Impact exercise strategies in the HRQOL of the sedentary adults

El objetivo del estudio fue analizar la eficacia de diferentes estrategias de intervención del ejercicio físico y relacionarlas con la percepción de la calidad de vida relacionada con la salud (CVRS) en adultos mayores sedentarios. Participaron 100 sujetos, con edades comprendidas entre los 60 y 70 años, que fueron divididos aleatoriamente en cuatro grupos: control, recomendación, prescripción y monitorización. La intervención de ejercicio físico tuvo una duración de 6 meses. Para la valoración de la CVRS se utilizó el cuestionario SF-36. Los grupos monitorización y prescripción obtuvieron los mayores valores en todos los dominios en el análisis intragrupos. La función física y la salud general y mental obtienen los mayores valores significativos entre grupos (p<.05). Entre los grupos prescripción y monitorización no existen diferencias significativas en ninguna dimensión. Sin embargo el grupo de monitorización obtuvo valores superiores en salud mental, no siendo así en salud físicaThe aim of the study was to analyze the effectiveness of different intervention strategies of exercise and relate the perception of quality of life related to health (HRQOL) in sedentary older adults. It involved 100 subjects, aged between 60 and 70, who were randomly divided into four groups: control, recommend, prescribe and monitor. The exercise intervention lasted 6 months. The SF-36 questionnaire was used for the assessment of HRQOL. The monitoring and prescription groups had higher values in all domains in the intragroup analysis. Physical function and health and mental health obtain the highest significant values between groups (p <.05). There are no significant differences at all in any domain among prescription and monitoring groups. However, the monitoring group obtained higher values in mental health, but were not in physical healt

Magnetic field frustration of the metal-insulator transition in V2 O3

Despite decades of efforts, the origin of metal-insulator transitions (MITs) in strongly correlated materials remains one of the main long-standing problems in condensed-matter physics. An archetypal example is V2O3, which undergoes simultaneous electronic, structural, and magnetic phase transitions. This remarkable feature highlights the many degrees of freedom at play in this material. In this work, acting solely on the magnetic degree of freedom, we reveal an anomalous feature in the electronic transport of V2O3: On cooling, the magnetoresistance changes from positive to negative values well above the MIT temperature, and shows divergent behavior at the transition. The effects are attributed to the magnetic field quenching antiferromagnetic fluctuations above the Néel temperature TN, and preventing long-range antiferromagnetic ordering below TN. In both cases, suppressing the antiferromagnetic ordering prevents the opening of the incipient electronic gap. This interpretation is supported by Hubbard model calculations which fully reproduce the experimental behavior. Our study sheds light on this classic problem providing a clear and physical interpretation of the nature of the metal-insulator transition.Fil: Trastoy, J.. University of California at San Diego; Estados UnidosFil: Camjayi, Alberto. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Ciudad Universitaria. Instituto de Física de Buenos Aires. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Instituto de Física de Buenos Aires; ArgentinaFil: Del Valle, J.. University of California at San Diego; Estados UnidosFil: Kalcheim, Y.. University of California at San Diego; Estados UnidosFil: Crocombette, J. P.. Université Paris-Saclay; FranciaFil: Gilbert, D.A.. University of Tennessee; Estados UnidosFil: Borchers, J.A.. Nist Center For Neutron Research; Estados UnidosFil: Villegas, J.E.. Université Paris-Saclay; FranciaFil: Ravelosona, D.. Center For Nanoscience And Nanotechnology; FranciaFil: Rozenberg, M.J.. Université Paris-Saclay; FranciaFil: Schuller, Ivan K.. University of California at San Diego; Estados Unido

Evolución reciente del glaciar del Infierno (Panticosa, Huesca)

Este artículo analiza la evolución del glaciar del pico Infierno desde un glaciar blanco hacia un glaciar cubierto y, tal vez, hacia un glaciar rocoso

OSL-dating of the Pleistocene-Holocene climatic transition in loess from China, Europe and North America, and evidence for accretionary pedogenesis

Loess deposits intercalated by paleosols are detailed terrestrial archives of Quaternary climate variability providing information on the global dust cycle and landscape dynamics. Their paleoclimatic significance is often explored by quantifying their mineral magnetic properties due to their sensitivity to local/regional hydroclimate variability. Detailed chronological assessment of such regional proxy records around the climatic transitions allow a better understanding of how regional records react to major global climatic transitions such as the Pleistocene-Holocene climatic transition. Logs of high-resolution magnetic susceptibility and its frequency dependence were used as paleoclimatic proxies to define the environmental transition from the last glacial loess to the current interglacial soil as reflected in nine loess-paleosol sequences across the northern hemisphere, from the Chinese Loess Plateau, the southeastern European loess belt and the central Great Plains, USA. The onset of increase in magnetic susceptibility above typical loess values was used to assess the onset of, and developments during, the Pleistocene-Holocene climatic transition. High-resolution luminescence dating was applied on multiple grain-sizes (4–11 μm, 63–90 μm, 90–125 μm) of quartz extracts from the same sample in order to investigate the timing of Pleistocene-Holocene climatic transition in the investigated sites. The magnetic susceptibility signal shows a smooth and gradual increase for the majority of the sites from the typical low loess values to the interglacial ones. The initiation of this increase, interpreted as recording the initiation of the Pleistocene-Holocene climatic transition at each site, was dated to 14–17.5 ka or even earlier. Our chronological results highlight the need of combining paleoclimatic proxies (magnetic susceptibility) with absolute dating when investigating the Pleistocene-Holocene climatic transition as reflected by the evolution of this proxy in order to avoid chronostratigraphic misinterpretations in loess-paleosol records caused by simple pattern correlation. The detailed luminescence chronologies evidence the continuity of eolian mineral dust accumulation regardless of glacial or interglacial global climatic regimes. Coupled with magnetic susceptibility records this indicates that dust sedimentation and pedogenesis act simultaneously and result in a non-negligible accretional component in the formation of Holocene soils in loess regions across the Northern Hemisphere. The luminescence ages allowed the modeling of accumulation rates for the Holocene soil which are similar for European, Chinese and U.S.A. loess sites investigated and vary from 2 cm ka−1 to 9 cm ka−1. While accretional pedogenesis has often been implicitly or explicitly assumed in paleoclimatic interpretation of loess-paleosol sequences, especially in the Chinese Loess Plateau, our luminescence data add direct evidence for ongoing sedimentation as interglacial soils formed

Phenomenological Tests of Supersymmetric A_4 Family Symmetry Model of Neutrino Mass

Recently Babu, Ma and Valle proposed a model of quark and lepton mixing based on $A_4$ symmetry. Within this model the lepton and slepton mixings are intimately related. We perform a numerical study in order to derive the slepton masses and mixings in agreement with present data from neutrino physics. We show that, starting from three-fold degeneracy of the neutrino masses at a high energy scale, a viable low energy neutrino mass matrix can indeed be obtained in agreement with constraints on lepton flavour violating $\mu$ and $\tau$ decays. The resulting slepton spectrum must necessarily include at least one mass below 200 GeV which can be produced at the LHC. The predictions for the absolute Majorana neutrino mass scale $m_0 \geq 0.3$ eV ensure that the model will be tested by future cosmological tests and $\beta\beta_{0\nu}$ searches. Rates for lepton flavour violating processes $\ell_j \to \ell_i + \gamma$ in the range of sensitivity of current experiments are typical in the model, with BR(\mu \to e \gamma) \gsim 10^{-15} and the lower bound BR$(\tau \to \mu \gamma) > 10^{-9}$. To first approximation, the model leads to maximal leptonic CP violation in neutrino oscillations.Comment: 23 pages, 7 figure

High prognostic value of measurable residual disease detection by flow cytometry in chronic lymphocytic leukemia patients treated with front-line fludarabine, cyclophosphamide, and rituximab, followed by three years of rituximab maintenance

It has been postulated that monitoring measurable residual disease (MRD) could be used as a surrogate marker of progression-free survival (PFS) in chronic lymphocytic leukemia (CLL) patients after treatment with immunochemotherapy regimens. In this study, we analyzed the outcome of 84 patients at 3 years of follow-up after first-line treatment with fludarabine, cyclophosphamide and rituximab (FCR) induction followed by 36 months of rituximab maintenance thearpy. MRD was assessed by a quantitative four-color flow cytometry panel with a sensitivity level of 10-4. Eighty out of 84 evaluable patients (95.2%) achieved at least a partial response or better at the end of induction. After clinical evaluation, 74 patients went into rituximab maintenance and the primary endpoint was assessed in the final analysis at 3 years of follow-up. Bone marrow (BM) MRD analysis was performed after the last planned induction course and every 6 months in cases with detectable residual disease during the 36 months of maintenance therapy. Thirty-seven patients (44%) did not have detectable residual disease in the BM prior to maintenance therapy. Interestingly, 29 patients with detectable residual disease in the BM after induction no longer had detectable disease in the BM following maintenance therapy. After a median followup of 6.30 years, the median overall survival (OS) and PFS had not been reached in patients with either undetectable or detectable residual disease in the BM, who had achieved a complete response at the time of starting maintenance therapy. Interestingly, univariate analysis showed that after rituximab maintenance OS was not affected by IGHV status (mutated vs. unmutated OS: 85.7% alive at 7.2 years vs. 79.6% alive at 7.3 years, respectively). As per protocol, 15 patients (17.8%), who achieved a complete response and undetectable peripheral blood and BM residual disease after four courses of induction, were allowed to stop fludarabine and cyclophosphamide and complete two additional courses of rituximab and continue with maintenance therapy for 18 cycles. Surprisingly, the outcome in this population was similar to that observed in patients who received the full six cycles of the induction regimen. These data show that, compared to historic controls, patients treated with FCR followed by rituximab maintenance have high-quality responses with fewer relapses and improved OS. The tolerability of this regime is favorable. Furthermore, attaining an early undetectable residual disease status could shorten the duration of chemoimmunotherapy, reducing toxicities and preventing long-term side effects. The analysis of BM MRD after fludarabine-based induction could be a powerful predictor of post-maintenance outcomes in patients with CLL undergoing rituximab maintenance and could be a valuable tool to identify patients at high risk of relapse, influencing further treatment strategies

Quantum transport through STM-lifted single PTCDA molecules

Using a scanning tunneling microscope we have measured the quantum conductance through a PTCDA molecule for different configurations of the tip-molecule-surface junction. A peculiar conductance resonance arises at the Fermi level for certain tip to surface distances. We have relaxed the molecular junction coordinates and calculated transport by means of the Landauer/Keldysh approach. The zero bias transmission calculated for fixed tip positions in lateral dimensions but different tip substrate distances show a clear shift and sharpening of the molecular chemisorption level on increasing the STM-surface distance, in agreement with experiment.Comment: accepted for publication in Applied Physics

Corrosion behaviour of Mg–Zn–Y–Mischmetal alloys in phosphate buffer saline solution

The influence of the processing route and chemical composition in the corrosion behaviour of two Mg-Zn-Y-Mischmetal alloys has been evaluated in phosphate buffer saline solution. The corrosion resistance of the alloy processed by conventional techniques was substantially higher than that found for the same alloy processed from atomised powders. Fine homogeneous distribution of the second-phase particles promoted severe attack due to the enhanced number of galvanic microcells. A higher concentration of zinc and a lower content of rare earth additions improved the corrosion resistance of the alloys due to the lower volume fraction of second-phase particles. © 2012 Elsevier Ltd.Peer Reviewe

Surgical treatment for colorectal cancer: Analysis of the influence of an enhanced recovery programme on long-term oncological outcomes-a study protocol for a prospective, multicentre, observational cohort study

Introduction The evidence currently available from enhanced recovery after surgery (ERAS) programmes concerns their benefits in the immediate postoperative period, but there is still very little evidence as to whether their correct implementation benefits patients in the long term. The working hypothesis here is that, due to the lower response to surgical aggression and lower rates of postoperative complications, ERAS protocols can reduce colorectal cancer-related mortality. The main objective of this study is to analyse the impact of an ERAS programme for colorectal cancer on 5-year survival. As secondary objectives, we propose to analyse the weight of each of the predefined items in the oncological results as well as the quality of life. Methods and analysis A multicentre prospective cohort study was conducted in patients older than 18 years of age who are scheduled to undergo surgery for colorectal cancer. The study involved 12 hospitals with an implemented enhanced recovery protocol according to the guidelines published by the Spanish National Health Service. The intervention group includes patients with a minimum implementation level of 70%, and the control group includes those who fail to reach this level. Compliance will be studied using 18 key performance indicators, and the results will be analysed using cancer survival indicators, including overall survival, cancer-specific survival and relapse-free survival. The time to recurrence, perioperative morbidity and mortality, hospital stay and quality of life will also be studied, the latter using the validated EuroQol Five questionnaire. The propensity index method will be used to create comparable treatment and control groups, and a multivariate regression will be used to study each variable. The Kaplan-Meier estimator will be used to estimate survival and the log-rank test to make comparisons. A p value of less than 0.05 (two-tailed) will be considered to be significant. Ethics and dissemination Ethical approval for this study was obtained from the Aragon Ethical Committee (C.P.-C.I. PI20/086) on 4 March 2020. The findings of this study will be submitted to peer-reviewed journals (BMJ Open, JAMA Surgery, Annals of Surgery, British Journal of Surgery). Abstracts will be submitted to relevant national and international meetings. Trial registration number NCT04305314