80 research outputs found

    Performance and incentives In mutual fund industry

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    I study various aspects of mutual funds in my thesis. These are divided over four chapters. The first chapter is an introduction to the thesis and sets out an executive summary of my research. The second to fourth chapters each deal with a new concept. The second chapter shows that the sensitivity of an investor's reaction to a mutual fund's recent performance increases with the fund's historical performance. Put differently, bad (good) performance combined with a good-history for a fund results in a greater fraction of capital outflows (inflows) relative to a fund with a poor past history. The evidence is puzzling as we would expect investors to stick with a fund having a good-history, even after a single bad performance. I solve this problem using a model with investors of differing attentiveness. In equilibrium, fund owner's attentiveness increases the historical record of a fund. With this mechanism, the model can explain the higher sensitivity of outflows for higher reputation funds. The chapter is important in that it shows that return-chasing behavior is not ubiquitous. It also provides a clear evidence where the market is slow to incorporate the new information into decision making. The third chapter studies the managerial side of the mutual funds industry regarding the risk-taking behavior of the mutual funds. Mutual fund managers are compared against a benchmark or with the peers. The employment, as well as investor's capital flows, depends on how the manager fares in the competition. I present new evidence in the chapter that the exposure of a manager to these risks is heterogeneous, and manager's historical performance governs it. The evidence implies that the risk-appetite and behavior of a manager depends on his historical performance. I find strong support in the data for this hypothesis. I show that funds with poor historical performance do not boost the portfolio risk to catch up with the peers if they are lagging at the interim date. In general, the risk appetite of the poor-history manager is less driven by their interim performance. But the good-history managers respond to their midyear position and more so during the bull years. The evidence on risk-shifting is consistent with the evidence on how each incentive behaves for good and poor history managers over bull and bear phases. The fourth chapter shows that capital movement in and out of a mutual fund is more sensitive to fund performance during periods of high market volatility. I explain this result using a model where the manager has picking as well as timing skill. A volatile market presents an opportunity to generate timing value and to that extent produces speedy learning about managerial timing ability. Persistence in volatility boosts the sensitivity of flows to performance during such times. Given the counter-cyclical nature of market volatility, the model predicts that the flow sensitivity is higher during the recessions. Data supports the model prediction. The chapter provides a clear example when the trade volume (here capital flows) is linked positively with the volatility. Usually, literature has shown how the volatile periods slows the learning and hence trade volumes too. But my model indicates that there could be substantial learning going on during volatile times about critical economics parameters, mainly because those parameters are revealed only during volatile times

    Linear quotients of connected ideals of graphs

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    As a higher analogue of the edge ideal of a graph, we study the tt-connected ideal Jt\operatorname{J}_{t}. This is the monomial ideal generated by the connected subsets of size tt. For trees, we show that Jt\operatorname{J}_{t} has a linear resolution iff the tree is tt-gap-free, and that this is equivalent to having linear quotients. We then show that if GG is any gap-free and tt-claw-free graph, then Jt(G)\operatorname{J}_{t}(G) has linear quotients and hence, linear resolution.Comment: Comments welcome

    Long-COVID versus adverse event following COVID vaccination among students and staff of tertiary care teaching hospital

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    Background: Long COVID is an important public health concern requiring proper defining, quantifying and describing following SARS-CoV infection with differentiation from adverse events due to COVID vaccination. So, this study was planned to analyze adverse effect of COVID19 vaccination or drug for COVID treatment versus consequences of COVID19 infection. Methods: Self-reported data was collected through questionnaire-based survey by voluntary participation of healthcare staff. Percentage of participant developing various events was analyzed by enlisting sign, symptom, co-morbidity and medication history. Association between COVID-19 infection with number of doses of COVID-19 vaccine taken was analyzed by Chi Square Test with p value <0.05. Association between presence of specific sign, symptom after COVID infection or side effect after COVID vaccination was analyzed by Chi-Square Test with p value <0.05.  Results: Overall total 985 (59.58%) participants were analyzed and among them maximum number of participants (60.30%) reported as COVID-19 positive during the third wave with history of diagnosed COVID positive twice (57.87%). Participants with presence of co-morbidity were more likely to develop symptoms (p<0.001). On analysis, fever, body ache, headache, sore throat and fatigue were significantly more likely to develop after COVID infection as compared to after COVID vaccination (p<0.001).  Conclusions: This study by exploratory survey highlights heterogeneity of Long COVID sign or symptom that’s seen predominantly in person with co-morbidity and a few of them were mimicking adverse events after COVID vaccinations

    Energy Storage in Electrochemical Cells with Molten Sb Electrodes

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    An energy-storage concept is proposed using molten Sb as the fuel in a reversible solid-oxide electrochemical cell (SOEC). Because both Sb and Sb2O3 are liquids at typical SOEC operating temperatures, it is possible to flow Sb from an external tank and use it as the fuel under fuel-cell conditions and then electrolyze Sb2O3 during recharging. This concept was tested using a button cell with a Sc-stabilized zirconia electrolyte at 973 K by measuring the impedances under fuel-cell and electrolyzer conditions for a range of stirred Sb-Sb2O3 compositions. The Sb-Sb2O3 electrode impedances were found to be on the order of 0.15 Ωcm2 for both fuel-cell and electrolyzer conditions, for compositions up to 30% Sb and 70% Sb2O3. The open circuit voltages (OCV) were 0.75 V, independent of oxygen composition. Some features of using molten Sb as an energy-storage medium are discussed

    Prevalence & antibiogram of Pseudomonas aeruginosa at S.S.G. Hospital, Baroda, Gujarat, India

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    Background: Pseudomonas aeruginosa is a gram negative bacterium that continues to be a major cause of opportunistic nosocomial infections, causing around 9-10% of hospital infections. It is hard to treat because of intrinsic resistance of the species and its ability to further resistance to multiple groups including β-lactams, aminoglycosides and fluoroquinolones. Aims: This study was undertaken to determine the prevalence of Pseudomonas and their susceptibility pattern at S.S.G. Hospital, BARODA. Materials and Methods: Between March 2015 to May 2015, 150strains of P. aeruginosa were isolated from different clinical specimens. The samples were selected on the basis of their growth on Mac Conkey and nutrient agar medium with oxidase positive. Colonies were subjected to biochemical tests to identify species. Antimicrobial susceptibility of all the isolates was performed by disc diffusion (Kirby –Bauer) method according to CLSIs guidelines. Results: Majority of isolates of P. aeruginosa were obtained from specimens of blood, pus, wound, sputum, tracheal aspirates, pleural fluid, ICD fluid, bile fluid.The prevalence of pathogen was 4.15% and 98% pathogens were sensitive Piperacillin+Tazobactum followed by Meropenem (93.33%), Levofloxacin (92.66%) , Ceftazidime (82%), Cefoperazone(81.33%), Piperacillin (80.66%), Amikacin(56%), Gentamicin(54.66%). Conclusion: The results confirmed the occurrence of drug resistant strains of P. aeruginosa. Meropenem, Levofloxacin and Piperacillin+Tazobactumwere found to be the most effective antimicrobial drugs. It is rational treatment regimens prescription by the physicians to limit the further spread of antimicrobial resistance among the P. aeruginosa strains

    A role for non-B DNA forming sequences in mediating microlesions causing human inherited disease

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    Missense/nonsense mutations and micro-deletions/micro-insertions of <21bp together represent ~76% of all mutations causing human inherited disease. Previous studies have shown that their occurrence is influenced by sequences capable of non-B DNA formation (direct, inverted and mirror repeats; G-quartets). We found that a greater than expected proportion (~21%) of both micro-deletions and micro-insertions occur within direct repeats and are explicable by slipped misalignment. A novel mutational mechanism, non-B DNA triplex formation followed by DNA repair, is proposed to explain ~5 % of micro-deletions and micro-insertions at mirror repeats. Further, G-quadruplex-forming sequences, direct and inverted repeats appear to play a prominent role in mediating missense mutations, whereas only direct and inverted repeats mediate nonsense mutations. We suggest a mutational mechanism involving slipped strand mispairing, slipped structure formation and DNA repair, to explain ~15% of missense and ~12% of nonsense mutations leading to the formation of perfect direct repeat s from imperfect repeats, or to the extension of existing direct repeats. Similar proportions of missense and nonsense mutations were explicable by the mechanism of hairpin loop formation and DNA repair leading to the formation of perfect inverted repeats from imperfect repeats. The proposed mechanisms provide new insights into mutagenesis underlying pathogenic micro-lesions

    Physicochemical surface properties of brewing yeast influencing their immobilization onto spent grains in a continuous reactor

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    Immobilization of brewing yeast onto a cellulosebased carrier obtained from spent grains, a brewing byproduct, by acid/base treatment has been studied in a continuously operating bubble-column reactor. The aim of this work was to study the mechanisms of brewing yeast immobilization onto spent grain particles through the information on physicochemical surface properties of brewing yeast and spent grain particles. Three mechanisms of brewing yeast immobilization onto spent grains carrier were proposed: cell-carrier adhesion, cell-cell attachment, and cell adsorption (accumulation) inside natural shelters (carrier’s surface roughness). The possibility of stable cell-carrier adhesion regarding the free energy of interaction was proved and the relative importance of longrange forces (Derjaguin-Landau-Verwey-Overbeek theory) and interfacial free energies was discussed. As for the cell-cell attachment leading to a multilayer yeast immobilization, a physicochemical interaction through localized hydrophobic regions on cell surface was hypothesized. However, neither flocculation nor chain formation mechanism can be excluded so far. The adsorption of brewing yeast inside sufficiently large crevices (pores) was documented with photomicrographs. A positive effect of higher dilution rate and increased hydrophobicity of base-treated spent grains on the yeast immobilization rate has also been found.Fundação para Ciência e Tecnologia (FCT

    Application of silver in microtubular solid oxide fuel cells

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    In this paper, the behaviour of silver as cathode conductive material, interconnect wire, and sealing for anode lead connection for microtubular solid oxide fuel cells (µSOFC) is reported. The changes in silver morphology are examined by scanning electron microscopy on cells that had been operated under reformed methane. It is found that using silver in an solid oxide fuel cell (SOFC) stack can improve the cell performance. However, it is also concluded that silver may be responsible for cell degradation. This report brings together and explains all the known problems with application of silver for SOFCs. The results show that silver is unstable in interconnect and in cathode environments. It is found that the process of cell passivation/activation promotes silver migration. The difference in thermal expansion of silver and sealant results in damage to the glass. It is concluded that when silver is exposed to a dual atmosphere condition, high levels of porosity formation is seen in the dense silver interconnect. The relevance of application of silver in SOFC stacks is discussed

    Applications of yeast flocculation in biotechnological processes

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    A review on the main aspects associated with yeast flocculation and its application in biotechnological processes is presented. This subject is addressed following three main aspects – the basics of yeast flocculation, the development of “new” flocculating yeast strains and bioreactor development. In what concerns the basics of yeast flocculation, the state of the art on the most relevant aspects of mechanism, physiology and genetics of yeast flocculation is reported. The construction of flocculating yeast strains includes not only the recombinant constitutive flocculent brewer’s yeast, but also recombinant flocculent yeast for lactose metabolisation and ethanol production. Furthermore, recent work on the heterologous β-galactosidase production using a recombinant flocculent Saccharomyces cerevisiae is considered. As bioreactors using flocculating yeast cells have particular properties, mainly associated with a high solid phase hold-up, a section dedicated to its operation is presented. Aspects such as bioreactor productivity and culture stability as well as bioreactor hydrodynamics and mass transfer properties of flocculating cell cultures are considered. Finally, the paper concludes describing some of the applications of high cell density flocculation bioreactors and discussing potential new uses of these systems.Fundação para a Ciência e a Tecnologia (FCT) – PRAXIS XXI - BD11306/97
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