e-Science at the University of Minnesota: a collaborative approach

In 2008 the University of Minnesota Libraries formed the E-science and Data Services Collaborative (EDSC). The group was formed amid an environment of emerging initiatives related to e-science at the University, and was intended to leverage our existing expertise, such as our nationally recognized assessments of researcher behavior, to develop new capacity and engage with campus partners to support e-science and data services. We will report on the EDSC’s progress to date, including the following four areas of focus: • A Data Stewardship Report assessing requirements for support of e-science and data services, determining gaps in our capacity, and seeking out opportunities to develop necessary expertise including data curation, data preservation, data policies and virtual organizations. • A staff education program assessing the needs of libraries staff related to e-science and data services to establish a position description framework that includes E-scholarship: a potential new model for library liaison roles across campus that supports interdisciplinary and data intensive research. • In coordination with the University’s Research Cyberinfrastructure Alliance (members include the Libraries, Office of Information Technology, Office of the Vice President for Research, and Minnesota Super Computing Institute), a two-phased plan for a Web Development project that defines our core services and areas of expertise in “data services” in the context of other campus services and initiatives. • Increasing campus awareness of data management issues through the creation of a library Web site and skills-based workshop for faculty, students and researchers about data management best practices and university policies, including those that support open data initiatives

Malaxis monophyllos var. brachypoda, One-leaved Malaxis, new to the Northwest Territories, Canada

The orchid, Malaxis monophyllos var. brachypoda, is reported from Yellowknife, this being the first record for the Northwest Territories and an extension of about 650 kilometers to the northeast from the nearest population in northern British Columbia

Urban Appalachian Festival Proposal

We at COAL think that Appalachian culture has been marginalized by American urban centers and being an Appalachian American comes with many negative stereotypes. This is especially felt right here in the Franklinton neighborhood of Columbus, Ohio. We want to make an impact in the community in a way that lessens stereotypes towards Appalachian Americans and help the city of Columbus be more inclusive towards Appalachian culture. We propose to do this by organizing an Appalachian cultural festival that will both address the specific needs of Franklinton and celebrate its Appalachian roots. The specific issues we wish to address include socioeconomic instability and lack of cultural and community pride within the Franklinton and greater Columbus Area. This festival will feature local foods, music, vendors, adult beverages and education events that will promote Appalachian culture and lifestyles. This will help the residents of Columbus experience a taste of Appalachia and educate on the culture in ways that should help in reducing negative stereotypes and foster an environment of acceptance and inclusion. Strongwater Food and Spirits, a venue located in Franklinton, has already agreed to host the festival. The materials we will need financial support to cover will be the purchase the permits and police detail for the closure of the section of Lucas Street between West Town Street and West Rich Street. We will also need financial support to cover other additional festival related expenses related the festival. We need this financial support because we want this event to be as accessible as possible to the resident of Franklinton and will not be charging an entrance fee. We will only be making money on sales of beer that was donated by local breweries and vendor fees. We do not foresee these limited revenues being able to cover our numerous expenses but this festival would be absolutely beneficial in making Columbus a more inclusive community toward Appalachian Cultures and Lifestyles

Pannexin 1 regulates adipose stromal cell differentiation and fat accumulation

Pannexin 1 (Panx1) is a channel-forming glycoprotein important in paracrine signaling and cellular development. In this study, we discovered that mice globally lacking Panx1 (KO) have significantly greater total fat mass and reduced lean mass compared to wild type (WT) mice under a normal diet. Despite having higher fat content, Panx1 KO mice on a high fat diet exhibited no differences in weight gain and blood markers of obesity as compared to WT controls, except for an increase in glucose and insulin levels. However, metabolic cage data revealed that these Panx1 KO mice display significantly increased activity levels, higher ambulatory activity, and reduced sleep duration relative to their WT littermates on a high-fat diet. To uncover the cellular mechanism responsible for the increased fat content in the KO, we isolated primary cultures of adipose-derived stromal cells (ASCs) from WT and KO fat pads. In WT ASCs we observed that Panx1 protein levels increase upon induction into an adipogenic lineage. ASCs isolated from Panx1 KO mice proliferate less but demonstrate enhanced adipogenic differentiation with increased intracellular lipid accumulation, glycerol-3-phosphate dehydrogenase (GPDH) enzyme activity, and adipokine secretion, as compared to WT ASCs. This was consistent with the increased adipocyte size and decreased adipocyte numbers observed in subcutaneous fat of the Panx1 KO mice compared to WT. We concluded that Panx1 plays a key role in adipose stromal cells during the early stages of adipogenic proliferation and differentiation, regulating fat accumulation in vivo

Influence of Exercise Type on Maternal Blood Pressure Adaptation throughout Pregnancy

BACKGROUND: It has been reported that 10% of all pregnancies are complicated by a hypertensive disorder of pregnancy. Previous research has shown that moderate-vigorous intensity exercise has a positive effect on maternal resting blood pressure. A research gap, however, exists related to how different types of exercise (resistance, aerobic, combined resistance and aerobic) affect maternal blood pressure. Most of the previous studies solely focused on aerobic exercise. OBJECTIVE: The aim of this study was to examine the effects of exercise types on maternal blood pressure throughout pregnancy. STUDY DESIGN: This study employed a secondary analysis using data from a randomized controlled prenatal exercise intervention trial. This study utilized 3 exercise intervention groups (aerobic, resistance, combination) and compared the results with those of a nonexercize control group. Participants completed 3 50-minute sessions weekly from 16 weeks of gestation until delivery. Maternal vital signs and physical measurements such as systolic blood pressure, diastolic blood pressure, and heart rate were measured every 4 weeks throughout the intervention period. Between-group mean differences in maternal measurements were assessed using Pearson's chi-square tests for continuous (age, prepregnancy body mass index, heart rate, systolic blood pressure, diastolic blood pressure, pulse pressure) variables. For gravida, exact Wilcox 2-sample tests were performed to determine between-group differences in mean values. Hierarchical linear growth curves were used to estimate maternal trajectories of systolic blood pressure and diastolic blood pressure from 16 weeks to 36 weeks’ gestation in each of the 4 groups (aerobic, combination, control, and resistance). RESULTS: There were no differences among the groups in maternal age or prepregnancy body mass index. Controlling for maternal body mass index, the lowest significant systolic blood pressure curve was noted throughout the pregnancy for women who participated in resistance exercise, followed by women in the aerobic exercise group all relative to the no exercise control group. At 36 weeks’ gestation, the systolic blood pressure was lower in the resistance group by 12.17 mm Hg (P<.001) and in the aerobic group by 7.90 mm Hg (P<.001) relative to controls. No significant change in systolic blood pressure was noted in the combination group in comparison with controls at 36 weeks’ gestation. Similarly, we demonstrated a significantly lower linear growth curve in diastolic blood pressure that was maintained throughout pregnancy in any exercise type relative to controls. After controlling for maternal body mass index, all 3 exercise types (combination, resistance, and aerobic) significantly predicted a similar decrease in diastolic blood pressure that was maintained throughout pregnancy. At 36 weeks’ gestation, the diastolic blood pressure was lower in the aerobic group by 7.30 mm Hg (P<.01), in the combination group by 6.43 mm Hg (P<.05), and in the resistance group relative to controls. CONCLUSION: Overall, all exercise types were beneficial in lowering maternal resting blood pressure throughout pregnancy. Resistance training was noted to be the most beneficial in improving systolic blood pressure, followed by aerobic exercise. All 3 exercise groups were noted to improve diastolic blood pressure equally. Further research needs to be done to determine if either resistance or aerobic exercise throughout pregnancy decreases the risk for hypertensive disorders of pregnancy and the associated morbidity and mortality

KSU Choral Ensembles present Messiah with KSU Symphony Orchestra

Kennesaw State University Choral Ensembles present Messiah by George Frideric Handel with KSU Symphony Orchestra.https://digitalcommons.kennesaw.edu/musicprograms/1123/thumbnail.jp

The status of the world's land and marine mammals: diversity, threat, and knowledge

Knowledge of mammalian diversity is still surprisingly disparate, both regionally and taxonomically. Here, we present a comprehensive assessment of the conservation status and distribution of the world's mammals. Data, compiled by 1700+ experts, cover all 5487 species, including marine mammals. Global macroecological patterns are very different for land and marine species but suggest common mechanisms driving diversity and endemism across systems. Compared with land species, threat levels are higher among marine mammals, driven by different processes (accidental mortality and pollution, rather than habitat loss), and are spatially distinct (peaking in northern oceans, rather than in Southeast Asia). Marine mammals are also disproportionately poorly known. These data are made freely available to support further scientific developments and conservation action

G-CSF/anti-G-CSF antibody complexes drive the potent recovery and expansion of CD11b+Gr-1+ myeloid cells without compromising CD8+ T cell immune responses

BACKGROUND: Administration of recombinant G-CSF following cytoreductive therapy enhances the recovery of myeloid cells, minimizing the risk of opportunistic infection. Free G-CSF, however, is expensive, exhibits a short half-life, and has poor biological activity in vivo. METHODS: We evaluated whether the biological activity of G-CSF could be improved by pre-association with anti-G-CSF mAb prior to injection into mice. RESULTS: We find that the efficacy of G-CSF therapy can be enhanced more than 100-fold by pre-association of G-CSF with an anti-G-CSF monoclonal antibody (mAb). Compared with G-CSF alone, administration of G-CSF/anti-G-CSF mAb complexes induced the potent expansion of CD11b(+)Gr-1(+) myeloid cells in mice with or without concomitant cytoreductive treatment including radiation or chemotherapy. Despite driving the dramatic expansion of myeloid cells, in vivo antigen-specific CD8(+) T cell immune responses were not compromised. Furthermore, injection of G-CSF/anti-G-CSF mAb complexes heightened protective immunity to bacterial infection. As a measure of clinical value, we also found that antibody complexes improved G-CSF biological activity much more significantly than pegylation. CONCLUSIONS: Our findings provide the first evidence that antibody cytokine complexes can effectively expand myeloid cells, and furthermore, that G-CSF/anti-G-CSF mAb complexes may provide an improved method for the administration of recombinant G-CSF