Evidence for a highly dynamic West Antarctic Ice Sheet during the Pliocene

Major ice loss in the Amundsen Sea sector of the West Antarctic Ice Sheet (WAIS) is hypothesized to have triggered ice sheet collapses during past warm periods such as those in the Pliocene. International Ocean Discovery Program (IODP) Expedition 379 recovered continuous late Miocene to Holocene sediments from a sediment drift on the continental rise, allowing assessment of sedimentation processes in response to climate cycles and trends since the late Miocene. Via seismic correlation to the shelf, we interpret massive prograding sequences that extended the outer shelf by 80 km during the Pliocene through frequent advances of grounded ice. Buried grounding zone wedges indicate prolonged periods of ice-sheet retreat, or even collapse, during an extended mid-Pliocene warm period from ∼4.2‒3.2 Ma inferred from Expedition 379 records. These results indicate that the WAIS was highly dynamic during the Pliocene and major retreat events may have occurred along the Amundsen Sea margin

Ice-Age Climate Adaptations Trap the Alpine Marmot in a State of Low Genetic Diversity.

Some species responded successfully to prehistoric changes in climate [1, 2], while others failed to adapt and became extinct [3]. The factors that determine successful climate adaptation remain poorly understood. We constructed a reference genome and studied physiological adaptations in the Alpine marmot (Marmota marmota), a large ground-dwelling squirrel exquisitely adapted to the "ice-age" climate of the Pleistocene steppe [4, 5]. Since the disappearance of this habitat, the rodent persists in large numbers in the high-altitude Alpine meadow [6, 7]. Genome and metabolome showed evidence of adaptation consistent with cold climate, affecting white adipose tissue. Conversely, however, we found that the Alpine marmot has levels of genetic variation that are among the lowest for mammals, such that deleterious mutations are less effectively purged. Our data rule out typical explanations for low diversity, such as high levels of consanguineous mating, or a very recent bottleneck. Instead, ancient demographic reconstruction revealed that genetic diversity was lost during the climate shifts of the Pleistocene and has not recovered, despite the current high population size. We attribute this slow recovery to the marmot's adaptive life history. The case of the Alpine marmot reveals a complicated relationship between climatic changes, genetic diversity, and conservation status. It shows that species of extremely low genetic diversity can be very successful and persist over thousands of years, but also that climate-adapted life history can trap a species in a persistent state of low genetic diversity.This work was supported by the Francis Crick Institute which receives its core funding from Cancer Research UK (FC001134), the UK Medical Research Council (FC001134), and the Wellcome Trust (FC001134). CB and AC are supported by the Agence Nationale de la Recherche (project ANR-13-JSV7-0005) and the Centre National de la Recherche Scientifique (CNRS), CB is supported by the Rhône-Alpes region (Grant 15.005146.01). LD is supported by Agence Nationale de la Recherche (project ANR-12-ADAP-0009). TIG is supported by a Leverhulme Early Career Fellowship (Grant ECF-2015-453) and a NERC grant (NE/N013832/1). JMG is supported by a Hertha Finberg Fellowship (FWF T703). LDR is supported by the Diabetes UK RD Lawrence Fellowship (16/0005382)

Peri-operative red blood cell transfusion in neonates and infants: NEonate and Children audiT of Anaesthesia pRactice IN Europe: A prospective European multicentre observational study

BACKGROUND: Little is known about current clinical practice concerning peri-operative red blood cell transfusion in neonates and small infants. Guidelines suggest transfusions based on haemoglobin thresholds ranging from 8.5 to 12 g dl-1, distinguishing between children from birth to day 7 (week 1), from day 8 to day 14 (week 2) or from day 15 (≥week 3) onwards. OBJECTIVE: To observe peri-operative red blood cell transfusion practice according to guidelines in relation to patient outcome. DESIGN: A multicentre observational study. SETTING: The NEonate-Children sTudy of Anaesthesia pRactice IN Europe (NECTARINE) trial recruited patients up to 60 weeks' postmenstrual age undergoing anaesthesia for surgical or diagnostic procedures from 165 centres in 31 European countries between March 2016 and January 2017. PATIENTS: The data included 5609 patients undergoing 6542 procedures. Inclusion criteria was a peri-operative red blood cell transfusion. MAIN OUTCOME MEASURES: The primary endpoint was the haemoglobin level triggering a transfusion for neonates in week 1, week 2 and week 3. Secondary endpoints were transfusion volumes, 'delta haemoglobin' (preprocedure - transfusion-triggering) and 30-day and 90-day morbidity and mortality. RESULTS: Peri-operative red blood cell transfusions were recorded during 447 procedures (6.9%). The median haemoglobin levels triggering a transfusion were 9.6 [IQR 8.7 to 10.9] g dl-1 for neonates in week 1, 9.6 [7.7 to 10.4] g dl-1 in week 2 and 8.0 [7.3 to 9.0] g dl-1 in week 3. The median transfusion volume was 17.1 [11.1 to 26.4] ml kg-1 with a median delta haemoglobin of 1.8 [0.0 to 3.6] g dl-1. Thirty-day morbidity was 47.8% with an overall mortality of 11.3%. CONCLUSIONS: Results indicate lower transfusion-triggering haemoglobin thresholds in clinical practice than suggested by current guidelines. The high morbidity and mortality of this NECTARINE sub-cohort calls for investigative action and evidence-based guidelines addressing peri-operative red blood cell transfusions strategies. TRIAL REGISTRATION: ClinicalTrials.gov, identifier: NCT02350348

Ocean – ice sheet interaction in West Antarctica: First results from core-log seismic integration in the Amundsen Sea Sector

Throughout past decades, the West Antarctic Ice Sheet (WAIS) reacted increasingly sensitive to ocean and atmospheric forcing resulting in increased ice shelf thinning, accelerated ice flow and grounding line retreat. Its future stability therefore remains to be a critical unknown in global climate projections. In order to evaluate the threat of a potential future partial or full WAIS disintegration, reliable information on past ice sheet dynamics and its interaction with oceanic processes is essential for calibrating and improving such future projections, particularly for periods in earth’s past that were warmer than present and thus may serve as analogues for projected future scenarios. However, information on past ice sheet dynamics and interaction with ocean circulation processes in the Amundsen Sea sector, a key area for understanding past and present WAIS stability, are scarce. During the International Ocean Discovery Program (IODP) Expedition 379, sediment cores covering those critical periods were recovered at two sites on the Amundsen Sea continental rise. Those nearly continuous late Miocene-Pleistocene records are located on a seismic network allowing for a regional horizon correlation and seismic sequence characterization by applying core-log seismic integration. The sediment records provide insight into a large sediment drift and further enable comparison to other Amundsen and Bellingshausen Sea drift bodies by seismic correlation. The results of the core-log seismic integration with synthetic seismogram calculation are used to correlate key seismic horizons, e.g. prominent boundaries between Miocene and Pliocene, mid-Pliocene as well as Pliocene and Pleistocene. They may further allow statements about variations in sediment deposition and transport activity related to past ice sheet dynamic

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Image1_West Antarctic Ice Sheet Dynamics in the Amundsen Sea Sector since the Late Miocene—Tying IODP Expedition 379 Results to Seismic Data.JPEG

Observations of rapid ongoing grounding line retreat, ice shelf thinning and accelerated ice flow from the West Antarctic Ice Sheet (WAIS) may forebode a possible collapse if global temperatures continue to increase. Understanding and reconstructing West Antarctic Ice Sheet dynamics in past warmer-than-present times will inform about its behavior as an analogue for future climate scenarios. International Ocean Discovery Program (IODP) Expedition 379 visited the Amundsen Sea sector of Antarctica to obtain geological records suitable for this purpose. During the expedition, cores from two drill sites at the Resolution Drift on the continental rise returned sediments whose deposition was possibly influenced by West Antarctic Ice Sheet dynamics from late Miocene to Holocene times. To examine the West Antarctic Ice Sheet dynamics, shipboard physical properties and sedimentological data are correlated with seismic data and extrapolated across the Resolution Drift via core-log-seismic integration. An interval with strongly variable physical properties, high diatom abundance and ice-rafted debris occurrence, correlating with partially high amplitude seismic reflection characteristics was identified between 4.2 and 3.2 Ma. Sedimentation during this interval is interpreted as having occurred during an extended warm period with a dynamic West Antarctic Ice Sheet in the Amundsen Sea sector. These records compare to those of other drill sites in the Ross Sea and the Bellingshausen Sea, and thus suggest an almost simultaneous occurrence of extended warm periods in all three locations.</p

Image2_West Antarctic Ice Sheet Dynamics in the Amundsen Sea Sector since the Late Miocene—Tying IODP Expedition 379 Results to Seismic Data.JPEG

Observations of rapid ongoing grounding line retreat, ice shelf thinning and accelerated ice flow from the West Antarctic Ice Sheet (WAIS) may forebode a possible collapse if global temperatures continue to increase. Understanding and reconstructing West Antarctic Ice Sheet dynamics in past warmer-than-present times will inform about its behavior as an analogue for future climate scenarios. International Ocean Discovery Program (IODP) Expedition 379 visited the Amundsen Sea sector of Antarctica to obtain geological records suitable for this purpose. During the expedition, cores from two drill sites at the Resolution Drift on the continental rise returned sediments whose deposition was possibly influenced by West Antarctic Ice Sheet dynamics from late Miocene to Holocene times. To examine the West Antarctic Ice Sheet dynamics, shipboard physical properties and sedimentological data are correlated with seismic data and extrapolated across the Resolution Drift via core-log-seismic integration. An interval with strongly variable physical properties, high diatom abundance and ice-rafted debris occurrence, correlating with partially high amplitude seismic reflection characteristics was identified between 4.2 and 3.2 Ma. Sedimentation during this interval is interpreted as having occurred during an extended warm period with a dynamic West Antarctic Ice Sheet in the Amundsen Sea sector. These records compare to those of other drill sites in the Ross Sea and the Bellingshausen Sea, and thus suggest an almost simultaneous occurrence of extended warm periods in all three locations.</p

Table1_West Antarctic Ice Sheet Dynamics in the Amundsen Sea Sector since the Late Miocene—Tying IODP Expedition 379 Results to Seismic Data.DOCX

Observations of rapid ongoing grounding line retreat, ice shelf thinning and accelerated ice flow from the West Antarctic Ice Sheet (WAIS) may forebode a possible collapse if global temperatures continue to increase. Understanding and reconstructing West Antarctic Ice Sheet dynamics in past warmer-than-present times will inform about its behavior as an analogue for future climate scenarios. International Ocean Discovery Program (IODP) Expedition 379 visited the Amundsen Sea sector of Antarctica to obtain geological records suitable for this purpose. During the expedition, cores from two drill sites at the Resolution Drift on the continental rise returned sediments whose deposition was possibly influenced by West Antarctic Ice Sheet dynamics from late Miocene to Holocene times. To examine the West Antarctic Ice Sheet dynamics, shipboard physical properties and sedimentological data are correlated with seismic data and extrapolated across the Resolution Drift via core-log-seismic integration. An interval with strongly variable physical properties, high diatom abundance and ice-rafted debris occurrence, correlating with partially high amplitude seismic reflection characteristics was identified between 4.2 and 3.2 Ma. Sedimentation during this interval is interpreted as having occurred during an extended warm period with a dynamic West Antarctic Ice Sheet in the Amundsen Sea sector. These records compare to those of other drill sites in the Ross Sea and the Bellingshausen Sea, and thus suggest an almost simultaneous occurrence of extended warm periods in all three locations.</p

Image3_West Antarctic Ice Sheet Dynamics in the Amundsen Sea Sector since the Late Miocene—Tying IODP Expedition 379 Results to Seismic Data.JPEG

Observations of rapid ongoing grounding line retreat, ice shelf thinning and accelerated ice flow from the West Antarctic Ice Sheet (WAIS) may forebode a possible collapse if global temperatures continue to increase. Understanding and reconstructing West Antarctic Ice Sheet dynamics in past warmer-than-present times will inform about its behavior as an analogue for future climate scenarios. International Ocean Discovery Program (IODP) Expedition 379 visited the Amundsen Sea sector of Antarctica to obtain geological records suitable for this purpose. During the expedition, cores from two drill sites at the Resolution Drift on the continental rise returned sediments whose deposition was possibly influenced by West Antarctic Ice Sheet dynamics from late Miocene to Holocene times. To examine the West Antarctic Ice Sheet dynamics, shipboard physical properties and sedimentological data are correlated with seismic data and extrapolated across the Resolution Drift via core-log-seismic integration. An interval with strongly variable physical properties, high diatom abundance and ice-rafted debris occurrence, correlating with partially high amplitude seismic reflection characteristics was identified between 4.2 and 3.2 Ma. Sedimentation during this interval is interpreted as having occurred during an extended warm period with a dynamic West Antarctic Ice Sheet in the Amundsen Sea sector. These records compare to those of other drill sites in the Ross Sea and the Bellingshausen Sea, and thus suggest an almost simultaneous occurrence of extended warm periods in all three locations.</p