Negative affect, explanatory style, and stressful life events in an elementary school population

The prevalence of childhood depression is largely unknown due to widely discrepant methods, different assessment instruments, varying definitions of childhood depression, and different populations under investigation. Theoretical arguments have been made to suggest that gifted children are a population at risk for emotional and psychological disruption. Specifically, their advanced cognitive abilities are considered an emotional liability that could increase the chances of a depressive episode or even suicide. In addition, there have been theoretical articles to suggest that two correlates of depression are stressful life events and explanatory style. Students who experience more stress in their lives are more likely to be depressed, and those students who hold a pessimistic cognitive style for explaining situational events are more likely to be depressed. This present study focused on 178 students in grades 4, 5, and 6 in two elementary public schools in a large urban Canadian city. They were asked to complete three inventories that assessed their negative affect, explanatory style and stressful life events. Teachers were also asked to comment on each student by completing a rating scale of negative affect. Overall the results of the study revealed that fourth through sixth grade students reported lower levels of negative affect than reported elsewhere in the literature. Despite theoretical arguments to the contrary, gifted students scored no differently on measures of negative affect or explanatory style. There was a very significant relationship between explanatory style and negative affect and a moderate relationship between stressful life events and negative affect. Teachers were more accurate in identifying students who were not experiencing negative affect that those reporting higher levels of negative affect. Implications for future research and treatment interventions are discussed

Spin/disorder correlations and duality in the c=1/2 string

We use the method of discrete loop equations to calculate exact correlation functions of spin and disorder operators on the sphere and on the boundary of a disk in the $c = 1/2$ string, both in the Ising and dual Ising matrix model formulations. For both the Ising and dual Ising theories the results on the sphere are in agreement with the KPZ/DDK scaling predictions based on Liouville theory; the results on the disk agree with the scaling predictions of Martinec, Moore, and Seiberg for boundary operators. The calculation of Ising disorder correlations on the sphere requires the use of boundary variables introduced in [hep-th/9510199], which have no matrix model analog. A subtlety in the calculation on the disk arises because the expansions of the correlation functions have leading singular terms which are nonuniversal; we show that this issue may be resolved by using separate cosmological constants for each boundary domain. These results give evidence that the Kramers-Wannier duality symmetry of the $c = 1/2$ conformal field theory survives coupling to quantum gravity, implying a duality symmetry of the $c = 1/2$ string even in the presence of boundary operators.Comment: 19 pages, LaTeX; final publication versio

Against the Compositional View of Facts

It is commonly assumed that facts would be complex entities made out of particulars and universals. This thesis, which I call Compositionalism, holds that parthood may be construed broadly enough so that the relation that holds between a fact and the entities it ‘ties’ together counts as a kind of parthood. I argue firstly that Compositionalism is incompatible with the possibility of certain kinds of fact and universal, and, secondly, that such facts and universals are possible. I conclude that Compositionalism is false. What all these kinds of fact and universal have in common is a violation of supplementation principles governing any relation that may be intelligibly regarded as a kind of parthood. Although my arguments apply to Compositionalism generally, I focus on recent work by David Armstrong, who is a prominent and explicit Compositionalist

Measuring magnetism in the Milky Way with the Square Kilometre Array

Magnetic fields in the Milky Way are present on a wide variety of sizes and strengths, influencing many processes in the Galactic ecosystem such as star formation, gas dynamics, jets, and evolution of supernova remnants or pulsar wind nebulae. Observation methods are complex and indirect; the most used of these are a grid of rotation measures of unresolved polarized extragalactic sources, and broadband polarimetry of diffuse emission. Current studies of magnetic fields in the Milky Way reveal a global spiral magnetic field with a significant turbulent component; the limited sample of magnetic field measurements in discrete objects such as supernova remnants and HII regions shows a wide variety in field configurations; a few detections of magnetic fields in Young Stellar Object jets have been published; and the magnetic field structure in the Galactic Center is still under debate. The SKA will unravel the 3D structure and configurations of magnetic fields in the Milky Way on sub-parsec to galaxy scales, including field structure in the Galactic Center. The global configuration of the Milky Way disk magnetic field, probed through pulsar RMs, will resolve controversy about reversals in the Galactic plane. Characteristics of interstellar turbulence can be determined from the grid of background RMs. We expect to learn to understand magnetic field structures in protostellar jets, supernova remnants, and other discrete sources, due to the vast increase in sample sizes possible with the SKA. This knowledge of magnetic fields in the Milky Way will not only be crucial in understanding of the evolution and interaction of Galactic structures, but will also help to define and remove Galactic foregrounds for a multitude of extragalactic and cosmological studies.Comment: 19 pages, 2 figures; to appear as part of 'Cosmic Magnetism' in Proceedings 'Advancing Astrophysics with the SKA (AASKA14)', PoS(AASKA14)09

Analytic Detection Thresholds for Measurements of Linearly Polarized Intensity Using Rotation Measure Synthesis

A fully analytic statistical formalism does not yet exist to describe radio-wavelength measurements of linearly polarized intensity that are produced using rotation measure synthesis. In this work we extend the analytic formalism for standard linear polarization, namely that describing measurements of the quadrature sum of Stokes Q and U intensities, to the rotation measure synthesis environment. We derive the probability density function and expectation value for Faraday-space polarization measurements for both the case where true underlying polarized emission is present within unresolved Faraday components, and for the limiting case where no such emission is present. We then derive relationships to quantify the statistical significance of linear polarization measurements in terms of standard Gaussian statistics. The formalism developed in this work will be useful for setting signal-to-noise ratio detection thresholds for measurements of linear polarization, for the analysis of polarized sources potentially exhibiting multiple Faraday components, and for the development of polarization debiasing schemes.Comment: 14 pages, 6 figures, accepted for publication in MNRA

Dystrophin Gene Mutation Location and the Risk of Cognitive Impairment in Duchenne Muscular Dystrophy

Contains fulltext : 88828.pdf (publisher's version ) (Open Access)BACKGROUND: A significant component of the variation in cognitive disability that is observed in Duchenne muscular dystrophy (DMD) is known to be under genetic regulation. In this study we report correlations between standardised measures of intelligence and mutational class, mutation size, mutation location and the involvement of dystrophin isoforms. METHODS AND RESULTS: Sixty two male subjects were recruited as part of a study of the cognitive spectrum in boys with DMD conducted at the Sydney Children's Hospital (SCH). All 62 children received neuropsychological testing from a single clinical psychologist and had a defined dystrophin gene (DMD) mutation; including DMD gene deletions, duplications and DNA point mutations. Full Scale Intelligence Quotients (FSIQ) in unrelated subjects with the same mutation were found to be highly correlated (r = 0.83, p = 0.0008), in contrast to results in previous publications. In 58 cases (94%) it was possible to definitively assign a mutation as affecting one or more dystrophin isoforms. A strong association between the risk of cognitive disability and the involvement of groups of DMD isoforms was found. In particular, improvements in the correlation of FSIQ with mutation location were identified when a new classification system for mutations affecting the Dp140 isoform was implemented. SIGNIFICANCE: These data represent one of the largest studies of FSIQ and mutational data in DMD patients and is among the first to report on a DMD cohort which has had both comprehensive mutational analysis and FSIQ testing through a single referral centre. The correlation between FSIQ results with the location of the dystrophin gene mutation suggests that the risk of cognitive deficit is a result of the cumulative loss of central nervous system (CNS) expressed dystrophin isoforms, and that correct classification of isoform involvement results in improved estimates of risk

A geometric approach to free variable loop equations in discretized theories of 2D gravity

We present a self-contained analysis of theories of discrete 2D gravity coupled to matter, using geometric methods to derive equations for generating functions in terms of free (noncommuting) variables. For the class of discrete gravity theories which correspond to matrix models, our method is a generalization of the technique of Schwinger-Dyson equations and is closely related to recent work describing the master field in terms of noncommuting variables; the important differences are that we derive a single equation for the generating function using purely graphical arguments, and that the approach is applicable to a broader class of theories than those described by matrix models. Several example applications are given here, including theories of gravity coupled to a single Ising spin ($c = 1/2$), multiple Ising spins ($c = k/2$), a general class of two-matrix models which includes the Ising theory and its dual, the three-state Potts model, and a dually weighted graph model which does not admit a simple description in terms of matrix models.Comment: 40 pages, 8 figures, LaTeX; final publication versio

Cross modal perception of body size in domestic dogs (Canis familiaris)

While the perception of size-related acoustic variation in animal vocalisations is well documented, little attention has been given to how this information might be integrated with corresponding visual information. Using a cross-modal design, we tested the ability of domestic dogs to match growls resynthesised to be typical of either a large or a small dog to size- matched models. Subjects looked at the size-matched model significantly more often and for a significantly longer duration than at the incorrect model, showing that they have the ability to relate information about body size from the acoustic domain to the appropriate visual category. Our study suggests that the perceptual and cognitive mechanisms at the basis of size assessment in mammals have a multisensory nature, and calls for further investigations of the multimodal processing of size information across animal species

The Alzheimer's-related amyloid beta peptide is internalised by R28 neuroretinal cells and disrupts the microtubule associated protein 2 (MAP-2)

Age-related Macular Degeneration (AMD) is a common, irreversible blinding condition that leads to the loss of central vision. AMD has a complex aetiology with both genetic as well as environmental risks factors, and share many similarities with Alzheimer's disease. Recent findings have contributed significantly to unravelling its genetic architecture that is yet to be matched by molecular insights. Studies are made more challenging by observations that aged and AMD retinas accumulate the highly pathogenic Alzheimer's-related Amyloid beta (A?) group of peptides, for which there appears to be no clear genetic basis. Analyses of human donor and animal eyes have identified retinal A? aggregates in retinal ganglion cells (RGC), the inner nuclear layer, photoreceptors as well as the retinal pigment epithelium. A? is also a major drusen constituent; found correlated with elevated drusen-load and age, with a propensity to aggregate in retinas of advanced AMD. Despite this evidence, how such a potent driver of neurodegeneration might impair the neuroretina remains incompletely understood, and studies into this important aspect of retinopathy remains limited. In order to address this we exploited R28 rat retinal cells which due to its heterogeneous nature, offers diverse neuroretinal cell-types in which to study the molecular pathology of A?. R28 cells are also unaffected by problems associated with the commonly used RGC-5 immortalised cell-line, thus providing a well-established model in which to study dynamic A? effects at single-cell resolution. Our findings show that R28 cells express key neuronal markers calbindin, protein kinase C and the microtubule associated protein-2 (MAP-2) by confocal immunofluorescence which has not been shown before, but also calretinin which has not been reported previously. For the first time, we reveal that retinal neurons rapidly internalised A?1-42, the most cytotoxic and aggregate-prone amongst the A? family. Furthermore, exposure to physiological amounts of A?1-42 for 24 h correlated with impairment to neuronal MAP-2, a cytoskeletal protein which regulates microtubule dynamics in axons and dendrites. Disruption to MAP-2 was transient, and had recovered by 48 h, although internalised A? persisted as discrete puncta for as long as 72 h. To assess whether A? could realistically localise to living retinas to mediate such effects, we subretinally injected nanomolar levels of oligomeric A?1-42 into wildtype mice. Confocal microscopy revealed the presence of focal A? deposits in RGC, the inner nuclear and the outer plexiform layers 8 days later, recapitulating naturally-occurring patterns of A? aggregation in aged retinas. Our novel findings describe how retinal neurons internalise A? to transiently impair MAP-2 in a hitherto unreported manner. MAP-2 dysfunction is reported in AMD retinas, and is thought to be involved in remodelling and plasticity of post-mitotic neurons. Our insights suggest a molecular pathway by which this could occur in the senescent eye leading to complex diseases such as AMD