1,233 research outputs found
A grid-enabled problem solving environment for parallel computational engineering design
This paper describes the development and application of a piece of engineering software that provides a problem solving environment (PSE) capable of launching, and interfacing with, computational jobs executing on remote resources on a computational grid. In particular it is demonstrated how a complex, serial, engineering optimisation code may be efficiently parallelised, grid-enabled and embedded within a PSE.
The environment is highly flexible, allowing remote users from different sites to collaborate, and permitting computational tasks to be executed in parallel across multiple grid resources, each of which may be a parallel architecture. A full working prototype has been built and successfully applied to a computationally demanding engineering optimisation problem. This particular problem stems from elastohydrodynamic lubrication and involves optimising the computational model for a lubricant based on the match between simulation results and experimentally observed data
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SRE STANDARD OPERATING PROCEDURES
General SRE operating instructions, limits, and procedures are listed. Specific operating instructions are given for the reactor, sodium heat-transfer systems, sodium service systems, service cooling system, helium system, nitrogen and dehumidification systems, vent system, liquid waste system, fuel handling machine, building ventilation systems, wash cells, emergency power system, pump coolant systems, crane operation, off-normal conditions, and special procedures. (W.D.M.
Extracellular bacterial lymphatic metastasis drives Streptococcus pyogenes systemic infection
Unassisted metastasis through the lymphatic system is a mechanism of dissemination thus far ascribed only to cancer cells. Here, we report that Streptococcus pyogenes also hijack lymphatic vessels to escape a local infection site, transiting through sequential lymph nodes and efferent lymphatic vessels to enter the bloodstream. Contrasting with previously reported mechanisms of intracellular pathogen carriage by phagocytes, we show S. pyogenes remain extracellular during transit, first in afferent and then efferent lymphatics that carry the bacteria through successive draining lymph nodes. We identify streptococcal virulence mechanisms important for bacterial lymphatic dissemination and show that metastatic streptococci within infected lymph nodes resist and subvert clearance by phagocytes, enabling replication that can seed intense bloodstream infection. The findings establish the lymphatic system as both a survival niche and conduit to the bloodstream for S. pyogenes, explaining the phenomenon of occult bacteraemia. This work provides new perspectives in streptococcal pathogenesis with implications for immunity
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Field Demonstrations of Logging Technologies for Reservoir Characterization
The Influence of the Degree of Heterogeneity on the Elastic Properties of Random Sphere Packings
The macroscopic mechanical properties of colloidal particle gels strongly
depend on the local arrangement of the powder particles. Experiments have shown
that more heterogeneous microstructures exhibit up to one order of magnitude
higher elastic properties than their more homogeneous counterparts at equal
volume fraction. In this paper, packings of spherical particles are used as
model structures to computationally investigate the elastic properties of
coagulated particle gels as a function of their degree of heterogeneity. The
discrete element model comprises a linear elastic contact law, particle bonding
and damping. The simulation parameters were calibrated using a homogeneous and
a heterogeneous microstructure originating from earlier Brownian dynamics
simulations. A systematic study of the elastic properties as a function of the
degree of heterogeneity was performed using two sets of microstructures
obtained from Brownian dynamics simulation and from the void expansion method.
Both sets cover a broad and to a large extent overlapping range of degrees of
heterogeneity. The simulations have shown that the elastic properties as a
function of the degree of heterogeneity are independent of the structure
generation algorithm and that the relation between the shear modulus and the
degree of heterogeneity can be well described by a power law. This suggests the
presence of a critical degree of heterogeneity and, therefore, a phase
transition between a phase with finite and one with zero elastic properties.Comment: 8 pages, 6 figures; Granular Matter (published online: 11. February
2012
Stress response inside perturbed particle assemblies
The effect of structural disorder on the stress response inside three
dimensional particle assemblies is studied using computer simulations of
frictionless sphere packings. Upon applying a localised, perturbative force
within the packings, the resulting {\it Green's} function response is mapped
inside the different assemblies, thus providing an explicit view as to how the
imposed perturbation is transmitted through the packing. In weakly disordered
arrays, the resulting transmission of forces is of the double-peak variety, but
with peak widths scaling linearly with distance from the source of the
perturbation. This behaviour is consistent with an anisotropic elasticity
response profile. Increasing the disorder distorts the response function until
a single-peak response is obtained for fully disordered packings consistent
with an isotropic description.Comment: 8 pages, 7 figure captions To appear in Granular Matte
Coisotropic D8-branes and Model-building
Up to now chiral type IIA vacua have been mostly based on intersecting
D6-branes wrapping special Lagrangian 3-cycles on a CY three-fold. We argue
that there are additional BPS D-branes which have so far been neglected, and
which seem to have interesting model-building features. They are coisotropic
D8-branes, in the sense of Kapustin and Orlov. The D8-branes wrap 5-dimensional
submanifolds of the CY which are trivial in homology, but contain a worldvolume
flux that induces D6-brane charge on them. This induced D6-brane charge not
only renders the D8-brane BPS, but also creates D=4 chirality when two
D8-branes intersect. We discuss in detail the case of a type IIA Z2 x Z2
orientifold, where we provide explicit examples of coisotropic D8-branes. We
study the chiral spectrum, SUSY conditions, and effective field theory of
different systems of D8-branes in this orientifold, and show how the magnetic
fluxes generate a superpotential for untwisted Kahler moduli. Finally, using
both D6-branes and coisotropic D8-branes we construct new examples of MSSM-like
type IIA vacua.Comment: 63 pages, 11 figures. Typos corrected and comments adde
Photoactivated linkage isomerism in single crystals of nickel, palladium and platinum di-nitro complexes: A photocrystallographic investigation
Granular Solid Hydrodynamics
Granular elasticity, an elasticity theory useful for calculating static
stress distribution in granular media, is generalized to the dynamic case by
including the plastic contribution of the strain. A complete hydrodynamic
theory is derived based on the hypothesis that granular medium turns
transiently elastic when deformed. This theory includes both the true and the
granular temperatures, and employs a free energy expression that encapsulates a
full jamming phase diagram, in the space spanned by pressure, shear stress,
density and granular temperature. For the special case of stationary granular
temperatures, the derived hydrodynamic theory reduces to {\em hypoplasticity},
a state-of-the-art engineering model.Comment: 42 pages 3 fi
Across-arc geochemical variations in the Southern Volcanic Zone, Chile (34.5- 38.0°S): Constraints on Mantle Wedge and Input Compositions
Crustal assimilation (e.g. Hildreth and Moorbath, 1988) and/or subduction erosion (e.g. Stern, 1991; Kay et al., 2005) are believed to control the geochemical variations along the northern portion of the Chilean Southern Volcanic Zone. In order to evaluate these hypotheses, we present a comprehensive geochemical data set (major and trace elements and O-Sr-Nd-Hf-Pb isotopes) from Holocene primarily olivine-bearing volcanic rocks across the arc between 34.5-38.0°S, including volcanic front centers from Tinguiririca to Callaqui, the rear arc centers of Infernillo Volcanic Field, Laguna del Maule and Copahue, and extending 300 km into the backarc. We also present an equivalent data set for Chile Trench sediments outboard of this profile. The volcanic arc (including volcanic front and rear arc) samples primarily range from basalt to andesite/trachyandesite, whereas the backarc rocks are low-silica alkali basalts and trachybasalts. All samples show some characteristic subduction zone trace element enrichments and depletions, but the backarc samples show the least. Backarc basalts have higher Ce/Pb, Nb/U, Nb/Zr, and Ta/Hf, and lower Ba/Nb and Ba/La, consistent with less of a slab-derived component in the backarc and, consequently, lower degrees of mantle melting. The mantle-like δ18O in olivine and plagioclase phenocrysts (volcanic arc = 4.9-5.6 and backarc = 5.0-5.4 per mil) and lack of correlation between δ18O and indices of differentiation and other isotope ratios, argue against significant crustal assimilation. Volcanic arc and backarc samples almost completely overlap in Sr and Nd isotopic composition. High precision (double-spike) Pb isotope ratios are tightly correlated, precluding significant assimilation of older sialic crust but indicating mixing between a South Atlantic Mid Ocean-Ridge Basalt (MORB) source and a slab component derived from subducted sediments and altered oceanic crust. Hf-Nd isotope ratios define separate linear arrays for the volcanic arc and backarc, neither of which trend toward subducting sediment, possibly reflecting a primarily asthenospheric mantle array for the volcanic arc and involvement of enriched Proterozoic lithospheric mantle in the backarc. We propose a quantitative mixing model between a mixed-source, slab-derived melt and a heterogeneous mantle beneath the volcanic arc. The model is consistent with local geodynamic parameters, assuming water-saturated conditions within the slab
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