Affective Systems Induce Formal Thought Disorder in Early-Stage Psychosis

Although formal thought disorder (FTD) has been described since early conceptualizations of psychosis, its underlying mechanisms are unclear. Evidence suggests FTD may be influenced by affective and cognitive systems; however, few have examined these relationships—with none focusing on early-stage psychosis (EP). In this study, positive FTD and speech production were measured in sex- and race-matched EP (n = 19) and healthy control (n = 19) groups by assessing “reactivity”—a change in experimental compared with baseline conditions—across baseline, affective, and cognitive conditions. Relationships with functioning were also examined within each group. Three key findings emerged: (a) the EP group displayed large differences in positive FTD and speech production, (b) those with EP exhibited affective reactivity for positive FTD, and (c) positive FTD and affective reactivity were linked with poor real-world functioning in EP and these relationships did not considerably change when controlling for positive symptom (e.g., delusions, hallucinations) severity. Our findings provide preliminary evidence that affective, but not cognitive, systems play a critical role in positive FTD. Affective reactivity, in particular, may aid in predicting those with EP who go on to develop serious social impairments. Future work should focus on whether affective systems differentially influence those at separate points on the psychosis-spectrum in an effort to establish evidence-based treatments for FTD

Interstellar H_2 in M 33 detected with FUSE

FUSE spectra of the four brightest H II regions in M 33 show absorption by interstellar gas in the Galaxy and in M 33. On three lines of sight molecular hydrogen in M 33 is detected. This is the first measurement of diffuse H_2 in absorption in a Local Group galaxy other than the Magellanic Clouds. A quantitative analysis is difficult because of the low signal to noise ratio and the systematic effects produced by having multiple objects in the FUSE aperture. We use the M 33 FUSE data to demonstrate in a more general manner the complexity of interpreting interstellar absorption line spectra towards multi-object background sources. We derive H_2 column densities of approximately 10^16 to 10^17 cm^{-2} along 3 sight lines (NGC 588, NGC 592, NGC 595). Because of the systematic effects, these values most likely represent upper limits and the non-detection of H_2 towards NGC 604 does not exclude the existence of significant amounts of molecular gas along this sight line

Semantic coherence in psychometric schizotypy: An investigation using Latent Semantic Analysis

Technological advancements have led to the development of automated methods for assessing semantic coherence in psychiatric populations. Latent Semantic Analysis (LSA) is an automated method that has been used to quantify semantic coherence in schizophrenia-spectrum disorders. The current study examined whether: 1) Semantic coherence reductions extended to psychometrically-defined schizotypy and 2) Greater cognitive load further reduces semantic coherence. LSA was applied to responses generated during category fluency tasks in baseline and cognitive load conditions. Significant differences between schizotypy and non-schizotypy groups were not observed. Findings suggest that semantic coherence may be relatively preserved at this point on the schizophrenia-spectrum

Conceptual Disorganization Weakens Links in Cognitive Pathways: Disentangling Neurocognition, Social Cognition, and Metacognition in Schizophrenia

Disentangling links between neurocognition, social cognition, and metacognition offers the potential to improve interventions for these cognitive processes. Disorganized symptoms have shown promise for explaining the limiting relationship that neurocognition holds with both social cognition and metacognition. In this study, primary aims included: 1) testing whether conceptual disorganization, a specific disorganized symptom, moderated relationships between cognitive processes, and 2) examining the level of conceptual disorganization necessary for links between cognitive processes to break down. To accomplish these aims, comprehensive assessments of conceptual disorganization, neurocognition, social cognition, and metacognition were administered to 67 people with schizophrenia-spectrum disorders. We found that conceptual disorganization significantly moderated the relationship between neurocognition and metacognition, with links between cognitive processes weakening when conceptual disorganization is present even at minimal levels of severity. There was no evidence that conceptual disorganization—or any other specific disorganized symptom—drove the limiting relationship of neurocognition on social cognition. Based on our findings, conceptual disorganization appears to be a critical piece of the puzzle when disentangling the relationship between neurocognition and metacognition. Roles of specific disorganized symptoms in the neurocognition – social cognition relationship were less clear. Findings from this study suggest that disorganized symptoms are an important treatment consideration when aiming to improve cognitive impairments

S3 guidelines for intensive care in cardiac surgery patients: hemodynamic monitoring and cardiocirculary system

Hemodynamic monitoring and adequate volume-therapy, as well as the treatment with positive inotropic drugs and vasopressors are the basic principles of the postoperative intensive care treatment of patient after cardiothoracic surgery. The goal of these S3 guidelines is to evaluate the recommendations in regard to evidence based medicine and to define therapy goals for monitoring and therapy. In context with the clinical situation the evaluation of the different hemodynamic parameters allows the development of a therapeutic concept and the definition of goal criteria to evaluate the effect of treatment

Agri-Environmental Policy Measures in Israel: The Potential of Using Market-Oriented Instruments

This paper examines the possibilities of developing agri-environmental policy measures in Israel, focusing on market-oriented instruments. A conceptual framework for developing agri-environmental policy measures is presented, first in very broad lines (mandatory regulations, economic instruments and advisory measures) and subsequently focusing on economic instruments, and specifically, on market-oriented ones. Two criteria of choice between the measures are suggested: their contribution to improving the effectiveness of the policy; and the feasibility of their implementation. This is the framework used for analyzing agri-environmental measures in Israel. Israel currently implements a mix of mandatory regulations, economic instruments and advisory measures to promote the agri-environment. The use of additional economic instruments may improve the effectiveness of the policy. When comparing the effectiveness of various economic measures, we found that the feasibility of implementation of market-oriented instruments is greater, due to the Israeli public’s preference for strengthening market orientation in the agricultural sector. Four market-oriented instruments were practiced in a pilot project conducted in an Israeli rural area. We found that in this case study, the institutional feasibility and acceptance by stakeholders were the major parameters influencing the implementation of the market-oriented instruments, whereas the instruments’ contribution to enhancing the ecological or economic effectiveness were hardly considered by the stakeholders as arguments in favor of their use

Prevention, diagnosis, therapy and follow-up care of sepsis: 1st revision of S-2k guidelines of the German Sepsis Society (Deutsche Sepsis-Gesellschaft e.V. (DSG)) and the German Interdisciplinary Association of Intensive Care and Emergency Medicine (Deutsche Interdisziplinäre Vereinigung für Intensiv- und Notfallmedizin (DIVI))

Practice guidelines are systematically developed statements and recommendations that assist the physicians and patients in making decisions about appropriate health care measures for specific clinical circumstances taking into account specific national health care structures. The 1st revision of the S-2k guideline of the German Sepsis Society in collaboration with 17 German medical scientific societies and one self-help group provides state-of-the-art information (results of controlled clinical trials and expert knowledge) on the effective and appropriate medical care (prevention, diagnosis, therapy and follow-up care) of critically ill patients with severe sepsis or septic shock. The guideline had been developed according to the “German Instrument for Methodological Guideline Appraisal” of the Association of the Scientific Medical Societies (AWMF). In view of the inevitable advancements in scientific knowledge and technical expertise, revisions, updates and amendments must be periodically initiated. The guideline recommendations may not be applied under all circumstances. It rests with the clinician to decide whether a certain recommendation should be adopted or not, taking into consideration the unique set of clinical facts presented in connection with each individual patient as well as the available resources

The massive binary companion star to the progenitor of supernova 1993J

The massive star which underwent core-collapse to produce SN1993J was identified as a non-variable red supergiant star in images of the galaxy M81 taken before explosion. However the stellar source showed an excess in UV and B-band colours that suggested it had either a hot, massive companion star or was embedded in an unresolved young stellar association. The spectra of SN1993J underwent a remarkable transformation between a hydrogen-rich Type II supernova and a helium-rich (hydrogen-deficient) Type Ib. The spectral and photometric peculiarities were explained by models in which the 13-20 solar mass supergiant had lost almost its entire hydrogen envelope to a close binary companion. The binary scenario is currently the best fitting model for the production of such type IIb supernovae, however the hypothetical massive companion stars have so far eluded discovery. Here we report the results of new photometric and spectroscopic observations of SN1993J, 10 years after explosion. At the position of the fading SN we detect the unambiguous signature of a massive star, the binary companion to the progenitor. This is evidence that this type of SN originate in interacting binary systems.Comment: 18 pages (3 figures

Euclid: the selection of quiescent and star-forming galaxies using observed colours

The Euclid mission will observe well over a billion galaxies out to z ∼ 6 and beyond. This will offer an unrivalled opportunity to investigate several key questions for understanding galaxy formation and evolution. The first step for many of these studies will be the selection of a sample of quiescent and star-forming galaxies, as is often done in the literature by using well-known colour techniques such as the ‘UVJ’ diagram. However, given the limited number of filters available for the Euclid telescope, the recovery of such rest-frame colours will be challenging. We therefore investigate the use of observed Euclid colours, on their own and together with ground-based u-band observations, for selecting quiescent and star-forming galaxies. The most efficient colour combination, among the ones tested in this work, consists of the (u − VIS) and (VIS − J) colours. We find that this combination allows users to select a sample of quiescent galaxies complete to above ∼70 per cent and with less than 15 per cent contamination at redshifts in the range 0.75 65 per cent completeness level and contamination below 20 per cent at 1 < z < 2 for finding quiescent galaxies. In comparison, the sample of quiescent galaxies selected with the traditional UVJ technique is only ∼20 per cent complete at z < 3, when recovering the rest-frame colours using mock Euclid observations. This shows that our new methodology is the most suitable one when only Euclid bands, along with u-band imaging, are available