361 research outputs found
PDB78 The cost-effectvenese of liraglutide vs exenatide for the treatment of type 2 diabetes in the United States
PRM85 Does differential framing of opt-out alternatives in discrete choice experiments (dces) matter? Comparison of random utility maximization (rum) and random regret minimization (rrm) models
Relativistic treatment of harmonics from impurity systems in quantum wires
Within a one particle approximation of the Dirac equation we investigate a
defect system in a quantum wire. We demonstrate that by minimally coupling a
laser field of frequency omega to such an impurity system, one may generate
harmonics of multiples of the driving frequency. In a multiple defect system
one may employ the distance between the defects in order to tune the cut-off
frequency.Comment: 9 pages Latex, 8 eps figures, section added, numerics improve
Ewald methods for polarizable surfaces with application to hydroxylation and hydrogen bonding on the (012) and (001) surfaces of alpha-Fe2O3
We present a clear and rigorous derivation of the Ewald-like method for
calculation of the electrostatic energy of the systems infinitely periodic in
two-dimensions and of finite size in the third dimension (slabs) which is
significantly faster than existing methods. Molecular dynamics simulations
using the transferable/polarizable model by Rustad et al. were applied to study
the surface relaxation of the nonhydroxylated, hydroxylated, and solvated
surfaces of alpha-Fe2O3 (hematite). We find that our nonhydroxylated structures
and energies are in good agreement with previous LDA calculations on
alpha-alumina by Manassidis et al. [Surf. Sci. Lett. 285, L517, 1993]. Using
the results of molecular dynamics simulations of solvated interfaces, we define
end-member hydroxylated-hydrated states for the surfaces which are used in
energy minimization calculations. We find that hydration has a small effect on
the surface structure, but that hydroxylation has a significant effect. Our
calculations, both for gas-phase and solution-phase adsorption, predict a
greater amount of hydroxylation for the (012) surface than for the (001)
surface. Our simulations also indicate the presence of four-fold coordinated
iron ions on the (001) surface.Comment: 23 pages, REVTeX (LaTeX), 8 figures not included, e-mail to
[email protected], paper accepted in Surface Scienc
Spin Susceptibility and Superexchange Interaction in the Antiferromagnet CuO
Evidence for the quasi one-dimensional (1D) antiferromagnetism of CuO is
presented in a framework of Heisenberg model. We have obtained an experimental
absolute value of the paramagnetic spin susceptibility of CuO by subtracting
the orbital susceptibility separately from the total susceptibility through the
Cu NMR shift measurement, and compared directly with the theoretical
predictions. The result is best described by a 1D antiferromagnetic
Heisenberg (AFH) model, supporting the speculation invoked by earlier authors.
We also present a semi-quantitative reason why CuO, seemingly of 3D structure,
is unexpectedly a quasi 1D antiferromagnet.Comment: 7 pages including 4 tables and 9 figure
Treatment-limiting renal tubulopathy in patients treated with tenofovir disoproxil fumarate.
OBJECTIVES: Tenofovir disoproxil fumarate (TDF) is widely used in the treatment or prevention of HIV and hepatitis B infection. TDF may cause renal tubulopathy in a small proportion of recipients. We aimed to study the risk factors for developing severe renal tubulopathy. METHODS: We conducted an observational cohort study with retrospective identification of cases of treatment-limiting tubulopathy during TDF exposure. We used multivariate Poisson regression analysis to identify risk factors for tubulopathy, and mixed effects models to analyse adjusted estimated glomerular filtration rate (eGFR) slopes. RESULTS: Between October 2002 and June 2013, 60 (0.4%) of 15,983 patients who had received TDF developed tubulopathy after a median exposure of 44.1 (IQR 20.4, 64.4) months. Tubulopathy cases were predominantly male (92%), of white ethnicity (93%), and exposed to antiretroviral regimens that contained boosted protease inhibitors (PI, 90%). In multivariate analysis, age, ethnicity, CD4 cell count and use of didanosine or PI were significantly associated with tubulopathy. Tubulopathy cases experienced significantly greater eGFR decline while receiving TDF than the comparator group (-6.60 [-7.70, -5.50] vs. -0.34 [-0.43, -0.26] mL/min/1.73 m2/year, p < 0.0001). CONCLUSIONS: Older age, white ethnicity, immunodeficiency and co-administration of ddI and PI were risk factors for tubulopathy in patients who received TDF-containing antiretroviral therapy. The presence of rapid eGFR decline identified TDF recipients at increased risk of tubulopathy
Caracteristicas epidemiologicas de 105 casos de criptococosis diagnosticados en la república Argentina entre 1981-1990
Velocity-space sensitivity of the time-of-flight neutron spectrometer at JET
The velocity-space sensitivities of fast-ion diagnostics are often described by so-called weight functions. Recently, we formulated weight functions showing the velocity-space sensitivity of the often dominant beam-target part of neutron energy spectra. These weight functions for neutron emission spectrometry (NES) are independent of the particular NES diagnostic. Here we apply these NES weight functions to the time-of-flight spectrometer TOFOR at JET. By taking the instrumental response function of TOFOR into account, we calculate time-of-flight NES weight functions that enable us to directly determine the velocity-space sensitivity of a given part of a measured time-of-flight spectrum from TOFOR
Mapping child growth failure across low- and middle-income countries
Childhood malnutrition is associated with high morbidity and mortality globally1. Undernourished children are more likely to experience cognitive, physical, and metabolic developmental impairments that can lead to later cardiovascular disease, reduced intellectual ability and school attainment, and reduced economic productivity in adulthood2. Child growth failure (CGF), expressed as stunting, wasting, and underweight in children under five years of age (0�59 months), is a specific subset of undernutrition characterized by insufficient height or weight against age-specific growth reference standards3�5. The prevalence of stunting, wasting, or underweight in children under five is the proportion of children with a height-for-age, weight-for-height, or weight-for-age z-score, respectively, that is more than two standard deviations below the World Health Organization�s median growth reference standards for a healthy population6. Subnational estimates of CGF report substantial heterogeneity within countries, but are available primarily at the first administrative level (for example, states or provinces)7; the uneven geographical distribution of CGF has motivated further calls for assessments that can match the local scale of many public health programmes8. Building from our previous work mapping CGF in Africa9, here we provide the first, to our knowledge, mapped high-spatial-resolution estimates of CGF indicators from 2000 to 2017 across 105 low- and middle-income countries (LMICs), where 99 of affected children live1, aggregated to policy-relevant first and second (for example, districts or counties) administrative-level units and national levels. Despite remarkable declines over the study period, many LMICs remain far from the ambitious World Health Organization Global Nutrition Targets to reduce stunting by 40 and wasting to less than 5 by 2025. Large disparities in prevalence and progress exist across and within countries; our maps identify high-prevalence areas even within nations otherwise succeeding in reducing overall CGF prevalence. By highlighting where the highest-need populations reside, these geospatial estimates can support policy-makers in planning interventions that are adapted locally and in efficiently directing resources towards reducing CGF and its health implications. © 2020, The Author(s)
Relationship of edge localized mode burst times with divertor flux loop signal phase in JET
A phase relationship is identified between sequential edge localized modes (ELMs) occurrence times in a set of H-mode tokamak plasmas to the voltage measured in full flux azimuthal loops in the divertor region. We focus on plasmas in the Joint European Torus where a steady H-mode is sustained over several seconds, during which ELMs are observed in the Be II emission at the divertor. The ELMs analysed arise from intrinsic ELMing, in that there is no deliberate intent to control the ELMing process by external means. We use ELM timings derived from the Be II signal to perform direct time domain analysis of the full flux loop VLD2 and VLD3 signals, which provide a high cadence global measurement proportional to the voltage induced by changes in poloidal magnetic flux. Specifically, we examine how the time interval between pairs of successive ELMs is linked to the time-evolving phase of the full flux loop signals. Each ELM produces a clear early pulse in the full flux loop signals, whose peak time is used to condition our analysis. The arrival time of the following ELM, relative to this pulse, is found to fall into one of two categories: (i) prompt ELMs, which are directly paced by the initial response seen in the flux loop signals; and (ii) all other ELMs, which occur after the initial response of the full flux loop signals has decayed in amplitude. The times at which ELMs in category (ii) occur, relative to the first ELM of the pair, are clustered at times when the instantaneous phase of the full flux loop signal is close to its value at the time of the first ELM
- …