Shock conditions and shock wave structures in a steady flow in a dissipative fluid

More precisely, calling xi the reciprocal of the Reynolds number based on the shock wave curvature radius, the xi terms of the first order are systematically taken into account. The most important result is a system of formulas giving a correction of order xi for the various RANKINE-HUGONIOT conditions. The suggested formulas may for instance have to be used instead of the conventional ones to evaluate the loss of the total pressure across the detached shock wave which is found at the nose of a very small probe in supersonic flow

Extreme Value Theory for Piecewise Contracting Maps with Randomly Applied Stochastic Perturbations

We consider globally invertible and piecewise contracting maps in higher dimensions and we perturb them with a particular kind of noise introduced by Lasota and Mackey. We got random transformations which are given by a stationary process: in this framework we develop an extreme value theory for a few classes of observables and we show how to get the (usual) limiting distributions together with an extremal index depending on the strength of the noise.Comment: 16 pages. arXiv admin note: text overlap with arXiv:1407.041

Environmental and genetic influences on neurocognitive development: the importance of multiple methodologies and time-dependent intervention

Genetic mutations and environmental factors dynamically influence gene expression and developmental trajectories at the neural, cognitive, and behavioral levels. The examples in this article cover different periods of neurocognitive development—early childhood, adolescence, and adulthood—and focus on studies in which researchers have used a variety of methodologies to illustrate the early effects of socioeconomic status and stress on brain function, as well as how allelic differences explain why some individuals respond to intervention and others do not. These studies highlight how similar behaviors can be driven by different underlying neural processes and show how a neurocomputational model of early development can account for neurodevelopmental syndromes, such as autism spectrum disorders, with novel implications for intervention. Finally, these studies illustrate the importance of the timing of environmental and genetic factors on development, consistent with our view that phenotypes are emergent, not predetermined

Dipyridamole plus aspirin versus aspirin alone in the secondary prevention after TIA or stroke: a meta-analysis by risk

Objectives: Our aim was to study the effect of combination therapy with aspirin and dipyridamole (A+D) over aspirin alone (ASA) in secondary prevention after transient ischemic attack or minor stroke of presumed arterial origin and to perform subgroup analyses to identify patients that might benefit most from secondary prevention with A+D. Data sources: The previously published meta-analysis of individual patient data was updated with data from ESPRIT (N=2,739); trials without data on the comparison of A+D versus ASA were excluded. Review methods: A meta-analysis was performed using Cox regression, including several subgroup analyses and following baseline risk stratification. Results: A total of 7,612 patients (5 trials) were included in the analyses, 3,800 allocated to A+D and 3,812 to ASA alone. The trial-adjusted hazard ratio for the composite event of vascular death, non-fatal myocardial infarction and non-fatal stroke was 0.82 (95% confidence interval 0.72-0.92). Hazard ratios did not differ in subgroup analyses based on age, sex, qualifying event, hypertension, diabetes, previous stroke, ischemic heart disease, aspirin dose, type of vessel disease and dipyridamole formulation, nor across baseline risk strata as assessed with two different risk scores. A+D were also more effective than ASA alone in preventing recurrent stroke, HR 0.78 (95% CI 0.68 – 0.90). Conclusion: The combination of aspirin and dipyridamole is more effective than aspirin alone in patients with TIA or ischemic stroke of presumed arterial origin in the secondary prevention of stroke and other vascular events. This superiority was found in all subgroups and was independent of baseline risk. ---------------------------7dc3521430776 Content-Disposition: form-data; name="c14_creators_1_name_family" Halke

Regulatory Taking: A Contract Approach

This Article begins by defining the parameters of the fifth amendment\u27s taking clause. The Article then reviews the various tests used in determining whether governmental action constitutes a taking, and discusses the recent Supreme Court decisions within the framework of case law as it has evolved since the Court\u27s 1922 landmark decision, Pennsylvania Coal Co. v. Mahon. Finally, the Article suggests a formula based on well-established contract principles for analyzing the impact of land use regulation on private property interests

Modelo de cabalgamiento profundo para el Alto Atlas (Marruecos). Implicaciones sísmicas en la zona de colisión entre Eurasia y Africa

Previous crustal models of the High Atlas suppose the existence of a mid-crustal detachment where all the surface thrusts merged and below which the lower crust was continuous. However, both seismic refraction data and gravity modeling detected a jump in crustal thickness between the High Atlas and the northern plains. Here we show that this rapid and vertical jump in the depth of Moho discontinuity suggests that a thrust fault may penetrate the lower crust and offset the Moho (deep-rooted “thick skinned” model). The distribution of Neogene and Quaternary volcanisms along and at the northern part of the High Atlas lineament can be related to the beginning of a partial continental subduction of the West African plate to the north underneath Moroccan microplate. Allowing from the complex problem of the plate boundary in the western zone of the Mediterranean, we propose to interpret the South-Atlasic fault zone as the actual northwestern boundary of the stable part of the African plate rather than the Azores-Gibraltar fault currently used.Los modelos geodinámicos existentes sobre la estructura profunda del alto Atlas suponen la existencia de un despegue medio-cortical donde convergen los cabalgamientos superficiales y bajo el cual la corteza inferior es continua. Los datos de sísmica de refracción y gravimetría, sin embargo, indican la existencia de una discontinuidad en el grosor de la corteza (profundidad del Moho) bajo el Alto Atlas. En este artículo ponemos de manifiesto que este salto rápido en la profundidad del Moho puede ser causado por un cabalgamiento que penetra la corteza inferior, desplazando la base de la misma (“deeprooted thick skinned model”). La distribución del volcanismo Neógeno y Cuaternario a lo largo de y al norte de la alineación del Alto Atlas pueden estar relacionados con el comienzo de una subducción continental parcial de la placa Africana occidental hacia el norte, bajo la microplaca marroquí. La expresión en superficie de este cabalgamiento, la zona de falla sud-atlásica, refleja la influencia de una sutura continental heredada de orogenias anteriores (panafricana, hercínica y rifting Jurásico). Por tanto, proponemos que este frente heredado representa el límite meridional de la zona de colisión mediterránea y el margen noroccidental de la porción estable de la placa africana

Transverse intrafascicular multichannel electrode (TIME) system for treatment of phantom limb pain in amputees

International audienceAIM: Phantom limb pain (PLP) develops in the lost limb in 50-80% of amputees. Today, it is not completely understood why the pain occurs, and no effective treatments are available. The favorable effect of electrical stimulation on PLP has been demonstrated. Our aim is to develop a novel system for manipulation of sensations by application of multi-channel microstimulation to the nerve stump of an amputee and explore this method as a treatment for clinched fist PLP (see figure). RESULTS: 1) Electrode design. Non-corrugated TIME electrodes with different dimensions and 8-12 active sites have been manufactued and tested in vivo and in vitro testing in the rat and pig. Methods for corrugated prototypes were developed and the first prototypes were realized. 2) Electrode selectivity modeling. A peripheral nerve model is under development to evaluate the electrode's selective stimulation properties and to optimize electrode design. Simulated currents and neural activity generated were qualitatively assessed using experimental data obtained from rat nerves. 3) Implant modeling. To optimize the implantation procedure, a theoretical peripheral nervous tissue model and a 3D FEM was implemented. Both models closely reproduce the experimental peripheral nervous tissue behaviour and simulate the insertion forces transmitted to the electrode during implantation. 4) Multi-channel stimulators and connectors. A 12-pole prototype, bench-top stimulator has been implemented and successfully tested in animal experiments. A high-count, implantable connector between stimulator and electrode has been designed. 5) Biocompatibility. Electrode materials were evaluated and did not induce immune rejection and significant inflammatory reaction after in vivo implantation in the rat. Electrode implantation will require an understanding of the fascicular characteristics of the target nerve. Morphological characteristics of the rat, pig and human nerves are currently evaluated and compared. 6) Animal testing. First TIME electrodes test were carried out in the acute rat and acute pig. Results indicated selective stimulation of different fascicles with graded recruitment. 7) Clinical evaluation: To quantify the location of artificially evoked sensations and evaluate the strength of artificially evoked sensations a psychophysical testing platform is under development. Main inclusion criteria for patient recruitment have been identified and protocols have been defined. CONCLUSION: The feasibility of the corrugated version of the TIME electrode has yet to be explored. Further work designing, optimizing and testing the TIME electrode and all technological developments will be carried out including theoretical stimulations and animal experimental work before the optimal electrode for human implant will be chosen

Size and power properties of some tests in the Birnbaum-Saunders regression model

The Birnbaum-Saunders distribution has been used quite effectively to model times to failure for materials subject to fatigue and for modeling lifetime data. In this paper we obtain asymptotic expansions, up to order $n^{-1/2}$ and under a sequence of Pitman alternatives, for the nonnull distribution functions of the likelihood ratio, Wald, score and gradient test statistics in the Birnbaum-Saunders regression model. The asymptotic distributions of all four statistics are obtained for testing a subset of regression parameters and for testing the shape parameter. Monte Carlo simulation is presented in order to compare the finite-sample performance of these tests. We also present an empirical application.Comment: Paper submitted for publication, with 13 pages and 1 figur