a scaled-up vaccination program for Mwanza Region from the perspective of the Tanzanian government, assuming that HPV vaccines would be delivered through the Expanded Programme on Immunization (EPI). RESULTS: Total economic project costs for delivering 3 doses of HPV vaccine to 4,211 girls were estimated at about US$349,400 (including a vaccine price of US$5 per dose). Costs per fully-immunized girl were lower for class-based delivery than for age-based delivery. Incremental economic scaled-up costs for class-based vaccination of 50,290 girls in Mwanza Region were estimated at US$1.3 million. Economic scaled-up costs per fully-immunized girl were US$26.41, including HPV vaccine at US$5 per dose. Excluding vaccine costs, vaccine could be delivered at an incremental economic cost of US$3.09 per dose and US$9.76 per fully-immunized girl. Financial scaled-up costs, excluding costs of the vaccine and salaries of existing staff were estimated at US$1.73 per dose. CONCLUSIONS: Project costs of class-based vaccination were found to be below those of age-based vaccination because of more eligible girls being identified and higher vaccine uptake. We estimate that vaccine can be delivered at costs that would make HPV vaccination a very cost-effective intervention. Potentially, integrating HPV vaccine delivery with cost-effective school-based health interventions and a reduction of vaccine price below US$5 per dose would further reduce the costs per fully HPV-immunized girl

Balmer-dominated shocks in Tycho's SNR: omnipresence of CRs

We present wide-field, spatially and highly resolved spectroscopic observations of Balmer filaments in the northeastern rim of Tycho's supernova remnant in order to investigate the signal of cosmic-ray (CR) acceleration. The spectra of Balmer-dominated shocks (BDSs) have characteristic narrow (FWHM $\sim$ 10 kms$^{-1}$) and broad (FWHM $\sim$ 1000 kms$^{-1}$) H$\alpha$ components. CRs affect the H$\alpha$-line parameters: heating the cold neutrals in the interstellar medium results in broadening of the narrow H$\alpha$-line width beyond 20 kms$^{-1}$, but also in reduction of the broad H$\alpha$-line width due to energy being removed from the protons in the post-shock region. For the first time we show that the width of the narrow H$\alpha$ line, much larger than 20 kms$^{-1}$, is not a resolution or geometric effect nor a spurious result of a neglected intermediate (FWHM $\sim$ 100 kms$^{-1}$) component resulting from hydrogen atoms undergoing charge exchange with warm protons in the broad-neutral precursor. Moreover, we show that a narrow line width $\gg$ 20 kms$^{-1}$ extends across the entire NE rim, implying CR acceleration is ubiquitous, and making it possible to relate its strength to locally varying shock conditions. Finally, we find several locations along the rim, where spectra are significantly better explained (based on Bayesian evidence) by inclusion of the intermediate component, with a width of 180 kms$^{-1}$ on average.Comment: Proceeding for contributed talk at the IAU Symposium No. 331: "SN 1987A, 30 years later - Cosmic Rays and Nuclei from Supernovae and their Aftermaths", 2017, La Reunion Island; References correcte

Balmer filaments in Tycho's supernova remnant: an interplay between cosmic-ray and broad-neutral precursors

We present H$\alpha$ spectroscopic observations and detailed modelling of the Balmer filaments in the supernova remnant Tycho. We used Galaxy H$\alpha$ Fabry-P\'erot Spectrometer on the William Herschel Telescope with a 3.4'$\times$3.4' field-of-view, 0.2" pixel scale and \sigma_\rm{instr}=8.1 km/s resolution at 1" seeing for $\sim10$ hours, resulting in 82 spatial-spectral bins that resolve the narrow H$\alpha$ line in the entire Tycho's northeastern rim. For the first time, we can mitigate artificial line broadening from unresolved differential motion, and probe H$\alpha$ emission parameters in varying shock and ambient medium conditions. Broad H$\alpha$ line remains unresolved within spectral coverage of 392 km/s. We employed Bayesian inference to obtain reliable parameter confidence intervals, and quantify the evidence for models with multiple line components. The median H$\alpha$ narrow-line full-width at half-maximum of all bins and models is W_\rm{NL}=(54.8\pm1.8) km/s at the $95\%$ confidence level, varying within [35, 72] km/s between bins and clearly broadened compared to the intrinsic (thermal) $\approx20$ km/s. Possible line splits are accounted for, significant in $\approx18\%$ of the filament, and presumably due to remaining projection effects. We also find wide-spread evidence for intermediate-line emission of a broad-neutral precursor, with median W_\rm{IL}=(180\pm14) km/s ($95\%$ confidence). Finally, we present a measurement of the remnant's systemic velocity, V_\rm{LSR}=-34 km/s, and map differential line-of-sight motions. Our results confirm the existence and interplay of shock precursors in Tycho's remnant. In particular, we show that suprathermal narrow-line emission is near-universal in Tycho and that, in absence of an alternative explanation, collisionless supernova remnant shocks constitute a viable acceleration source for Galactic TeV Cosmic-Ray protons.Comment: 36 pages, 17 figures, 5 tables, Paper accepted for publication in the Astrophysical Journal; References correcte

Stacked Tracking for CMS at Super-LHC

We report recent work on the design of a pixel detector for CMS at the Super-LHC. This work builds on previous studies of a tracking detector capable of providing track stubs to be used in the Level-1 Trigger (L1T). We now focus on the use of two ‘superlayers’ of tracking; each comprising a pair of pixel sensors with 50×50×50μm3 pitch (z×φ×r) separated by a few millimetres. Preliminary work on track reconstruction in Field Programmable Gate Arrays (FPGAs) is also presented

The Australian Corneal Graft Registry 2012 Report

The Australian Corneal Graft Registry (ACGR) opened in May 1985 and thus has now been in operation for over 26 years. However, the census dates for this report was 01/06/2010 for penetrating grafts and 12/10/2011 for lamellar grafts. Over the years, we have collected data on more than 23,000 corneal grafts. The majority of corneal grafts registered have been penetrating, but increasing numbers of lamellar grafts have also been registered over recent years, as patterns of surgical practice change. At registration, we seek information on the recipient, the donor, the eye bank practices and the operative procedure. Follow-up then occurs at approximately yearly intervals for an indefinite period, and ceases upon loss of the graft, or the death or loss-to-follow-up of the patient. At each round of follow-up, we request information on the graft and visual outcome, and upon relevant post-operative events and treatments. The data are entered into an Access database and checked for consistency. Descriptive, univariate and multivariate analyses are subsequently performed using SPSS and Stata software, and the report is eventually collated

Strontium isotope geochemistry of late cretaceous granodiorites, Jamaica and Haiti, greater Antilles

Initial 87Sr/86Sr ratios have been determined for a representative suite of Upper Cretaceous granodiorites and associated rocks from the Above Rocks composite stock in central Jamaica and the Terre-Neuve pluton in northwestern Haiti. The average initial 87Sr/86Sr ratio for severn samples of the Terre-Neuve intrusion is 0.7036, with a range of 0.7026-0.7047. For two samples of the Above Rocks the initial ratios are 0.7033 and 0.7034. A third sample from this intrusive has an initial ratio of 0.7084, which is tenatively attributed to contamination. The initial 87Sr/86Sr ratios indicate that neither ancient sialic crust nor sediments carried down a Benioff zone can be the primary source of the granodioritic magma. K/Rb ratios for these rocks range from 178 to 247, which are much lower than the average values (>=1000) for tholeiitic basalts. It is concluded that the magmas originated primarily by melting of downthrust oceanic crust or adjacent mantle material.Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/23675/1/0000644.pd

Intermediate- and High-Velocity Ionized Gas toward zeta Orionis

We combine UV spectra obtained with the HST/GHRS echelle, IMAPS, and Copernicus to study the abundances and physical conditions in the predominantly ionized gas seen at high (-105 to -65 km/s) and intermediate velocities (-60 to -10 km/s) toward zeta Ori. We have high resolution (FWHM ~ 3.3-4.5 km/s) and/or high S/N spectra for at least two significant ions of C, N, Al, Si, S, and Fe -- enabling accurate estimates for both the total N(H II) and the elemental depletions. C, N, and S have essentially solar relative abundances; Al, Si, and Fe appear to be depleted by about 0.8, 0.3-0.4, and 0.95 dex, respectively. While various ion ratios would be consistent with collisional ionization equilibrium (CIE) for T ~ 25,000-80,000 K, the widths of individual high-velocity absorption components indicate that T ~ 9000 K -- so the gas is not in CIE. Analysis of the C II fine-structure excitation equilibrium yields estimated densities (n_e ~ n_H ~ 0.1-0.2 cm^{-3}), thermal pressures (2 n_H T ~ 2000-4000 cm^{-3}K), and thicknesses (0.5-2.7 pc) for the individual clouds. We compare the abundances and physical properties derived for these clouds with those found for gas at similar velocities toward 23 Ori and tau CMa, and also with several models for shocked gas. While the shock models can reproduce some features of the observed line profiles and some of the observed ion ratios, there are also significant differences. The measured depletions suggest that \~10% of the Al, Si, and Fe originally locked in dust in the pre-shock medium may have been returned to the gas phase, consistent with predictions for the destruction of silicate dust in a 100 km/s shock. The near-solar gas phase abundance of carbon, however, seems inconsistent with the predicted longer time scales for the destruction of graphite grains.Comment: 50 pages, 9 figures; aastex; accepted by Ap

Laser-matter interactions in additive manufacturing of stainless steel SS316L and 13-93 bioactive glass revealed by in situ X-ray imaging

Laser-matter interactions in laser additive manufacturing (LAM) occur on short time scales (10−6–10−3 s) and have traditionally proven difficult to characterise. We investigate these interactions during LAM of stainless steel SS316L and 13-93 bioactive glass powders using a custom built LAM process replicator (LAMPR) with in situ and operando synchrotron X-ray real-time radiography. This reveals a wide range of melt track solidification phenomena as well as spatter and porosity formation. We hypothesise that the SS316L powder absorbs the laser energy at its surface while the trace elements in the 13-93 bioactive glass powder absorb and remit the infra-red radiation. Our results show that a low viscosity melt, e.g. 8 mPa s for SS316L, tends to generate spatter (diameter up to 250 μm and an average spatter velocity of 0.26 m s−1) and form a melt track by molten pool wetting. In contrast, a high viscosity melt, e.g. 2 Pa s for 13-93 bioactive glass, inhibits spatter formation by damping the Marangoni convection, forming a melt track via viscous flow. The viscous flow in 13-93 bioactive glass resists pore transport; combined with the reboil effect, this promotes pore growth during LAM, resulting in a pore size up to 600 times larger than that exhibited in the SS316L sample.Engineering and Physical Sciences Research Council (Reino Unido) | Ref. EP/I02249X/1Engineering and Physical Sciences Research Council (Reino Unido) | Ref. EP/M009688/

How to ask sensitive questions in conservation: A review of specialized questioning techniques

Tools for social research are critical for developing an understanding of conservation problems and assessing the feasibility of conservation actions. Social surveys are an essential tool frequently applied in conservation to assess both people’s behaviour and to understand its drivers. However, little attention has been given to the weaknesses and strengths of different survey tools. When topics of conservation concern are illegal or otherwise sensitive, data collected using direct questions are likely to be affected by non-response and social desirability biases, reducing their validity. These sources of bias associated with using direct questions on sensitive topics have long been recognised in the social sciences but have been poorly considered in conservation and natural resource management. We reviewed specialized questioning techniques developed in a number of disciplines specifically for investigating sensitive topics. These methods ensure respondent anonymity, increase willingness to answer, and critically, make it impossible to directly link incriminating data to an individual. We describe each method and report their main characteristics, such as data requirements, possible data outputs, availability of evidence that they can be adapted for use in illiterate communities, and summarize their main advantages and disadvantages. Recommendations for their application in conservation are given. We suggest that the conservation toolbox should be expanded by incorporating specialized questioning techniques, developed specifically to increase response accuracy. By considering the limitations of each survey technique, we will ultimately contribute to more effective evaluations of conservation interventions and more robust policy decisions

Schizotypy-Related Magnetization of Cortex in Healthy Adolescence Is Colocated With Expression of Schizophrenia-Related Genes.

BACKGROUND: Genetic risk is thought to drive clinical variation on a spectrum of schizophrenia-like traits, but the underlying changes in brain structure that mechanistically link genomic variation to schizotypal experience and behavior are unclear. METHODS: We assessed schizotypy using a self-reported questionnaire and measured magnetization transfer as a putative microstructural magnetic resonance imaging marker of intracortical myelination in 68 brain regions in 248 healthy young people (14-25 years of age). We used normative adult brain gene expression data and partial least squares analysis to find the weighted gene expression pattern that was most colocated with the cortical map of schizotypy-related magnetization. RESULTS: Magnetization was significantly correlated with schizotypy in the bilateral posterior cingulate cortex and precuneus (and for disorganized schizotypy, also in medial prefrontal cortex; all false discovery rate-corrected ps < .05), which are regions of the default mode network specialized for social and memory functions. The genes most positively weighted on the whole-genome expression map colocated with schizotypy-related magnetization were enriched for genes that were significantly downregulated in two prior case-control histological studies of brain gene expression in schizophrenia. Conversely, the most negatively weighted genes were enriched for genes that were transcriptionally upregulated in schizophrenia. Positively weighted (downregulated) genes were enriched for neuronal, specifically interneuronal, affiliations and coded a network of proteins comprising a few highly interactive "hubs" such as parvalbumin and calmodulin. CONCLUSIONS: Microstructural magnetic resonance imaging maps of intracortical magnetization can be linked to both the behavioral traits of schizotypy and prior histological data on dysregulated gene expression in schizophrenia