333 research outputs found
Planetary radio astronomy observations from Voyager-2 near Saturn
Voyager-2 planetry radio astronomy measurements obtained near Saturn are discussed. They indicate that Saturnian kilometric radiation is emitted by a strong, dayside source at auroral latitudes in the northern hemisphere and by a weaker (by more than an order of magnitude) source at complementary latitudes in the southern hemisphere. These emissions are variable both due to Saturn's rotation and, on longer time scales, probably due to influences of the solar wind and the satellite Dione. The Saturn electrostatic discharge bursts first discovered by Voyager-1 and attributed to emissions from the B-ring were again observed with the same broadband spectral properties and a 10(h)11(m) + or - 5(m) episodic recurrence period but with an occurrence frequency of only of about 30 percent of that detected with Voyager-1. During the crossing of the ring plane at a distance of 2.88 R sub S, an intense noise event is interpreted to be consequence of the impact/vaporization/ionization of charged micron-size G-ring particles distributed over a total vertical thickness of about 1500 km
Fragmentation and systematics of the Pygmy Dipole Resonance in the stable N=82 isotones
The low-lying electric dipole (E1) strength in the semi-magic nucleus 136Xe
has been measured which finalizes the systematic survey to investigate the
so-called pygmy dipole resonance (PDR) in all stable even N=82 isotones with
the method of nuclear resonance fluorescence using real photons in the entrance
channel. In all cases, a fragmented resonance-like structure of E1 strength is
observed in the energy region 5 MeV to 8 MeV. An analysis of the fragmentation
of the strength reveals that the degree of fragmentation decreases towards the
proton-deficient isotones while the total integrated strength increases
indicating a dependence of the total strength on the neutron-to-proton ratio.
The experimental results are compared to microscopic calculations within the
quasi-particle phonon model (QPM). The calculation includes complex
configurations of up to three phonons and is able to reproduce also the
fragmentation of the E1 strength which allows to draw conclusions on the
damping of the PDR. Calculations and experimental data are in good agreement in
the degree of fragmentation and also in the integrated strength if the
sensitivity limit of the experiments is taken into account
The geographical distribution and prevalence of Echinococcus multilocularis in animals in the European Union and adjacent countries : a systematic review and meta-analysis
Background
This study aimed to provide a systematic review on the geographical distribution of Echinococcus multilocularis in definitive and intermediate hosts in the European Union (EU) and adjacent countries (AC). The relative importance of the different host species in the life-cycle of this parasite was highlighted and gaps in our knowledge regarding these hosts were identified.
Methods
Six databases were searched for primary research studies published from 1900 to 2015. From a total of 2,805 identified scientific papers, 244 publications were used for meta-analyses.
Results
Studies in 21 countries reported the presence of E. multilocularis in red foxes, with the following pooled prevalence (PP): low (≤ 1 %; Denmark, Slovenia and Sweden); medium (> 1 % to 10 %; Czech Republic, Estonia, France, Germany, Latvia, Lithuania, Poland, Slovakia, Liechtenstein and Switzerland). Studies from Finland, Ireland, the United Kingdom and Norway reported the absence of E. multilocularis in red foxes. However, E. multilocularis was detected in Arctic foxes from the Arctic Archipelago of Svalbard in Norway.
Conclusions
Raccoon dogs (PP 2.2 %), golden jackals (PP 4.7 %) and wolves (PP 1.4 %) showed a higher E. multilocularis PP than dogs (PP 0.3 %) and cats (PP 0.5 %). High E. multilocularis PP in raccoon dogs and golden jackals correlated with high PP in foxes. For intermediate hosts (IHs), muskrats (PP 4.2 %) and arvicolids (PP 6.0 %) showed similar E. multilocularis PP as sylvatic definitive hosts (DHs), excluding foxes. Nutrias (PP 1.0 %) and murids (PP 1.1 %) could play a role in the life-cycle of E. multilocularis in areas with medium to high PP in red foxes. In areas with low PP in foxes, no other DH was found infected with E. multilocularis. When fox E. multilocularis PP was >3 %, raccoon dogs and golden jackals could play a similar role as foxes. In areas with high E. multilocularis fox PP, the wolf emerged as a potentially important DH. Dogs and cats could be irrelevant in the life-cycle of the parasite in Europe, although dogs could be important for parasite introduction into non-endemic areas. Muskrats and arvicolids are important IHs. Swine, insectivores, murids and nutrias seem to play a minor or no role in the life-cycle of the parasite within the EU and ACs
The high-efficiency {\gamma}-ray spectroscopy setup {\gamma}3 at HI{\gamma}S
The existing Nuclear Resonance Fluorescence (NRF) setup at the HI{\gamma}S
facility at the Triangle Universities Nuclear Laboratory at Duke University has
been extended in order to perform {\gamma}-{\gamma} coincidence experiments.
The new setup combines large volume LaBr3:Ce detectors and high resolution HPGe
detectors in a very close geometry to offer high efficiency, high energy
resolution as well as high count rate capabilities at the same time. The
combination of a highly efficient {\gamma}-ray spectroscopy setup with the
mono-energetic high-intensity photon beam of HI{\gamma}S provides a worldwide
unique experimental facility to investigate the {\gamma}-decay pattern of
dipole excitations in atomic nuclei. The performance of the new setup has been
assessed by studying the nucleus \sulfur at 8.125 MeV beam energy. The
{\gamma}-decay branching ratio from the level at 8125.4 keV to the first
excited state was determined to 15.7(3)%.Comment: 9 pages, 11 figure
Dipole Strength Distributions from HIGS Experiments
A series of photon scattering experiments has been performed on the double-beta decay partners 76Ge and 76Se, in order to investigate their dipole response up to the neutron separation threshold. Gamma-ray beams from bremsstrahlung at the S-DALINAC and from Compton-backscattering at HIGS have been used to measure absolute cross sections and parities of dipole excited states, respectively. The HIGS data allows for indirect measurement of averaged branching ratios, which leads to significant corrections in the observed excitation cross sections. Results are compared to statistical calculations, to test photon strength functions and the Axel-Brink hypothesi
Post-treatment follow-up study of abdominal cystic echinococcosis in Tibetan communities of northwest Sichuan Province, China
Background: Human cystic echinococcosis (CE), caused by the larval stage of Echinococcus granulosus, with the liver as the
most frequently affected organ, is known to be highly endemic in Tibetan communities of northwest Sichuan Province.
Antiparasitic treatment with albendazole remains the primary choice for the great majority of patients in this resource-poor
remote area, though surgery is the most common approach for CE therapy that has the potential to remove cysts and lead
to complete cure. The current prospective study aimed to assess the effectiveness of community based use of cyclic
albendazole treatment in Tibetan CE cases, and concurrently monitor the changes of serum specific antibody levels during
treatment.
Methodology/Principal Findings: Ultrasonography was applied for diagnosis and follow-up of CE cases after cyclic
albendazole treatment in Tibetan communities of Sichuan Province during 2006 to 2008, and serum specific IgG antibody
levels against Echinococcus granulosus recombinant antigen B in ELISA was concurrently monitored in these cases. A total of
196 CE cases were identified by ultrasound, of which 37 (18.9%) showed evidence of spontaneous healing/involution of
hepatic cyst(s) with CE4 or CE5 presentations. Of 49 enrolled CE cases for treatment follow-up, 32.7% (16) were considered
to be cured based on B-ultrasound after 6 months to 30 months regular albendazole treatment, 49.0% (24) were improved,
14.3% (7) remained unchanged, and 4.1% (2) became aggravated. In general, patients with CE2 type cysts (daughter cysts
present) needed a longer treatment course for cure (26.4 months), compared to cases with CE1 (univesicular cysts) (20.4
months) or CE3 type (detached cyst membrane or partial degeneration of daughter cysts) (9 months). In addition, the
curative duration was longer in patients with large (.10 cm) cysts (22.3 months), compared to cases with medium (5–
10 cm) cysts (17.3 months) or patients with small (,5 cm) cysts (6 months). At diagnosis, seven (53.8%) of 13 cases with CE1
type cysts without any previous intervention showed negative specific IgG antibody response to E. granulosus recombinant
antigen B (rAgB). However, following 3 months to 18 months albendazole therapy, six of these 7 initially seronegative CE1
cases sero-converted to be specific IgG antibody positive, and concurrently ultrasound scan showed that cysts changed to
CE3a from CE1 type in all the six CE cases. Two major profiles of serum specific IgG antibody dynamics during albendazole
treatment were apparent in CE cases: (i) presenting as initial elevation followed by subsequent decline, or (ii) a persistent
decline. Despite a decline, however, specific antibody levels remained positive in most improved or cured CE cases.
Conclusions: This was the first attempt to follow up community-screened cystic echinococcosis patients after albendazole
therapy using ultrasonography and serology in an endemic Tibetan region. Cyclic albendazole treatment proved to be
effective in the great majority of CE cases in this resource-poor area, but periodic abdominal ultrasound examination was
necessary to guide appropriate treatment. Oral albendazole for over 18 months was more likely to result in CE cure. Poor
drug compliance resulted in less good outcomes. Serology with recombinant antigen B could provide additional limited
information about the effectiveness of albendazole in CE cases. Post-treatment positive specific IgG antibody
seroconversion, in initially seronegative, CE1 patients was considered a good indication for positive therapeutic efficacy
of albendazole
Public health risks associated with food‐borne parasites
Parasites are important food-borne pathogens. Their complex lifecycles, varied transmission routes, and prolonged periods between infection and symptoms mean that the public health burden and relative importance of different transmission routes are often difficult to assess. Furthermore, there are challenges in detection and diagnostics, and variations in reporting. A Europe-focused ranking exercise, using multicriteria decision analysis, identified potentially food-borne parasites of importance, and that are currently not routinely controlled in food. These are Cryptosporidium spp., Toxoplasma gondii and Echinococcus spp. Infection with these parasites in humans and animals, or their occurrence in food, is not notifiable in all Member States. This Opinion reviews current methods for detection, identification and tracing of these parasites in relevant foods, reviews literature on food-borne pathways, examines information on their occurrence and persistence in foods, and investigates possible control measures along the food chain. The differences between these three parasites are substantial, but for all there is a paucity of well-established, standardised, validated methods that can be applied across the range of relevant foods. Furthermore, the prolonged period between infection and clinical symptoms (from several days for Cryptosporidium to years for Echinococcus spp.) means that source attribution studies are very difficult. Nevertheless, our knowledge of the domestic animal lifecycle (involving dogs and livestock) for Echinoccocus granulosus means that this parasite is controllable. For Echinococcus multilocularis, for which the lifecycle involves wildlife (foxes and rodents), control would be expensive and complicated, but could be achieved in targeted areas with sufficient commitment and resources. Quantitative risk assessments have been described for Toxoplasma in meat. However, for T.gondii and Cryptosporidium as faecal contaminants, development of validated detection methods, including survival/infectivity assays and consensus molecular typing protocols, are required for the development of quantitative risk assessments and efficient control measures
Treatment Response of Cystic Echinococcosis to Benzimidazoles: A Systematic Review
Over the past 30 years, benzimidazoles have increasingly been used to treat cystic echinococcosis (CE). The efficacy of benzimidazoles, however, remains unclear. We systematically searched MEDLINE, EMBASE, SIGLE, and CCTR to identify studies on benzimidazole treatment outcome. A large heterogeneity of methods in 23 reports precluded a meta-analysis of published results. Specialist centres were contacted to provide individual patient data. We conducted survival analyses for cyst response defined as inactive (CE4 or CE5 by the ultrasound-based World Health Organisation [WHO] classification scheme) or as disappeared. We collected data from 711 treated patients with 1,308 cysts from six centres (five countries). Analysis was restricted to 1,159 liver and peritoneal cysts. Overall, 1–2 y after initiation of benzimidazole treatment 50%–75% of active C1 cysts were classified as inactive/disappeared compared to 30%–55% of CE2 and CE3 cysts. Further in analyzing the rate of inactivation/disappearance with regard to cyst size, 50%–60% of cysts <6 cm responded to treatment after 1–2 y compared to 25%–50% of cysts >6 cm. However, 25% of cysts reverted to active status within 1.5 to 2 y after having initially responded and multiple relapses were observed; after the second and third treatment 60% of cysts relapsed within 2 y. We estimated that 2 y after treatment initiation 40% of cysts are still active or become active again. The overall efficacy of benzimidazoles has been overstated in the past. There is an urgent need for a pragmatic randomised controlled trial that compares standardized benzimidazole therapy on responsive cyst stages with the other treatment modalities
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