Gas phase mean opacities for varying [M/H], N/O, and C/O

We present a set of gas-phase Planck mean and Rosseland mean opacity tables applicable for simulations of star and planet formation, stellar evolution, disk modelling at various metallicities in hydrogen-rich environments. The tables are calculated for gas temperatures between 1000K and 10000K and total hydrogen number densities between 10^2 cm^-3 and 10^17 cm^-3. The carbon-to-oxygen ratio is varied from 0.43 to well above 2.0, the nitrogen-to-oxygen ration between 0.14 and 100.0. The tables are calculated for a range of metallicities down to [M/H]'= log N_M/N_H=-7.0. We demonstrate how the mean opacities and the abundances of the opacity species vary with C/O, N/O, and [M/H]'. We use the element abundances from Grevesse, Asplund & Sauval (2007), and we provide additional tables for the oxygen-abundance value from Caffau et al.(2008). All tables will be available online under http://star-www.st-and.ac.uk/$\sim$ch80/datasources.htmlComment: 10 pages, accepted for publication in MNRA

Comparison of results from different imputation techniques for missing data from an anti-obesity drug trial

BackgroundIn randomised trials of medical interventions, the most reliable analysis follows the intention-to-treat (ITT) principle. However, the ITT analysis requires that missing outcome data have to be imputed. Different imputation techniques may give different results and some may lead to bias. In anti-obesity drug trials, many data are usually missing, and the most used imputation method is last observation carried forward (LOCF). LOCF is generally considered conservative, but there are more reliable methods such as multiple imputation (MI).ObjectivesTo compare four different methods of handling missing data in a 60-week placebo controlled anti-obesity drug trial on topiramate.MethodsWe compared an analysis of complete cases with datasets where missing body weight measurements had been replaced using three different imputation methods: LOCF, baseline carried forward (BOCF) and MI.Results561 participants were randomised. Compared to placebo, there was a significantly greater weight loss with topiramate in all analyses: 9.5 kg (SE 1.17) in the complete case analysis (N = 86), 6.8 kg (SE 0.66) using LOCF (N = 561), 6.4 kg (SE 0.90) using MI (N = 561) and 1.5 kg (SE 0.28) using BOCF (N = 561).ConclusionsThe different imputation methods gave very different results. Contrary to widely stated claims, LOCF did not produce a conservative (i.e., lower) efficacy estimate compared to MI. Also, LOCF had a lower SE than MI

Changes in knee joint load indices from before to 12 months after arthroscopic partial meniscectomy:a prospective cohort study

Patients undergoing arthroscopic partial meniscectomy (APM) are at increased risk of knee osteoarthritis (OA). Meniscal damage and/or surgery may alter knee joint loading to increase OA risk. We investigated changes in knee joint loading following medial APM surgery, compared with the contra-lateral leg

Synthetic photometry for carbon-rich giants II. The effects of pulsation and circumstellar dust

By using self-consistent dynamic model atmospheres which simulate pulsation-enhanced dust-driven winds of AGB stars we studied in detail the influence of (i) pulsations of the stellar interiors, and (ii) the development of dusty stellar winds on the spectral appearance of long period variables with carbon-rich atmospheric chemistry. While the pulsations lead to large-amplitude photometric variability, the dusty envelopes cause pronounced circumstellar reddening. Based on one selected dynamical model which is representative of C-type Mira variables with intermediate mass loss rates, we calculated synthetic spectra and photometry for standard broad-band filters from the visual to the near-infrared. Our modelling allows to investigate in detail the substantial effect of circumstellar dust on the resultant photometry. The pronounced absorption of amorphous carbon dust grains leads to colour indices which are significantly redder than the corresponding ones based on hydrostatic dust-free models. Only if we account for this circumstellar reddening we get synthetic colours that are comparable to observations of evolved AGB stars. The photometric variations of the dynamical model were compared to observed lightcurves of the C-type Mira RU_Vir which appears to be quite similar to the model. We found good agreement concerning the principal behaviour of the BVRIJHKL lightcurves and also quantitatively fitting details. The analysed model is able to reproduce the variations of RU_Vir and other Miras in (J-H) vs. (H-K) diagrams throughout the light cycle. Contrasting the model photometry with observational data for a variety of galactic C-rich giants in such colour-colour diagrams proved that the chosen atmospheric model fits well into a sequence of objects with increasing mass loss rates, i.e., redder colour indices.Comment: Accepted for publication in A&

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Stikordsreferat fra Trafikdage i Aalborg, 28. august 201

Abundance analysis for long period variables. Velocity effects studied with O-rich dynamic model atmospheres

(abbreviated) Measuring the surface abundances of AGB stars is an important tool for studying the effects of nucleosynthesis and mixing in the interior of low- to intermediate mass stars during their final evolutionary phases. The atmospheres of AGB stars can be strongly affected by stellar pulsation and the development of a stellar wind, though, and the abundance determination of these objects should therefore be based on dynamic model atmospheres. We investigate the effects of stellar pulsation and mass loss on the appearance of selected spectral features (line profiles, line intensities) and on the derived elemental abundances by performing a systematic comparison of hydrostatic and dynamic model atmospheres. High-resolution synthetic spectra in the near infrared range were calculated based on two dynamic model atmospheres (at various phases during the pulsation cycle) as well as a grid of hydrostatic COMARCS models. Equivalent widths of a selection of atomic and molecular lines were derived in both cases and compared with each other. In the case of the dynamic models, the equivalent widths of all investigated features vary over the pulsation cycle. A consistent reproduction of the derived variations with a set of hydrostatic models is not possible, but several individual phases and spectral features can be reproduced well with the help of specific hydrostatic atmospheric models. In addition, we show that the variations in equivalent width that we found on the basis of the adopted dynamic model atmospheres agree qualitatively with observational results for the Mira R Cas over its light cycle. The findings of our modelling form a starting point to deal with the problem of abundance determination in strongly dynamic AGB stars (i.e., long-period variables).Comment: 13 pages, 22 figures, accepted for publication in A&

A novel derivative of thioridazine shows low toxicity and efficient activity against gram‐positive pathogens

Thioridazine hydrochloride (HCl) has been suggested as a promising antimicrobial helper compound for the treatment of infections with antimicrobial-resistant bacteria. Unfortunately, the therapeutic concentration of thioridazine HCl is generally higher than what can be tolerated clinically, in part due to its toxic side effects on the central nervous system. Therefore, we aimed to synthesize a less toxic thioridazine derivative that would still retain its properties as a helper compound. This resulted in a compound designated 1-methyl-2-(2-(2-(methylthio)-10H-phenothiazin-10-yl)ethyl)-1-pentylpiperidin-1-ium bromide (abbreviated T5), which exhibited low blood–brain barrier permeability. The lowest minimal inhibitory concentration (MIC) against Staphylococcus aureus exposed to the novel compound was reduced 32-fold compared to thioridazine HCl (from 32 µg/mL to 1 µg/mL). The MIC values for T5 against five Gram-positive pathogens ranged from 1 µg/mL to 8 µg/mL. In contrast to thioridazine HCl, T5 does not act synergistically with oxacillin. In silico predictive structure analysis of T5 suggests that an acceptably low toxicity and lack of induced cytotoxicity was demonstrated by a lactate dehydrogenase assay. Conclusively, T5 is suggested as a novel antimicrobial agent against Gram-positive bacteria. However, future pharmacokinetic and pharmacodynamic studies are needed to clarify the clinical potential of this novel discovery

Spatial behavior and habitat use in widely separated breeding and wintering distributions across three species of long-distance migrant <i>Phylloscopus</i> warblers

Aim: To investigate the ecological relationship between breeding and wintering in specialist and generalist long-distance migratory species, and the links between densities and range sizes. Location: Denmark, Senegal and Ghana. Methods: We use radio tracking to study spatial behavior and habitat use in three morphologically and ecologically similar and closely related Phylloscopus species on their widely separated breeding and wintering distributions. During wintering and breeding, willow warblers P. trochilus (winter: n = 9, breeding: n = 13), chiffchaffs P. collybita (n = 11, n = 7), and wood warblers P. sibilatrix (n = 17, n = 14) were tracked. Results: Willow warblers P. trochilus increased home range sizes in winter, whereas it was similar in chiffchaffs P. collybita and wood warblers P. sibilatrix, in both seasons. Home ranges overlapped more in winter than in the breeding season. In winter, home range overlap was similar among species but larger overlap during breeding was indicated for willow warblers. Tree cover was unrelated to home range size but significantly higher in breeding than in winter in all species. However, whereas willow warblers and wood warblers maintained some degree of tall tree cover inside their home ranges in winter, chiffchaffs changed from more than 80% to <1% tree cover, indicating a niche shift. Main conclusions: Individuals of all three species showed changes between breeding and wintering areas in spatial behavior and habitat availability, with larger overlap in winter. The differences in patterns were potentially related to being generalist (willow warbler) or specialist (chiffchaff and wood warbler). These ecological relationships are important for the conservation of migrants and for understanding the link between breeding and wintering distributions and ecology

Industry-supported meta-analyses compared with meta-analyses with non-profit or no support: Differences in methodological quality and conclusions

<p>Abstract</p> <p>Background</p> <p>Studies have shown that industry-sponsored meta-analyses of drugs lack scientific rigour and have biased conclusions. However, these studies have been restricted to certain medical specialities. We compared all industry-supported meta-analyses of drug-drug comparisons with those without industry support.</p> <p>Methods</p> <p>We searched PubMed for all meta-analyses that compared different drugs or classes of drugs published in 2004. Two authors assessed the meta-analyses and independently extracted data. We used a validated scale for judging the methodological quality and a binary scale for judging conclusions. We divided the meta-analyses according to the type of support in 3 categories: industry-supported, non-profit support or no support, and undeclared support.</p> <p>Results</p> <p>We included 39 meta-analyses. Ten had industry support, 18 non-profit or no support, and 11 undeclared support. On a 0–7 scale, the median quality score was 6 for meta-analyses with non-profit or no support and 2.5 for the industry-supported meta-analyses (P < 0.01). Compared with industry-supported meta-analyses, more meta-analyses with non-profit or no support avoided bias in the selection of studies (P = 0.01), more often stated the search methods used to find studies (P = 0.02), searched comprehensively (P < 0.01), reported criteria for assessing the validity of the studies (P = 0.02), used appropriate criteria (P = 0.04), described methods of allocation concealment (P = 0.05), described methods of blinding (P = 0.05), and described excluded patients (P = 0.08) and studies (P = 0.15). Forty percent of the industry-supported meta-analyses recommended the experimental drug without reservations, compared with 22% of the meta-analyses with non-profit or no support (P = 0.57).</p> <p>In a sensitivity analysis, we contacted the authors of the meta-analyses with undeclared support. Eight who replied that they had not received industry funding were added to those with non-profit or no support, and 3 who did not reply were added to those with industry support. This analysis did not change the results much.</p> <p>Conclusion</p> <p>Transparency is essential for readers to make their own judgment about medical interventions guided by the results of meta-analyses. We found that industry-supported meta-analyses are less transparent than meta-analyses with non-profit support or no support.</p