PMS48 Cost-Effectiveness of Tocilizumab for The Management of Inadequately Responding Rheumatoid Arthritis Patients

Weiner, LawrencePrimer pla de l'obra. Tres grans paral·lelepípedes de formigó, amb aparença de sarcòfags.Repartits al llarg de l'avinguda. Tots porten uns versos, escrits el 1845, quan tenia 15 anys, pel premi Nobel Frederic Mistral

S=1 kagom\'e Ising model with triquadratic interactions, single-ion anisotropy and magnetic field: exact phase diagrams

We consider a S=1 kagom\'e Ising model with triquadratic interactions around each triangular face of the kagom\'e lattice, single-ion anisotropy and an applied magnetic field. A mapping establishes an equivalence between the magnetic canonical partition function of the model and the grand canonical partition function of a kagom\'e lattice-gas model with localized three-particle interactions. Since exact phase diagrams are known for condensation in the one-parameter lattice-gas model, the mapping directly provides the corresponding exact phase diagrams of the three-parameter S=1 Ising model. As anisotropy competes with interactions, results include the appearance of confluent singularities effecting changes in the topology of the phase diagrams, phase boundary curves (magnetic field vs temperature) with purely positive or negative slopes as well as intermediate cases showing nonmonotonicity, and coexistence curves (magnetization vs temperature) with varying shapes and orientations, in some instances entrapping a homogeneous phase.Comment: 14 pages plus 11 figures; to be published in Physica

Constructive Dimension and Turing Degrees

This paper examines the constructive Hausdorff and packing dimensions of Turing degrees. The main result is that every infinite sequence S with constructive Hausdorff dimension dim_H(S) and constructive packing dimension dim_P(S) is Turing equivalent to a sequence R with dim_H(R) <= (dim_H(S) / dim_P(S)) - epsilon, for arbitrary epsilon > 0. Furthermore, if dim_P(S) > 0, then dim_P(R) >= 1 - epsilon. The reduction thus serves as a *randomness extractor* that increases the algorithmic randomness of S, as measured by constructive dimension. A number of applications of this result shed new light on the constructive dimensions of Turing degrees. A lower bound of dim_H(S) / dim_P(S) is shown to hold for the Turing degree of any sequence S. A new proof is given of a previously-known zero-one law for the constructive packing dimension of Turing degrees. It is also shown that, for any regular sequence S (that is, dim_H(S) = dim_P(S)) such that dim_H(S) > 0, the Turing degree of S has constructive Hausdorff and packing dimension equal to 1. Finally, it is shown that no single Turing reduction can be a universal constructive Hausdorff dimension extractor, and that bounded Turing reductions cannot extract constructive Hausdorff dimension. We also exhibit sequences on which weak truth-table and bounded Turing reductions differ in their ability to extract dimension.Comment: The version of this paper appearing in Theory of Computing Systems, 45(4):740-755, 2009, had an error in the proof of Theorem 2.4, due to insufficient care with the choice of delta. This version modifies that proof to fix the error

Universal fluctuations in subdiffusive transport

Subdiffusive transport in tilted washboard potentials is studied within the fractional Fokker-Planck equation approach, using the associated continuous time random walk (CTRW) framework. The scaled subvelocity is shown to obey a universal law, assuming the form of a stationary Levy-stable distribution. The latter is defined by the index of subdiffusion alpha and the mean subvelocity only, but interestingly depends neither on the bias strength nor on the specific form of the potential. These scaled, universal subvelocity fluctuations emerge due to the weak ergodicity breaking and are vanishing in the limit of normal diffusion. The results of the analytical heuristic theory are corroborated by Monte Carlo simulations of the underlying CTRW

Smart packaging for photonics

Unlike silicon microelectronics, photonics packaging has proven to be low yield and expensive. One approach to make photonics packaging practical for low cost applications is the use of {open_quotes}smart{close_quotes} packages. {open_quotes}Smart{close_quotes} in this context means the ability of the package to actuate a mechanical change based on either a measurement taken by the package itself or by an input signal based on an external measurement. One avenue of smart photonics packaging, the use of polysilicon micromechanical devices integrated with photonic waveguides, was investigated in this research (LDRD 3505.340). The integration of optical components with polysilicon surface micromechanical actuation mechanisms shows significant promise for signal switching, fiber alignment, and optical sensing applications. The optical and stress properties of the oxides and nitrides considered for optical waveguides and how they are integrated with micromechanical devices were investigated

The PKC, HOG and Ca2+ signalling pathways co-ordinately regulate chitin synthesis in Candida albicans

Open Access via PMC2649417Peer reviewedPublisher PD

Polynomial diffeomorphisms of C^2, IV: The measure of maximal entropy and laminar currents

This paper concerns the dynamics of polynomial automorphisms of ${\bf C}^2$. One can associate to such an automorphism two currents $\mu^\pm$ and the equilibrium measure $\mu=\mu^+\wedge\mu^-$. In this paper we study some geometric and dynamical properties of these objects. First, we characterize $\mu$ as the unique measure of maximal entropy. Then we show that the measure $\mu$ has a local product structure and that the currents $\mu^\pm$ have a laminar structure. This allows us to deduce information about periodic points and heteroclinic intersections. For example, we prove that the support of $\mu$ coincides with the closure of the set of saddle points. The methods used combine the pluripotential theory with the theory of non-uniformly hyperbolic dynamical systems

Unstimulated cortisol secretory activity in everyday life and its relationship with fatigue and chronic fatigue syndrome : a systematic review and subset meta-analysis

Copyright © 2013 The Authors. Published by Elsevier Ltd.. All rights reserved.Peer reviewedPublisher PD

Gravitational collapse of a Hagedorn fluid in Vaidya geometry

The gravitational collapse of a high-density null charged matter fluid, satisfying the Hagedorn equation of state, is considered in the framework of the Vaidya geometry. The general solution of the gravitational field equations can be obtained in an exact parametric form. The conditions for the formation of a naked singularity, as a result of the collapse of the compact object, are also investigated. For an appropriate choice of the arbitrary integration functions the null radial outgoing geodesic, originating from the shell focussing central singularity, admits one or more positive roots. Hence a collapsing Hagedorn fluid could end either as a black hole, or as a naked singularity. A possible astrophysical application of the model, to describe the energy source of gamma-ray bursts, is also considered.Comment: 14 pages, 2 figures, to appear in Phys. Rev.