The Wendelstein Calar Alto Pixellensing Project (WeCAPP): the M31 Nova catalogue

We present light curves from the novae detected in the long-term, M31 monitoring WeCAPP project. The goal of WeCAPP is to constrain the compact dark matter fraction of the M31 halo with microlensing observations. As a by product we have detected 91 novae benefiting from the high cadence and highly sensitive difference imaging technique required for pixellensing. We thus can now present the largest CCD and optical filters based nova light curve sample up-to-date towards M31. We also obtained thorough coverage of the light curve before and after the eruption thanks to the long-term monitoring. We apply the nova taxonomy proposed by Strope et al. (2010) to our nova candidates and found 29 S-class novae, 10 C-class novae, 2 O-class novae and 1 J-class nova. We have investigated the universal decline law advocated by Hachichu and Kato (2006) on the S-class novae. In addition, we correlated our catalogue with the literature and found 4 potential recurrent novae. Part of our catalogue has been used to search for optical counter-parts of the super soft X-ray sources detected in M31 (Pietsch et al. 2005). Optical surveys like WeCAPP, and coordinated with multi-wavelength observation, will continue to shed light on the underlying physical mechanism of novae in the future.Comment: 15 pages, 15 figures, 7 tables, A&A accepted for publication. The appendix is stored in the Data Conservanc

Microlensing toward crowded fields: Theory and applications to M31

We present a comprehensive treatment of the pixel-lensing theory and apply it to lensing experiments and their results toward M31. Using distribution functions for the distances, velocities, masses, and luminosities of stars, we derive lensing event rates as a function of the event observables. In contrast to the microlensing regime, in the pixel-lensing regime (crowded or unresolved sources) the observables are the maximum excess flux of the source above a background and the full width at half-maximum (FWHM) time of the event. To calculate lensing event distribution functions depending on these observables for the specific case of M31, we use data from the literature to construct a model of M31, reproducing consistently photometry, kinematics and stellar population. We predict the halo- and self-lensing event rates for bulge and disk stars in M31 and treat events with and without finite source signatures separately. We use the M31 photon noise profile and obtain the event rates as a function of position, field of view, and S/N threshold at maximum magnification. We calculate the expected rates for WeCAPP and for a potential Advanced Camera for Surveys (ACS) lensing campaign. The detection of two events with a peak signal-to-noise ratio larger than 10 and a timescale larger than 1 day in the WeCAPP 2000/2001 data is in good agreement with our theoretical calculations. We investigate the luminosity function of lensed stars for noise characteristics of WeCAPP and ACS. For the pixel-lensing regime, we derive the probability distribution for the lens masses in M31 as a function of the FWHM timescale, flux excess and color, including the errors of these observables.Comment: 45 pages, 27 figures LaTeX; corrected typos; published in the Astrophysical Journal Supplemen

X-ray monitoring of optical novae in M31 from July 2004 to February 2005

Optical novae have recently been identified as the major class of supersoft X-ray sources in M31 based on ROSAT and early XMM-Newton and Chandra observations. This paper reports on a search for X-ray counterparts of optical novae in M31 based on archival Chandra HRC-I and ACIS-I as well as XMM-Newton observations of the galaxy center region obtained from July 2004 to February 2005. We systematically determine X-ray brightness or upper limit for counterparts of all known optical novae with outbursts between November 2003 to the end of the X-ray coverage. In addition, we determine the X-ray brightnesses for counterparts of four novae with earlier outbursts. For comparison with the X-ray data we created a catalogue of optical novae in M31 based on our own nova search programs and on all novae reported in the literature. We collected all known properties and named the novae consistently following the CBAT scheme. We detect eleven out of 34 novae within a year after the optical outburst in X-rays. While for eleven novae we detect the end of the supersoft source phase, seven novae are still bright more than 1200, 1600, 1950, 2650, 3100, 3370 and 3380 d after outburst. One nova is detected to turn on 50 d, another 200 d after outburst. Three novae unexpectedly showed short X-ray outbursts starting within 50 d after the optical outburst and lasting only two to three months. The X-ray emission of several of the novae can be characterized as supersoft from hardness ratios and/or X-ray spectra or by comparing HRC-I count rates with ACIS-I count rates or upper limits. The number of detected optical novae at supersoft X-rays is much higher than previously estimated (>30%). We use the X-ray light curves to estimate the burned masses of the White Dwarf and of the ejecta

X-Ray Monitoring of Classical Novae in the Central Region of M31. I. June 2006 - March 2007

Context. Classical novae (CNe) have recently been reported to represent the major class of supersoft X-ray sources (SSSs) in the central region of our neighbour galaxy M 31. Aims. We carried out a dedicated monitoring of the M 31 central region with XMM-Newton and Chandra in order to find SSS coun-terparts of CNe, determine the duration of their SSS phase and derive physical outburst parameters. Methods. We systematically searched our data for X-ray counterparts of CNe and determined their X-ray light curves and spectral properties. Additionally, we determined luminosity upper limits for all novae from previous studies which are not detected anymore and for all CNe in our field of view with optical outbursts between May 2005 and March 2007. Results. We detected eight X-ray counterparts of CNe in M 31, four of which were not previously known. Seven sources can be classified as SSSs, one is a candidate SSS. Two SSSs are still visible more than nine years after the nova outburst, whereas two other nova counterparts show a short SSS phase of less than 150 days. Of the latter sources, M31N 2006-04a exhibits a short-time variable X-ray light curve with an apparent period of (1.6 ±0.3) h. This periodicity could indicate the binary period of the system. There is no X-ray detection for 23 out of 25 CNe which were within the field of view of our observations and had their outburst from about one year before the start of the monitoring until its end. From the 14 SSS nova counterparts known from previous studies, ten are not detected anymore. Additionally, we found four SSSs in our XMM-Newton data without a nova counterpart, one of which is a new source. Conclusions. Out of eleven SSSs detected in our monitoring, seven are counterparts of CNe. We therefore confirm the earlier finding that CNe are the major class of SSSs in the central region of M 31. We use the measured SSS turn-on and turn-offtimes to estimate the mass ejected in the nova outburst and the mass burned on the white dwarf. Classical novae with short SSS phases seem to be an important contributor to the overall population

Stellar disc truncations and extended haloes in face-on spiral galaxies

We use data from the IAC Stripe82 Legacy Project to study the surface photometry of 22 nearby, face-on to moderately inclined spiral galaxies. The reprocessed and combined Stripe 82 g',r' and I' images allow us to probe the galaxy down to 29-30 r'-magnitudes arcsec-2 and thus reach into the very faint outskirts of the galaxies. Truncations are found in three galaxies. An additional 15 galaxies are found to have an apparent extended stellar halo. Simulations show that the scattering of light from the inner galaxy by the point spread function (PSF) can produce faint structures resembling haloes, but this effect is insufficient to fully explain the observed haloes. The presence of these haloes and of truncations is mutually exclusive, and we argue that the presence of a stellar halo and/or light scattered by the PSF can hide truncations. Furthermore, we find that the onset of the stellar halo and the truncations scales tightly with galaxy size. Interestingly, the fraction of light does not correlate with dynamic mass. Nineteen galaxies are found to have breaks in their profiles, the radius of which also correlates with galaxy size

A comparison of machine learning algorithms for chemical toxicity classification using a simulated multi-scale data model

<p>Abstract</p> <p>Background</p> <p>Bioactivity profiling using high-throughput <it>in vitro </it>assays can reduce the cost and time required for toxicological screening of environmental chemicals and can also reduce the need for animal testing. Several public efforts are aimed at discovering patterns or classifiers in high-dimensional bioactivity space that predict tissue, organ or whole animal toxicological endpoints. Supervised machine learning is a powerful approach to discover combinatorial relationships in complex <it>in vitro/in vivo </it>datasets. We present a novel model to simulate complex chemical-toxicology data sets and use this model to evaluate the relative performance of different machine learning (ML) methods.</p> <p>Results</p> <p>The classification performance of Artificial Neural Networks (ANN), K-Nearest Neighbors (KNN), Linear Discriminant Analysis (LDA), Naïve Bayes (NB), Recursive Partitioning and Regression Trees (RPART), and Support Vector Machines (SVM) in the presence and absence of filter-based feature selection was analyzed using K-way cross-validation testing and independent validation on simulated <it>in vitro </it>assay data sets with varying levels of model complexity, number of irrelevant features and measurement noise. While the prediction accuracy of all ML methods decreased as non-causal (irrelevant) features were added, some ML methods performed better than others. In the limit of using a large number of features, ANN and SVM were always in the top performing set of methods while RPART and KNN (k = 5) were always in the poorest performing set. The addition of measurement noise and irrelevant features decreased the classification accuracy of all ML methods, with LDA suffering the greatest performance degradation. LDA performance is especially sensitive to the use of feature selection. Filter-based feature selection generally improved performance, most strikingly for LDA.</p> <p>Conclusion</p> <p>We have developed a novel simulation model to evaluate machine learning methods for the analysis of data sets in which in vitro bioassay data is being used to predict in vivo chemical toxicology. From our analysis, we can recommend that several ML methods, most notably SVM and ANN, are good candidates for use in real world applications in this area.</p

The Recent Stellar Archeology of M31 - The Nearest Red Disk Galaxy

We examine the star-forming history (SFH) of the M31 disk during the past few hundred Myr. The luminosity functions (LFs) of main sequence stars at distances R_GC > 21 kpc (i.e. > 4 disk scale lengths) are matched by models that assume a constant star formation rate (SFR). However, at smaller R_GC the LFs suggest that during the past ~10 Myr the SFR was 2 - 3 times higher than during the preceding ~100 Myr. The rings of cool gas that harbor a significant fraction of the current star-forming activity are traced by stars with ages ~100 Myr, indicating that (1) these structures have ages of at least 100 Myr, and (2) stars in these structures do not follow the same relation between age and random velocity as their counterparts throughout the disks of other spiral galaxies, probably due to the inherently narrow orbital angular momentum distribution of the giant molecular clouds in these structures. The distribution of evolved red stars is not azimuthally symmetric, in the sense that their projected density along the north east segment of the major axis is roughly twice that on the opposite side of the galaxy. The north east arm of the major axis thus appears to be a fossil star-forming area that dates to intermediate epochs. Such a structure may be the consequence of interactions with a companion galaxy.Comment: To appear in The Astrophysical Journa

Network Neighbors of Drug Targets Contribute to Drug Side-Effect Similarity

In pharmacology, it is essential to identify the molecular mechanisms of drug action in order to understand adverse side effects. These adverse side effects have been used to infer whether two drugs share a target protein. However, side-effect similarity of drugs could also be caused by their target proteins being close in a molecular network, which as such could cause similar downstream effects. In this study, we investigated the proportion of side-effect similarities that is due to targets that are close in the network compared to shared drug targets. We found that only a minor fraction of side-effect similarities (5.8 %) are caused by drugs targeting proteins close in the network, compared to side-effect similarities caused by overlapping drug targets (64%). Moreover, these targets that cause similar side effects are more often in a linear part of the network, having two or less interactions, than drug targets in general. Based on the examples, we gained novel insight into the molecular mechanisms of side effects associated with several drug targets. Looking forward, such analyses will be extremely useful in the process of drug development to better understand adverse side effects

Identifying Compound-Target Associations by Combining Bioactivity Profile Similarity Search and Public Databases Mining

Molecular target identification is of central importance to drug discovery. Here, we developed a computational approach, named bioactivity profile similarity search (BASS), for associating targets to small molecules by using the known target annotations of related compounds from public databases. To evaluate BASS, a bioactivity profile database was constructed using 4296 compounds that were commonly tested in the US National Cancer Institute 60 human tumor cell line anticancer drug screen (NCI-60). Each compound was used as a query to search against the entire bioactivity profile database, and reference compounds with similar bioactivity profiles above a threshold of 0.75 were considered as neighbor compounds of the query. Potential targets were subsequently linked to the identified neighbor compounds by using the known targets o