Does GD 356 have a Terrestrial Planetary Companion?

GD 356 is unique among magnetic white dwarfs because it shows Zeeman-split Balmer lines in pure emission. The lines originate from a region of nearly uniform field strength (delta B/B is approximately 0.1) that covers 10 per cent of the stellar surface in which there is a temperature inversion. The energy source that heats the photosphere remains a mystery but it is likely to be associated with the presence of a companion. Based on current models we use archival Spitzer IRAC observations to place a new and stringent upper limit of 12 Jupiter masses for the mass of such a companion. In the light of this result and the recent discovery of a 115 min photometric period for GD 356, we exclude previous models that invoke accretion and revisit the unipolar inductor model that has been proposed for this system. In this model a highly conducting planet with a metallic core orbits the magnetic white dwarf and, as it cuts through field lines, a current is set flowing between the two bodies. This current dissipates in the photosphere of the white dwarf and causes a temperature inversion. Such a planet is unlikely to have survived the RGB/AGB phases of evolution so we argue that it may have formed from the circumstellar disc of a disrupted He or CO core during a rare merger of two white dwarfs. GD 356 would then be a white dwarf counterpart of the millisecond binary pulsar PSR 1257+12 which is known to host a planetary system.Comment: 9 pages, 4 figures, accepted by MNRA

Mechanical Activation of a Multimeric Adhesive Protein Through Domain Conformational Change

The mechanical force-induced activation of the adhesive protein von Willebrand factor (VWF), which experiences high hydrodynamic forces, is essential in initiating platelet adhesion. The importance of the mechanical force-induced functional change is manifested in the multimeric VWF's crucial role in blood coagulation, when high fluid shear stress activates plasma VWF (PVWF) multimers to bind platelets. Here, we showed that a pathological level of high shear stress exposure of PVWF multimers results in domain conformational changes, and the subsequent shifts in the unfolding force allow us to use force as a marker to track the dynamic states of the multimeric VWF. We found that shear-activated PVWF multimers are more resistant to mechanical unfolding than nonsheared PVWF multimers, as indicated in the higher peak unfolding force. These results provide insight into the mechanism of shear-induced activation of PVWF multimers

Relativistic deflection of background starlight measures the mass of a nearby white dwarf star

Based in part on observations made with the NASA/ESA Hubble Space Telescope, obtained at STScI, which is operated by the Association of Universities for Research in Astronomy, Inc., under NASA contract NAS 5-26555. HST data used in this paper are available from the Mikulski Archive for Space Telescopes at STScI (https://archive.stsci.edu/hst/search.php), under proposal ID 13457 and 14448. Support for this program was provided by NASA through a grant from STScI. The Pan-STARRS1 Surveys (PS1) have been made possible through contributions of the Institute for Astronomy, the University of Hawaii, the Pan-STARRS Project Office, the Max-Planck Society and its participating institutes, The Johns Hopkins University, Durham University, the University of Edinburgh, Queen's University Belfast, the Harvard-Smithsonian Center for Astrophysics, the Las Cumbres Observatory Global Telescope Network Incorporated, the National Central University of Taiwan, the Space Telescope Science Institute, NASA Administration under Grant No. NNX08AR22G, the National Science Foundation under Grant No. AST-1238877, the University of Maryland, and Eotvos Lorand University. MD thanks Qatar National Research Fund (QNRF) for support by grant NPRP 09-476-1-078.Gravitational deflection of starlight around the Sun during the 1919 total solar eclipse provided measurements that confirmed Einstein's general theory of relativity. We have used the Hubble Space Telescope to measure the analogous process of astrometric microlensing caused by a nearby star, the white dwarf Stein 2051 B. As Stein 2051 B passed closely in front of a background star, the background star's position was deflected. Measurement of this deflection at multiple epochs allowed us to determine the mass of Stein 2051 B - the sixth-nearest white dwarf to the Sun - as 0.675 ± 0.051 solar masses. This mass determination provides confirmation of the physics of degenerate matter and lends support to white dwarf evolutionary theory.PostprintPeer reviewe

Structural changes and potential vertebrate responses following simulated partial harvesting of boreal mixedwood stands

Partial harvesting, where different numbers and arrangements of live trees are retained in forest stands, has been proposed for maintaining late-successional structure and associated vertebrate species within managed boreal forests. Using the stand dynamics model SORTIE-ND, we examined 80-year patterns of structural change in response to different intensities (30–70% basal area removal) and spatial patterns (22–273m2 mean patch size) of harvesting. We also applied habitat models for seven late-successional vertebrates to the structural conditions present after harvesting to assess potential species responses. Partial harvesting increased understory and downed woody debris (DWD) cover and decreased overstory structure for the first 25 years after harvest, in comparison to unharvested stands, with this effect subsequently reversing as harvest-induced regeneration reached the canopy. Although harvesting enhanced long-term structural development in this regard, large trees, large snags, and largeDWDall remained below unharvested levels throughout the simulation period. Harvesting also produced transient increases in early-decayDWDand ground exposure. Most changes in structural attributes increased in proportion to harvest intensity, but structural differencesamongharvest patterns were generally small. Dispersed harvesting induced somewhat less pronounced decreases in vertical structure, and produced more post-harvest slash, than aggregated harvesting. All seven vertebrate species decreased in abundance as harvest intensity increased from 30 to 70%. In comparison to their pre-harvest abundances in old stands, vertebrates associated with DWD (redback salamander, marten, red-backed vole) showed neutral or positive responses at one or more harvest intensities, whereas those associated with large trees and snags (brown creeper, flying squirrel) consistently exhibited substantial adverse impacts

First semi-empirical test of the white dwarf mass-radius relationship using a single white dwarf via astrometric microlensing

Funding: Support for this research was provided by NASA through grants from STScI. HST data used in this paper are available from the Mikulski Archive for Space Telescopes at STScI (https://archive.stsci.edu/hst/search.php) under proposal IDs 15705, 15961 and 16251. PM acknowledges studentship funding support from the United Kingdom Science and Technology Facilities Council (STFC) and the Cambridge Centre for Doctoral Training in Data Intensive Science (CDT-DIS). MBN acknowledges support from the UK Space Agency. This research is based on observations made with the NASA/ESA Hubble Space Telescope obtained from the Space Telescope Science Institute, which is operated by the Association of Universities for Research in Astronomy, Inc., under NASA contract NAS 5–26555. This work presents results from the European Space Agency (ESA) space mission Gaia. Gaia data are being processed by the Gaia Data Processing and Analysis Consortium (DPAC). Funding for the DPAC is provided by national institutions, in particular the institutions participating in the Gaia Multi-Lateral Agreement (MLA). The Gaia mission website is https://www.cosmos.esa.int/gaia. The Gaia Archive website is http://archives.esac.esa.int/gaia.In November 2019 the nearby single, isolated DQ-type white dwarf LAWD 37 (LP 145-141) aligned closely with a distant background source and caused an astrometric microlensing event. Leveraging astrometry from Gaia and followup data from the Hubble Space Telescope we measure the astrometric deflection of the background source and obtain a gravitational mass for LAWD 37. The main challenge of this analysis is in extracting the lensing signal of the faint background source whilst it is buried in the wings of LAWD 37's point spread function. Removal of LAWD 37's point spread function induces a significant amount of correlated noise which we find can mimic the astrometric lensing signal. We find a deflection model including correlated noise caused by the removal of LAWD 37's point spread function best explains the data and yields a mass for LAWD 37 of 0.56 ± 0.08 M ⊙. This mass is in agreement with the theoretical mass-radius relationship and cooling tracks expected for CO core white dwarfs. Furthermore, the mass is consistent with no or trace amounts of hydrogen that is expected for objects with helium-rich atmospheres like LAWD 37. We conclude that further astrometric followup data on the source is likely to improve the inference on LAWD 37's mass at the ≈3 percent level and definitively rule out purely correlated noise explanations of the data. This work provides the first semi-empirical test of the white dwarf mass-radius relationship using a single, isolated white dwarf and supports current model atmospheres of DQ white dwarfs and white dwarf evolutionary theory.PreprintPostprintPeer reviewe

Pan-Cancer Analysis of lncRNA Regulation Supports Their Targeting of Cancer Genes in Each Tumor Context

Long noncoding RNAs (lncRNAs) are commonly dys-regulated in tumors, but only a handful are known toplay pathophysiological roles in cancer. We inferredlncRNAs that dysregulate cancer pathways, onco-genes, and tumor suppressors (cancer genes) bymodeling their effects on the activity of transcriptionfactors, RNA-binding proteins, and microRNAs in5,185 TCGA tumors and 1,019 ENCODE assays.Our predictions included hundreds of candidateonco- and tumor-suppressor lncRNAs (cancerlncRNAs) whose somatic alterations account for thedysregulation of dozens of cancer genes and path-ways in each of 14 tumor contexts. To demonstrateproof of concept, we showed that perturbations tar-geting OIP5-AS1 (an inferred tumor suppressor) andTUG1 and WT1-AS (inferred onco-lncRNAs) dysre-gulated cancer genes and altered proliferation ofbreast and gynecologic cancer cells. Our analysis in-dicates that, although most lncRNAs are dysregu-lated in a tumor-specific manner, some, includingOIP5-AS1, TUG1, NEAT1, MEG3, and TSIX, synergis-tically dysregulate cancer pathways in multiple tumorcontexts

Pan-cancer Alterations of the MYC Oncogene and Its Proximal Network across the Cancer Genome Atlas

Although theMYConcogene has been implicated incancer, a systematic assessment of alterations ofMYC, related transcription factors, and co-regulatoryproteins, forming the proximal MYC network (PMN),across human cancers is lacking. Using computa-tional approaches, we define genomic and proteo-mic features associated with MYC and the PMNacross the 33 cancers of The Cancer Genome Atlas.Pan-cancer, 28% of all samples had at least one ofthe MYC paralogs amplified. In contrast, the MYCantagonists MGA and MNT were the most frequentlymutated or deleted members, proposing a roleas tumor suppressors.MYCalterations were mutu-ally exclusive withPIK3CA,PTEN,APC,orBRAFalterations, suggesting that MYC is a distinct onco-genic driver. Expression analysis revealed MYC-associated pathways in tumor subtypes, such asimmune response and growth factor signaling; chro-matin, translation, and DNA replication/repair wereconserved pan-cancer. This analysis reveals insightsinto MYC biology and is a reference for biomarkersand therapeutics for cancers with alterations ofMYC or the PMN

Genomic, Pathway Network, and Immunologic Features Distinguishing Squamous Carcinomas

This integrated, multiplatform PanCancer Atlas study co-mapped and identified distinguishing molecular features of squamous cell carcinomas (SCCs) from five sites associated with smokin

Spatial Organization and Molecular Correlation of Tumor-Infiltrating Lymphocytes Using Deep Learning on Pathology Images

Beyond sample curation and basic pathologic characterization, the digitized H&E-stained images of TCGA samples remain underutilized. To highlight this resource, we present mappings of tumorinfiltrating lymphocytes (TILs) based on H&E images from 13 TCGA tumor types. These TIL maps are derived through computational staining using a convolutional neural network trained to classify patches of images. Affinity propagation revealed local spatial structure in TIL patterns and correlation with overall survival. TIL map structural patterns were grouped using standard histopathological parameters. These patterns are enriched in particular T cell subpopulations derived from molecular measures. TIL densities and spatial structure were differentially enriched among tumor types, immune subtypes, and tumor molecular subtypes, implying that spatial infiltrate state could reflect particular tumor cell aberration states. Obtaining spatial lymphocytic patterns linked to the rich genomic characterization of TCGA samples demonstrates one use for the TCGA image archives with insights into the tumor-immune microenvironment