391 research outputs found
Buprenorphine and its formulations: a comprehensive review.
Buprenorphine, a novel long-acting analgesic, was developed with the intention of two purposes: analgesia and opioid use disorder. Regarding its pharmacodynamics, it is a partial agonist at mu receptors, an inverse agonist at kappa receptors, and an antagonist at delta receptors. For the purpose of analgesia, three formulations of buprenorphine were developed: IV/IM injectable formulation (Buprenex®), transdermal patch formulation (Butrans®), and buccal film formulation (Belbuca®). Related to opioid dependence, the formulations developed were subcutaneous extended release (Sublocade®), subdermal implant (Probuphine®), and sublingual tablets (Subutex®). Lastly, in order to avoid misuse of buprenorphine for opioid dependence, two combination formulations paired with naloxone were developed: film formulation (Suboxone®) and tablet formulation (Zubsolv®). In this review, we present details of each formulation along with their similarities and differences between each other and clinical considerations
Recent Developments in Fiber Genomics of Tetraploid Cotton Species
Cotton (Gossypium spp.) produces naturally soft, single-celled trichomes as fiber on the seed coat supplying the main source of natural raw material for the textile industry. It is economically considered as one of the most leading cash crops in the world and evolutionarily very important as a model system for detailed scientific investigations. Cotton production is going through a big transition stage such as losing the market share in competition with the synthetic fibers, high popularity of Bt and herbicide resistance genes in cotton cultivars, and the recent shift of fiber demands to meet the standard fiber quality due to change of textile technologies to produce high superior quality of fibers in the global market. Recently, next-generation sequencing technologies through high-throughput sequencing at greatly reduced costs provided opportunities to sequence the diploid and tetraploid cotton genomes. With the availability of large volume of literatures on molecular mapping, new genomic resources, characterization of cotton genomes, discoveries of many novel genes, regulatory elements including small and microRNAs and new genetic tools such as gene silencing or gene editing technique for genome manipulation, this report attempted to provide the readers a comprehensive review on the recent advances of cotton fiber genomics research
Kepler-68: Three Planets, One With a Density Between That of Earth and Ice Giants
NASA's Kepler Mission has revealed two transiting planets orbiting Kepler-68.
Follow-up Doppler measurements have established the mass of the innermost
planet and revealed a third jovian-mass planet orbiting beyond the two
transiting planets. Kepler-68b, in a 5.4 day orbit has mass 8.3 +/- 2.3 Earth,
radius 2.31 +/- 0.07 Earth radii, and a density of 3.32 +/- 0.92 (cgs), giving
Kepler-68b a density intermediate between that of the ice giants and Earth.
Kepler-68c is Earth-sized with a radius of 0.953 Earth and transits on a 9.6
day orbit; validation of Kepler-68c posed unique challenges. Kepler-68d has an
orbital period of 580 +/- 15 days and minimum mass of Msin(i) = 0.947 Jupiter.
Power spectra of the Kepler photometry at 1-minute cadence exhibit a rich and
strong set of asteroseismic pulsation modes enabling detailed analysis of the
stellar interior. Spectroscopy of the star coupled with asteroseismic modeling
of the multiple pulsation modes yield precise measurements of stellar
properties, notably Teff = 5793 +/- 74 K, M = 1.079 +/- 0.051 Msun, R = 1.243
+/- 0.019 Rsun, and density 0.7903 +/- 0.0054 (cgs), all measured with
fractional uncertainties of only a few percent. Models of Kepler-68b suggest it
is likely composed of rock and water, or has a H and He envelope to yield its
density of about 3 (cgs).Comment: 32 pages, 13 figures, Accepted to Ap
Kepler-21b: A 1.6REarth Planet Transiting the Bright Oscillating F Subgiant Star HD 179070
We present Kepler observations of the bright (V=8.3), oscillating star HD
179070. The observations show transit-like events which reveal that the star is
orbited every 2.8 days by a small, 1.6 R_Earth object. Seismic studies of HD
179070 using short cadence Kepler observations show that HD 179070 has a
frequencypower spectrum consistent with solar-like oscillations that are
acoustic p-modes. Asteroseismic analysis provides robust values for the mass
and radius of HD 179070, 1.34{\pm}0.06 M{\circ} and 1.86{\pm}0.04 R{\circ}
respectively, as well as yielding an age of 2.84{\pm}0.34 Gyr for this F5
subgiant. Together with ground-based follow-up observations, analysis of the
Kepler light curves and image data, and blend scenario models, we
conservatively show at the >99.7% confidence level (3{\sigma}) that the transit
event is caused by a 1.64{\pm}0.04 R_Earth exoplanet in a 2.785755{\pm}0.000032
day orbit. The exoplanet is only 0.04 AU away from the star and our
spectroscopic observations provide an upper limit to its mass of ~10 M_Earth
(2-{\sigma}). HD 179070 is the brightest exoplanet host star yet discovered by
Kepler.Comment: Accepted to Ap
Chitin recognition via chitotriosidase promotes pathologic type-2 helper T cell responses to cryptococcal infection
Pulmonary mycoses are often associated with type-2 helper T (Th2) cell responses. However, mechanisms of Th2 cell accumulation are multifactorial and incompletely known. To investigate Th2 cell responses to pulmonary fungal infection, we developed a peptide-MHCII tetramer to track antigen-specific CD4+ T cells produced in response to infection with the fungal pathogen Cryptococcus neoformans. We noted massive accruement of pathologic cryptococcal antigen-specific Th2 cells in the lungs following infection that was coordinated by lung-resident CD11b+ IRF4-dependent conventional dendritic cells. Other researchers have demonstrated that this dendritic cell subset is also capable of priming protective Th17 cell responses to another pulmonary fungal infection, Aspergillus fumigatus. Thus, higher order detection of specific features of fungal infection by these dendritic cells must direct Th2 cell lineage commitment. Since chitin-containing parasites commonly elicit Th2 responses, we hypothesized that recognition of fungal chitin is an important determinant of Th2 cell-mediated mycosis. Using C. neoformans mutants or purified chitin, we found that chitin abundance impacted Th2 cell accumulation and disease. Importantly, we determined Th2 cell induction depended on cleavage of chitin via the mammalian chitinase, chitotriosidase, an enzyme that was also prevalent in humans experiencing overt cryptococcosis. The data presented herein offers a new perspective on fungal disease susceptibility, whereby chitin recognition via chitotriosidase leads to the initiation of harmful Th2 cell differentiation by CD11b+ conventional dendritic cells in response to pulmonary fungal infection
Barrett's esophagus: prevalence–incidence and etiology–origins
Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/86957/1/j.1749-6632.2011.06042.x.pd
Planet Occurrence within 0.25 AU of Solar-type Stars from Kepler
We report the distribution of planets as a function of planet radius (R_p),
orbital period (P), and stellar effective temperature (Teff) for P < 50 day
orbits around GK stars. These results are based on the 1,235 planets (formally
"planet candidates") from the Kepler mission that include a nearly complete set
of detected planets as small as 2 Earth radii (Re). For each of the 156,000
target stars we assess the detectability of planets as a function of R_p and P.
We also correct for the geometric probability of transit, R*/a. We consider
first stars within the "solar subset" having Teff = 4100-6100 K, logg =
4.0-4.9, and Kepler magnitude Kp < 15 mag. We include only those stars having
noise low enough to permit detection of planets down to 2 Re. We count planets
in small domains of R_p and P and divide by the included target stars to
calculate planet occurrence in each domain. Occurrence of planets varies by
more than three orders of magnitude and increases substantially down to the
smallest radius (2 Re) and out to the longest orbital period (50 days, ~0.25
AU) in our study. For P < 50 days, the radius distribution is given by a power
law, df/dlogR= k R^\alpha. This rapid increase in planet occurrence with
decreasing planet size agrees with core-accretion, but disagrees with
population synthesis models. We fit occurrence as a function of P to a power
law model with an exponential cutoff below a critical period P_0. For smaller
planets, P_0 has larger values, suggesting that the "parking distance" for
migrating planets moves outward with decreasing planet size. We also measured
planet occurrence over Teff = 3600-7100 K, spanning M0 to F2 dwarfs. The
occurrence of 2-4 Re planets in the Kepler field increases with decreasing
Teff, making these small planets seven times more abundant around cool stars
than the hottest stars in our sample. [abridged]Comment: Submitted to ApJ, 22 pages, 10 figure
NGTS clusters survey -- II. White-light flares from the youngest stars in Orion
We present the detection of high energy white-light flares from pre-main
sequence stars associated with the Orion complex, observed as part of the Next
Generation Transit Survey (NGTS). With energies up to erg
these flares are some of the most energetic white-light flare events seen to
date. We have used the NGTS observations of flaring and non-flaring stars to
measure the average flare occurrence rate for 4 Myr M0-M3 stars. We have also
combined our results with those from previous studies to predict average rates
for flares above ergs for early M stars in nearby young
associations.STFC ST/M001962/1; ST/P000495/
Comment on Spracklandus Hoser, 2009 (Reptilia, Serpentes, ELAPIDAE): request for confirmation of the availability of the generic name and for the nomenclatural validation of the journal in which it was published (Case 3601; see BZN 70: 234–237; 71: 30–38, 133–135, 181–182, 252–253)
Planetary Candidates Observed by Kepler, III: Analysis of the First 16 Months of Data
New transiting planet candidates are identified in sixteen months (May 2009 -
September 2010) of data from the Kepler spacecraft. Nearly five thousand
periodic transit-like signals are vetted against astrophysical and instrumental
false positives yielding 1,091 viable new planet candidates, bringing the total
count up to over 2,300. Improved vetting metrics are employed, contributing to
higher catalog reliability. Most notable is the noise-weighted robust averaging
of multi-quarter photo-center offsets derived from difference image analysis
which identifies likely background eclipsing binaries. Twenty-two months of
photometry are used for the purpose of characterizing each of the new
candidates. Ephemerides (transit epoch, T_0, and orbital period, P) are
tabulated as well as the products of light curve modeling: reduced radius
(Rp/R*), reduced semi-major axis (d/R*), and impact parameter (b). The largest
fractional increases are seen for the smallest planet candidates (197% for
candidates smaller than 2Re compared to 52% for candidates larger than 2Re) and
those at longer orbital periods (123% for candidates outside of 50-day orbits
versus 85% for candidates inside of 50-day orbits). The gains are larger than
expected from increasing the observing window from thirteen months (Quarter 1--
Quarter 5) to sixteen months (Quarter 1 -- Quarter 6). This demonstrates the
benefit of continued development of pipeline analysis software. The fraction of
all host stars with multiple candidates has grown from 17% to 20%, and the
paucity of short-period giant planets in multiple systems is still evident. The
progression toward smaller planets at longer orbital periods with each new
catalog release suggests that Earth-size planets in the Habitable Zone are
forthcoming if, indeed, such planets are abundant.Comment: Submitted to ApJS. Machine-readable tables are available at
http://kepler.nasa.gov, http://archive.stsci.edu/kepler/results.html, and the
NASA Exoplanet Archiv
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