Rapid and Temporary Improvement of Depression and Anxiety Observed Following Niraparib Administration: A Case Report

Background: Cancer patients are disproportionately affected by generalized anxiety and major depression. For many, current treatments for these conditions are ineffective. In this case report, we present a serendipitous case of anxiety and depression improvement following administration of the poly (ADP-ribose) polymerase (PARP) inhibitor niraparib. Case presentation: A 61-year old woman with a 20-year history of mild depression developed recurrent ovarian carcinoma and was placed on niraparib for maintenance chemotherapy. With the original onset of ovarian cancer, she experienced an episode of major depression that was resolved with sertraline. After recurrence of ovarian cancer, she experienced a recurrence of major depression and a new onset of generalized anxiety that failed to completely respond to multiple medications. After beginning niraparib therapy the patient noticed a rapid resolution of the symptoms of her anxiety and depression, an effect that was limited to 10-14 days. Due to bone marrow suppression, the patient was taken off and restarted on niraparib several times. Each discontinuation of niraparib resulted in return of her depression and anxiety, while each recontinuation of niraparib resulted in an improvement in her mood and anxiety. Conclusions: This case demonstrates rapid and temporary improvement of anxiety and depression following niraparib administration. There is ample preclinical data that PARP signaling may play a role in psychiatric illness. A small amount of indirect data from clinical trials also shows that niraparib may have psychiatric benefits. Further research on PARP inhibition and its potential psychoactive effects is sorely needed

Climate Science Special Report: Fourth National Climate Assessment (NCA4), Volume I

New observations and new research have increased our understanding of past, current, and future climate change since the Third U.S. National Climate Assessment (NCA3) was published in May 2014. This Climate Science Special Report (CSSR) is designed to capture that new information and build on the existing body of science in order to summarize the current state of knowledge and provide the scientific foundation for the Fourth National Climate Assessment (NCA4)

Ocean changes – warming, stratification, circulation, acidification, and deoxygenation

1. The world’s oceans have absorbed about 93% of the excess heat caused by greenhouse gas warming since the mid-20th century, making them warmer and altering global and regional climate feedbacks. Ocean heat content has increased at all depths since the 1960s and surface waters have warmed by about 1.3° ± 0.1°F (0.7° ± 0.08°C) per century globally since 1900 to 2016. Under a high emissions scenario, a global increase in average sea surface temperature of 4.9° ± 1.3°F (2.7° ± 0.7°C) by 2100 is projected, with even higher changes in some U.S. coastal regions. (Very high confidence) 2. The potential slowing of the Atlantic Meridional Overturning Circulation (AMOC) (of which the Gulf Stream is one component)—as a result of increasing ocean heat content and freshwater driven buoyancy changes—could have dramatic climate feedbacks as the ocean absorbs less heat and CO2 from the atmosphere. This slowing would also affect the climates of North America and Europe. Any slowing documented to date cannot be directly tied to anthropogenic forcing primarily due to lack of adequate observational data and to challenges in modeling ocean circulation changes. Under a high emissions scenario (RCP8.5) in CMIP5 simulations, it is likely that the AMOC will weaken over the 21st century by 12% to 54%. (Low confidence) 3. The world’s oceans are currently absorbing more than a quarter of the CO2 emitted to the atmosphere annually from human activities, making them more acidic (very high confidence), with potential detrimental impacts to marine ecosystems. In particular, higher-latitude systems typically have a lower buffering capacity against pH change, exhibiting seasonally corrosive conditions sooner than low-latitude systems. Acidification is regionally increasing along U.S. coastal systems as a result of upwelling (for example, in the Pacific Northwest) (high confidence), changes in freshwater inputs (for example, in the Gulf of Maine) (medium confidence), and nutrient input (for example, in urbanized estuaries) (high confidence). The rate of acidification is unparalleled in at least the past 66 million years (medium confidence). Under RCP8.5, the global average surface ocean acidity is projected to increase by 100% to 150% (high confidence). 4. Increasing sea surface temperatures, rising sea levels, and changing patterns of precipitation, winds, nutrients, and ocean circulation are contributing to overall declining oxygen concentrations at intermediate depths in various ocean locations and in many coastal areas. Over the last half century, major oxygen losses have occurred in inland seas, estuaries, and in the coastal and open ocean (high confidence). Ocean oxygen levels are projected to decrease by as much as 3.5% under the RCP8.5 scenario by 2100 relative to preindustrial values (high confidence)

Ocean acidification information exchange: a community responding to ocean acidification through collaboration

Ocean and coastal acidification is a complex problem with a variety of concerned stakeholders working to understand its progression, its impacts on marine life and human communities, and how to adapt to or mitigate expected changes. The acidification community has recognized the value of a collaborative approach to addressing science, education, management, and policy responses to the issue, and individuals from the Salish Sea region have lead the nation in developing networks/working groups at a variety of geographic scales to foster this approach. The US Interagency Working Group on Ocean Acidification in collaboration with NERACOOS (Northeast Regional Association of IOOS) have launched a collaboration website to foster community interactions and advance efforts related to ocean and coastal acidification. This website provides anyone interested in acidification, from researchers and regulators to aquaculturists and resource managers, a better way to share resources, access up-to-date information, and interact across disciplines and regions. The heart of the website is interactive, self-forming “teams” that use the website’s collaboration tools to focus on specific topics. Teams can share resources via the website and engage in online discussions, and team activities will serve as a way to advance science efforts related to acidification, enhance stakeholder interactions, and share and grow knowledge. We invite those from the Salish Sea ecoregion to join this online community focused on ocean acidification, and will use this presentation to demonstrate the sites capabilities and help new users understand how the website can aid their work

Climate Science Special Report: Fourth National Climate Assessment (NCA4), Volume I

The article of record as published may be found at https://doi.org/10.7930

Marine Life 2030: Forecasting Changes to Ocean Biodiversity to Inform Decision-Making: A Critical Role for the Marine Biodiversity Observation Network (MBON)

Abstract Marine Life 2030 is a program to establish the globally coordinated system to deliver actionable, transdisciplinary knowledge of ocean life to those who need it, promoting human well-being, sustainable development, and ocean conservation (Figure 1). The diversity of marine habitats and species is fundamental for human survival. Biodiversity provides opportunities for multiple fisheries, the tourism industry, and harbor medicines and materials. The Marine Biodiversity Observation Network (MBON) is the platform to build the community of practice to implement Marine Life 2030. MBON fosters collaborations to coordinate collection, sharing, and application of biodiversity information. Benefits of joining MBON include expanded capacity to address research goals, leveraging resources and best practices; linking natural and social sciences to answer policy questions; engaging diverse and early-career researchers; and addressing issues of concern to humanity

Climate Science Special Report: Fourth National Climate Assessment (NCA4), Volume I

New observations and new research have increased our understanding of past, current, and future climate change since the Third U.S. National Climate Assessment (NCA3) was published in May 2014. This Climate Science Special Report (CSSR) is designed to capture that new information and build on the existing body of science in order to summarize the current state of knowledge and provide the scientific foundation for the Fourth National Climate Assessment (NCA4).</p