Propuesta de implementación de un sistema de planeamiento, control de la producción y gestión logística para aumentar la rentabilidad en la empresa By Franco E. I. R. L.

El autor no autoriza la publicación de la tesis

Las ficciones y la vida: Los mundos narrativos en Muñequita linda de Jorge Ninapayta

Aplica los conceptos de la semántica ficcional de los mundos posibles a los cuentos de Muñequita linda para demostrar que se cumplen sus postulados y características. Analiza la construcción de sus mundos en relación a sus categorías y modalidades; y utilizar la semántica intensional en sus funciones de autentificación y saturación. Analiza los mundos ficcionales de Muñequita linda mediante la teoría de la inmersión ficcional en sus tres clases: espacial, temporal y emocional. Demuestra que en Muñequita linda las nociones de ficción no solo son un instrumento teórico aplicativo ni un motivo temático, sino que en la mayor parte de los cuentos del libro se manifiesta de manera implícita una poética de la ficción. Es decir, que muchas de las cuestiones sobre la ficción se resuelven en los mismos mundos ficcionales de los cuentos.Tesi

Mutant huntingtin enhances activation of dendritic Kv4 K+ channels in striatal spiny projection neurons

Huntington\u27s disease (HD) is initially characterized by an inability to suppress unwanted movements, a deficit attributable to impaired synaptic activation of striatal indirect pathway spiny projection neurons (iSPNs). To better understand the mechanisms underlying this deficit, striatal neurons in ex vivo brain slices from mouse genetic models of HD were studied using electrophysiological, optical and biochemical approaches. Distal dendrites of iSPNs from symptomatic HD mice were hypoexcitable, a change that was attributable to increased association of dendritic Kv4 potassium channels with auxiliary KChIP subunits. This association was negatively modulated by TrkB receptor signaling. Dendritic excitability of HD iSPNs was rescued by knocking-down expression of Kv4 channels, by disrupting KChIP binding, by restoring TrkB receptor signaling or by lowering mutant-Htt (mHtt) levels with a zinc finger protein. Collectively, these studies demonstrate that mHtt induces reversible alterations in the dendritic excitability of iSPNs that could contribute to the motor symptoms of HD

An automated tuberculosis screening strategy combining X-ray-based computer-aided detection and clinical information.

Lack of human resources and radiological interpretation expertise impair tuberculosis (TB) screening programmes in TB-endemic countries. Computer-aided detection (CAD) constitutes a viable alternative for chest radiograph (CXR) reading. However, no automated techniques that exploit the additional clinical information typically available during screening exist. To address this issue and optimally exploit this information, a machine learning-based combination framework is introduced. We have evaluated this framework on a database containing 392 patient records from suspected TB subjects prospectively recruited in Cape Town, South Africa. Each record comprised a CAD score, automatically computed from a CXR, and 12 clinical features. Comparisons with strategies relying on either CAD scores or clinical information alone were performed. Our results indicate that the combination framework outperforms the individual strategies in terms of the area under the receiving operating characteristic curve (0.84 versus 0.78 and 0.72), specificity at 95% sensitivity (49% versus 24% and 31%) and negative predictive value (98% versus 95% and 96%). Thus, it is believed that combining CAD and clinical information to estimate the risk of active disease is a promising tool for TB screening

RHOA GTPase Controls YAP-Mediated EREG Signaling in Small Intestinal Stem Cell Maintenance

RHOA, a founding member of the Rho GTPase family, is critical for actomyosin dynamics, polarity, and morphogenesis in response to developmental cues, mechanical stress, and inflammation. In murine small intestinal epithelium, inducible RHOA deletion causes a loss of epithelial polarity, with disrupted villi and crypt organization. In the intestinal crypts, RHOA deficiency results in reduced cell proliferation, increased apoptosis, and a loss of intestinal stem cells (ISCs) that mimic effects of radiation damage. Mechanistically, RHOA loss reduces YAP signaling of the Hippo pathway and affects YAP effector epiregulin (EREG) expression in the crypts. Expression of an active YAP (S112A) mutant rescues ISC marker expression, ISC regeneration, and ISC-associated Wnt signaling, but not defective epithelial polarity, in RhoA knockout mice, implicating YAP in RHOA-regulated ISC function. EREG treatment or active β-catenin Catnblox(ex3) mutant expression rescues the RhoA KO ISC phenotypes. Thus, RHOA controls YAP-EREG signaling to regulate intestinal homeostasis and ISC regeneration

Natural killer cells act as an extrinsic barrier for <i>in vivo</i> reprogramming

The ectopic expression of transcription factors Oct4, Sox2, Klf4 and Myc (OSKM) enables reprogramming of differentiated cells into pluripotent embryonic stem cells. Methods based on partial and reversible in vivo reprogramming are a promising strategy for tissue regeneration and rejuvenation. However, little is known about the barriers that impair reprogramming in an in vivo context. We report that natural killer (NK) cells significantly limit reprogramming, both in vitro and in vivo. Cells and tissues at the intermediate states of reprogramming upregulate the expression of NK activating ligands, such as MULT1 and ICAM1. NK cells recognize and kill partially reprogrammed cells in a degranulation-dependent manner. Importantly, in vivo partial reprogramming is strongly reduced by adoptive transfer of NK cells, whereas it is significantly improved by depletion of NK cells. Notably, in the absence of NK cells, the pancreatic organoids derived from OSKM-expressing mice are remarkably large, suggesting the generation of cells with progenitor properties. We conclude that NK cells pose an important barrier for in vivo reprogramming, and this concept may apply to other contexts of transient cellular plasticity

Valorización de la reputación corporativa

La reputación corporativa (RC) es una ventaja competitiva inherente y única para cada organización, además de ser un activo intangible cuantificable. Ante ello el presente trabajo de investigación está motivado por el interés de conocer cuál es la mejor forma de valorizar la RC. Asimismo, la importancia del estudio radica en el interés creciente de las organizaciones por conocer la contribución subyacente de la RC en el valor de la empresa ya que en la medida que esto sea conocido motivará a crear, desarrollar y mantener la RC como parte de su estrategia de sostenibilidad y crecimiento. Para emprender este trabajo, se utilizó el proceso secuencial de Revisión de Literatura-MAGG, siendo este una adaptación del modelo de revisión de literatura de Machi y McEvoy (2009) y la guía para hacer una revisión de literatura de Chris Hart (2003). En base al objetivo de la presente tesis, se realizó la revisión de literatura de diversos estudios de investigación y se lograron identificar las variables que pueden contribuir a determinar la forma de calcular la valorización de la RC, asimismo, se identificaron los elementos que afectan el cálculo de la valorización para estas variables, sin embargo, no se encontraron modelos de medición cuantitativos para valorizar la RC que puedan ser aplicados de manera general o estándar en las organizaciones, ya que las formas de valorizar la RC que se encontraron estaban asociadas a situaciones, limitaciones y restricciones particulares. El presente trabajo tiene como finalidad brindar los elementos necesarios para tener un punto de partida en la construcción de modelos que puedan cuantificar el aporte de la RC en el valor de la empresa. Así el trabajo permite concluir que la valorización de la RC se puede obtener en función de los indicadores financieros (ROA, valor en libros, ventas y valor del mercado), estos a su vez pueden variar por la influencia de elementos como el tamaño de la empresa, el tiempo y el sector económico.Corporate reputation (CR) is an inherent and unique competitive advantage for every organization, and is a quantifiable intangible asset. The present research is motivated by the interest to know which the best way to value the CR is. In addition, the importance of this study is based on the increasing interest of companies to know the underlying contribution of CR in the value of the company and to the extent that this value is known it will motivate you to build, develop and maintain the CR as part of their sustainability and development strategy. To develop this study, the secuencial process of literature review- MAGG was used, as an adaptation of Machi and McEvoy (2009) model for literature review and the Guide to make a literature review of Chris Hart (2003). Based on the objective of the present thesis, a review of the diverse investigative studies was made and be able to identify the variables that contribute to determine the way of calculating the value of the CR, in addition, the elements that affect the calculation of the value of these variables were identified. No models of quantitative measurement necessary to value the CR were, however, found, that can be applied in a general or standard manner in the organizations, since the forms of the CR value found were associated with situations, particular limitations and restrictions. The present study is intended to be able to offer the necessary elements to have a starting point in the construction of models that can quantify the input of the CR in the value of a company. This research concludes that the valuation of the CR can be obtained as a financial metrics function (ROA, book value, sales, and market value). These metrics may vary, as well, given other factors such as the size of the enterprise, time, and the economic sector.Tesi

[Association between exclusive breastfeeding and obesity in children: a cross-sectional study of three Latin American countries].

OBJECTIVE: To determine if breastfeeding for at least the first six months of life is associated with overweight and obesity in children 2 to 5 years old. METHOD: Cross sectional analysis of data from national demographic and health surveys conducted in Bolivia, Colombia and Peru. Overweight and obesity were defined using World Health Organization standard definitions. Odds ratios (OR) were calculated using multinomial logistic regression. RESULTS: The prevalence of obesity in children 2 to 5 years old was 10.4% (95% confidence interval [95%CI]: 8.2-12.6) in Bolivia, 4.9% in Colombia (95%CI: 4.0-5.8), and 6.4% (95%CI: 5.2-8.0) in Peru. Prevalence of exclusive breastfeeding for at least the first 6 months in the study population was 89.9% (95%CI: 87.8-91.9) in Bolivia, 73.9% (95%CI: 72.2-75.6) in Colombia, and 92.8% (95%CI: 91.2-92.4) in Peru. Exclusive breastfeeding was associated with a decreased risk of obesity in children as compared to no breastfeeding or breastfeeding for less than 6 months in Bolivia (OR = .30; 95%CI: .16-.57) and a marginal association in Colombia (OR = .71; 95%CI: .47-1.06) and Peru (OR = .49; 95%CI: 0.23-1.04). No association between breastfeeding and overweight was found. CONCLUSION: Exclusive breastfeeding for at least the first six months of life decreases the risk of obesity in children 2 to 5 years old in Bolivia. A similar but weaker pattern was observed for children in Colombia and Peru

Problemas de cálculo diferencial e integral

1 archivo PDF (127 páginas) 2a ed. 1999, 7a reimpresión 2006.Recopilación de problemas de cálculo diferencial e integral, los cuales han sido utilizados por sus autores en los cursos de cálculo I y II. Se presenta en tres partes la primera problemas para cálculo I, la segunda problemas para cálculo II y por último una miscelánea de problemas de aplicación

SMAC is expressed de novo in a subset of cervical cancer tumors

BACKGROUND: Smac/Diablo is a recently identified protein that is released from mitochondria after apoptotic stimuli. It binds IAPs, allowing caspase activation and cell death. In view of its activity it might participate in carcinogenesis. In the present study, we analyzed Smac expression in a panel of cervical cancer patients. METHODS: We performed semi quantitative RT-PCR on 41 cervical tumor and 6 normal tissue samples. The study included 8 stage I cases; 16 stage II; 17 stage III; and a control group of 6 samples of normal cervical squamous epithelial tissue. RESULTS: Smac mRNA expression was below the detection limit in the normal cervical tissue samples. In contrast, 13 (31.7%) of the 41 cervical cancer biopsies showed detectable levels of this transcript. The samples expressing Smac were distributed equally among the stages (5 in stage I, 4 in stage II and 4 in stage III) with similar expression levels. We found no correlation between the presence of Smac mRNA and histology, menopause, WHO stage or disease status. CONCLUSIONS: Smac is expressed de novo in a subset of cervical cancer patients, reflecting a possible heterogeneity in the pathways leading to cervical cancer. There was no correlation with any clinical variable