Last one over the wall: the Massachusetts experiment in closing reform schools

(print) xxi, 279 p. ; 23 cm2nd editionPreface to the second edition -- Preface -- Acknowledgments -- I. Going to Massachusetts -- 1. Juvenile justice rhetoric. p.3 -- 2. A preview of deinstitutionalization. p.16 -- 3. Background. p.23 -- 4. The invitation. p.32 -- 5. Punishment vs. restoration. p.43 -- II. A brief tour -- 6. Waiting rooms. p.55 -- 7. Warehouses. p.61 -- III. Reforming reform schools -- 8. Finding a direction. p.83 -- 9. Reverberations. p.108 -- 10. Anticipating the worst. p.117 -- 11. Doing least harm: humane institutions. p.132 -- IV. The alternative system -- 12. Deinstitutionalization. p.153 -- 13. Community-based alternatives. p.177 -- 14. The myth of "violent" teenagers. p.191 -- 15. Side effects: the county training schools. p.199 -- 16. Backlash. p.204 -- 17. Results: after almost all is said and done. p.218 -- V. Ponderings on criminals and criminologists -- 18. Of psychopaths and allopaths. p.229 -- 19. In search of aliens. p.240 -- Notes -- Bibliography -- Index

Mapping the Electromagnetic Near-Field Enhancements of Gold Nanocubes

International audienceWe imaged and quantitatively characterized electromagnetic hot spots near the surfaces of plasmon resonant gold nanocubes. The strongest fields are localized at the nanocube corners as compared to those on the sides. The near-field enhancement on the surface of the cube was imaged as a function of incident polarization, leading to information on the localization of fields on specific regions on the surface. We found that the field intensity drops dramatically when the nanocube corner is slightly tilted with respect to the incident laser polarization. This dramatic dependence on angle was verified by electrodynamics simulations. These results will enable the use of gold nanocubes in field enhancement applications and refractive-index sensing

Favorable Climate Change Response Explains Non-Native Species' Success in Thoreau's Woods

Invasive species have tremendous detrimental ecological and economic impacts. Climate change may exacerbate species invasions across communities if non-native species are better able to respond to climate changes than native species. Recent evidence indicates that species that respond to climate change by adjusting their phenology (i.e., the timing of seasonal activities, such as flowering) have historically increased in abundance. The extent to which non-native species success is similarly linked to a favorable climate change response, however, remains untested. We analyzed a dataset initiated by the conservationist Henry David Thoreau that documents the long-term phenological response of native and non-native plant species over the last 150 years from Concord, Massachusetts (USA). Our results demonstrate that non-native species, and invasive species in particular, have been far better able to respond to recent climate change by adjusting their flowering time. This demonstrates that climate change has likely played, and may continue to play, an important role in facilitating non-native species naturalization and invasion at the community level

Chandra Detections of Two Quiescent Black Hole X-Ray Transients

Using the Chandra X-ray Observatory, we have detected the black hole transients V4641 Sgr and XTE J1859+226 in their low luminosity, quiescent states. The 0.3-8 keV luminosities are (4.0^(+3.3)_(-2.4))E31 (d/7 kpc)^2 erg/s and (4.2^(+4.8)_(-2.2))E31 (d/11 kpc)^2 erg/s for V4641 Sgr and XTE J1859+226, respectively. With the addition of these 2 systems, 14 out of the 15 transients with confirmed black holes (via compact object mass measurements) now have measured quiescent luminosities or sensitive upper limits. The only exception is GRS 1915+105, which has not been in quiescence since its discovery in 1992. The luminosities for V4641 Sgr and XTE J1859+226 are consistent with the median luminosity of 2E31 erg/s for the systems with previous detections. Our analysis suggests that the quiescent X-ray spectrum of V4641 Sgr is harder than for the other systems in this group, but, due to the low statistical quality of the spectrum, it is not clear if V4641 Sgr is intrinsically hard or if the column density is higher than the interstellar value. Focusing on V4641 Sgr, we compare our results to theoretical models for X-ray emission from black holes in quiescence. Also, we obtain precise X-ray positions for V4641 Sgr and XTE J1859+226 via cross-correlation of the X-ray sources detected near our targets with IR sources in the 2 Micron All-Sky Survey catalog.Comment: 4 pages, Accepted by ApJ Letter

K-shell ionization of elements Ca to Zn for 0.5 to 2.5-MeV/amu 14N-ion bombardment

Article discussing K-shell ionization elements Ca to Zn for 0.5 to 2.5-MeV/amu 14N-ion bombardment

Large-scale genome-wide association studies and meta-analyses of longitudinal change in adult lung function.

BACKGROUND: Genome-wide association studies (GWAS) have identified numerous loci influencing cross-sectional lung function, but less is known about genes influencing longitudinal change in lung function. METHODS: We performed GWAS of the rate of change in forced expiratory volume in the first second (FEV1) in 14 longitudinal, population-based cohort studies comprising 27,249 adults of European ancestry using linear mixed effects model and combined cohort-specific results using fixed effect meta-analysis to identify novel genetic loci associated with longitudinal change in lung function. Gene expression analyses were subsequently performed for identified genetic loci. As a secondary aim, we estimated the mean rate of decline in FEV1 by smoking pattern, irrespective of genotypes, across these 14 studies using meta-analysis. RESULTS: The overall meta-analysis produced suggestive evidence for association at the novel IL16/STARD5/TMC3 locus on chromosome 15 (P  =  5.71 × 10(-7)). In addition, meta-analysis using the five cohorts with ≥3 FEV1 measurements per participant identified the novel ME3 locus on chromosome 11 (P  =  2.18 × 10(-8)) at genome-wide significance. Neither locus was associated with FEV1 decline in two additional cohort studies. We confirmed gene expression of IL16, STARD5, and ME3 in multiple lung tissues. Publicly available microarray data confirmed differential expression of all three genes in lung samples from COPD patients compared with controls. Irrespective of genotypes, the combined estimate for FEV1 decline was 26.9, 29.2 and 35.7 mL/year in never, former, and persistent smokers, respectively. CONCLUSIONS: In this large-scale GWAS, we identified two novel genetic loci in association with the rate of change in FEV1 that harbor candidate genes with biologically plausible functional links to lung function

Panton-Valentine Leukocidin Does Play a Role in the Early Stage of Staphylococcus aureus Skin Infections: A Rabbit Model

Despite epidemiological data linking necrotizing skin infections with the production of Panton-Valentine leukocidin (PVL), the contribution of this toxin to the virulence of S. aureus has been highly discussed as a result of inconclusive results of in vivo studies. However, the majority of these results originate from experiments using mice, an animal species which neutrophils - the major target cells for PVL - are highly insensitive to the action of this leukocidin. In contrast, the rabbit neutrophils have been shown to be as sensitive to PVL action as human cells, making the rabbit a better experimental animal to explore the PVL role. In this study we examined whether PVL contributes to S. aureus pathogenicity by means of a rabbit skin infection model. The rabbits were injected intradermally with 108 cfu of either a PVL positive community-associated methicillin-resistant S. aureus isolate, its isogenic PVL knockout or a PVL complemented knockout strain, and the development of skin lesions was observed. While all strains induced skin infection, the wild type strain produced larger lesions and a higher degree of skin necrosis compared to the PVL knockout strain in the first week after the infection. The PVL expression in the rabbits was indirectly confirmed by a raise in the serum titer of anti-LukS-PV antibodies observed only in the rabbits infected with PVL positive strains. These results indicate that the rabbit model is more suitable for studying the role of PVL in staphylococcal diseases than other animal models. Further, they support the epidemiological link between PVL producing S. aureus strains and necrotizing skin infections

Quantum state preparation and macroscopic entanglement in gravitational-wave detectors

Long-baseline laser-interferometer gravitational-wave detectors are operating at a factor of 10 (in amplitude) above the standard quantum limit (SQL) within a broad frequency band. Such a low classical noise budget has already allowed the creation of a controlled 2.7 kg macroscopic oscillator with an effective eigenfrequency of 150 Hz and an occupation number of 200. This result, along with the prospect for further improvements, heralds the new possibility of experimentally probing macroscopic quantum mechanics (MQM) - quantum mechanical behavior of objects in the realm of everyday experience - using gravitational-wave detectors. In this paper, we provide the mathematical foundation for the first step of a MQM experiment: the preparation of a macroscopic test mass into a nearly minimum-Heisenberg-limited Gaussian quantum state, which is possible if the interferometer's classical noise beats the SQL in a broad frequency band. Our formalism, based on Wiener filtering, allows a straightforward conversion from the classical noise budget of a laser interferometer, in terms of noise spectra, into the strategy for quantum state preparation, and the quality of the prepared state. Using this formalism, we consider how Gaussian entanglement can be built among two macroscopic test masses, and the performance of the planned Advanced LIGO interferometers in quantum-state preparation