22 research outputs found
Decrease of virulence for BALB/c mice produced by continuous subculturing of Nocardia brasiliensis
- Author
- A Calmette
- A Licón-Trillo
- A Palma-Ramos
- AS Pym
- CC Guimarães
- CN Ellis
- H Zlotnik
- Hector G Lozano-Garza
- Janeth A Almaguer-Chávez
- JE Barrick
- Jorge Ocampo-Candiani
- L Vera-Cabrera
- Lucio Vera-Cabrera
- ML Gonzalez-Suarez
- NA Espinoza-González
- Oliverio Welsh
- PI Folb
- PI Folb
- R López-Martínez
- RL Modlin
- Salvador Said-Fernández
- Víktor J Romero-Díaz
- WJ Philipp
- Publication venue
- BioMed Central
- Publication date
- 01/01/2011
- Field of study
<p>Abstract</p> <p>Background</p> <p>Subculturing has been extensively used to attenuate human pathogens. In this work we studied the effect of continuous subculturing of <it>Nocardia brasiliensis </it>HUJEG-1 on virulence in a murine model.</p> <p>Methods</p> <p><it>Nocardia brasiliensis </it>HUJEG-1 was subcultured up to 130 times on brain heart infusion over four years. BALB/c mice were inoculated in the right foot pad with the bacteria subcultured 0, 40, 80, 100 and 130 times (T<sub>0</sub>, T<sub>40</sub>, T<sub>80 </sub>T<sub>100 </sub>and T<sub>130</sub>). The induction of resistance was tested by using T<sub>130 </sub>to inoculate a group of mice followed by challenge with T0 12 weeks later. Biopsies were taken from the newly infected foot-pad and immunostained with antibodies against CD4, CD8 and CD14 in order to analyze the in situ immunological changes.</p> <p>Results</p> <p>When using T<sub>40</sub>, T<sub>80 </sub>T<sub>100 </sub>and T<sub>130 </sub>as inoculums we observed lesions in 10, 5, 0 and 0 percent of the animals, respectively, at the end of 12 weeks. In contrast, their controls produced mycetoma in 80, 80, 70 and 60% of the inoculated animals. When studying the protection of T<sub>130</sub>, we observed a partial resistance to the infection. Immunostaining revealed an intense CD4+ lymphocytic and macrophage infiltrate in healing lesions.</p> <p>Conclusions</p> <p>After 130 in vitro passages of <it>N. brasiliensis </it>HUJEG-1 a severe decrease in its virulence was observed. Immunization of BALB/c mice, with these attenuated cells, produced a state of partial resistance to infection with the non-subcultured isolate.</p
Combinatorial Morphology in Visual Languages
- Author
- A Yannicopoulou
- BJ Phillips
- C Carello
- C Forceville
- C Forceville
- C Forceville
- C Forceville
- C Forceville
- D Gross
- D Premack
- DC Burr
- DC Burr
- DP Newton
- DP Wilkins
- FL Schodt
- G Booij
- G Fauconnier
- G Lakoff
- G Lakoff
- GT Stump
- H Ito
- H Katsuno
- H Kim
- HM Wellman
- HM Wellman
- J Audring
- J Green
- J Nakazawa
- J Schilperoord
- J Schilperoord
- J Wildfeuer
- JE Díaz Vera
- JE Díaz Vera
- JM Sadock
- K Mori
- K Pratha
- K Shinohara
- L Talmy
- M Abbott
- M Danesi
- M Walker
- N Cohn
- N Cohn
- N Cohn
- N Cohn
- N Cohn
- N Cohn
- N Cohn
- N Cohn
- N Cohn
- N Fay
- ND Munn
- ND Munn
- PW Culicover
- R Jackendoff
- R Jackendoff
- R Jackendoff
- RS Petersen
- S Garrod
- S Kerr
- S McCloud
- S Parsons
- S Wichmann
- SL Friedman
- SR Anderson
- T Kawabe
- T Kawabe
- WA Koch
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 14/04/2018
- Field of study
Yeasts associated with the production of distilled alcoholic beverages
- Author
- A León-Rodríguez De
- A León-Rodríguez De
- A López-Álvarez
- A Peña-Álvarez
- A Peña-Álvarez
- A Verdugo Valdez
- AC Muñoz-Muñoz
- AM Vera-Guzmán
- AM Vera-Guzmán
- AM Vera-Guzmán
- B Pech
- C Fiore
- D Aguirre
- DC Watson
- DJ McGill
- DM Díaz-Montaño
- DW Lachenmeier
- E Soto-García
- E Waleckx
- GA Morán-Marroquín
- GC Ríos-Deras De los
- GM Walker
- GM Walker
- GM Walker
- GM Walker
- GM Walker
- GM Walker
- Graeme M. Walker
- Graeme Walker
- Graeme Walker
- H Garza De la
- H Garza-Toledo De la
- I Goodall
- I Jeličić
- IS Pretorius
- IW González-Robles
- IW González-Robles
- J Arrizon
- J Arrizon
- J Arrizon
- JA Molina-Guerrero
- JA Narváez-Zapata
- JB Páez-Lerma
- JE López-Ramírez
- JF Martínez-Aguilar
- JH Bryce
- JO Valle-Rodríguez
- KC Thomas
- L Amaya-Delgado
- L Fahrasmane
- L Pinal
- LE Segura-García
- M Arellano
- M Cedeño
- M Kirchmayr
- M Korhola
- MA Lachance
- ME Núñez-Guerrero
- MH Reyes-Valdés
- MJ Garcia-Soto
- ML Álvarez-Ainza
- ML Álvarez-Ainza
- MR Kirchmayr
- N Mancilla-Margalli
- N Mancilla-Margalli
- N Prado-Jaramillo
- OM Rutiaga-Quiñones
- P Escalante-Minakata
- P Lappe
- P Lappe-Oliveras
- R Hansen
- R Prado-Ramírez
- RC Jones
- S Beek van
- S Watanabe
- SG Ceballos-Magaña
- U Bond
- V Passoth
- Publication venue
- Publication date
- 16/09/2019
- Field of study
Distilled alcoholic beverages are produced firstly by fermenting sugars emanating from cereal starches (in the case of whiskies), sucrose-rich plants (in the case of rums), fructooligosaccharide-rich plants (in the case of tequila) or from fruits (in the case of brandies). Traditionally, such fermentations were conducted in a spontaneous fashion, relying on indigenous microbiota, including wild yeasts. In modern practices, selected strains of Saccharomyces cerevisiae are employed to produce high levels of ethanol together with numerous secondary metabolites (eg. higher alcohols, esters, carbonyls etc.) which greatly influence the final flavour and aroma characteristics of spirits following distillation of the fermented wash. Therefore, distillers, like winemakers, must carefully choose their yeast strain which will be very important in providing the alcohol content and the sensory profiles of spirit beverages. This Chapter discusses yeast and fermentation aspects associated with the production of selected distilled spirits and highlights similarities and differences with the production of wine
A922 Sequential measurement of 1 hour creatinine clearance (1-CRCL) in critically ill patients at risk of acute kidney injury (AKI)
- Author
- Abbott TE
- Abdallah RI
- Abdel-Aal IR
- Abdelmonem SA
- Abdo WF
- Abellan AN
- Abellán AN
- Abellán AN
- Abellán AN
- Abrams ST
- Ackerley C
- Acuña M
- Adda M
- Adhikari NK
- Adriano G
- Adrie C
- Affatato R
- Affatato R
- Afonso-Rivero D
- Agarossi A
- Agarwal LK
- Ageeva T
- Agrawal R
- Aguayo-DeHoyos E
- Aguilar AL
- Aguilar-Alonso E
- Aguilar-Alonso E
- Aguilar-Alonso E
- Aguirregabyria M
- Ahmadnia E
- Ahn C
- Ahn JY
- Ahn JY
- Ahn MY
- Ahn MY
- Aitken LM
- Akalaev R
- Akbarzadeh A
- Akcan-Arikan A
- Akhlagh SH
- Akhtar N
- AKI Research Group
- Akiduki N
- Akin S
- Akizuki N
- Akkoc T
- Ala-Kokko T
- Alanio A
- Albaiceta GM
- Albaladejo P
- Alberto F
- Albuisson E
- Alcala MA
- Alcázar L
- Aldabo-Pallas T
- Aldana NN
- Aldecoa C
- Alegría L
- Alejandro R
- Alejo GC
- Alejos RM
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- Anand RK
- Andersen LW
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- Andrade AH
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- Antonio C
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- Antón DG
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- Araujo NJ
- Araujo VF
- ARIAM registry of adult cardiac surgery
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- Arias CC
- Arias N
- Arias-Verdu MD
- Arias-Verdu MD
- Arias-Verdu MD
- Armaganidis A
- Arora MK
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- Aslanian P
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- CAPCRI Study
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- Chernyshuk S
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- Chrétien JM
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- ENVIN-HELICS Study Group
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- FINNRESUSCI Study Group
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- FROG ICU Investigators
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- Garcia-Alvarez JM
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- García-Martínez MV
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- GETGAG Working Group
- GETGAG/SEMICYUC
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- Grossestreuer A
- Guanziroli M
- Guarracino F
- Guarracino F
- Gubianas CM
- Guerrero AP
- Guerrero JE
- Guerrero-Lopez F
- Guerrero-López F
- Guervilly C
- Guidet B
- Guillamon LN
- Guillen JA
- Guillot M
- Guitard PG
- Guitard PG
- Guitard PG
- Gul F
- Gupta A
- Gupta D
- Gupta O
- Gustad LT
- Gutierrez LA
- Gutiérrez-Pizarraya A
- Guérin C
- Guérin C
- Guérin C
- Gálvez V
- Géri G
- Gómez LC
- Gómez-Jiménez C
- Gómez-Jiménez C
- Güven G
- Ha JK
- Hadley JS
- Haghbin S
- Haines R
- Hala P
- Hall D
- Hallows G
- Hallows G
- Hamilton A
- Han HS
- Han SH
- Han SH
- Handler E
- Hanekom S
- Haniffa R
- Hanna AA
- Haritydi T
- Harm S
- Harridge SD
- Harrison D
- Harrison M
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- Hart R
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- Hashimoto Y
- Hassanin H
- Hatakeyama J
- Hatib F
- Hawkins K
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- Hayakawa M
- Hayakawa M
- Hayakawa M
- Hayakawa M
- Hayashi K
- He X
- Healey AJ
- Hebert P
- Hegazy S
- Hellevuo H
- Helmy TA
- Helyar S
- Helyar S
- Hempel D
- Henderson MA
- Hendra H
- Henschel B
- Heras G
- Hernandis V
- Hernández A
- Hernández AA
- Hernández AA
- Hernández AA
- Hernández AA
- Hernández AA
- Hernández AA
- Hernández G
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- Herpain A
- Herrera AN
- Herrera AN
- Herrera AN
- Herrera AN
- Herrera AN
- Herrera AN
- Herruzo-Aviles A
- Heunks LM
- Hewitt H
- Heyne T
- Hickey S
- Hidalgo C
- Hikasa Y
- Hillier SD
- Himmel Y
- Himpe D
- Hinojosa-Perez R
- Hirata A
- Hirayama T
- Hirohata S
- Hodgson LE
- Hodgson LE
- Hofmeijer J
- Hollands S
- Hom H
- Hopkins PA
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- Hoppu S
- Hoppu S
- Horkan CM
- Horstmann C
- Horton A
- Horvat A
- Hou DS
- Houzé S
- Houzé S
- Howes D
- Hozhabri K
- Hrachovina M
- Hraiech S
- Hravnak M
- Hu HC
- Hua Y
- Hualde JB
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- Hualde JB
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- Hualde JB
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- Huang CH
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- Huang WC
- Hubbard A
- Huber W
- Huddart S
- Hull AM
- Hung CY
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- Huot B
- Husheer SL
- Hutchings S
- Hutchison R
- Hwang GS
- Hwang GS
- Ibañes PG
- Ibsen M
- Idei M
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- Idone FA
- Iesu E
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- Ignacio ML
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- IPREA Study Group
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- Itenov TS
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- Jacques T
- Jaffal K
- Jamali S
- Jang BH
- Janotka M
- Janotka M
- Janotka M
- Jansen D
- Jansen N
- Japan Septic Disseminated Intravascular Coagulation (JSEPTIC DIC) study group
- Jardim JJ
- Jardim M
- Jareño A
- Javadpour S
- Jayasinghe S
- Jean-Baptiste S
- Jean-Baptiste S
- Jensen AE
- Jensen JU
- Jeon YD
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- Jeong IY
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- Jian Z
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- Jibaja M
- Jimenez-Herrera MF
- Jiménez GJ
- Jo YH
- Joachim J
- Jochmans S
- John G
- Jonas M
- Jonas M
- Jonas M
- Jones C
- Joshi R
- Joshi V
- Jovaisa T
- JSEPTIC (Japanese Society of Education for Physicians and Trainees in Intensive Care) Clinical Trial Group
- Juan WC
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- Juez A
- Juliarena A
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- Jung K
- Jung KW
- Junior JM
- Kaczirek K
- Kaese S
- Kalani N
- Kalenka A
- Kalfon P
- Kamali E
- Kaminsky GE
- Kaneko M
- Kang M
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- Kang PL
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- Kao KC
- Kappler F
- Kara A
- Karachi F
- Karanjia N
- Karbing DS
- Karsten E
- Kasdan H
- Kashiya S
- Kashyap R
- Katabami K
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- Katira BH
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- Kawamura N
- Kawano S
- Kay FU
- Kayaaslan B
- Kayambu G
- Kazutoshi F
- Ke MW
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- Keller E
- Kellner F
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- Kerhuel L
- Kerr C
- Kezyte G
- Khadjibaev A
- Khaliq W
- Khine H
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- King HS
- Kinnear J
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- Kirca H
- Kirman M
- Kirwan CJ
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- Klapsing P
- Klaus DA
- Kleinpell R
- Kluge S
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- Ko JI
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- Kobayashi A
- Koco E
- Kodate A
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- Kokkini S
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- Komuro T
- Kondili E
- Kongpolprom N
- Kooner G
- Kostalas M
- Kosuk ME
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- Kou PS
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- Kovacikova L
- Kox M
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- Kristof J
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- Kubik M
- Kubota K
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- Kunze-Szikszay N
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- Kurth T
- Kurtz P
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- Kwon HM
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- Kye YC
- Kyle UG
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- Labaune MA
- Labra C
- Lacerda P
- Laerkner E
- Lafaurie M
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- Lagonidis D
- Lagos R
- Lahmer T
- Lai CC
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- Lin KC
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- Lissonde F
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- Lortat-Jacob B
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- Maistry N
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- Mezidi M
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- Okayama Research Investigation Organizing Network (ORION)investigators
- Olaechea P
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- Romeu JD
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- Santana MC
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- Santiago AI
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- Santos F
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- Sanz ER
- Sanz ER
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- Sanz NM
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- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 01/01/2016
- Field of study
Meeting abstrac
Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition)1.
- Author
- Abdel-Aziz AK
- Abdelfatah S
- Abdellatif M
- Abdoli A
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- Chen ZS
- Cheng H
- Cheng J
- Cheng S-Y
- Cheng W
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- Chernyak BV
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- Álvarez ÉMC
- Ávalos Y
- Önal G
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- Čolić M
- Đokić J
- Žerovnik E
- Publication venue
- 'Informa UK Limited'
- Publication date
- 01/01/2021
- Field of study
In 2008, we published the first set of guidelines for standardizing research in autophagy. Since then, this topic has received increasing attention, and many scientists have entered the field. Our knowledge base and relevant new technologies have also been expanding. Thus, it is important to formulate on a regular basis updated guidelines for monitoring autophagy in different organisms. Despite numerous reviews, there continues to be confusion regarding acceptable methods to evaluate autophagy, especially in multicellular eukaryotes. Here, we present a set of guidelines for investigators to select and interpret methods to examine autophagy and related processes, and for reviewers to provide realistic and reasonable critiques of reports that are focused on these processes. These guidelines are not meant to be a dogmatic set of rules, because the appropriateness of any assay largely depends on the question being asked and the system being used. Moreover, no individual assay is perfect for every situation, calling for the use of multiple techniques to properly monitor autophagy in each experimental setting. Finally, several core components of the autophagy machinery have been implicated in distinct autophagic processes (canonical and noncanonical autophagy), implying that genetic approaches to block autophagy should rely on targeting two or more autophagy-related genes that ideally participate in distinct steps of the pathway. Along similar lines, because multiple proteins involved in autophagy also regulate other cellular pathways including apoptosis, not all of them can be used as a specific marker for bona fide autophagic responses. Here, we critically discuss current methods of assessing autophagy and the information they can, or cannot, provide. Our ultimate goal is to encourage intellectual and technical innovation in the field
Evaluation of appendicitis risk prediction models in adults with suspected appendicitis
- Author
- Abbas Sh
- Abbas Sh
- Abbassi Oa
- Abbott T
- Abdelgadir Am
- Abdelrahman A
- Abdelrahman M
- Abdelrahman M
- Abdelwahed A
- Abellan M
- Abellán Am
- Abellán Am
- Abulafi M
- Acharya A
- Acosta A
- Adam Me
- Adams Re
- Adegbola So
- Adegbola So
- Adimonye A
- Adnan M
- Afshar S
- Agresta F
- Agua Ia
- Aguayo Jl
- Agudo Ar
- Ahad A
- Ahel J
- Ahern Dp
- Ahmad A
- Ahmed B
- Ahmed G
- Ahmed Os
- Ahmed Os
- Ahmed S
- Ainsworth P
- Ais G
- Ais G
- Aisoni F
- Akbari K
- Akhtar K
- Akinsola O
- Akram F
- Al-Faham Z
- Al-Khafaji N
- Al-Khyatt W
- Al-Musawi S
- Al-Sarireh B
- Al-Sheikh M
- Alagna V
- Alani M
- Alberca-Paramo A
- Aldrey I
- Alexander R
- Alhammali T
- Alhammali T
- Ali M
- Aljorfi A
- Allen M
- Allington J
- Alonzo A
- Alshafei A
- Altomare Ma
- Alvarez Cm
- Alvarez E
- Alvarez-Gallego M
- Amaducci E
- Amarasinghe R
- Amayo A
- Ambrona-Zafra D
- Amin V
- Ammendola M
- Amtul N
- Amtul N
- Amuthalingam T
- Anandan L
- Anania G
- Anania M
- Anderson Dj
- Anderson O
- Andolfi E
- Andreani Sm
- Andreani Sm
- Andrews B
- Ang A
- Ang A
- Angelieri D
- Angelini M
- Angrisani M
- Anguita F
- Ansaloni L
- Ansari A
- Aravind B
- Archer Je
- Arcuri Ga
- Arcuri Ga
- Aremu Ma
- Arenal-Vera Jj
- Aresu S
- Aresu S
- Argenio G
- Argenti F
- Armellini A
- Arnau M
- Arredondo J
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- Bhangu A. Nepogodiev D
- Bhangu A
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- Bianchi Cl
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- Bolton W
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- Branagan G
- Bravo-Gutiérrez Af
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- Brennan S
- Brett M
- Brewer H
- Brewer Hk
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- Brews R
- Brien Jo
- Bronder C
- Brown A
- Brown Ag
- Brown Ce
- Brown Ce
- Brown Ce
- Brown M
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- Brown Od
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- Brunelli Db
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- Bukhari W
- Bull C
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- Busuttil A
- Byrne Be
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- Campagnaro T
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- Campbell U
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- Carrano Fm
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- Cartwright H
- Carvalho Lc
- Carvalho N
- Casimiro C
- Castagnoli G
- Castagnoli G
- Caula C
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- Cavallo D
- Cavero A
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- Cerdán-Santacruz C
- Cerdán-Santacruz C
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- Cervellera M
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- Chillitupa Cz
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- Choong Jh
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- García-Novoa A
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- Murray Mp
- Murru Ml
- Mustafa Ak
- Muzaffar M
- Muñoz-Muñoz E
- Myatt A
- Nadeem A
- Nagarajan D
- Nagendram S
- Nair A
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- Naismith Kn
- Nambiar K
- Nana Gr
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- Napetti S
- Nascimento Ca
- Nash D
- Nash Z
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- Naumann Dn
- Navarro G
- Navarro-Morales L
- Navas-Cuéllar Ja
- Navas-Cuéllar Ja
- Navas-Cuéllar Ja
- Navas-Cuéllar Ja
- Navidad Ms
- Navidad Ms
- Nazarian S
- Nazarian S
- Neagle G
- Neale A
- Neary Pm
- Nehikhare I
- Nelli T
- Neophytou Gi
- Nepogodiev D
- Nepogodiev D
- Nepogodiev D
- Nepogodiev D.
- Newton Rc
- Newton Rc
- Ng J
- Ng M
- Ng S
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- Niaz O
- Nickson S
- Nicol D
- Nicolosi A
- Nigro A
- Nimako E
- Niolu P
- Nistri C
- Nitti D
- Nogueira St
- Nora Mf
- Norcia Gg
- Nyeko-Lacek M
- O'Brien J
- O'Connor Br
- O'Connor Br
- O'Hagan Sc
- O'Leary Dp
- O'Neill E
- O'Neill M
- O'Neill N
- O'Neill R
- O'Sullivan D
- Oakey M
- Obeid N
- Occhioni G
- Odeh A
- Ogboru S
- Ogbuokiri C
- Ojea-Ruiz-Yherla L
- Okekunle B
- Okorocha E
- Olagbaiye O
- Oliva I
- Olivares-Oliver C
- Oliver Jr
- Olivier Jb
- Olivier Jb
- Olmos V
- Ooi R
- Orawiec P
- Orizu M
- Orizu M
- Orlando G
- Orme N
- Ormiston R
- Ormiston R
- Osterberg A
- Padilla E
- Padilla-Valverde D
- Paget C
- Pais M
- Pala M
- Palani-Velu Lk
- Palani-Velu Lk
- Pan Y
- Panagiotopoulos Sp
- Panda N
- Panda N
- Panda N
- Pandey V
- Pandya D
- Pandya R
- Paniagua M
- Pankin Gp
- Papandrea M
- Parajó Ae
- Paramasevon Kr
- Pareja-Ciuró F
- Parisi A
- Park Jh
- Park Jh
- Parkola Mj
- Parra Jm
- Parwaiz I
- Pascua-Sole M
- Pascual-Miguelañez I
- Pasquali S
- Pata F
- Pata F
- Pata F
- Pata F
- Pata F
- Pata F.
- Pata G
- Pata G
- Pata G
- Patel As
- Patel By
- Patel By
- Patel C
- Patel H
- Patel Mm
- Patel N
- Patel Pk
- Patel Rt
- Patil Sd
- Patti S
- Pau R
- Payne Cj
- Payne Re
- Payá-Llorente C
- Payá-Llorente C
- Peacock M
- Pearce J
- Pearce J
- Pearce L
- Pearce L
- Pearson R
- Pedder A
- Peirce Cb
- Peiris Gb
- Peixoto R
- Peleki A
- Peleki A
- Pellegrino L
- Pellicanò Ga
- Pellicer-Franco E
- Pellino G
- Pento V
- Pento V
- Peponis C
- Peprah D
- Pereira A
- Pereira Am
- Pereira J
- Pereira-Mosquera E
- Perera Mi
- Perez-Calvo J
- Perin A
- Pertile D
- Pertile D
- Peña-Barturen C
- Phelan L
- Photiou D
- Pierre R
- Pietrabissa A
- Pigem A
- Pila U
- Pilkington Jp
- Pineño-Flores C
- Pinillos-Somalo A
- Pinkney Td
- Pinkney Td
- Pinkney Td
- Pinna E
- Pino-Perez O
- Pirari Pf
- Pisanu A
- Piu F
- Planellas P
- Plua-Muniz Kt
- Poacher A
- Podda F
- Podda M
- Podda M
- Podda M
- Poillucci G
- Pollard H
- Ponchietti L
- Popova D
- Poudevigne M
- Prats Ma
- Prideaux A
- Prieto-Nieto Mi
- Primo Jc
- Pronin S
- Provenza G
- Puerta E
- Pulighe F
- Pullabatla-Venkata Up
- Punj S
- Pérez-Sanchez Le
- Quddus A
- Quill S
- Quinn Em
- Quinn Hc
- Rabie M
- Rabie Ma
- Rabie Mr
- Radwan Rw
- Radwan Rw
- Rahim A
- Rahman M
- Rahmani Ls
- Rajagopal S
- Rajaram R
- Rajaretnam N
- Rajjoub Y
- Rallage H
- Ramcharan S
- Ramirez L
- Ramirez-Redondo Aa
- Ramos Xh
- Ramos-Bernado Mi
- Ramírez-Faraco M
- Ranathunga S
- Rangarajan K
- Rao M
- Rao V
- Raofi A
- Rashid M
- Rate A
- Ravindran R
- Raymond M
- Raza Ss
- Recreo Ac
- Reddy A
- Reddy A
- Redmond Ae
- Redondo E
- Redondo E
- Redondo-Calvo Fj
- Reese G
- Regina G
- Rehman S
- Rehman S
- Rekhraj S
- Ren Kz
- Renshaw S
- Renshaw S
- Renzi Cr
- Resende Fm
- Rezacova M
- Rezvani S
- Riaz W
- Riba-Combatti L
- Ribaudo M
- Ribeiro B
- Rich Je
- Richardson Td
- Ridaura N
- Riera E
- Rigby S
- Rigney B
- Rinkoff S
- Ripoli Mc
- Robb Hd
- Robertson C
- Robinson A
- Robinson A
- Robinson D
- Robinson D
- Rocha R
- Rodger V
- Rodicio-Miravalles Jl
- Rodriguez L
- Rodriguez-Lopez M
- Rodriguez-Lopez M
- Rodriguez-Lopez M
- Rodríguez Ec
- Rojo Ja
- Roldán-Ortiz S
- Rolph R
- Romano J
- Romano R
- Romario Uf
- Romoli L
- Roncero Ls
- Ronda Rn
- Roomi S
- Rosa Mj
- Rosat A
- Roscio F
- Roscio F
- Roscio F
- Rossi C
- Rossi D
- Rossi Gm
- Roth N
- Rothnie K
- Roxburgh C
- Roy C
- Ruano A
- Rubbini M
- Rudland I
- Ruffolo C
- Rufo E
- Ruggiu Gv
- Ruiz-Marín M
- Ruiz-Marín M
- Rupani S
- Rupasinghe Sn
- Rupasinghe Sn
- Rutherford Dg
- Ruzvidzo F
- Ruzzenente A
- Saad M
- Saad M
- Saavedra-Chacón M
- Saba A
- Sabia D
- Sacco R
- Sacks R
- Sadek S
- Saghir N
- Sagnotta A
- Sagnotta A
- Saha A
- Sahay Sj
- Sahnan K
- Sahnan K
- Sainz B
- Sainz B
- Sajid Ms
- Salama Y
- Salamone G
- Salamone G
- Salamone G
- Salamone G
- Salandini Mc
- Salem A
- Salim S
- Salva Ab
- Salvador H
- Samartin C
- Sammarco G
- Sammarco G
- Samuel M
- Sana S
- Sanchez Er
- Sanchez Er
- Sanchez L
- Sanchez-Garcia S
- Sanchez-Guillen L
- Sanchez-Guillen L
- Sanchez-Martinez A
- Sancho-Muriel J
- Sandu L
- Sanna S
- Santamaria C
- Santamaría Pc
- Santarrufina-Martínez S
- Santos Sc
- Santurro L
- Sanz-Navarro S
- Sarmah P
- Sarmah P
- Sarmah P
- Sarveswaran J
- Sasia D
- Sasia D
- Saunders S
- Savill A
- Savino G
- Savino G
- Savioli F
- Scabini S
- Scabini S
- Scabini S
- Scandroglio Is
- Scanlon K
- Scatizzi M
- Scialandrone G
- Scricciolo M
- Sebastian Jf
- Sebastián-Tomás Jc
- Seddon Tc
- Segalini E
- Segura-Sampedro Jj
- Sena G
- Sena-Ruiz F
- Seneviratne N
- Sepe C
- Serventi F
- Serventi F
- Seth M
- Setshwaelo T
- Sezen E
- Sgardelis P
- Sgrò A
- Sgrò A
- Sgrò A
- Shah J
- Shah K
- Shah Sm
- Shah Sm
- Shaikh Ia
- Shakoor Z
- Shanmuganathan V
- Shanmugarajah K
- Sharma A
- Sharma A
- Sharma P
- Sharp Ol
- Sharp Ol
- Shaw Av
- Shepherd Ja
- Sherif Ma
- Shet S
- Shetty Vd
- Shingler G
- Shiwani Mh
- Shrestha D
- Shurlock J
- Sian T
- Siaw O
- Siddique K
- Siddiqui Mn
- Siddiqui Za
- Sierra-Grañón Je
- Siggens Kl
- Sihra N
- Silva A
- Silva I
- Silvestri V
- Simioni A
- Simmonds L
- Simmonds L
- Simo V
- Simoes J
- Simpson Dj
- Singh A
- Singh J
- Singh P
- Singh S
- Singhal T
- Singhal T
- Sivaloganathan P
- Skalamera I
- Skerritt C
- Slezak I
- Smallcombe N
- Smart Cj
- Smart Cj
- Smart Nj
- Smart Nj
- Smoker H
- Soares A. S.
- Soares As
- Soares As
- Soares As
- Soares As
- Soares As
- Soh B
- Solaini L
- Solar-García L
- Soliani P
- Solinas L
- Sooriyamoorthy T
- Soria-Aledo V
- Soria-Aledo V
- Soriano Jt
- Sorrentino L
- Sousa Hs
- Souter J
- Sparta C
- Spaziani A
- Speake D
- Speake D
- Springate El
- Sreedharan L
- Sreedharan L
- Staderini F
- Stecca T
- Stella M
- Stephens Gf
- Stephens Gf
- Stevenson R
- Stewart Dj
- Stoica I
- Storey R
- Stoyanov Ti
- Strachan E
- Strange Ja
- Stubbs Bm
- Stupalkowska W
- Stupalkowska W
- Suarez-Cabrera A
- Suero Ca
- Sultana A
- Summerfield L
- Sunter H
- Surg Pt
- Suriyakumar S
- Suárez-Sánchez A
- Swords C
- Symons N
- Szentpali K
- Szucs A
- Szucs A
- Sánchez-Cifuentes A
- Sánchez-Fuentes Mn
- Sánchez-Rubio M
- Tabain V
- Taglietti L
- Tague Le
- Tahir W
- Tailor K
- Tallon-Aguilar L
- Tallon-Aguilar L
- Tamayo-López Mj
- Tamborska A
- Tamini N
- Tamini N
- Tamini N
- Tan Cy
- Tan Cy
- Tan E
- Tan Hl
- Tan S
- Tang Am
- Tapiolas I
- Tarazi M
- Tatulli F
- Tay Yh
- Tayeh S
- Taylor M
- Taylor Ns
- Taylor Ns
- Taze D
- Tee A
- Tejero-Pintor Fj
- Tenconi Sm
- Tezas S
- Thaha Ma
- Thakral N
- Thakur D
- Thava B
- Thavanesan N
- Thavanesan N
- Thaventhiran Aj
- Theodoropoulou K
- Thomas At
- Thomas L
- Thompson C
- Thompson Db
- Thompson Db
- Thompson R
- Thompson R
- Thoukididou Sn
- Tiedt La
- Tiedt La
- Ting N
- Tinoco-González J
- Tinsley Bj
- Tognarelli Jm
- Tojal A
- Tokidis E
- Tomasoni M
- Tonini V
- Toomey D
- Toomey Db
- Torkington J
- Torkington J
- Torrado Aa
- Torrance A
- Torrance A
- Townsend Dc
- Townsend Dc
- Tozer Pj
- Trail M
- Trail M
- Trastulli S
- Trew F
- Trostchansky I
- Trujillo-Diaz Jj
- Tsang B
- Tudyka V
- Tudyka V
- Turnbull A
- Turner Ej
- Tutino R
- Twum-Barima Cs
- Twum-Barima Cs
- Tyler R
- Tyler R
- Ugarte-Sierra B
- Vacca A
- Vaccari S
- Vakis S
- Valente Pm
- Valiani Sv
- Vallejo-Bernad C
- Vallve-Bernal M
- Van Boxel Gi
- Vance-Daniel J
- Vannucchi A
- Varcada M
- Vargas-Pierola Hj
- Vaughan Em
- Vaughan Em
- Vazquez-Fernandez Ap
- Vega L
- Velchuru Vr
- Velho R
- Venkata Up
- Venkatasubramaniam Ak
- Venn Ml
- Venn Ml
- Venugopal R
- Verea S
- Veres T
- Veres T
- Verroiotou M
- Vescio G
- Vettoretto N
- Vigorita V
- Vijay V
- Vila-Zarate C
- Villarejo-Campos P
- Vinnicombe Z
- Viscosi F
- Vitish-Sharma P
- Viviani E
- Viñas Nl
- Vohra R
- Vohra R
- Vulcano I
- Waite K
- Walji Hd
- Walsh E
- Walsh Tn
- Walters Kj
- Walters U
- Wardle Bg
- Wardle Bg
- Wardle Sd
- Warren O
- Warren Oj
- Warusavitarne J
- Watfah J
- Watson N
- Wauchope J
- Weatherburn Lw
- Weaver J
- Weegenaar Cr
- Weegenaar Cr
- Welsh S
- Wensley F
- West H
- West H
- Wheatstone S
- Wheeler C
- Whewell He
- White F
- Whitehorn Se
- Whitehorn Se
- Whitehouse P
- Whiteman E
- Whittaker L
- Wiggill S
- Wijesundera K
- Wilcox G
- Wilkin R
- Wilkin R
- Wilkin R
- Wilkin R
- Wilkin R. J. W.
- Williams Gl
- Williams M
- Williams R
- Williams S
- Wilson Ej
- Wilson M
- Winter Dc
- Winter Dc
- Wolff J
- Wong A
- Wong C
- Wong J
- Wong J
- Wong Ml
- Wong Sy
- Woo R
- Wood Cs
- Woodrow C
- Woodward A
- Woodward B
- Woodward B
- Worku D
- Worku D
- Wright E
- Wright Hl
- Wu F
- Xidas A
- Yalamarthi S
- Yang P
- Yanni F
- Yardimci E
- Yasin T
- Yen Sk
- Yeung K
- Yeung K
- Yoganathan S
- Yoong S
- Youssef H
- Yow L
- Yow L
- Zaborowski A
- Zadi Az
- Zalla T
- Zarka Za
- Zarka Za
- Zarog Ma
- Zelazek M
- Zerpa C
- Zhang Ay
- Zhou S
- Zorrilla L
- Zuin M
- Zurleni Tz
- Publication venue
- 'Wiley'
- Publication date
- 01/01/2019
- Field of study
Background
Appendicitis is the most common general surgical emergency worldwide, but its diagnosis remains challenging. The aim of this study was to determine whether existing risk prediction models can reliably identify patients presenting to hospital in the UK with acute right iliac fossa (RIF) pain who are at low risk of appendicitis.
Methods
A systematic search was completed to identify all existing appendicitis risk prediction models. Models were validated using UK data from an international prospective cohort study that captured consecutive patients aged 16–45 years presenting to hospital with acute RIF in March to June 2017. The main outcome was best achievable model specificity (proportion of patients who did not have appendicitis correctly classified as low risk) whilst maintaining a failure rate below 5 per cent (proportion of patients identified as low risk who actually had appendicitis).
Results
Some 5345 patients across 154 UK hospitals were identified, of which two‐thirds (3613 of 5345, 67·6 per cent) were women. Women were more than twice as likely to undergo surgery with removal of a histologically normal appendix (272 of 964, 28·2 per cent) than men (120 of 993, 12·1 per cent) (relative risk 2·33, 95 per cent c.i. 1·92 to 2·84; P < 0·001). Of 15 validated risk prediction models, the Adult Appendicitis Score performed best (cut‐off score 8 or less, specificity 63·1 per cent, failure rate 3·7 per cent). The Appendicitis Inflammatory Response Score performed best for men (cut‐off score 2 or less, specificity 24·7 per cent, failure rate 2·4 per cent).
Conclusion
Women in the UK had a disproportionate risk of admission without surgical intervention and had high rates of normal appendicectomy. Risk prediction models to support shared decision‐making by identifying adults in the UK at low risk of appendicitis were identified
Impact of the treatment of pancreatic exocrine insufficiency on survival of patients with unresectable pancreatic cancer: a retrospective analysis
- Author
- A Landers
- AM Cooperman
- American Joint Committee on Cancer
- CL Case
- CM Halloran
- CM Seiler
- D Li
- DW Golden
- E Richter
- GJ Harris
- HM Gooden
- Ihab Abdulkader
- J Bachmann
- J Mossner
- J Ockenga
- J Toouli
- Javier López-Díaz
- JE Dominguez-Munoz
- JE Dominguez-Munoz
- JE Dominguez-Munoz
- Jose Lariño-Noia
- Juan Enrique Domínguez-Muñoz
- Julio Iglesias-Garcia
- K Ridwelski
- K Spanknebel
- KC Conlon
- L Rahib
- Laura Nieto-Garcia
- M Carpelan-Holmstrom
- M Trede
- M Vujasinovic
- MJ Bruno
- MM Perez
- P Layer
- R Freelove
- R Vera
- RD Dintinjana
- RJ Geer
- RL Siegel
- S Partelli
- SF Sener
- SJ Wigmore
- SM Woo
- T Saito
- T Trang
- V Thorat
- W Davidson
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- Field of study
Accommodation-induced intraocular pressure changes in progressing myopes and emmetropes
- Author
- A Tomlinson
- AJ Lee
- BJ Curtin
- C Leydolt
- DL Nickla
- DO Mutti
- DO Mutti
- DV Muttuvelu
- E Vandewalle
- EAH Mallen
- EC Woodman
- EL Smith
- F Jenssen
- FA Vera-Díaz
- FA Young
- H Jensen
- H Nomura
- J Gwiazda
- J Huang
- JE Gwiazda
- JMM Jorge
- L Huibin
- L Xuemin
- L Yan
- N Feltgen
- P Brusini
- R David
- RE Manny
- RR Mauger
- S Tsukahara
- SA Read
- SA Read
- SA Read
- SM Saw
- T Kida
- TW Walker
- W Drexler
- W Schreiber
- X Jichun
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- Field of study
Consensus guidelines for diagnosis, treatment and follow-up of patients with pancreatic cancer in Spain
- Author
- A Andriulli
- A Maraveyas
- A Stark
- A Wang-Gillam
- A. Calsina
- A. Carmona
- A. López
- A. Martínez
- A. Muñoz
- A. Sanjuanbenito
- AA Khorana
- AC Berger
- AC Moss
- AH Ko
- Alfredo Carrato
- AT Stafford
- B. G. de Paredes
- B. Laquente
- C Guillen-Ponce
- C. Guillén-Ponce
- C. López
- CA Dykewicz
- CA Munroe
- CL Loprinzi
- CW Tzeng
- DB Evans
- DD Hoff Von
- E Ragulin-Coyne
- E. de Madaria
- E. Martín
- EA Mellon
- EP Tamm
- ER Witkowski
- ES Glazer
- F Miura
- F. López-Ríos
- FG Uzunoglu
- G Cwik
- G Morris-Stiff
- Gastrointestinal Tumor Study Group
- GH Lyman
- GH Lyman
- GR Varadhachary
- GY Locker
- GY Yang
- H Mahaseth
- H Nawaz
- H Oettle
- H Oettle
- HA Burris
- HJ Asbun
- HP Siriwardana
- I Ozola Zalite
- I. Alés
- I. González
- I. Peiró
- IJ Sarfeh
- J Arends
- J Yu
- J. Adeva
- J. Blázquez
- J. C. Plaza
- J. Gallego
- J. J. Reina
- J. Martínez
- J. Montans
- JD Roder
- JE Faris
- JE Hooft Van
- JE Kim
- JH Klinkenbijil
- JL Humphris
- JL Humphris
- JM Alamo
- JM Herman
- JM Wyse
- JP Neoptolemos
- JP Neoptolemos
- JW Poley
- K Christians
- K Fearon
- K Foley
- K Nishida
- KD Lillemoe
- KM Sheffield
- L Hazard
- L Marthey
- L. Díez
- M Benavides
- M Bockhorn
- M Braga
- M Ducreux
- M Hameed
- M Hidalgo
- M Porta
- M Søgaard
- M. E. Gallardo
- M. Hidalgo
- M. Salgado
- MA Rothlin
- MH Katz
- MH Katz
- MH Katz
- MI Canto
- MI Canto
- MI Canto
- MJ Bartel
- MM Al-Hawary
- MM Assifi
- MM Corsini
- MP Callery
- N Arkadopoulos
- N Kondo
- NA Gaag Van der
- O. Hernando
- OE Rahma
- P Bertocchi
- P Hammel
- P. Jiménez
- PA Hart
- PF Peddi
- PJ Hosein
- Q Ben
- R Alvarez
- R Thota
- R. Díaz
- R. Pazo
- R. Vera
- R. Yaya
- R. Álvarez
- S Cascinu
- S Gill
- S Gillen
- S Mercadante
- S Mukherjee
- S. Arévalo
- ST Chari
- T Conroy
- T. Fernández
- T. Macarulla
- TJ Smith
- U Boggi
- U Pelzer
- V Pinol
- W Hartwig
- W Hartwig
- WC Liao
- WF Regine
- YG Chen
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 01/01/2016
- Field of study
The management of patients with pancreatic cancer has advanced over the last few years. We convey a multidisciplinary group of experts in an attempt to stablish practical guidelines for the diagnoses, staging and management of these patients. This paper summarizes the main conclusions of the working group. Patients with suspected pancreatic ductal adenocarcinoma should be rapidly evaluated and referred to high-volume centers. Multidisciplinary supervision is critical for proper diagnoses, staging and to frame a treatment plan. Surgical resection together with chemotherapy offers the highest chance for cure in early stage disease. Patients with advanced disease should be classified in treatment groups to guide systemic treatment. New chemotherapeutic regimens have resulted in improved survival. Symptomatic management is critical in this disease. Enrollment in a clinical trial is, in general, recommended
The Impact of Expanded Biofuel Production on Living Nature
- Author
- A Balmford
- A Dobson
- A Fournier
- A Gerakis
- A Hector
- A Lavi
- A Marjokorpi
- A Weigelt
- AA Batabyal
- AB Carey
- AE Lugo
- AJ Symstad
- B Nordén
- B Walker
- B Worm
- BJ Cardinale
- BJM Vries de
- BV Ramovs
- C Castañeda
- C Delire
- C Emmerling
- C Folke
- C Hamilton
- C Kremen
- C Schleupner
- CA Klink
- CB Halpern
- CJ Strange
- CM Duarte
- CM Shackleton
- CO Delang
- D Gustafsson
- D Lamb
- D Lawrence
- D Paré
- D Pimentel
- D Tilman
- D Tilman
- D Tilman
- D Tilman
- DA Fornara
- DA Heemsbergen
- DA Perry
- DA Wardle
- DB Lindenmayer
- DC Nepstad
- DJ Robison
- DJA Johansson
- DP Garrity
- DS Powlson
- E Eriksson
- E Hooper
- ED Grosholz
- F Grifo
- F Jordan
- F Moberg
- F Schläpfer
- G Brown
- G Kerr
- G Marland
- GA Tuskan
- GC Daily
- GC Daily
- GE MacDonald
- GP Nyaupane
- GQA Anderson
- GS Hartshorn
- H Foresta De
- H Haberl
- H Haberl
- HG Zechmeister
- HR Grau
- HW Nugteren
- IPCC
- J Barlow
- J Braun von
- J Börner
- J Cochrane
- J Fargione
- J Goldemberg
- J Goldemberg
- J Lelieveld
- J Liira
- J Lovelock
- J Mikola
- J Rudolphi
- J Withgott
- JA Bird
- JA McNeely
- JB Watkins
- JB Zedler
- JE Duffy
- JE Duffy
- JN Barney
- JS Eklöf
- K Brown
- KA Brauman
- KAM Engelhardt
- KG Lyons
- KJ Wallace
- L Brussaard
- L Christersson
- L Fahrig
- LM Potter
- LP Koh
- LTA Diepen van
- M Cao
- M Carmen Vera-Diaz Del
- M Hoogwijk
- M Loreau
- M Mowforth
- M Noordwijk van
- M Notaro
- M Scheffer
- M Williams
- MA Brennan
- MA Huston
- MC Emmerson
- ME Bowen
- MGA Heijden van der
- MK Jarecki
- ML Imhoff
- MO Gessner
- MR Williams
- MS Reddy
- N Schneider
- N Stern
- N Williams
- N Yamashita
- NB Peet
- OL Petchey
- P Bagla
- P Balvanera
- P Flombaum
- P Gundersen
- P Martens
- P Shanley
- P Sukhdev
- P Vedeld
- PH Gleick
- PM Vitousek
- PO Salonius
- PR Armsworth
- PW Gallagher
- R Betts
- R Chen
- R Costanza
- R Costanza
- R Hajjar
- R Naidoo
- R Otsamo
- R Ptacnik
- R Sage
- RA Betts
- RA Houghton
- RA McPherson
- Renewable Fuels Agency
- RH Marrs
- RK Monson
- RL Naylor
- RT Paine
- S Díaz
- S Díaz
- S Lavergne
- S Mahmood
- S Naeem
- S Nash
- S Raghu
- S Sielhorst
- SC Bhattacharya
- SJ Milton
- SL Postel
- T Mutimukuru
- T Nord-Larsen
- T Searchinger
- T Tscharntke
- TA Carr
- TBH Reusch
- TD Drezner
- TD Drezner
- U Karlowski
- World Bank
- WR Turner
- Y Li
- Y Luo
- Y Malhi
- Z Liu
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 01/01/2009
- Field of study