378 research outputs found
Solution of the radiative transfer equation in an absorbing and scattering Nd:YAG laser-induced plume
International audienc
Dissolved barium in the Southern Ocean: conservative vs. non-conservative behaviour as constrained by a multiple end-member mixing model
Modeling the Nd isotopic composition in the North Atlantic basin using an eddy-permitting model
International audienceBoundary Exchange (BE â exchange of elementsbetween continental margins and the open ocean) hasbeen emphasized as a key process in the oceanic cycle ofneodymium (Nd) (Lacan and Jeandel, 2005a). Here, we usea regional eddy-permitting resolution Ocean General CirculationModel (1/4) of the North Atlantic basin to simulatethe distribution of the Nd isotopic composition, consideringBE as the only source. Results show good agreementwith the data, confirming previous results obtained using thesame parameterization of the source in a coarse resolutionglobal model (Arsouze et al., 2007), and therefore the majorcontrol played by the BE processes in the Nd cycle onthe regional scale. We quantified the exchange rate of theBE, and found that the time needed for the continental marginsto significantly imprint the chemical composition of thesurrounding seawater (further referred as characteristic exchangetime) is of the order of 0.2 years. However, thetimescale of the BE may be subject to large variations as avery short exchange time (a few days) is needed to reproducethe highly negative values of surface waters in the LabradorSea, whereas a longer one (up to 0.5 years) is required tosimulate the radiogenic influence of basaltic margins and distinguishthe negative isotopic signatures of North AtlanticDeep Water from the more radiogenic southern origin watermasses. This likely represents geographical variations inerosion fluxes and the subsequent particle load onto the continentalmargins. Although the parameterization of the BEis the same in both configurations of the model, the characteristicexchange time in the eddy-permitting configuration issignificantly lower than the previous evaluations using a lowresolution configuration (6 months to 10 years), but howeverin agreement with the available seawater Nd isotope data.This results highlights the importance of the model dynamicsin simulating the BE proces
A modeling sensitivity study of the influence of the Atlantic meridional overturning circulation on neodymium isotopic composition at the Last Glacial Maximum
Using a simple parameterisation that resolves the first order global Nd isotopic composition (hereafter expressed as &epsilon;<sub>Nd</sub> in an Ocean Global Circulation Model, we have tested the impact of different circulation scenarios on the &epsilon;<sub>Nd</sub> in the Atlantic for the Last Glacial Maximum (LGM), relative to a modern control run. Three different LGM freshwater forcing experiments are performed to test for variability in the &epsilon;<sub>Nd</sub> oceanic distribution as a function of ocean circulation. Highly distinct representations of the ocean circulation are generated in the three simulations, which drive significant differences in &epsilon;<sub>Nd</sub>, particularly in deep waters of the western part of the basin. However, at the LGM, the Atlantic is more radiogenic than in the modern control run, particularly in the Labrador basin and in the Southern Ocean. A fourth experiment shows that changes in Nd sources and bathymetry drive a shift in the &epsilon;<sub>Nd</sub> signature of the basin that is sufficient to explain the changes in the &epsilon;<sub>Nd</sub> signature of the northern end-member (NADW or GNAIW glacial equivalent) in our LGM simulations. All three of our LGM circulation scenarios show good agreement with the existing intermediate depth &epsilon;<sub>Nd</sub> paleo-data. This study cannot indicate the likelihood of a given LGM oceanic circulation scenario, even if simulations with a prominent water mass of southern origin provide the most conclusive results. Instead, our modeling results highlight the need for more data from deep and bottom waters from western Atlantic, where the &epsilon;<sub>Nd</sub> change in the three LGM scenarios is the most important (up to 3 &epsilon;<sub>Nd</sub>. This would also aid more precise conclusions concerning the evolution of the northern end-member &epsilon;<sub>Nd</sub> signature, and thus the potential use of &epsilon;<sub>Nd</sub> as a tracer of past oceanic circulation
Quantum computation with devices whose contents are never read
In classical computation, a "write-only memory" (WOM) is little more than an
oxymoron, and the addition of WOM to a (deterministic or probabilistic)
classical computer brings no advantage. We prove that quantum computers that
are augmented with WOM can solve problems that neither a classical computer
with WOM nor a quantum computer without WOM can solve, when all other resource
bounds are equal. We focus on realtime quantum finite automata, and examine the
increase in their power effected by the addition of WOMs with different access
modes and capacities. Some problems that are unsolvable by two-way
probabilistic Turing machines using sublogarithmic amounts of read/write memory
are shown to be solvable by these enhanced automata.Comment: 32 pages, a preliminary version of this work was presented in the 9th
International Conference on Unconventional Computation (UC2010
Coastal Ocean and Shelf-Sea Biogeochemical Cycling of Trace Elements and Isotopes: Lessons Learned from GEOTRACES
Continental shelves and shelf seas play a central role in the global carbon cycle. However, their importance with respect to trace element and isotope (TEI) inputs to ocean basins is less well understood. Here, we present major findings on shelf TEI biogeochemistry from the GEOTRACES programme as well as a proof of concept for a new method to estimate shelf TEI fluxes. The case studies focus on advances in our understanding of TEI cycling in the Arctic, transformations within a major river estuary (Amazon), shelf sediment micronutrient fluxes and basin-scale estimates of submarine groundwater discharge. The proposed shelf flux tracer is 228-radium (T1/2 = 5.75 yr), which is continuously supplied to the shelf from coastal aquifers, sediment porewater exchange and rivers. Model-derived shelf 228Ra fluxes are combined with TEI/ 228Ra ratios to quantify ocean TEI fluxes from the western North Atlantic margin. The results from this new approach agree well with previous estimates for shelf Co, Fe, Mn and Zn inputs and exceed published estimates of atmospheric deposition by factors of approximately 3-23. Lastly, recommendations are made for additional GEOTRACES process studies and coastal margin-focused section cruises that will help refine the model and provide better insight on the mechanisms driving shelf-derived TEI fluxes to the ocean.This article is part of the themed issue \u27Biological and climatic impacts of ocean trace element chemistry\u27
Paleogene deepwater mass composition of the tropical Pacific and implications for thermohaline circulation in a greenhouse world
Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/94621/1/ggge1162.pd
Rapid cognitive decline, one-year institutional admission and one-year mortality: Analysis of the ability to predict and inter-tool agreement of four validated clinical frailty indexes in the safes cohort
Objectives: To evaluate the predictive ability of four clinical frailty indexes as regards one-year rapid cognitive decline (RCD â defined as the loss of at least 3 points on the MMSE score), and one-year institutional admission (IA) and mortality respectively; and to measure their agreement for identifying groups at risk of these severe outcomes. Design: One-year follow-up and multicentre study of old patients participating in the SAFEs cohort study. Setting: Nine university hospitals in France. Participants: 1,306 patients aged 75 or older (mean age 85±6 years; 65% female) hospitalized in medical divisions through an Emergency department. Measurements: Four frailty indexes (Winograd; Rockwood; Donini; and Schoevaerdts) reflecting the multidimensionality of the frailty concept, using an ordinal scoring system able to discriminate different grades of frailty, and constructed based on the accumulation of identified deficits after comprehensive geriatric assessment conducted during the first week of hospital stay, were used to categorize participants into three different grades of frailty: Gl â not frail; G2 â moderately frail; and G3 â severely frail. Comparisons between groups were performed using Fisher's exact test. Agreement between indexes was evaluated using Cohen's Kappa coefficient. Results: All patients were classified as frail by at least one of the four indexes. The Winograd and Rockwood indexes mainly classified subjects as G2 (85% and 96%), and the Donini and Schoevaerdts indexes mainly as G3 (71% and 67%). Among the SAFEs cohort population, 250, 1047 and 1,306 subjects were eligible for analyses of predictability for RCD, 1-year IA and 1-year mortality respectively. At 1 year, 84 subjects (34%) experienced RCD, 377 (36%) were admitted into an institutional setting, and 445 (34%) had died With the Rockwood index, all subjects who expenenced RCD were classified in G2; and in G2 and G3 when the Donini and Schoevaerdts indexes were used No significant difference was found between frailty grade and RCD, whereas frailty grade was significantly associated with an increased risk of IA and death, whatever the frailty index considered. Agreement between the different indexes of frailty was poor with Kappa coefficients ranging from â0.02 to 0.15. Conclusion: These findings confirm the poor clinimetric properties of these current indexes to measure frailty, underlining the fact that further work is needed to develop a better and more widely-accepted definition of frailty and therefore a better understanding of its pathophysiolog
Abnormal T-cell phenotype in episodic angioedema with hypereosinophilia (Gleich's syndrome): frequency, clinical implication and prognosis
BACKGROUND: Episodic Angioedema with eosinophilia (EAE, Gleich\u27s syndrome) is a rare disorder consisting of recurrent episodes of angioedema, hypereosinophilia and frequent elevated serum Immunoglobin M.
METHODS: We conducted a retrospective multicenter nationwide study regarding the clinical spectrum and therapeutic management of patients with EAE in France.
RESULTS: Thirty patients were included with a median age at diagnosis of 41 years [5-84]. The median duration of each crisis was 5.5 days [1-90] with swelling affecting mainly the face and the upper limbs. Total serum IgM levels were increased in 20 patients (67%). Abnormal T-cell immunophenotypes were detected in 12 patients (40%) among which 5 (17%) showed evidence of clonal TCR Îł gene rearrangement. Median follow-up duration was 53 months [31-99]. The presence of an abnormal T-cell population was the sole factor associated with a shorter time to flare (hazard ratio 4.15 [CI 95% 1.18-14.66; p=0.02). At last follow-up, 3 patients (10%) were able to withdraw all treatments and 11 (37%) were in clinical and biological remission with less than 10 mg of daily prednisone.
CONCLUSION: EAE is a heterogeneous condition that encompasses several disease forms. Although patients usually respond well to glucocorticoids, those with evidence of abnormal T-cell phenotype have a shorter time to flare
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Sources and input mechanisms of hafnium and neodymium in surface waters of the Atlantic sector of the Southern Ocean
Radiogenic isotopes of hafnium (Hf) and neodymium (Nd) are powerful tracers for water mass transport and trace metal cycling in the present and past oceans. However, due to the scarcity of available data the processes governing their distribution are not well understood. Here we present the first combined dissolved Hf and Nd isotope and concentration data from surface waters of the Atlantic sector of the Southern Ocean. The samples were collected along the Zero Meridian, in the Weddell Sea and in the Drake Passage during RV Polarstern expeditions ANTXXIV/3 and ANTXXIII/3 in the frame of the International Polar Year (IPY) and the GEOTRACES program. The general distribution of Hf and Nd concentrations in the region is similar. However, at the northernmost station located 200 km southwest of Cape Town a pronounced increase of the Nd concentration is observed, whereas the Hf concentration is minimal, suggesting much less Hf than Nd is released by the weathering of the South African Archean cratonic rocks. From the southern part of the Subtropical Front (STF) to the Polar Front (PF) Hf and Nd show the lowest concentrations (<0.12 pmol/kg and 10 pmol/kg, respectively), most probably due to the low terrigenous flux in this area and efficient scavenging of Hf and Nd by biogenic opal. In the vicinity of landmasses the dissolved Hf and Nd isotope compositions are clearly labeled by terrigenous inputs. Near South Africa Nd isotope values as low as Δ[subscript Nd] = â18.9 indicate unradiogenic inputs supplied via the Agulhas Current. Further south the isotopic data show significant increases to Δ[subscript Hf] = 6.1 and Δ[subscript Nd] = â4.0 documenting exchange of seawater Nd and Hf with the Antarctic Peninsula. In the open Southern Ocean the Nd isotope compositions are relatively homogeneous (Δ[subscript Nd] ⌠â8 to â8.5) towards the STF, within the Antarctic Circumpolar Current, in the Weddell Gyre, and the Drake Passage. The Hf isotope compositions in the entire study area only show a small range between Δ[subscript Hf] = + 6.1 and +2.8 support Hf to be more readily released from young mafic rocks compared to old continental ones. The Nd isotope composition ranges from Δ[subscript Nd] = â18.9 to â4.0 showing Nd isotopes to be a sensitive tracer for the provenance of weathering inputs into surface waters of the Southern Ocean.This is the publisherâs final pdf. The article is sponsored by the Geochemical Society and the Meteoritical Society and published by Elsevier. It can be found at: http://www.journals.elsevier.com/geochimica-et-cosmochimica-acta
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