Climatic causes of maize production loss under global warming in Northeast China

Maize (Zea mays L.) is one of the most important staple crops in Northeast China, and yield losses are mainly induced by climate anomalies, plant diseases and pests. To understand how maize yield loss is affected by global warming, daily precipitation and temperatures, together with provincial agricultural data sets, were analyzed. The results showed that the accumulated temperature, an important factor in agricultural productivity, increased by 5% in 1991–2017, compared to 1961–1990, and that the frequency of low temperatures decreased by 14.8% over the same time period. An increase in drought by 21.6% was observed from 1961–1990 to 1991–2017, caused by decreased growing-season precipitation by −4 mm/decade. In addition, days with heavy rain in August and September increased slightly in Northeast China. In general, maize growth responded positively to the increased thermal conditions; in 1961–1990, 22.7% of observed maize yield-loss cases were due to low temperatures, but only 10% in 1991–2017. However, during the same time, the number of drought-induced yield loss cases increased from 27.3% to 46.7%. Moreover, yield loss cases caused by heavy rainstorms increased from 4.5% to 13.3%, indicating that heavy rainstorms have become an increasing threat to agriculture in Northeast China over the last three decades. In total, at least 70% of cases of provincial yield losses in Northeast China over the last three decades could be attributed to climatic factors. The frequency of climate hazards has changed under global warming, resulting in new challenges for agriculture. While drought and low temperatures were the primary causes for climate-induced yield losses before the 1990s, negative impacts from extreme events, mainly drought but also heavy precipitation, have increased in the last three decades, associated with global change. Farmers, agricultural scientists, and government policy makers could use these results when planning for adaptation to climate change.</jats:p

European ancient settlements - A guide to their composition and morphology based on soil micromorphology and associated geoarchaeological techniques; introducing the contrasting sites of Chalcolithic Bordus, ani-Popina, Borcea River, Romania and Viking Age Heimdaljordet, Vestfold, Norway

Specific soil micromorphological, broader geoarchaeological and environmental archaeology signatures of settlement activities and land use have been identified from numerous case studies across Europe – from Romania to western Norway. In order to demonstrate how such investigations contribute to our understanding of settlement morphology and its wider landscape, an improved way of organising site-specific information or guide was created (Macphail and Goldberg, in press). Activities and land use are divided into ‘Within Settlement’, ‘Peripheral to Settlement’ and ‘The Settlement's Wider Landscape’. Major themes identified are: Constructions (and materials), Trackways and paths (and other communication/transport-associated features), Animal Management, Water Management, Waste Disposal (1: middening; 2: human waste), Specialist Domestic and Industrial Activities and Funerary Practices. In the case of trackway deposits, their characterisation aids the identification of intensely occupied areas compared to rural communications, although changing land use within urban areas has also produced ‘rural signatures’ (e.g. as associated with animal management), for example in Late Roman cities. Specialist activities such as fish and crop processing or working with lead and other metals, in-field and within-wall manuring, stabling and domestic occupation floor-use evidence, and identification of different funerary practice – cremations, boat graves and other inhumations, and excarnation features – and peripheral constructions such as boat-houses, are also noted. New information from the Chalcolithic tell site of Borduşani-Popină, Romania and seasonally occupied Viking settlement of Heimdaljordet, Norway, is introduced

Tumor-associated lymphocytes and macrophages are related to stromal elastosis and vascular invasion in breast cancer

The tumor microenvironment plays a critical role in breast cancer progression. Here, we investigated tumor-infiltrating lymphocytes (TILs) and associations with macrophage numbers, tumor stromal elastosis, vascular invasion, and tumor detection mode. We performed a population-based retrospective study using data from The Norwegian Breast Cancer Screening Program in Vestfold County (2004-2009), including 200 screen-detected and 82 interval cancers. The number of TILs (CD45+, CD3+, CD4+, CD8+, and FOXP3+) and tumor-associated macrophages (CD163+) was counted using immunohistochemistry on tissue microarray slides. Lymphatic and blood vessel invasion (LVI and BVI) were recorded using D2-40 and CD31 staining, and the amount of elastosis (high/low) was determined on regular HE-stained slides. High numbers of all TIL subsets were associated with LVI (p ≤ 0.04 for all), and high counts of several TIL subgroups (CD8+, CD45+, and FOXP3+) were associated with BVI (p ≤ 0.04 for all). Increased levels of all TIL subsets, except CD4+, were associated with estrogen receptor-negative tumors (p < 0.001) and high tumor cell proliferation by Ki67 (p < 0.001). Furthermore, high levels of all TIL subsets were associated with high macrophage counts (p < 0.001) and low-grade stromal elastosis (p ≤ 0.02). High counts of CD3+, CD8+, and FOXP3+ TILs were associated with interval detected tumors (p ≤ 0.04 for all). Finally, in the luminal A subgroup, high levels of CD3+ and FOXP3+ TILs were associated with shorter recurrence-free survival, and high counts of FOXP3+ were linked to reduced breast cancer-specific survival. In conclusion, higher levels of different TIL subsets were associated with stromal features such as high macrophage counts (CD163+), presence of vascular invasion, absence of stromal elastosis, as well as increased tumor cell proliferation and interval detection mode. Our findings support a link between immune cells and vascular invasion in more aggressive breast cancer. Notably, presence of TIL subsets showed prognostic value within the luminal A category.publishedVersio

Drought variation of western Chinese Loess Plateau since 1568 and its linkages with droughts in western North America

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Fee Arrangements and Fee Shifting: Lessons From the Experience in Ontario

About one-third of oestrogen receptor alpha-positive breast cancer patients treated with tamoxifen relapse. Here we identify the nuclear receptor retinoic acid receptor alpha as a marker of tamoxifen resistance. Using quantitative mass spectrometry-based proteomics, we show that retinoic acid receptor alpha protein networks and levels differ in a tamoxifen-sensitive (MCF7) and a tamoxifen-resistant (LCC2) cell line. High intratumoural retinoic acid receptor alpha protein levels also correlate with reduced relapse-free survival in oestrogen receptor alpha-positive breast cancer patients treated with adjuvant tamoxifen solely. A similar retinoic acid receptor alpha expression pattern is seen in a comparable independent patient cohort. An oestrogen receptor alpha and retinoic acid receptor alpha ligand screening reveals that tamoxifen-resistant LCC2 cells have increased sensitivity to retinoic acid receptor alpha ligands and are less sensitive to oestrogen receptor alpha ligands compared with MCF7 cells. Our data indicate that retinoic acid receptor alpha may be a novel therapeutic target and a predictive factor for oestrogen receptor alpha-positive breast cancer patients treated with adjuvant tamoxifen

An Improved ångström-type model for estimating solar radiation over the tibetan plateau

© 2017 by the authors. For estimating the annual mean of daily solar irradiation in plateau mountainous regions, observed data from 15 radiation stations were used to validate different empirical estimation methods over the Tibetan Plateau. Calibration indicates that sunshine-based site-dependent models perform better than temperature-based ones. Then, the highly rated sunshine-based Ångström model and temperature-based Bristow model were selected for regional application. The geographical models perform much better than the average models, but still not ideally. To achieve better performance, the Ångström-type model was improved using altitude and water vapor pressure as the leading factors. The improved model can accurately predict the coefficients at all the stations, and performs the best among all models with an average Nash-Sutcliffe Efficiency value of 0.856. Spatial distribution of the annual mean of daily solar irradiation was then estimated with the improved model. It is indicated that there is an increasing trend of radiation from east to west, with a great center of the annual mean of daily solar irradiation on southwest Tibetan Plateau ranging from 20 to 24 MJm2. The improved model should be further validated against observations before its applications in other plateau mountainous regions

Climate variability in the subarctic area for the last 2 millennia

To put recent climate change in perspective, it is necessary to extend the instrumental climate records with proxy data from paleoclimate archives. Arctic climate variability for the last 2 millennia has been investigated using statistical and signal analyses from three regionally averaged records from the North Atlantic, Siberia and Alaska based on many types of proxy data archived in the Arctic 2k database v1.1.1. In the North Atlantic and Alaska, the major climatic trend is characterized by long-term cooling interrupted by recent warming that started at the beginning of the 19th century. This cooling is visible in the Siberian region at two sites, warming at the others. The cooling of the Little Ice Age (LIA) was identified from the individual series, but it is characterized by wide-range spatial and temporal expression of climate variability, in contrary to the Medieval Climate Anomaly. The LIA started at the earliest by around AD 1200 and ended at the latest in the middle of the 20th century. The widespread temporal coverage of the LIA did not show regional consistency or particular spatial distribution and did not show a relationship with archive or proxy type either. A focus on the last 2 centuries shows a recent warming characterized by a well-marked warming trend parallel with increasing greenhouse gas emissions. It also shows a multidecadal variability likely due to natural processes acting on the internal climate system on a regional scale. A similar to 16-30-year cycle is found in Alaska and seems to be linked to the Pacific Decadal Oscillation, whereas similar to 20-30- and similar to 50-90-year periodicities characterize the North Atlantic climate variability, likely in relation with the Atlantic Multidecadal Oscillation. These regional features are probably linked to the sea ice cover fluctuations through ice-temperature positive feedback.Peer reviewe

Polymorphisms in the vascular endothelial growth factor gene and breast cancer in the Cancer Prevention Study II cohort

INTRODUCTION: Vascular endothelial growth factor (VEGF) plays a central role in promoting angiogenesis and is over-expressed in breast cancer. At least four polymorphisms in the VEGF gene have been associated with changes in VEGF expression levels: -2578C/A, -1154G/A and -634G/C are all located in the promoter region; and +936C/T is located in the 3'-untranslated region. METHOD: We examined the association between these four VEGF polymorphisms and risk for breast cancer among postmenopausal women in CPS-II (Cancer Prevention Study II) Nutrition Cohort. This cohort was established in 1992 and participants were invited to provide a blood sample between 1998 and 2001. Included in this analysis were 501 postmenopausal women who provided a blood sample and were diagnosed with breast cancer between 1992 and 2001 (cases). Control individuals were 504 cancer-free postmenopausal women matched to the cases with respect to age, race/ethnicity, and date of blood collection (controls). RESULTS: We found no association between any of the polymorphisms examined and overall breast cancer risk. However, associations were markedly different in separate analyses of invasive cancer (n = 380) and in situ cancer (n = 107). The -2578C and -1154G alleles, which are both hypothesized to increase expression of VEGF, were associated with increased risk for invasive breast cancer (odds ratio [OR] 1.46, 95% confidence interval [CI] 1.00–2.14 for -2578 CC versus AA; OR 1.64, 95% CI 1.02–2.64 for -1154 GG versus AA) but they were not associated with risk for in situ cancer. The +936C allele, which is also hypothesized to increase VEGF expression, was not clearly associated with invasive breast cancer (OR 1.21, 95% CI 0.88–1.67 for +936 CC versus TT/CT), but it was associated with reduced risk for in situ cancer (OR 0.59, 95% CI 0.37–0.93 for CC versus TT/CT). The -634 C/G polymorphism was not associated with either invasive or in situ cancer. CONCLUSION: Our findings provide limited support for the hypothesis that the -2578C and -1154G VEGF alleles are associated with increased risk for invasive but not in situ breast cancer in postmenopausal women