12 research outputs found

    The Research Agenda in ICU Telemedicine: A Statement From the Critical Care Societies Collaborative

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    ICU telemedicine uses audiovisual conferencing technology to provide critical care from a remote location. Research is needed to best define the optimal use of ICU telemedicine, but efforts are hindered by methodological challenges and the lack of an organized delivery approach. We convened an interdisciplinary working group to develop a research agenda in ICU telemedicine, addressing both methodological and knowledge gaps in the field. To best inform clinical decision-making and health policy, future research should be organized around a conceptual framework that enables consistent descriptions of both the study setting and the telemedicine intervention. The framework should include standardized methods for assessing the preimplementation ICU environment and describing the telemedicine program. This framework will facilitate comparisons across studies and improve generalizability by permitting context-specific interpretation. Research based on this framework should consider the multidisciplinary nature of ICU care and describe the specific program goals. Key topic areas to be addressed include the effect of ICU telemedicine on the structure, process, and outcome of critical care delivery. Ideally, future research should attempt to address causation instead of simply associations and elucidate the mechanism of action in order to determine exactly how ICU telemedicine achieves its effects. ICU telemedicine has significant potential to improve critical care delivery, but high-quality research is needed to best inform its use. We propose an agenda to advance the science of ICU telemedicine and generate research with the greatest potential to improve patient care

    Growth and decay of a marine terminating sector of the last British-Irish ice sheet: a geomorphological reconstruction

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    The boundary conditions that govern ice sheet dynamics can change significantly with the development of marine margins. This paper uses the glacial landscape in western Scotland to reconstruct changes in the British–Irish Ice Sheet that accompanied the growth and decay of a marine sector over the Malin Shelf. Ice advanced from a restricted mountain ice sheet with tidewater margins after ∌35 ka BP, and reached the continental shelf in ∌7 ka (average rate of ∌30 m a−1). Early ice flow had been directed through north-south, geologically controlled, over-deepened fjords that were carved during previous ‘restricted’ glaciations. This flow regime was abandoned with development of the Malin Shelf ice sheet sector; ice flow direction switched by ∌90° and was drawn westwards towards the shelf edge. The marine ice sheet phase saw episodes of west-east ice divide migration by up to 60 km over west central Scotland, possibly linked to ice streaming and calving events at the ice sheet margin. However, permanent and stationary ice divides and zones of cold-based ice, associated with subglacial topographic highs, also characterised the marine glacial stage over western Scotland. The North Channel ice divide remained a constant, though migratory feature while the BIIS occupied the Malin Shelf; it finally collapsed at the end of the Killard Point Stadial when the Irish Ice Sheet began to rapidly decay ∌16.5 ka BP. This permitted the Scottish Ice Sheet to temporarily advance over north-east Ireland (previously identified as the East Antrim Coastal Readvance) before it too retreated, at rates in the order of 102 m a−1. Although the imprint of extensive shelf-edge ice sheet glaciation exists in the coastal landscape of western Scotland, the dominant landscape features relate to a restricted, marine-proximal mountain ice sheet with markedly different flow configurations. Similar first-order geomorphological features, relating to ‘restricted’ glacial conditions, are likely to be preserved in subglacial highlands under interior parts of modern ice sheetssector; ice flow direction switched by ~90° and was drawn westwards towards the shelf edge. The marine ice sheet phase saw episodes of west-east ice divide migration by up to 60 km over west central Scotland, possibly linked to ice streaming and calving events at the ice sheet margin. However, permanent and stationary ice divides and zones of cold-based ice, associated with subglacial topographic highs, also characterised the marine glacial stage over western Scotland. The North Channel ice divide remained a constant, though migratory feature while the BIIS occupied the Malin Shelf; it finally collapsed at the end of the Killard Point Stadial when the Irish Ice Sheet began to rapidly decay ~16.5 ka BP. This permitted the Scottish Ice Sheet to temporarily advance over north-east Ireland (previously identified as the East Antrim Coastal Readvance) before it too retreated, at rates in the order of 102 m/a−1. Although the imprint of extensive shelf-edge ice sheet glaciation exists in the coastal landscape of western Scotland, the dominant landscape features relate to a restricted, marine-proximal mountain ice sheet with markedly different flow configurations. Similar first-order geomorphological features, relating to ‘restricted’ glacial conditions, are likely to be preserved in subglacial highlands under interior parts of modern ice sheets

    Polyamine-mediated channel block of ionotropic glutamate receptors and its regulation by auxiliary proteins

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