205 research outputs found
Searching for Giant Exoplanets around M-dwarf Stars (GEMS) I: Survey Motivation
Recent discoveries of transiting giant exoplanets around M-dwarf stars
(GEMS), aided by the all-sky coverage of TESS, are starting to stretch theories
of planet formation through the core-accretion scenario. Recent upper limits on
their occurrence suggest that they decrease with lower stellar masses, with
fewer GEMS around lower-mass stars compared to solar-type. In this paper, we
discuss existing GEMS both through confirmed planets, as well as protoplanetary
disk observations, and a combination of tests to reconcile these with
theoretical predictions. We then introduce the \textit{Searching for GEMS}
survey, where we utilize multi-dimensional nonparameteric statistics to
simulate hypothetical survey scenarios to predict the required sample size of
transiting GEMS with mass measurements to robustly compare their bulk-density
with canonical hot-Jupiters orbiting FGK stars. Our Monte-Carlo simulations
predict that a robust comparison requires about 40 transiting GEMS (compared to
the existing sample of 15) with 5- mass measurements.
Furthermore, we discuss the limitations of existing occurrence estimates for
GEMS, and provide a brief description of our planned systematic search to
improve the occurrence rate estimates for GEMS.Comment: 16 pages + references, including 7 figures. Accepted in AAS Journal
Auditory brainstem measures and genotyping boost the prediction of literacy : a longitudinal study on early markers of dyslexia
Literacy acquisition is impaired in children with developmental dyslexia resulting in lifelong struggle to read and spell. Proper diagnosis is usually late and commonly achieved after structured schooling started, which causes delayed interventions. Legascreen set out to develop a preclinical screening to identify children at risk of developmental dyslexia. To this end we examined 93 preliterate German children, half of them with a family history of dyslexia and half of them without a family history. We assessed standard demographic and behavioral precursors of literacy, acquired saliva samples for genotyping, and recorded speech-evoked brainstem responses to add an objective physiological measure. Reading and spelling was assessed after two years of structured literacy instruction. Multifactorial regression analyses considering demographic information, genotypes, and auditory brainstem encoding, predicted children’s literacy skills to varying degrees. These predictions were improved by adding the standard psychometrics with a slightly higher impact on spelling compared to reading comprehension. Our findings suggest that gene-brain-behavior profiling has the potential to determine the risk of developmental dyslexia. At the same time our results imply the need for a more sophisticated assessment to fully account for the disparate cognitive profiles and the multifactorial basis of developmental dyslexia
TOI-4201: An Early M-dwarf Hosting a Massive Transiting Jupiter Stretching Theories of Core-Accretion
We confirm TOI-4201 b as a transiting Jovian mass planet orbiting an early M
dwarf discovered by the Transiting Exoplanet Survey Satellite. Using ground
based photometry and precise radial velocities from NEID and the Planet Finder
Spectrograph, we measure a planet mass of 2.59 M,
making this one of the most massive planets transiting an M-dwarf. The planet
is 0.4\% the mass of its 0.63 M host and may have a heavy
element mass comparable to the total dust mass contained in a typical Class II
disk. TOI-4201 b stretches our understanding of core-accretion during the
protoplanetary phase, and the disk mass budget, necessitating giant planet
formation to either take place much earlier in the disk lifetime, or perhaps
through alternative mechanisms like gravitational instability.Comment: To be submitted to AAS journals on 14th July 202
Searching for a Stochastic Background of Gravitational Waves with LIGO
The Laser Interferometer Gravitational-wave Observatory (LIGO) has performed
the fourth science run, S4, with significantly improved interferometer
sensitivities with respect to previous runs. Using data acquired during this
science run, we place a limit on the amplitude of a stochastic background of
gravitational waves. For a frequency independent spectrum, the new limit is
. This is currently the most sensitive
result in the frequency range 51-150 Hz, with a factor of 13 improvement over
the previous LIGO result. We discuss complementarity of the new result with
other constraints on a stochastic background of gravitational waves, and we
investigate implications of the new result for different models of this
background.Comment: 37 pages, 16 figure
Quinpramine Ameliorates Rat Experimental Autoimmune Neuritis and Redistributes MHC Class II Molecules
Activation of inflammatory cells is central to the pathogenesis of autoimmune demyelinating diseases of the peripheral nervous system. The novel chimeric compound quinpramine—generated from imipramine and quinacrine—redistributes cholesterol rich membrane domains to intracellular compartments. We studied the immunological and clinical effects of quinpramine in myelin homogenate induced Lewis rat experimental autoimmune neuritis (EAN), a model system for acute human inflammatory neuropathies, such as the Guillain-Barré syndrome. EAN animals develop paresis of all limbs due to autoimmune inflammation of peripheral nerves. Quinpramine treatment ameliorated clinical disease severity of EAN and infiltration of macrophages into peripheral nerves. It reduced expression of MHC class II molecules on antigen presenting cells and antigen specific T cell proliferation both in vitro and in vivo. Quinpramine exerted its anti-proliferatory effect on antigen presenting cells, but not on responder T cells. Our data suggest that quinpramine represents a candidate pharmaceutical for inflammatory neuropathies
On Stability and Transport of Cold Holographic Matter
We use gauge-gravity duality to study the stability of zero-temperature,
finite baryon density states of N=4 supersymmetric SU(Nc) Yang-Mills theory
coupled to a single massive fundamental-representation N=2 hypermultiplet in
the large-Nc and large-coupling limits. In particular, we study the spectrum of
mesons. The dual description is a probe D7-brane in anti-de Sitter space with a
particular configuration of worldvolume fields. The meson spectrum is dual to
the spectrum of fluctuations of worldvolume fields about that configuration. We
use a combination of analytical and numerical techniques to compute the
spectrum, including a special numerical technique designed to deal with
singular points in the fluctuations' equations of motion. Despite
circumstantial evidence that the system might be unstable, such as a finite
entropy density at zero temperature and the existence of instabilities in
similar theories, we find no evidence of any instabilities, at least for the
ranges of frequency and momenta that we consider. We discover a pole on the
imaginary frequency axis in a scalar meson two-point function, similar to the
diffusive mode in the two-point function of a conserved charge.Comment: 40 pages, 7 figure
Self-prioritization and perceptual matching: The effects of temporal construal.
Recent research has revealed that self-referential processing enhances perceptual judgments - the so-called self-prioritization effect. The extent and origin of this effect remains unknown, however. Noting the multifaceted nature of the self, here we hypothesized that temporal influences on self-construal (i.e., past/future-self continuity) may serve as an important determinant of stimulus prioritization. Specifically, as representations of the self increase in abstraction as a function of temporal distance (i.e., distance from now), self-prioritization may only emerge when stimuli are associated with the current self. The results of three experiments supported this prediction. Self-relevance only enhanced performance in a standard perceptual-matching task when stimuli (i.e., geometric shapes) were connected with the current self; representations of the self in the future (Expts. 1 & 2) and past (Expt. 3) failed to facilitate decision making. To identify the processes underlying task performance, data were interrogated using a hierarchical drift diffusion model (HDDM) approach. Results of these analyses revealed that self-prioritization was underpinned by a stimulus bias (i.e., rate of information uptake). Collectively, these findings elucidate when and how self-relevance influences decisional processing
No interactions between previously associated 2-hour glucose gene variants and physical activity or BMI on 2-hour glucose levels.
Gene-lifestyle interactions have been suggested to contribute to the development of type 2 diabetes. Glucose levels 2 h after a standard 75-g glucose challenge are used to diagnose diabetes and are associated with both genetic and lifestyle factors. However, whether these factors interact to determine 2-h glucose levels is unknown. We meta-analyzed single nucleotide polymorphism (SNP) × BMI and SNP × physical activity (PA) interaction regression models for five SNPs previously associated with 2-h glucose levels from up to 22 studies comprising 54,884 individuals without diabetes. PA levels were dichotomized, with individuals below the first quintile classified as inactive (20%) and the remainder as active (80%). BMI was considered a continuous trait. Inactive individuals had higher 2-h glucose levels than active individuals (β = 0.22 mmol/L [95% CI 0.13-0.31], P = 1.63 × 10(-6)). All SNPs were associated with 2-h glucose (β = 0.06-0.12 mmol/allele, P ≤ 1.53 × 10(-7)), but no significant interactions were found with PA (P > 0.18) or BMI (P ≥ 0.04). In this large study of gene-lifestyle interaction, we observed no interactions between genetic and lifestyle factors, both of which were associated with 2-h glucose. It is perhaps unlikely that top loci from genome-wide association studies will exhibit strong subgroup-specific effects, and may not, therefore, make the best candidates for the study of interactions
The genetics of blood pressure regulation and its target organs from association studies in 342,415 individuals
To dissect the genetic architecture of blood pressure and assess effects on target-organ damage, we analyzed 128,272 SNPs from targeted and genome-wide arrays in 201,529 individuals of European ancestry and genotypes from an additional 140,886 individuals were used for validation. We identified 66 blood pressure loci, of which 17 were novel and 15 harbored multiple distinct association signals. The 66 index SNPs were enriched for cis-regulatory elements, particularly in vascular endothelial cells, consistent with a primary role in blood pressure control through modulation of vascular tone across multiple tissues. The 66 index SNPs combined in a risk score showed comparable effects in 64,421 individuals of non-European descent. The 66-SNP blood pressure risk score was significantly associated with target-organ damage in multiple tissues, with minor effects in the kidney. Our findings expand current knowledge of blood pressure pathways and highlight tissues beyond the classic renal system in blood pressure regulation
Genome-wide association meta-analyses and fine-mapping elucidate pathways influencing albuminuria
Abstract: Increased levels of the urinary albumin-to-creatinine ratio (UACR) are associated with higher risk of kidney disease progression and cardiovascular events, but underlying mechanisms are incompletely understood. Here, we conduct trans-ethnic (n = 564,257) and European-ancestry specific meta-analyses of genome-wide association studies of UACR, including ancestry- and diabetes-specific analyses, and identify 68 UACR-associated loci. Genetic correlation analyses and risk score associations in an independent electronic medical records database (n = 192,868) reveal connections with proteinuria, hyperlipidemia, gout, and hypertension. Fine-mapping and trans-Omics analyses with gene expression in 47 tissues and plasma protein levels implicate genes potentially operating through differential expression in kidney (including TGFB1, MUC1, PRKCI, and OAF), and allow coupling of UACR associations to altered plasma OAF concentrations. Knockdown of OAF and PRKCI orthologs in Drosophila nephrocytes reduces albumin endocytosis. Silencing fly PRKCI further impairs slit diaphragm formation. These results generate a priority list of genes and pathways for translational research to reduce albuminuria
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