8,947 research outputs found
CP violation with a dynamical Higgs
We determine the complete set of independent gauge and gauge-Higgs CP-odd
effective operators for the generic case of a dynamical Higgs, up to four
derivatives in the chiral expansion. The relation with the linear basis of
dimension six CP-odd operators is clarified. Phenomenological applications
include bounds inferred from electric dipole moment limits, and from present
and future collider data on triple gauge coupling measurements and Higgs
signals.Comment: 41 pages, 3 figures; V2: citations added, typos corrected, version
published on JHE
Study of thermal protection requirements for a lifting body entry vehicle suitable for near-earth missions Final report
Reentry and abort trajectory analyses, and thermal protection requirements for lifting body entry vehicle
Spatial clustering of mental disorders and associated characteristics of the neighbourhood context in Malmö, Sweden, in 2001
Study objective: Previous research provides preliminary evidence of spatial variations of mental disorders and associations between neighbourhood social context and mental health. This study expands past literature by (1) using spatial techniques, rather than multilevel models, to compare the spatial distributions of two groups of mental disorders (that is, disorders due to psychoactive substance use, and neurotic, stress related, and somatoform disorders); and (2) investigating the independent impact of contextual deprivation and neighbourhood social disorganisation on mental health, while assessing both the magnitude and the spatial scale of these effects.
Design: Using different spatial techniques, the study investigated mental disorders due to psychoactive substance use, and neurotic disorders.
Participants: All 89 285 persons aged 40–69 years residing in Malmö, Sweden, in 2001, geolocated to their place of residence.
Main results: The spatial scan statistic identified a large cluster of increased prevalence in a similar location for the two mental disorders in the northern part of Malmö. However, hierarchical geostatistical models showed that the two groups of disorders exhibited a different spatial distribution, in terms of both magnitude and spatial scale. Mental disorders due to substance consumption showed larger neighbourhood variations, and varied in space on a larger scale, than neurotic disorders. After adjustment for individual factors, the risk of substance related disorders increased with neighbourhood deprivation and neighbourhood social disorganisation. The risk of neurotic disorders only increased with contextual deprivation. Measuring contextual factors across continuous space, it was found that these associations operated on a local scale.
Conclusions: Taking space into account in the analyses permitted deeper insight into the contextual determinants of mental disorders
STRENGTHENING COOPERATION WITH THIRD COUNTRIES IN THE FIELD OF HIGHER EDUCATION. 14388/01 (Presse 437-G), 29 November 2001
BACKGROUND: In many European countries, medicines promotion is governed by voluntary codes of practice administered by the pharmaceutical industry under its own system of self-regulation. Involvement of industry organizations in policing promotion has been proposed to deter illicit conduct, but few detailed studies on self-regulation have been carried out to date. The objective of this study was to examine the evidence for promotion and self-regulation in the UK and Sweden, two countries frequently cited as examples of effective self-regulation. METHODS AND FINDINGS: We performed a qualitative content analysis of documents outlining the constitutions and procedures of these two systems. We also gathered data from self-regulatory bodies on complaints, complainants, and rulings for the period 2004-2012. The qualitative analysis revealed similarities and differences between the countries. For example, self-regulatory bodies in both countries are required to actively monitor promotional items and impose sanctions on violating companies, but the range of sanctions is greater in the UK where companies may, for instance, be audited or publicly reprimanded. In total, Swedish and UK bodies ruled that 536 and 597 cases, respectively, were in breach, equating to an average of more than one case/week for each country. In Sweden, 430 (47%) complaints resulted from active monitoring, compared with only two complaints (0.2%) in the UK. In both countries, a majority of violations concerned misleading promotion. Charges incurred on companies averaged €447,000 and €765,000 per year in Sweden and the UK, respectively, equivalent to about 0.014% and 0.0051% of annual sales revenues, respectively. One hundred cases in the UK (17% of total cases in breach) and 101 (19%) in Sweden were highlighted as particularly serious. A total of 46 companies were ruled in breach of code for a serious offence at least once in the two countries combined (n = 36 in the UK; n = 27 in Sweden); seven companies were in serious violation more than ten times each. A qualitative content analysis of serious violations pertaining to diabetes drugs (UK, n = 15; Sweden, n = 6; 10% of serious violations) and urologics (UK, n = 6; Sweden, n = 13; 9%) revealed various types of violations: misleading claims (n = 23; 58%); failure to comply with undertakings (n = 9; 23%); pre-licensing (n = 7; 18%) or off-label promotion (n = 2; 5%); and promotion of prescription drugs to the public (n = 6; 15%). Violations that go undetected or unpunished by self-regulatory bodies are the main limitation of this study, since they are likely to lead to an underestimate of industry misconduct. CONCLUSIONS: The prevalence and severity of breaches testifies to a discrepancy between the ethical standard codified in industry Codes of Conduct and the actual conduct of the industry. We discuss regulatory reforms that may improve the quality of medicines information, such as pre-vetting and intensified active monitoring of promotion, along with larger fines, and giving greater publicity to rulings. But despite the importance of improving regulatory arrangements in an attempt to ensure unbiased medicines information, such efforts alone are insufficient because simply improving oversight and increasing penalties fail to address additional layers of industry bias
Higgs ultraviolet softening
We analyze the leading effective operators which induce a quartic momentum
dependence in the Higgs propagator, for a linear and for a non-linear
realization of electroweak symmetry breaking. Their specific study is relevant
for the understanding of the ultraviolet sensitivity to new physics. Two
methods of analysis are applied, trading the Lagrangian coupling by: i) a
"ghost" scalar, after the Lee-Wick procedure; ii) other effective operators via
the equations of motion. The two paths are shown to lead to the same effective
Lagrangian at first order in the operator coefficients. It follows a
modification of the Higgs potential and of the fermionic couplings in the
linear realization, while in the non-linear one anomalous quartic gauge
couplings, Higgs-gauge couplings and gauge-fermion interactions are induced in
addition. Finally, all LHC Higgs and other data presently available are used to
constrain the operator coefficients; the future impact of data via off-shell Higgs exchange and of vector boson fusion data is
considered as well. For completeness, a summary of pure-gauge and gauge-Higgs
signals exclusive to non-linear dynamics at leading-order is included.Comment: 31 pages, 3 figures, 7 table
Disentangling a dynamical Higgs
The pattern of deviations from Standard Model predictions and couplings is
different for theories of new physics based on a non-linear realization of the
gauge symmetry breaking and those assuming a linear
realization. We clarify this issue in a model-independent way via its effective
Lagrangian formulation in the presence of a light Higgs particle, up to first
order in the expansions: dimension-six operators for the linear expansion and
four derivatives for the non-linear one. Complete sets of pure gauge and
gauge-Higgs operators are considered, implementing the renormalization
procedure and deriving the Feynman rules for the non-linear expansion. We
establish the theoretical relation and the differences in physics impact
between the two expansions. Promising discriminating signals include the
decorrelation in the non-linear case of signals correlated in the linear one:
some pure gauge versus gauge-Higgs couplings and also between couplings with
the same number of Higgs legs. Furthermore, anomalous signals expected at first
order in the non-linear realization may appear only at higher orders of the
linear one, and vice versa. We analyze in detail the impact of both type of
discriminating signals on LHC physics.Comment: Version published in JHE
A New bound on CP Violation in the Lepton Yukawa Coupling and electroweak baryogenesis
The origin of the matter-antimatter asymmetry in the Universe is a
fundamental question of physics. Electroweak baryogenesis is a compelling
scenario for explaining it but it requires beyond the Standard Model sources of
the CP symmetry violation. The simplest possibility is CP violation in the
third generation fermion Higgs couplings, widely investigated theoretically and
searched for experimentally. It has been found that the experimental bounds on
the CP violation in the quark Yukawa couplings exclude their significant role
in the electroweak baryogenesis, but it can be still played by the
lepton Yukawa coupling. It is shown in this paper that, within the context of
the Standard Model Effective Field Theory and assuming an underlying flavour
symmetry of the Wilson coefficients, the electron dipole moment bound on the
lepton Yukawa coupling is two orders of magnitude stronger than
previously reported. This sheds strong doubts on its role in the electroweak
baryogenesis, further stimulates the interest in its experimental verification
and makes electroweak baryogenesis even more difficult to explain.Comment: V2: references added; minor changes on the text; results unchanged;
version accepted for publication on JHE
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