50 research outputs found

    Sugarbeet Production Under Reduced Tillage Prospects And Problems

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    A study was initiated in the fall of 1977 to obtain base line data on the applicability of reduced tillage sugarbeet production in the Red River Valley. Three reduced tillage systems were compared to a conventional system which consisted of fall plow plus secondary tillage. Results indicated warmer early spring soil temperatures, better seedling emergence, lower ground-level wind speed and no significant yield loss under reduced tillage as compared to the conventional system

    Air-ground temperature coupling and subsurface propagation of annual temperature signals

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    Borehole-based reconstructions of ground surface temperature (GST) have been widely used as indicators of paleoclimate. These reconstructions assume that heat transport within the subsurface is conductive. Climatic interpretations of GST reconstructions also assume that GST is strongly coupled to surface air temperature (SAT) on timescales of decades and longer. We examine these two assumptions using records of SAT and subsurface temperature time series from Fargo, North Dakota; Prague, Czech Republic; Cape Henlopen State Park, Delaware; and Cape Hatteras National Seashore, North Carolina. The characteristics of downward propagating annual temperature signals at each site clearly indicate that heat transport can be described as one-dimensional conduction in a homogeneous medium. Extrapolations of subsurface observations to the ground surface yield estimates of annual GST signals and allow comparisons to annual SAT signals. All annual GST signals are modestly attenuated and negligibly phase shifted relative to SAT. The four sites collectively demonstrate that differences between annual GST and SAT signals arise in both summer and winter seasons, in amounts dependent on the climatic setting of each site

    The FANCM:p.Arg658* truncating variant is associated with risk of triple-negative breast cancer

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    Breast cancer is a common disease partially caused by genetic risk factors. Germline pathogenic variants in DNA repair genes BRCA1, BRCA2, PALB2, ATM, and CHEK2 are associated with breast cancer risk. FANCM, which encodes for a DNA translocase, has been proposed as a breast cancer predisposition gene, with greater effects for the ER-negative and triple-negative breast cancer (TNBC) subtypes. We tested the three recurrent protein-truncating variants FANCM:p.Arg658*, p.Gln1701*, and p.Arg1931* for association with breast cancer risk in 67,112 cases, 53,766 controls, and 26,662 carriers of pathogenic variants of BRCA1 or BRCA2. These three variants were also studied functionally by measuring survival and chromosome fragility in FANCM (-/-) patient-derived immortalized fibroblasts treated with diepoxybutane or olaparib. We observed that FANCM:p.Arg658* was associated with increased risk of ER-negative disease and TNBC (OR = 2.44, P = 0.034 and OR = 3.79; P = 0.009, respectively). In a country-restricted analysis, we confirmed the associations detected for FANCM:p.Arg658* and found that also FANCM:p.Arg1931* was associated with ER-negative breast cancer risk (OR = 1.96; P = 0.006). The functional results indicated that all three variants were deleterious affecting cell survival and chromosome stability with FANCM:p.Arg658* causing more severe phenotypes. In conclusion, we confirmed that the two rare FANCM deleterious variants p.Arg658* and p.Arg1931* are risk factors for ER-negative and TNBC subtypes. Overall our data suggest that the effect of truncating variants on breast cancer risk may depend on their position in the gene. Cell sensitivity to olaparib exposure, identifies a possible therapeutic option to treat FANCM-associated tumors

    Measurement of the time-integrated <i>CP</i> asymmetry in <i>D</i><sup>0</sup> → <i>K <sub>S</sub></i> <sup>0</sup> <i>K <sub>S </sub></i><sup>0</sup> decays

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    A measurement of the time-integrated CPCP asymmetry in D0KS0KS0D^0\rightarrow K^0_S K^0_S decays is reported. The data correspond to an integrated luminosity of about 22 fb1^{-1} collected in 2015-2016 by the LHCb collaboration in pppp collisions at a centre-of-mass energy of 1313 TeV. The D0D^0 candidate is required to originate from a D+D0π+D^{\ast +} \rightarrow D^0 \pi^+ decay, allowing the determination of the flavour of the D0D^0 meson using the pion charge. The D0K+KD^0 \rightarrow K^{+}K^{-} decay, which has a well measured CPCP asymmetry, is used as a calibration channel. The CPCP asymmetry for D0KS0KS0D^0\rightarrow K^0_S K^0_S is measured to be \begin{equation*} \mathcal{A}^{CP}(D^0\rightarrow K^0_S K^0_S) = (4.3\pm 3.4\pm 1.0)\%, \end{equation*} where the first uncertainty is statistical and the second is systematic. This result is combined with the previous LHCb measurement at lower centre-of-mass energies to obtain \begin{equation*} \mathcal{A}^{CP}(D^0\rightarrow K^0_S K^0_S) = (2.3\pm 2.8\pm 0.9)\%. \end{equation*}Comment: All figures and tables, along with any supplementary material and additional information, are available at https://lhcbproject.web.cern.ch/lhcbproject/Publications/LHCbProjectPublic/LHCb-PAPER-2018-012.htm

    An Automatic Weather Station Network For North Dakota

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    The importance of having access to accurate weather information aids farmers in addressing potential future concerns which might arise with their crop
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