On virialization with dark energy

We review the inclusion of dark energy into the formalism of spherical collapse, and the virialization of a two-component system, made of matter and dark energy. We compare two approaches in previous studies. The first assumes that only the matter component virializes, e.g. as in the case of a classic cosmological constant. The second approach allows the full system to virialize as a whole. We show that the two approaches give fundamentally different results for the final state of the system. This might be a signature discriminating between the classic cosmological constant which cannot virialize and a dynamical dark energy mimicking a cosmological constant. This signature is independent of the measured value of the equation of state. An additional issue which we address is energy non-conservation of the system, which originates from the homogeneity assumption for the dark energy. We propose a way to take this energy loss into account.Comment: 15 pages, 5 figures. Accepted for publication in JCA

Static Configurations of Dark Energy and Dark Matter

We study static configurations of dark matter coupled to a scalar field responsible for the dark energy of the Universe. The dark matter is modelled as a Fermi gas within the Thomas-Fermi approximation. The mass of the dark matter particles is a function of the scalar field. We analyze the profile of the dark matter halos in galaxies. In this case our framework is equivalent to the model of the isothermal sphere. In the presence of a scalar field, the velocity of a massive object orbiting the galaxy is not of the order of the typical velocity of the dark matter particles, as in the conventional picture. Instead, it is reduced by a factor that quantifies the dependence of the dark matter mass on the scalar field. This has implications for dark matter searches. We derive new solutions of the Einstein equations which describe compact objects composed of dark matter. Depending on the scale of the dark matter mass, the size of these objects can vary between microscopic scales and cosmological distances. We determine the mass to radius relation and discuss the similarities with conventional neutron stars and exotic astrophysical objects.Comment: 23 pages, 3 figures, minor additions to the tex

Halo Mass Functions in Early Dark Energy Cosmologies

We examine the linear density contrast at collapse time, $\delta_c$ for large-scale structure in dynamical dark energy cosmologies, including models with early dark energy. Contrary to previous results, we find that as long as dark energy is homogeneous on small scales, $\delta_c$ is insensitive to dark energy properties for parameter values fitting current data, including the case of early dark energy. This is significant since using the correct $\delta_c$ is crucial for accurate Press-Schechter prediction of the halo mass function. Previous results have found an apparent failing of the extended Press-Schechter approach (Sheth-Tormen) for early dark energy. Our calculations demonstrate that with the correct $\delta_c$ the accuracy of this approach is restored. We discuss the significance of this result for the halo mass function and examine what dark energy physics would be needed to cause significant change in $\delta_c$, and the observational signatures this would leave.Comment: 5 pages, 2 figures. Accepted for MNRAS Letter

Ellipsoidal configurations in the de Sitter spacetime

The cosmological constant $\Lambda$ modifies certain properties of large astrophysical rotating configurations with ellipsoidal geometries, provided the objects are not too compact. Assuming an equilibrium configuration and so using the tensor virial equation with $\Lambda$ we explore several equilibrium properties of homogeneous rotating ellipsoids. One shows that the bifurcation point, which in the oblate case distinguishes the Maclaurin ellipsoid from the Jacobi ellipsoid, is sensitive to the cosmological constant. Adding to that, the cosmological constant allows triaxial configurations of equilibrium rotating the minor axis as solutions of the virial equations. The significance of the result lies in the fact that minor axis rotation is indeed found in nature. Being impossible for the oblate case, it is permissible for prolate geometries, with $\Lambda$ zero and positive. For the triaxial case, however, an equilibrium solution is found only for non-zero positive $\Lambda$. Finally, we solve the tensor virial equation for the angular velocity and display special effects of the cosmological constant there.Comment: 15 pages, 11 figures, published in Class. Quant. Grav. References adde

Características quantitativas e morfométricas da carcaça de ovinos mantidos em pastagens recebendo suplementação com doses crescentes de concentrado.

O objetivo do presente estudo foi avaliar as características quantitativas e morfométricas da carcaça de ovinos mantidos em pastagens irrigadas de Tifton 85 recebendo doses crescentes de suplemento concentrado

Rimeporide as a first- in-class NHE-1 inhibitor: Results of a phase Ib trial in young patients with Duchenne Muscular Dystrophy

Rimeporide, a first-in-class sodium/proton exchanger Type 1 inhibitor (NHE-1 inhibitor) is repositioned by EspeRare for patients with Duchenne Muscular Dystrophy (DMD). Historically, NHE-1 inhibitors were developed for cardiac therapeutic interventions. There is considerable overlap in the pathophysiological mechanisms in Congestive Heart Failure (CHF) and in cardiomyopathy in DMD, therefore NHE-1 inhibition could be a promising pharmacological approach to the cardiac dysfunctions observed in DMD. Extensive preclinical data was collected in various animal models including dystrophin-deficient (mdx) mice to characterise Rimeporide’s anti-fibrotic and anti-inflammatory properties and there is evidence that NHE-1 inhibitors could play a significant role in modifying DMD cardiac and also skeletal pathologies, as the NHE-1 isoform is ubiquitous. We report here the first study with Rimeporide in DMD patients. This 4-week treatment, open label phase Ib, multiple oral ascending dose study, enrolled 20 ambulant boys with DMD (6–11 years), with outcomes including safety, pharmacokinetic (PK) and pharmacodynamic (PD) biomarkers. Rimeporide was safe and well-tolerated at all doses. PK evaluations showed that Rimeporide was well absorbed orally reaching pharmacological concentrations from the lowest dose, with exposure increasing linearly with dose and with no evidence of accumulation upon repeated dosing. Exploratory PD biomarkers showed positive effect upon a 4-week treatment, supporting its therapeutic potential in patients with DMD, primarily as a cardioprotective treatment, and provide rationale for further efficacy studies

Large scale structure and the generalised Chaplygin gas as dark energy

The growth of large scale structure is studied in a universe containing both cold dark matter (CDM) and generalized Chaplygin gas (GCg). GCg is assumed to contribute only to the background evolution of the universe while the CDM component collapses and forms structures. We present some new analytical as well as numerical results for linear and non-linear growth in such model. The model passes the standard cosmological distance test without the need of a cosmological constant (LCDM). But we find that the scenario is severely constrained by current observations of large scale structure. Any small deviations of the GCg parameters away from the standard Lambda dominated cosmology (LCDM) produces substantial suppression for the growth of structures.Comment: 6 pages, matches version accepted for publication in Phys.Rev.D (in press

Construction and execution of experiments at the multi-purpose thermal hydraulic test facility TOPFLOW for generic investigations of two-phase flows and the development and validation of CFD codes - Final report

The works aimed at the further development and validation of models for CFD codes. For this reason, the new thermal-hydraulic test facility TOPFLOW was erected and equipped with wire-mesh sensors with high spatial and time resolution. Vertical test sections with nominal diameters of DN50 and DN200 operating with air-water as well as steam-water two-phase flows provided results on the evaluation of flow patterns, on the be¬haviour of the interfacial area as well as on interfacial momentum and heat transfer. The validation of the CFD-code for complex geometries was carried out using 3D void fraction and velocity distributions obtained in an experiment with an asymmetric obstacle in the large DN200 test section. With respect to free surface flows, stratified co- and counter-current flows as well as slug flows were studied in two horizontal test channels made from acrylic glass. Post-test calculations of these experiments succeeded in predicting the slug formation process. Corresponding to the main goal of the project, the experimental data was used for the model development. For vertical flows, the emphasis was put on lateral bubble forces (e.g. lift force). Different constitutive laws were tested using a Multi Bubble Size Class Test Solver that has been developed for this purpose. Basing on the results a generalized inhomogeneous Multiple Size Group (MUSIG) Model has been proposed and implemented into the CFD code CFX (ANSYS). Validation calculations with the new code resulted in the conclusion that particularly the models for bubble coalescence and fragmentation need further optimisation. Studies of single effects, like the assessment of turbulent dissipation in a bubbly flow and the analysis of trajectories of single bubbles near the wall, supplied other important results of the project

The clustering of galaxies in the SDSS-III Baryon Oscillation Spectroscopic Survey: cosmological implications of the large-scale two-point correlation function

We obtain constraints on cosmological parameters from the spherically averaged redshift-space correlation function of the CMASS Data Release 9 (DR9) sample of the Baryonic Oscillation Spectroscopic Survey (BOSS). We combine this information with additional data from recent CMB, SN and BAO measurements. Our results show no significant evidence of deviations from the standard flat-Lambda CDM model, whose basic parameters can be specified by Omega_m = 0.285 +- 0.009, 100 Omega_b = 4.59 +- 0.09, n_s = 0.96 +- 0.009, H_0 = 69.4 +- 0.8 km/s/Mpc and sigma_8 = 0.80 +- 0.02. The CMB+CMASS combination sets tight constraints on the curvature of the Universe, with Omega_k = -0.0043 +- 0.0049, and the tensor-to-scalar amplitude ratio, for which we find r < 0.16 at the 95 per cent confidence level (CL). These data show a clear signature of a deviation from scale-invariance also in the presence of tensor modes, with n_s <1 at the 99.7 per cent CL. We derive constraints on the fraction of massive neutrinos of f_nu < 0.049 (95 per cent CL), implying a limit of sum m_nu < 0.51 eV. We find no signature of a deviation from a cosmological constant from the combination of all datasets, with a constraint of w_DE = -1.033 +- 0.073 when this parameter is assumed time-independent, and no evidence of a departure from this value when it is allowed to evolve as w_DE(a) = w_0 + w_a (1 - a). The achieved accuracy on our cosmological constraints is a clear demonstration of the constraining power of current cosmological observations.Comment: 26 pages, 15 figures. Minor changes to match version accepted by MNRA