105 research outputs found
The algebra of adjacency patterns: Rees matrix semigroups with reversion
We establish a surprisingly close relationship between universal Horn classes
of directed graphs and varieties generated by so-called adjacency semigroups
which are Rees matrix semigroups over the trivial group with the unary
operation of reversion. In particular, the lattice of subvarieties of the
variety generated by adjacency semigroups that are regular unary semigroups is
essentially the same as the lattice of universal Horn classes of reflexive
directed graphs. A number of examples follow, including a limit variety of
regular unary semigroups and finite unary semigroups with NP-hard variety
membership problems.Comment: 30 pages, 9 figure
Radiomarcaje y estudios de biodistribución de nanopartículas poliméricas como adyuvantes para la vacunación oftálmica frente a la brucelosis
Objetivos: Optimizar el radiomarcaje con 99mTc de nanopartículas de Gantrez® manosiladas y cargadas
con el antígeno de Brucella Ovis (Man-NP-HS) y llevar a cabo estudios de biodistribución en ratón tras la
administración de las nanopartículas por vía ocular.
Metodología: Las Man-NP-HS se obtuvieron por el método de desplazamiento de disolvente. Se
purificaron, liofilizaron y caracterizaron. A continuación, se marcaron con 74 MBq de 99mTcO4
-
previamente reducido con una disolución ácida de cloruro de estaño, trabajando en ausencia de oxígeno
y con un pH final de 4. El rendimiento del marcaje se evaluó mediante TLC. Los estudios de
biodistribución se llevaron a cabo en ratones tras la administración oftálmica de la formulación y de un
control de 99mTcO4
- libre. Para ello, se sacrificaron los animales a las 2 y a las 24 horas tras la
administración ocular y se contaron los órganos en un contador gamma.
Resultados: Se obtuvo un rendimiento de marcaje superior al 90%. Los estudios de biodistribución de
99mTc-Man-NP-HS permitieron detectar la actividad concentrada en mucosa nasal y ocular y tracto
gastrointestinal tanto a las 2 como a las 24 horas, frente a la biodistribución de 99mTcO4
- libre que permaneció concentrado en la piel alrededor del ojo y en tracto gastrointestinal.
Conclusión: Los estudios de biodistribución de 99mTc-Man-NP-HS tras administración oftálmica han
permitido demostrar su biodistribución en mucosas y tracto gastrointestinal, característica
indispensable como sistema de liberación de antígenos a través de mucosa ocular. Esto, junto con su elevada respuesta inmune, efectiva protección y no virulencia, convierte a estas nanopartículas en una
vacuna ideal anti Brucelosis
Free Abelian 2-Form Gauge Theory: BRST Approach
We discuss various symmetry properties of the Lagrangian density of a four (3
+ 1)-dimensional (4D) free Abelian 2-form gauge theory within the framework of
Becchi-Rouet-Stora-Tyutin (BRST) formalism. The present free Abelian gauge
theory is endowed with a Curci-Ferrari type condition which happens to be a key
signature of the 4D non-Abelian 1-form gauge theory. In fact, it is due to the
above condition that the nilpotent BRST and anti-BRST symmetries of the theory
are found to be absolutely anticommuting in nature. For our present 2-form
gauge theory, we discuss the BRST, anti-BRST, ghost and discrete symmetry
properties of the Lagrangian densities and derive the corresponding conserved
charges. The algebraic structure, obeyed by the above conserved charges, is
deduced and the constraint analysis is performed with the help of the
physicality criteria where the conserved and nilpotent (anti-)BRST charges play
completely independent roles. These physicality conditions lead to the
derivation of the above Curci-Ferrari type restriction, within the framework of
BRST formalism, from the constraint analysis.Comment: LaTeX file, 21 pages, journal referenc
PET tracers for clinical imaging of breast cancer
Molecular imaging of breast cancer has undoubtedly permitted a substantial development of the overall diagnostic accuracy of this malignancy in the last years. Accurate tumour staging, design of individually suited therapies, response evaluation, early detection of recurrence and distant lesions have also evolved in parallel with the development of novel molecular imaging approaches. In this context, positron emission tomography (PET) can be probably seen as the most interesting molecular imaging technology with straightforward clinical application for such purposes. Dozens of radiotracers for PET imaging of breast cancer have been tested in laboratory animals. However, in this review we shall focus mainly in the smaller group of PET radiopharmaceuticals that have lead through into the clinical setting. PET imaging can be used to target general metabolic phenomena related to tumoural transformation, including glucose metabolism and cell proliferation, but can also be directed to specific hormone receptors that are characteristic of the breast cancer cell. Many other receptors and transport molecules present in the tumour cells could also be of interest for imaging. Furthermore, molecules related with the tumour microenvironment, tumour induced angiogenesis or even hypoxia could also be used as molecular biomarkers for breast cancer imaging
First observation of the decay and a measurement of the ratio of branching fractions
The first observation of the decay using
data collected by the LHCb detector at a centre-of-mass energy of 7 TeV,
corresponding to an integrated luminosity of 36 pb, is reported. A
signal of events is obtained and the absence of signal is
rejected with a statistical significance of more than nine standard deviations.
The branching fraction is measured relative to
that of : , where the first uncertainty is statistical, the second systematic and
the third is due to the uncertainty on the ratio of the and
hadronisation fractions.Comment: 10 pages, 3 figures, submitted to Phys. Lett. B; ISSN 0370-269
Consenso colombiano de atención, diagnóstico y manejo de la infección por SARS-COV-2/COVID-19 en establecimientos de atención de la salud Recomendaciones basadas en consenso de expertos e informadas en la evidencia
The “Asociación Colombiana de Infectología” (ACIN) and the “Instituto de Evaluación de Nuevas Tecnologías de la Salud” (IETS) created a task force to develop recommendations for Covid 19 health care diagnosis, management and treatment informed, and based, on evidence. Theses reccomendations are addressed to the health personnel on the Colombian context of health services. © 2020 Asociacion Colombiana de Infectologia. All rights reserved
Future and potential spending on health 2015-40: Development assistance for health, and government, prepaid private, and out-of-pocket health spending in 184 countries
Background: The amount of resources, particularly prepaid resources, available for health can affect access to health care and health outcomes. Although health spending tends to increase with economic development, tremendous variation exists among health financing systems. Estimates of future spending can be beneficial for policy makers and planners, and can identify financing gaps. In this study, we estimate future gross domestic product (GDP), all-sector government spending, and health spending disaggregated by source, and we compare expected future spending to potential future spending. Methods: We extracted GDP, government spending in 184 countries from 1980-2015, and health spend data from 1995-2014. We used a series of ensemble models to estimate future GDP, all-sector government spending, development assistance for health, and government, out-of-pocket, and prepaid private health spending through 2040. We used frontier analyses to identify patterns exhibited by the countries that dedicate the most funding to health, and used these frontiers to estimate potential health spending for each low-income or middle-income country. All estimates are inflation and purchasing power adjusted. Findings: We estimated that global spending on health will increase from US24.24 trillion (uncertainty interval [UI] 20.47-29.72) in 2040. We expect per capita health spending to increase fastest in upper-middle-income countries, at 5.3% (UI 4.1-6.8) per year. This growth is driven by continued growth in GDP, government spending, and government health spending. Lower-middle income countries are expected to grow at 4.2% (3.8-4.9). High-income countries are expected to grow at 2.1% (UI 1.8-2.4) and low-income countries are expected to grow at 1.8% (1.0-2.8). Despite this growth, health spending per capita in low-income countries is expected to remain low, at 195 (157-258) per capita in 2040. Increases in national health spending to reach the level of the countries who spend the most on health, relative to their level of economic development, would mean $321 (157-258) per capita was available for health in 2040 in low-income countries. Interpretation: Health spending is associated with economic development but past trends and relationships suggest that spending will remain variable, and low in some low-resource settings. Policy change could lead to increased health spending, although for the poorest countries external support might remain essential
Design and construction of the MicroBooNE detector
This paper describes the design and construction of the MicroBooNE liquid
argon time projection chamber and associated systems. MicroBooNE is the first
phase of the Short Baseline Neutrino program, located at Fermilab, and will
utilize the capabilities of liquid argon detectors to examine a rich assortment
of physics topics. In this document details of design specifications, assembly
procedures, and acceptance tests are reported
Prompt K_short production in pp collisions at sqrt(s)=0.9 TeV
The production of K_short mesons in pp collisions at a centre-of-mass energy
of 0.9 TeV is studied with the LHCb detector at the Large Hadron Collider. The
luminosity of the analysed sample is determined using a novel technique,
involving measurements of the beam currents, sizes and positions, and is found
to be 6.8 +/- 1.0 microbarn^-1. The differential prompt K_short production
cross-section is measured as a function of the K_short transverse momentum and
rapidity in the region 0 < pT < 1.6 GeV/c and 2.5 < y < 4.0. The data are found
to be in reasonable agreement with previous measurements and generator
expectations.Comment: 6+18 pages, 6 figures, updated author lis
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