94 research outputs found
Change Point Problem for Censored Data
Department of Probability and Mathematical StatisticsKatedra pravděpodobnosti a matematické statistikyMatematicko-fyzikálnà fakultaFaculty of Mathematics and Physic
Cortical AAV-CNTF gene therapy combined with intraspinal mesenchymal precursor cell transplantation promotes functional and morphological outcomes after spinal cord injury in adult rats
Ciliary neurotrophic factor (CNTF) promotes survival and enhances long-distance regeneration of injured axons in parts of the adult CNS. Here we tested whether CNTF gene therapy targeting corticospinal neurons (CSN) in motor-related regions of the cerebral cortex promotes plasticity and regrowth of axons projecting into the female adult F344 rat spinal cord after moderate thoracic (T10) contusion injury (SCI). Cortical neurons were transduced with a bicistronic adeno-associated viral vector (AAV1) expressing a secretory form of CNTF coupled to mCHERRY (AAV-CNTFmCherry) or with control AAV only (AAV-GFP) two weeks prior to SCI. In some animals, viable or nonviable F344 rat mesenchymal precursor cells (rMPCs) were injected into the lesion site two weeks after SCI to modulate the inhibitory environment. Treatment with AAV-CNTFmCherry, as well as with AAV-CNTFmCherry combined with rMPCs, yielded functional improvements over AAV-GFP alone, as assessed by open-field and Ladderwalk analyses. Cyst size was significantly reduced in the AAV-CNTFmCherry plus viable rMPC treatment group. Cortical injections of biotinylated dextran amine (BDA) revealed more BDA-stained axons rostral and alongside cysts in the AAV-CNTFmCherry versus AAV-GFP groups. After AAV-CNTFmCherry treatments, many sprouting mCherry-immunopositive axons were seen rostral to the SCI, and axons were also occasionally found caudal to the injury site. These data suggest that CNTF has the potential to enhance corticospinal repair by transducing parent CNS populations
Novel signatures for vector-like quarks
We consider supersymmetric extensions of the standard model with a vector-like doublet (T B) of quarks with charge 2/3 and −1/3, respectively. Compared to non-supersymmetric models, there is a variety of new decay modes for the vector-like quarks, involving the extra scalars present in supersymmetry. The importance of these new modes, yielding multi-top, multi-bottom and also multi-Higgs signals, is highlighted by the analysis of several benchmark scenarios. We show how the triangles commonly used to represent the branching ratios of the ‘standard’ decay modes of the vector-like quarks involving W, Z or Higgs bosons can be generalised to include additional channels. We give an example by recasting the limits of a recent heavy quark search for this more general case.The work of J.A. Aguilar-Saavedra has been supported by MINECO Projects FPA 2016-
78220-C3-1-P and FPA 2013-47836-C3-2-P (including ERDF), and by Junta de Andaluc a
Project FQM-101. The work of D.E. L opez-Fogliani has been supported by the Argentinian
CONICET. The work of C. Mu~noz has been supported in part by the Programme SEV-
2012-0249 `Centro de Excelencia Severo Ochoa'. D.E. L opez-Fogliani and C. Mu~noz also
acknowledge the support of the Spanish grant FPA2015-65929-P (MINECO/FEDER, UE),
and MINECO's Consolider-Ingenio 2010 Programme under grant MultiDark CSD2009-
00064
The impact of the ATLAS zero-lepton, jets and missing momentum search on a CMSSM fit
Recent ATLAS data significantly extend the exclusion limits for
supersymmetric particles. We examine the impact of such data on global fits of
the constrained minimal supersymmetric standard model (CMSSM) to indirect and
cosmological data. We calculate the likelihood map of the ATLAS search, taking
into account systematic errors on the signal and on the background. We validate
our calculation against the ATLAS determinaton of 95% confidence level
exclusion contours. A previous CMSSM global fit is then re-weighted by the
likelihood map, which takes a bite at the high probability density region of
the global fit, pushing scalar and gaugino masses up.Comment: 16 pages, 7 figures. v2 has bigger figures and fixed typos. v3 has
clarified explanation of our handling of signal systematic
Biogenic weathering bridges the nutrient gap in pristine ecosystems - a global comparison
In many pristine ecosystems there seems to be negative nutrient budget existent, meaning that export exceeds the input received by aeolian deposition and physico-chemical weathering. Such ecosystems should degrade rather quickly, but are often found surprisingly stable on the long run. Our hypothesis was that this nutrient gap is an artefact caused by not considering the contribution of photoassimilatory-mediated biogenic weathering to the overall nutrient input, which might constitute an additional, energetically directed and demand driven pathway. Here, we firstly evaluated the evolution of mutualistic biogenic weathering along an Antarctic chronosequence and secondly compared the biogenic weathering rates under mycorrhized ecosystems over a global gradient of contrasting states of soil development. We found the ability to perform biogenic weathering increasing along its evolutionary development in photoautotroph-symbiont interaction and furthermore a close relation between fungal biogenic weathering and available potassium across all 16 forested sites in the study, regardless of the dominant mycorrhiza type (AM or EM), climate, and plant-species composition. Our results point towards a general alleviation of nutrient limitation at ecosystem scale via directional, energy driven and on-demand biogenic weathering
Naturalness and Fine Tuning in the NMSSM: Implications of Early LHC Results
We study the fine tuning in the parameter space of the semi-constrained
NMSSM, where most soft Susy breaking parameters are universal at the GUT scale.
We discuss the dependence of the fine tuning on the soft Susy breaking
parameters M_1/2 and m0, and on the Higgs masses in NMSSM specific scenarios
involving large singlet-doublet Higgs mixing or dominant Higgs-to-Higgs decays.
Whereas these latter scenarios allow a priori for considerably less fine tuning
than the constrained MSSM, the early LHC results rule out a large part of the
parameter space of the semi-constrained NMSSM corresponding to low values of
the fine tuning.Comment: 19 pages, 10 figures, bounds from Susy searches with ~1/fb include
Optimization of Planck/LFI on--board data handling
To asses stability against 1/f noise, the Low Frequency Instrument (LFI)
onboard the Planck mission will acquire data at a rate much higher than the
data rate allowed by its telemetry bandwith of 35.5 kbps. The data are
processed by an onboard pipeline, followed onground by a reversing step. This
paper illustrates the LFI scientific onboard processing to fit the allowed
datarate. This is a lossy process tuned by using a set of 5 parameters Naver,
r1, r2, q, O for each of the 44 LFI detectors. The paper quantifies the level
of distortion introduced by the onboard processing, EpsilonQ, as a function of
these parameters. It describes the method of optimizing the onboard processing
chain. The tuning procedure is based on a optimization algorithm applied to
unprocessed and uncompressed raw data provided either by simulations, prelaunch
tests or data taken from LFI operating in diagnostic mode. All the needed
optimization steps are performed by an automated tool, OCA2, which ends with
optimized parameters and produces a set of statistical indicators, among them
the compression rate Cr and EpsilonQ. For Planck/LFI the requirements are Cr =
2.4 and EpsilonQ <= 10% of the rms of the instrumental white noise. To speedup
the process an analytical model is developed that is able to extract most of
the relevant information on EpsilonQ and Cr as a function of the signal
statistics and the processing parameters. This model will be of interest for
the instrument data analysis. The method was applied during ground tests when
the instrument was operating in conditions representative of flight. Optimized
parameters were obtained and the performance has been verified, the required
data rate of 35.5 Kbps has been achieved while keeping EpsilonQ at a level of
3.8% of white noise rms well within the requirements.Comment: 51 pages, 13 fig.s, 3 tables, pdflatex, needs JINST.csl, graphicx,
txfonts, rotating; Issue 1.0 10 nov 2009; Sub. to JINST 23Jun09, Accepted
10Nov09, Pub.: 29Dec09; This is a preprint, not the final versio
Off-line radiometric analysis of Planck/LFI data
The Planck Low Frequency Instrument (LFI) is an array of 22
pseudo-correlation radiometers on-board the Planck satellite to measure
temperature and polarization anisotropies in the Cosmic Microwave Background
(CMB) in three frequency bands (30, 44 and 70 GHz). To calibrate and verify the
performances of the LFI, a software suite named LIFE has been developed. Its
aims are to provide a common platform to use for analyzing the results of the
tests performed on the single components of the instrument (RCAs, Radiometric
Chain Assemblies) and on the integrated Radiometric Array Assembly (RAA).
Moreover, its analysis tools are designed to be used during the flight as well
to produce periodic reports on the status of the instrument. The LIFE suite has
been developed using a multi-layered, cross-platform approach. It implements a
number of analysis modules written in RSI IDL, each accessing the data through
a portable and heavily optimized library of functions written in C and C++. One
of the most important features of LIFE is its ability to run the same data
analysis codes both using ground test data and real flight data as input. The
LIFE software suite has been successfully used during the RCA/RAA tests and the
Planck Integrated System Tests. Moreover, the software has also passed the
verification for its in-flight use during the System Operations Verification
Tests, held in October 2008.Comment: Planck LFI technical papers published by JINST:
http://www.iop.org/EJ/journal/-page=extra.proc5/1748-022
The Higgs sector of the munuSSM and collider physics
The SSM is a supersymmetric standard model that accounts for light
neutrino masses and solves the problem of the MSSM by simply using
right-handed neutrino superfields. Since this mechanism breaks R-parity, a
peculiar structure for the mass matrices is generated. The neutral Higgses are
mixed with the right- and left-handed sneutrinos producing 88 neutral
scalar mass matrices. We analyse the Higgs sector of the SSM in detail,
with special emphasis in possible signals at colliders. After studying in
general the decays of the Higges, we focus on those processes that are genuine
of the SSM, and could serve to distinguish it from other supersymmetric
models. In particular, we present viable benchmark points for LHC searches. For
example, we find decays of a MSSM-like Higgs into two lightest neutralinos,
with the latter decaying inside the detector leading to displaced vertices, and
producing final states with 4 and 8 -jets plus missing energy. Final states
with leptons and missing energy are also found.Comment: Final version to appear in JHEP. The discussion on signals at
colliders, expanded. 33 pages, 8 figures and 9 table
Planck pre-launch status: Low Frequency Instrument calibration and expected scientific performance
We give the calibration and scientific performance parameters of the Planck
Low Frequency Instrument (LFI) measured during the ground cryogenic test
campaign. These parameters characterise the instrument response and constitute
our best pre-launch knowledge of the LFI scientific performance. The LFI shows
excellent stability and rejection of instrumental systematic effects;
measured noise performance shows that LFI is the most sensitive instrument of
its kind. The set of measured calibration parameters will be updated during
flight operations through the end of the mission.Comment: Accepted for publications in Astronomy and Astrophysics. Astronomy &
Astrophysics, 2010 (acceptance date: 12 Jan 2010
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