A calibrated mammal scale for the Neogene of Western Europe. State of the art

A magnetobiostratigraphically calibrated mammal scale for the Neogene of Western Europe is presented in this paper. The Mammal Neogene MN units originally proposed by Mein [Report on activity RCMNS-Working groups] 1975 have been re-defined here on the basis of first appearances of selected small and large mammal taxa. The chronology of the lower boundaries of each unit had been established mostly after the significant magnetobiostratigraphic framework developed in the last decade in a number of Spanish basins: Ebro, Calatayud-Daroca, Vallès-Penedès, Teruel, Fortuna, Cabriel and Guadix-Baza. In the case of the early and middle Miocene particularly, MN 1, MN 2 and MN 3 , the authors have also taken into account the magnetobiostratigraphic framework developed in the North Alpine Foreland Basin. Some alternative correlations of the magnetostratigraphic data from this last basin are proposed in order to achieve a higher degree of consistence with the data from the Iberian basins. A quite well established magnetostratigraphic calibration of the MN boundaries can be proposed for most of the Neogene, from Middle Miocene to Late Pliocene. On the other hand, the chronological boundaries of the Early Miocene MN units are still poorly constrained due to: (1) scarcity of well-studied, continuous, thick magnetostratigraphic sections; (2) the difficulty in defining the boundaries of the MN zones for this time-span due to the relative homogeneity and persistence of the fossil rodent faunas and the absence of significant large mammal dispersal events. Some of the troubles which arise with the application of the MN units strengthen the need to take into account the palaeobiogeographical meaning of these units and their real suitability to date and correlate through extensive geographic areas

Ethyl-cellulose rumen-protected methionine alleviates inflammation and oxidative stress and improves neutrophil function during the periparturient period and early lactation in Holstein dairy cows.

The periparturient period is the most critical phase in the productive cycle of dairy cows and is characterized by impairment of the immune system. Our objective was to evaluate the effect of feeding ethyl-cellulose rumen-protected methionine (RPM) starting at d -28 from expected parturition through 60 d in milk on biomarkers of inflammation, oxidative stress, and liver function as well as leukocyte function. Sixty multiparous Holstein cows were used in a block design and assigned to either a control or the control plus ethyl-cellulose RPM (Mepron, Evonik Nutrition & Care GmbH). Mepron was supplied from -28 to 60 d in milk at a rate of 0.09% and 0.10% dry matter during the prepartum and postpartum period. That rate ensured that the ratio of Lys to Met in the metabolizable protein was close to 2.8:1. Blood samples from 15 clinically healthy cows per treatment were collected at d -30, -14, 1, 7, 21, 30, and 60 and analyzed for biomarkers of liver function, inflammation, and oxidative stress. Neutrophil and monocyte function in whole blood was measured in vitro at -14, 1, 7, 21, and 30 d in milk. The statistical model included the random effect of block and fixed effect of treatment, time, and its interaction. Compared with control, ethyl-cellulose RPM increased plasma cholesterol and paraoxonase after parturition. Among the inflammation biomarkers measured, ethyl-cellulose RPM led to greater albumin (negative acute-phase protein) and lower haptoglobin than control cows. Although concentration of IL-1β was not affected by treatments, greater IL-6 concentration was detected in response to ethyl-cellulose RPM. Cows supplemented with ethyl-cellulose RPM had greater plasma concentration of ferric-reducing antioxidant power, β-carotene, tocopherol, and total and reduced glutathione, whereas reactive oxygen metabolites were lower compared with control cows. Compared with control, ethyl-cellulose RPM enhanced neutrophil phagocytosis and oxidative burst. Overall, the results indicate that ethyl-cellulose RPM supply to obtain a Lys-to-Met ratio of 2.8:1 in the metabolizable protein during the periparturient period and early lactation is an effective approach to help mitigate oxidative stress and inflammation as well as enhance liver and neutrophil function in dairy cows

MgO-mediated activation of active carbon as an affordable strategy to “in situ” degradation of lindane in contaminated soils

The accumulation in soil landfills of toxic and persistent lindane, widely used as an insecticide, triggers the risk of leaching with the concomitant contamination of surrounding rivers. Thus, viable remediation to eliminate in situ high concentrations of lindane in soil and water becomes an urgent demand. In this line, a simple and costeffective composite is proposed, including the use of industrial wastes. It includes reductive and non-reductive base-catalyzed strategies to remove lindane in the media. A mixture of magnesium oxide (MgO) and activated carbon (AC) was selected for that purpose. The use of MgO provides a basic pH. In addition, the specific selected MgO forms double-layered hydroxides in water which permits the total adsorption of the main heavy metals in contaminated soils. AC provides adsorption microsites to hold the lindane and a reductive atmosphere that was increased when combined with the MgO. These properties trigger highly efficient remediation of the composite. It permits a complete elimination of lindane in the solution. In soils doped with lindane and heavy metals, it produces a rapid, complete, and stable elimination of lindane and immobilization of the metals. Finally, the composite tested in lindane-highly contaminated soils permits the “in situ” degradation of nearly 70% of the initial lindane. The proposed strategy opens a promising way to face this environmental issue with a simple, costeffective composite to degrade lindane and fix heavy metals in contaminated soils

Permeability and conductivity of platelet-reinforced membranes and composites

We present large scale simulations of the diffusion constant $D$ of a random composite consisting of aligned platelets with aspect ratio $a/b>>1$ in a matrix (with diffusion constant $D_0$) and find that $D/D_0 = 1/(1+ c_1 x + c_2 x^2)$, where $x= a v_f/b$ and $v_f$ is the platelet volume fraction. We demonstrate that for large aspect ratio platelets the pair term ($x^2$) dominates suggesting large property enhancements for these materials. However a small amount of face-to-face ordering of the platelets markedly degrades the efficiency of platelet reinforcement.Comment: RevTeX, 5 pages, 4 figures, submitted to PR

Improvement of nutritional quality of greenhouse-grown lettuce by arbuscular mycorrhizal fungi is conditioned by the source of phosphorus nutrition

The improvement of the nutritional quality of lettuce by its association with arbuscular mycorrhizal fungi (AMF) has been recently reported in a previous study. The aim of this research was to evaluate if the fertilization with three P sources differing in water solubility affects the effectiveness of AMF for improving lettuce growth and nutritional quality. The application of either water-soluble P sources (Hewitt's solution and single superphosphate) or the water-insoluble (WI) fraction of a “rhizosphere-controlled fertilizer” did not exert negative effects on the establishment of the mycorrhizal symbiosis. AMF improved lettuce growth and nutritional quality. Nevertheless, the effect was dependent on the source of P and cultivar. Batavia Rubia Munguía (green cultivar) benefited more than Maravilla de Verano (red cultivar) in terms of mineral nutrients, total soluble sugars, and ascorbate contents. The association of lettuce with AMF resulted in greater quantities of anthocyanins in plants fertilized with WI, carotenoids when plants received either Hewitt's solution or WI, and phenolics regardless of the P fertilizer applied

Evidencias de actividad glaciar durante el Dryas reciente (12, 9-11, 7 ka BP) en la Península Ibérica

El Dryas Reciente (Younger Dryas) (GS-1, entre 12, 9 y 11, 7 ka BP) se caracterizó por un marcado descenso de la temperatura a escala global. La consecuencia fue un re avance de los glaciares que afectó también a las cordilleras más importantes de la Península Ibérica. Este trabajo revisa la información disponible sobre la localización, evolución y extensión de tales glaciares. La actividad geomorfológica durante el Dryas Reciente en la Península Ibérica se ha identificado mediante depósitos morrénicos, umbrales rocosos pulidos por el hielo, y glaciares rocosos, datados en la mayor parte de los casos mediante métodos cosmogénicos. Los mejores ejemplos de morrenas del Dryas Reciente se localizan en los Pirineos, donde se desarrollaron cortas lenguas glaciares de hasta 4 km de longitud en los macizos más elevados y numerosos glaciares de circo. También hay evidencias de pequeños glaciares de circo y glaciares rocosos en la Cordillera Cantábrica y en el Sistema Central (sierras de Gredos y Guadarrama), como indican umbrales rocosos y depósitos morrénicos en el frente de circos glaciares. En cambio, en Sierra Nevada, en el extremo meridional de la Península Ibérica, las únicas evidencias del Younger Dryas son glaciares rocosos que se desarrollaron durante el Dryas Antiguo y estuvieron funcionales durante todo el Dryas reciente. The Younger Dryas (GS-1, entre 12, 9 y 11, 7 ka BP) was characterized by a remarkable declining in temperature at a global scale. The consequence was a moderate re-advance of glaciers that also affected the main ranges of the Iberian Peninsula. This paper reviews the available information on the location, evolution and extent of such glaciers. The geomorphological activity during the Younger Dryas in the Iberian Peninsula has been identified throughout the presence of morainic deposits (dated in most cases with cosmogenic exposure ages), rocky thresholds polished by the ice, and rock glaciers. The best examples of Younger Dryas moraines were found in the Central Pyrenees, with short ice tongues of up to 4 km in length in the highest massifs and a number of glacial cirques. There is also evidence of small cirque glaciers in the Cantabrian Range and the Central System Range (Gredos and Guadarrama sierras), as deduced by rocky thresholds and morainic deposits close to cirque headwalls. Conversely, in Sierra Nevada (southernmost sector of the Iberian Peninsula) the only evidence of the Younger Dryas is the presence of rock glaciers that were developed during the Oldest Dryas and survived during the Younger Dryas

Assessment of Osteoarthritis Candidate Genes in a Meta-Analysis of Nine Genome-Wide Association Studies

Objective To assess candidate genes for association with osteoarthritis (OA) and identify promising genetic factors and, secondarily, to assess the candidate gene approach in OA. Methods A total of 199 candidate genes for association with OA were identified using Human Genome Epidemiology (HuGE) Navigator. All of their single-nucleotide polymorphisms (SNPs) with an allele frequency of >5% were assessed by fixed-effects meta-analysis of 9 genome-wide association studies (GWAS) that included 5,636 patients with knee OA and 16,972 control subjects and 4,349 patients with hip OA and 17,836 control subjects of European ancestry. An additional 5,921 individuals were genotyped for significantly associated SNPs in the meta-analysis. After correction for the number of independent tests, P values less than 1.58 × 10−5 were considered significant. Results SNPs at only 2 of the 199 candidate genes (COL11A1 and VEGF) were associated with OA in the meta-analysis. Two SNPs in COL11A1 showed association with hip OA in the combined analysis: rs4907986 (P = 1.29 × 10−5, odds ratio [OR] 1.12, 95% confidence interval [95% CI] 1.06−1.17) and rs1241164 (P = 1.47 × 10−5, OR 0.82, 95% CI 0.74−0.89). The sex-stratified analysis also showed association of COL11A1 SNP rs4908291 in women (P = 1.29 × 10−5, OR 0.87, 95% CI 0.82−0.92); this SNP showed linkage disequilibrium with rs4907986. A single SNP of VEGF, rs833058, showed association with hip OA in men (P = 1.35 × 10−5, OR 0.85, 95% CI 0.79−0.91). After additional samples were genotyped, association at one of the COL11A1 signals was reinforced, whereas association at VEGF was slightly weakened. Conclusion Two candidate genes, COL11A1 and VEGF, were significantly associated with OA in this focused meta-analysis. The remaining candidate genes were not associated

Integrative taxonomy of the genus Dudgeodes Sartori, 2008 (Insecta, Ephemeroptera, Teloganodidae) from the Philippines with description of new species and supplementary descriptions of Southeast Asian species.

COI sequences were used as an initial clustering method to delimit putative species of the genus Dudgeodes in the Philippines. An overview of the diagnostic characters of Philippine species and characters with high intraspecific variability are given. Six new species of Dudgeodes are described and illustrated: D. bauernfeindi Garces & Sartori, sp. nov., D. freitagi Garces & Sartori, sp. nov., D. luntian Garces & Sartori, sp. nov., D. pangantihoni Garces & Sartori, sp. nov., D. tabang Garces & Sartori, sp. nov., and D. vonrinteleni Garces & Sartori, sp. nov., all known from the nymphal stage. Supplementary descriptions are provided for D. pescadori Sartori, 2008, D. hutanis Sartori, 2008, D. stephani Sartori, 2008, D. ulmeri Sartori, 2008, and D. celebensis Sartori, 2008. A key to the nymphs of Philippine Dudgeodes species is proposed

Advanced fuzzy-logic-based context-driven control for HVAC management systems in buildings

Control in HVAC (heating, ventilation and air-conditioning) systems of buildings is not trivial, and its design is considered challenging due to the complexity in the analysis of the dynamics of its nonlinear characteristics for the identification of its mathematical model. HVAC systems are complex since they consist of several elements, such as heat pumps, chillers, valves, heating/cooling coils, boilers, air-handling units, fans, liquid/air distribution systems, and thermal storage systems. This article proposes the application of LAMDA (learning algorithm for multivariable data analysis) for advanced control in HVAC systems for buildings. LAMDA addresses the control problem using a fuzzy classification approach without requiring a mathematical model of the plant/system. The method determines the degree of adequacy of a system for every class and subsequently determines its similarity degree, and it is used to identify the functional state or class of the system. Then, based on a novel inference method that has been added to LAMDA, a control action is computed that brings the system to a zero-error state. The LAMDA controller performance is analyzed via evaluation on a regulation problem of an HVAC system of a building, and it is compared with other similar approaches. According to the results, our method performs impressively in these systems, thereby leading to a trustable model for the implementation of improved building management systems. The LAMDA control performs very well for disturbances by proposing control actions that are not abrupt, and it outperforms the compared approaches. © 2013 IEEE