Mars aerocapture using bank modulation

Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/77136/1/AIAA-2000-4424-274.pd

Spatially Resolved Images of Dust Belt(s) Around the Planet-hosting Subgiant Kappa CrB

We present Herschel spatially resolved images of the debris disc orbiting the subgiant Kappa CrB. Not only are these the first resolved images of a debris disc orbiting a subgiant, but Kappa CrB is a rare example of an intermediate mass star where a detailed study of the structure of the planetary system can be made, including both planets and planetesimal belt(s). The only way to discover planets around such stars using the radial velocity technique is to observe 'retired' A stars, which are cooler and slower rotators compared to their main-sequence counterparts. A planetary companion has already been detected orbiting the subgiant Kappa CrB, with revised parameters of m sin i = 2.1MJ and apl = 2.8AU (Johnson et al. 2008a). We present additional Keck I HIRES radial velocity measurements that provide evidence for a second planetary companion, alongside Keck II AO imaging that places an upper limit on the mass of this companion. Modelling of our Herschel images shows that the dust is broadly distributed, but cannot distinguish between a single wide belt (from 20 to 220AU) or two narrow dust belts (at around 40 and 165AU). Given the existence of a second planetary companion beyond approximately 3AU it is possible that the absence of dust within approximately 20AU is caused by dynamical depletion, although the observations are not inconsistent with depletion of these regions by collisional erosion, which occurs at higher rates closer to the star.Comment: Updated abstrac

The Complexity of Microglial Interactions With Innate and Adaptive Immune Cells in Alzheimer’s Disease

In the naïve mouse brain, microglia and astrocytes are the most abundant immune cells; however, there is a complexity of other immune cells present including monocytes, neutrophils, and lymphocytic cells, such as natural killer (NK) cells, T cells, and B cells. In Alzheimer’s disease (AD), there is high inflammation, reactive microglia, and astrocytes, leaky blood–brain barrier, the buildup of amyloid-beta (Aβ) plaques, and neurofibrillary tangles which attract infiltrating peripheral immune cells that are interacting with the resident microglia. Limited studies have analyzed how these infiltrating immune cells contribute to the neuropathology of AD and even fewer have analyzed their interactions with the resident microglia. Understanding the complexity and dynamics of how these immune cells interact in AD will be important for identifying new and novel therapeutic targets. Thus, this review will focus on discussing our current understanding of how macrophages, neutrophils, NK cells, T cells, and B cells, alongside astrocytes, are altered in AD and what this means for the disorder, as well as how these cells are affected relative to the resident microglia

Bohmian trajectories and the Path Integral Paradigm. Complexified Lagrangian Mechanics

David Bohm shown that the Schr{\"o}dinger equation, that is a "visiting card" of quantum mechanics, can be decomposed onto two equations for real functions - action and probability density. The first equation is the Hamilton-Jacobi (HJ) equation, a "visiting card" of classical mechanics, to be modified by the Bohmian quantum potential. And the second is the continuity equation. The latter can be transformed to the entropy balance equation. The Bohmian quantum potential is transformed to two Bohmian quantum correctors. The first corrector modifies kinetic energy term of the HJ equation, and the second one modifies potential energy term. Unification of the quantum HJ equation and the entropy balance equation gives complexified HJ equation containing complex kinetic and potential terms. Imaginary parts of these terms have order of smallness about the Planck constant. The Bohmian quantum corrector is indispensable term modifying the Feynman's path integral by expanding coordinates and momenta to imaginary sector.Comment: 14 pages, 3 figures, 46 references, 48 equation

Spatially resolved images of dust belt(s) around the planet-hosting subgiant κ CrB

We present Herschel spatially resolved images of the debris disc orbiting the subgiant κ Coronae Borealis (κ CrB). Not only are these the first resolved images of a debris disc orbiting a subgiant, but κ CrB is a rare example of an intermediate mass star where a detailed study of the structure of the planetary system can be made, including both planets and planetesimal belt(s). The only way to discover planets using the radial velocity technique around such stars is to observe ‘retired’ A stars, which are cooler and slower rotators compared to their main-sequence counterparts. A planetary companion has already been detected orbiting the subgiant κ CrB, with revised parameters of msin i = 2.1 M_J and a_(pl) = 2.8 au (Johnson et al. 2008). We present additional Keck I HIRES (High Resolution Echelle Spectrometer) radial velocity measurements that provide evidence for a second planetary companion, alongside Keck II adaptive optics imaging that places an upper limit on the mass of this companion. Modelling of our Herschel images shows that the dust is broadly distributed, but cannot distinguish between a single wide belt (from 20 to 220 au) or two narrow dust belts (at around 40 and 165 au). Given the existence of a second planetary companion beyond ∼3 au it is possible that the absence of dust within ∼20 au is caused by dynamical depletion, although the observations are not inconsistent with depletion of these regions by collisional erosion, which occurs at higher rates closer to the star

Resistant starch and exercise independently attenuate weight regain on a high fat diet in a rat model of obesity

<p>Abstract</p> <p>Background</p> <p>Long-term weight reduction remains elusive for many obese individuals. Resistant starch (RS) and exercise may be useful for weight maintenance. The effects of RS, with or without exercise, on weight regain was examined during relapse to obesity on a high carbohydrate, high fat (HC/HF) diet.</p> <p>Methods</p> <p>Obesity-prone rats were fed <it>ad libitum </it>for 16 weeks then weight reduced on a low fat diet to induce a 17% body weight loss (weight reduced rats). Weight reduced rats were maintained on an energy-restricted low fat diet for 18 weeks, with or without a daily bout of treadmill exercise. Rats were then allowed free access to HC/HF diet containing low (0.3%) or high (5.9%) levels of RS. Weight regain, energy balance, body composition, adipocyte cellularity, and fuel utilization were monitored as rats relapsed to obesity and surpassed their original, obese weight.</p> <p>Results</p> <p>Both RS and exercise independently attenuated weight regain by reducing the energy gap between the drive to eat and suppressed energy requirements. Exercise attenuated the deposition of lean mass during relapse, whereas its combination with RS sustained lean mass accrual as body weight returned. Early in relapse, RS lowered insulin levels and reduced the deposition of fat in subcutaneous adipose tissue. Exercise cessation at five weeks of relapse led to increased weight gain, body fat, subcutaneous adipocytes, and decreased lean mass; all detrimental consequences to overall metabolic health.</p> <p>Conclusions</p> <p>These data are the first to show the complimentary effects of dietary RS and regular exercise in countering the metabolic drive to regain weight following weight loss and suggest that exercise cessation, in the context of relapse on a HC/HF diet, may have dire metabolic consequences.</p

Obesity and Surgical Wound Healing: A Current Review

Objective. The correlation between obesity and deficient wound healing has long been established. This review examines the current literature on the mechanisms involved in obesity-related perioperative morbidity. Methods. A literature search was performed using Medline, PubMed, Cochrane Library, and Internet searches. Keywords used include obesity, wound healing, adipose healing, and bariatric and surgical complications. Results. Substantial evidence exists demonstrating that obesity is associated with a number of postoperative complications. Specifically in relation to wound healing, explanations include inherent anatomic features of adipose tissue, vascular insufficiencies, cellular and composition modifications, oxidative stress, alterations in immune mediators, and nutritional deficiencies. Most recently, advances made in the field of gene array have allowed researchers to determine a few plausible alterations and deficiencies in obese individuals that contribute to their increased risk of morbidity and mortality, especially wound complications. Conclusion. While the literature discusses how obesity may negatively affect health on various of medical fronts, there is yet to be a comprehensive study detailing all the mechanisms involved in obesity-related morbidities in their entirety. Improved knowledge and understanding of obesity-induced physiological, cellular, molecular, and chemical changes will facilitate better assessments of surgical risks and outcomes and create efficient treatment protocols for improved patient care of the obese patient population

Propuesta de virtualización de servidores con Hyper-V en el centro de datos de la Facultad de Ciencias Médicas de la UNAN-Managua

La importancia del crecimiento en la potencia de cómputo y la existencia de problemas relacionados con el uso del hardware, ha hecho de la virtualización la solución más idónea para resolver tales dificultades, dentro de sus propósitos se encuentran hacer uso eficiente de los recursos y disminuir el costo total asociado a los mismos. Este trabajo de investigación fue realizado con la finalidad de proponer una solución para la virtualización servidores. La virtualización es una tecnología que permite la creación de equipos, basados en software, que reproducen el ambiente de una máquina física en sus aspectos de CPU, memoria, almacenamiento y entrada y salida de dispositivos. Se limita a trabajar básicamente con Hyper-V con el fin de acotar y definir la solución de virtualización , debido a la numerosa cantidad de soluciones que existen actualmente, como lo son VMware, Cytrix, entre otros. El enfoque principal se encontrará relacionado principalmente a la virtualización de servidores, a la disposición de Hyper-V para trabajar en cluster y al tipo de cluster que se puede implementar. El objetivo general de este trabajo es entonces, proponer una solución para efectuar la virtualización ya manera explicativa se describe como trabaja un cluster de alta disponibilidad con Hyper-V para efectuar tareas de migración de maquinas virtuales, empleando técnicas propias que vienen incorporadas en el software, como Live Migration ó Quick Migration que facilitan de gran forma la gestión y administración del entorno virtual. También se describirá brevemente los detalles técnicos para la implementación del centro de datos, la disposición de las áreas funcionales, el diagrama de distribución y otros parámetros importantes a tenerse en cuenta para disponer de un centro de datos confiable

The International Deep Planet Survey I. The frequency of wide-orbit massive planets around A-stars

Breakthrough direct detections of planetary companions orbiting A-type stars confirm the existence of massive planets at relatively large separations, but dedicated surveys are required to estimate the frequency of similar planetary systems. To measure the first estimation of the giant exoplanetary systems frequency at large orbital separation around A-stars, we have conducted a deep-imaging survey of young (8-400 Myr), nearby (19-84 pc) A- and F-stars to search for substellar companions in the 10-300 AU range. The sample of 42 stars combines all A-stars observed in previous AO planet search surveys reported in the literature with new AO observations from VLT/NaCo and Gemini/NIRI. It represents an initial subset of the International Deep Planet Survey (IDPS) sample of stars covering M- to B-stars. The data were obtained with diffraction-limited observations in H- and Ks-band combined with angular differential imaging to suppress the speckle noise of the central stars, resulting in typical 5-sigma detection limits in magnitude difference of 12 mag at 1", 14 mag at 2" and 16 mag at 5" which is sufficient to detect massive planets. A detailed statistical analysis of the survey results is performed using Monte Carlo simulations. Considering the planet detections, we estimate the fraction of A-stars having at least one massive planet (3-14 MJup) in the range 5-320 AU to be inside 5.9-18.8% at 68% confidence, assuming a flat distribution for the mass of the planets. By comparison, the brown dwarf (15-75 MJup) frequency for the sample is 2.0-8.9% at 68% confidence in the range 5-320 AU. Assuming power law distributions for the mass and semimajor axis of the planet population, the AO data are consistent with a declining number of massive planets with increasing orbital radius which is distinct from the rising slope inferred from radial velocity (RV) surveys around evolved A-stars.Comment: 20 pages, 10 figures, 7 tables. Accepted for publication in A&