Prenatal diagnosis of fetal aneuploidies: post-genomic developments

Prenatal diagnosis of fetal aneuploidies and chromosomal anomalies is likely to undergo a profound change in the near future. On the one hand this is mediated by new technical developments, such as chromosomal microarrays, which allow a much more precise delineation of minute sub-microscopic chromosomal aberrancies than the classical G-band karyotype. This will be of particular interest when investigating pregnancies at risk of unexplained development delay, intellectual disability or certain forms of autism. On the other hand, great strides have been made in the non-invasive determination of fetal genetic traits, largely through the analysis of cell-free fetal nucleic acids. It is hoped that, with the assistance of cutting-edge tools such as digital PCR or next generation sequencing, the long elusive goal of non-invasive prenatal diagnosis for fetal aneuploidies can finally be attained

The wider value of rural rail provision

In the context of recent plans for public sector expenditure, the value for money provided by rural public transport is an important issue in Britain and elsewhere, and one aspect of this is the option and non-use value placed on public transport by residents. Whilst there are a small number of studies which have estimated option and non-use values, they rest largely on contingent valuation methods which are subject to dangers of bias, and concentrate on commuter services into cities rather than truly rural services. This paper seeks to overcome these problems by conducting a Stated Preference (SP) experiment in rural communities, which values the provision of rail services and compares this against Post Office provision. We believe that using this approach, and allowing respondents to compare willingness to pay for rail services with that for another important rural service subject to threatened cuts, should produce more reliable results; moreover we achieve this using self completion questionnaires rather than much more expensive interviews. Our results show much lower values for rail than previous studies, though this is to be expected in truly rural areas where the likelihood of commuting by rail is much lower. Other non-use values are greater than option values in this context

Ariel - Volume 8 Number 1

Executive Editor James W. Lockard, Jr. Issue Editor Michael J. Grimes Business Manager Neeraj K. Kanwal Managing Editor Edward H. Jasper University News Richard J. Perry World News William D.B. Hiller Opinions Elizabeth A. McGuire Features Patrick P. Sokas Sports Desk Shahab S. Minassian Managing Associate Brenda Peterson Photography Robert D. Lehman, Jr. Graphics Christine M. Kuhnl

Ariel - Volume 4 Number 6

Editors David A. Jacoby Eugenia Miller Tom Williams Associate Editors Paul Bialas Terry Burt Michael Leo Gail Tenikat Editor Emeritus and Business Manager Richard J. Bonnano Movie Editor Robert Breckenridge Staff Richard Blutstein Mary F. Buechler J.D. Kanofsky Rocket Weber David Maye

Prospectus, September 9, 1991

https://spark.parkland.edu/prospectus_1991/1012/thumbnail.jp

Beyond The Horizon

Student affairs professionals have an obligation and an opportunity to support students moving through the college-years stages of psychosocial development by helping them use technology in approrpriate ways

Prospectus, August 26, 1991

https://spark.parkland.edu/prospectus_1991/1011/thumbnail.jp

Are situation awareness and decision-making in driving totally conscious processes? Results of a Hazard Prediction task

Detecting danger in the driving environment is an indispensable task to guarantee safety which depends on the driver's ability to predict upcoming hazards. But does correct prediction lead to an appropriate response? This study advances hazard perception research by investigating the link between successful prediction and response selection. Three groups of drivers (learners, novices and experienced drivers) were recruited, with novice and experienced drivers further split into offender and non-offender groups. Specifically, this works aims to develop an improved Spanish Hazard Prediction Test and to explore the differences in Situation Awareness, (SA: perception, comprehension and prediction) and Decision-Making ("DM") among learners, younger inexperienced and experienced drivers and between driving offenders and non-offenders. The contribution of the current work is not only theoretical; the Hazard Prediction Test is also a valid way to test Hazard Perception. The test, as well as being useful as part of the test for a driving license, could also serve a purpose in the renewal of licenses after a ban or as a way of training drivers. A sample of 121 participants watched a series of driving video clips that ended with a sudden occlusion prior to a hazard. They then answered questions to assess their SA ("What is the hazard?" "Where is it located?" "What happens next?") and "DM" ("What would you do in this situation?"). This alternative to the Hazard Perception Test demonstrates a satisfactory internal consistency (Alpha=0.750), with eleven videos achieving discrimination indices above 0.30. Learners performed significantly worse than experienced drivers when required to identify and locate the hazard. Interestingly, drivers were more accurate in answering the "DM" question than questions regarding SA, suggesting that drivers can choose an appropriate response manoeuvre without a totally conscious knowledge of the exact hazard

Between a conditional’s antecedent and its consequent: Discourse coherence vs. probabilistic relevance

Reasoning with conditionals is central to everyday life, yet there is long-standing disagreement about the meaning of the conditional. One example is the puzzle of so-called missing-link conditionals such as ‘‘if raccoons have no wings, they cannot breathe under water.” Their oddity may be taken to show that con- ditionals require a connection between antecedent (‘‘raccoons have no wings”) and consequent (‘‘they cannot breathe under water”), yet most accounts of conditionals attribute the oddity to natural- language pragmatics. We present an experimental study disentangling the pragmatic requirement of dis- course coherence from a stronger notion of connection: probabilistic relevance. Results indicate that mere discourse coherence is not enough to make conditionals assertable

Cognitive-behavioral intervention for distress in patients with melanoma

BACKGROUND Melanoma accounts for > 79% of skin cancer-related deaths, although it accounts for only 4% of skin cancer incidence. Given the potential for lethality, it is likely that patients with melanoma may experience significant emotional distress. The current study was designed to determine the effect of a cognitive-behavioral intervention on distress and health-related quality of life (HRQOL) in patients with melanoma who had medium-to-high distress. METHODS Forty-eight patients who had Global Severity Index scores ≥ 60 2 months after their initial visit to the multidisciplinary melanoma clinic were randomized to receive either standard care or 4 sessions of a cognitive-behavioral intervention (CBI). Repeated assessments using the Brief Symptom Inventory, the Medical Outcomes Survey Short Form-36, and the State-Trait Anxiety Inventory occurred at baseline, at 2 months, and at 6 months after intervention for both groups. RESULTS An intent-to-treat analysis did not reveal significantly lower distress in the CBI group at 2 months or 6 months of follow-up, although differences were noted in anxiety and HRQOL. An effect-of-intervention analysis did reveal lower levels of distress in the CBI group at 2 months, with differences approaching significance at 6 months. CONCLUSIONS The four-session CBI significantly reduced distress and improved HRQOL for a period of 2 months in patients with melanoma who had medium-to-high distress, with improved general health evident 6 months after the intervention. Some variation in results was revealed in an intent-to-treat analysis. The initial evidence from the current study showed that a brief intervention may be effective for creating change in individuals with cancer who have increased distress, although further research is needed to identify the most optimal approach for delivering the intervention. Cancer 2003;98:854–64. © 2003 American Cancer Society. DOI 10.1002/cncr.11579Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/34378/1/11579_ftp.pd