33 research outputs found
e-Pilly TROP Maladies infectieuses tropicales
Lâe-Pilly TROP est un ouvrage dâinfectiologie tropicale destinĂ© aux mĂ©decins et aux Ă©tudiants en mĂ©decine des pays francophones du Sud. La prise en compte des diffĂ©rents niveaux de la pyramide sanitaire dans ces pays le rend aussi accessible aux infirmiers des centres de santĂ© communautaires urbains et des structures de santĂ© intermĂ©diaires des zones rurales. Par dĂ©finition, les Pays En DĂ©veloppement accroissant progressivement leurs capacitĂ©s de diagnostic biologique et de traitement, les outils de prise en charge correspondent aux moyens des niveaux pĂ©riphĂ©riques comme Ă ceux des niveaux hospitaliers de rĂ©fĂ©rence
Antiretroviral-naive and -treated HIV-1 patients can harbour more resistant viruses in CSF than in plasma
Objectives The neurological disorders in HIV-1-infected patients remain prevalent. The HIV-1 resistance in plasma and CSF was compared in patients with neurological disorders in a multicentre study. Methods Blood and CSF samples were collected at time of neurological disorders for 244 patients. The viral loads were >50 copies/mL in both compartments and bulk genotypic tests were realized. Results On 244 patients, 89 and 155 were antiretroviral (ARV) naive and ARV treated, respectively. In ARV-naive patients, detection of mutations in CSF and not in plasma were reported for the reverse transcriptase (RT) gene in 2/89 patients (2.2%) and for the protease gene in 1/89 patients (1.1%). In ARV-treated patients, 19/152 (12.5%) patients had HIV-1 mutations only in the CSF for the RT gene and 30/151 (19.8%) for the protease gene. Two mutations appeared statistically more prevalent in the CSF than in plasma: M41L (Pâ=â0.0455) and T215Y (Pâ=â0.0455). Conclusions In most cases, resistance mutations were present and similar in both studied compartments. However, in 3.4% of ARV-naive and 8.8% of ARV-treated patients, the virus was more resistant in CSF than in plasma. These results support the need for genotypic resistance testing when lumbar puncture is performe
First results of the Instrumentation Line for the deep-sea ANTARES neutrino telescope
In 2005, the ANTARES Collaboration deployed and operated at a depth of 2500 m a so-called Mini Instrumentation Line equipped with Optical Modules (MILOM) at the ANTARES site. The various data acquired during the continuous operation from April to December 2005 of the MILOM confirm the satisfactory performance of the Optical Modules, their front-end electronics and readout system. as well as the calibration devices of the detector. The in situ measurement of the Optical Module time response yields a resolution better than 0.5 ns. The performance of the acoustic positioning system, which enables the spatial reconstruction of the ANTARES detector with a precision of about 10 cm, is verified. These results demonstrate that with the full ANTARES neutrino telescope the design angular resolution of better than 0.3 degrees can be realistically achieved
The data acquisition system for the ANTARES neutrino telescope
The ANTARES neutrino telescope is being constructed in the Mediterranean Sea.
It consists of a large three-dimensional array of photo-multiplier tubes. The
data acquisition system of the detector takes care of the digitisation of the
photo-multiplier tube signals, data transport, data filtering, and data
storage. The detector is operated using a control program interfaced with all
elements. The design and the implementation of the data acquisition system are
described.Comment: 20 pages, 6 figures, accepted for publication in Nucl. Instrum. Meth.
Autoantibodies against type I IFNs in patients with life-threatening COVID-19
Interindividual clinical variability in the course of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection is vast. We report that at least 101 of 987 patients with life-threatening coronavirus disease 2019 (COVID-19) pneumonia had neutralizing immunoglobulin G (IgG) autoantibodies (auto-Abs) against interferon-w (IFN-w) (13 patients), against the 13 types of IFN-a (36), or against both (52) at the onset of critical disease; a few also had auto-Abs against the other three type I IFNs. The auto-Abs neutralize the ability of the corresponding type I IFNs to block SARS-CoV-2 infection in vitro. These auto-Abs were not found in 663 individuals with asymptomatic or mild SARS-CoV-2 infection and were present in only 4 of 1227 healthy individuals. Patients with auto-Abs were aged 25 to 87 years and 95 of the 101 were men. A B cell autoimmune phenocopy of inborn errors of type I IFN immunity accounts for life-threatening COVID-19 pneumonia in at least 2.6% of women and 12.5% of men
Bacterial culture through selective and non-selective conditions: the evolution of culture media in clinical microbiology
International audienc
âHelcococcus massiliensisâ sp. nov., a new bacterial species isolated from the vaginal sample of a woman with bacterial vaginosis living in Dielmo, Senegal
We report here the isolation of a new bacterial species âHelcococcus massiliensisâ strain Marseille P4590 (CSURP4590), isolated from the vaginal sample of a woman with bacterial vaginosis. Keywords: Culturomics, Genomics, Helcococcus massiliensis, Taxonogenomics, Taxonom
Isolation and culture of Methanobrevibacter smithii by co-culture with hydrogen-producing bacteria on agar plates
International audienc
Hepatitis A outbreak in HIV-infected patients in Southeastern France: questions and responses?
International audienc
âCollinsella provencensisâ sp. nov., âParabacteroides bouchesdurhonensisâ sp. nov. and âSutterella seckii,â sp. nov., three new bacterial species identified from human gut microbiota
We report here the main characteristics of âCollinsella provencensisâ strain Marseille-P3740 (CSUR P3740), âParabacteroides bouchesdurhonensisâ strain Marseille-P3763 (CSUR P3763) and âSutterella seckiiâ strain Marseille-P3660 (CSUR P3660), which were isolated using culturomics from the human gut microbiota of healthy individuals living in Marseille. Keywords: Collinsella provencensis, culturomics, Parabacteroides bouchesdurhonensis, Sutterella secki