Source energy spectra from demodulation of solar particle data by interplanetary and coronal transport

The data on source energy spectra of solar cosmic rays (SCR), i.e. the data on the spectrum form and on the absolute SCR are of interest for three reasons: (1) the SCR contain the energy comparable to the total energy of electromagnetic flare radiation (less than or equal to 10 to the 32nd power ergs); (2) the source spectrum form indicates a possible acceleration mechanism (or mechanism); and (3) the accelerated particles are efficiently involved in nuclear electromagnetic and plasma processes in the solar atmosphere. Therefore, the data on SCR source spectra are necessary for a theoretical description of the processes mentioned and for the formulation of the consistent flare model. Below it is attempted to sound solar particle sources by means of SCR energy spectrum obtained near the Sun, at the level of the roots of the interplanetary field lines in the upper solar corona. Data from approx. 60 solar proton events (SPE) between 1956-1981. These data were obtained mainly by the interplanetary demodulation of observed fluxes near the Earth. Further, a model of coronal azimuthal transport is used to demodulate those spectra, and to obtain the source energy spectra

Comparisons of Production Costs and Profit of Three Different Technology Levels of Papaya Production in Tabasco, Mexico

The survey was carried out from September 2006 to January 2007 in three papaya production sites located in main papaya production zones in Tabasco; SE Mexico. There are differences in size of the cultivated area, in the yield of the papaya as well as in production costs and profit, according to the different technology levels in the farming systems: low, medium and high technology cultivation level. The financial evaluations were carried out in three sites with different productive technologies. The comparison of the agronomic and economic traits results for low technology level in: V AN of 2359.00 USD, BCR in 1.9 and an equilibrium point of 3750.00 USD, TIR of 0.25. In order to avoid loses, a quantity of 10714 kg papaya should be sold. In medium technology VAN is 1605.10 USD, BCR is 1.7, TIR 0.20 and the equilibrium point is 12800.00 USD. 36571 kg of papaya should be yearly sold. In high technology level VAN is 11749.40, BCR is 2.73, TIR 0.43 and the equilibrium point is 12187.50 USD, 34821 kg papaya should be sold yearly. The indicators showed that all three levels are profitable and economically viable

A putative relay circuit providing low-threshold mechanoreceptive input to lamina I projection neurons via vertical cells in lamina II of the rat dorsal horn

Background: Lamina I projection neurons respond to painful stimuli, and some are also activated by touch or hair movement. Neuropathic pain resulting from peripheral nerve damage is often associated with tactile allodynia (touch-evoked pain), and this may result from increased responsiveness of lamina I projection neurons to non-noxious mechanical stimuli. It is thought that polysynaptic pathways involving excitatory interneurons can transmit tactile inputs to lamina I projection neurons, but that these are normally suppressed by inhibitory interneurons. Vertical cells in lamina II provide a potential route through which tactile stimuli can activate lamina I projection neurons, since their dendrites extend into the region where tactile afferents terminate, while their axons can innervate the projection cells. The aim of this study was to determine whether vertical cell dendrites were contacted by the central terminals of low-threshold mechanoreceptive primary afferents. Results: We initially demonstrated contacts between dendritic spines of vertical cells that had been recorded in spinal cord slices and axonal boutons containing the vesicular glutamate transporter 1 (VGLUT1), which is expressed by myelinated low-threshold mechanoreceptive afferents. To confirm that the VGLUT1 boutons included primary afferents, we then examined vertical cells recorded in rats that had received injections of cholera toxin B subunit (CTb) into the sciatic nerve. We found that over half of the VGLUT1 boutons contacting the vertical cells were CTb-immunoreactive, indicating that they were of primary afferent origin. Conclusions: These results show that vertical cell dendritic spines are frequently contacted by the central terminals of myelinated low-threshold mechanoreceptive afferents. Since dendritic spines are associated with excitatory synapses, it is likely that most of these contacts were synaptic. Vertical cells in lamina II are therefore a potential route through which tactile afferents can activate lamina I projection neurons, and this pathway could play a role in tactile allodynia

Precise measurement of the W-boson mass with the CDF II detector

We have measured the W-boson mass MW using data corresponding to 2.2/fb of integrated luminosity collected in proton-antiproton collisions at 1.96 TeV with the CDF II detector at the Fermilab Tevatron collider. Samples consisting of 470126 W->enu candidates and 624708 W->munu candidates yield the measurement MW = 80387 +- 12 (stat) +- 15 (syst) = 80387 +- 19 MeV. This is the most precise measurement of the W-boson mass to date and significantly exceeds the precision of all previous measurements combined

An Influenza A/H1N1/2009 Hemagglutinin Vaccine Produced in Escherichia coli

The A/H1N1/2009 influenza pandemic made evident the need for faster and higher-yield methods for the production of influenza vaccines. Platforms based on virus culture in mammalian or insect cells are currently under investigation. Alternatively, expression of fragments of the hemagglutinin (HA) protein in prokaryotic systems can potentially be the most efficacious strategy for the manufacture of large quantities of influenza vaccine in a short period of time. Despite experimental evidence on the immunogenic potential of HA protein constructs expressed in bacteria, it is still generally accepted that glycosylation should be a requirement for vaccine efficacy.We expressed the globular HA receptor binding domain, referred to here as HA(63-286)-RBD, of the influenza A/H1N1/2009 virus in Escherichia coli using a simple, robust and scalable process. The recombinant protein was refolded and purified from the insoluble fraction of the cellular lysate as a single species. Recombinant HA(63-286)-RBD appears to be properly folded, as shown by analytical ultracentrifugation and bio-recognition assays. It binds specifically to serum antibodies from influenza A/H1N1/2009 patients and was found to be immunogenic, to be capable of triggering the production of neutralizing antibodies, and to have protective activity in the ferret model.Projections based on our production/purification data indicate that this strategy could yield up to half a billion doses of vaccine per month in a medium-scale pharmaceutical production facility equipped for bacterial culture. Also, our findings demonstrate that glycosylation is not a mandatory requirement for influenza vaccine efficacy