38 research outputs found
Quantum techniques for classical black holes
- Author
- Publication venue
- The University of Edinburgh
- Publication date
- 26/11/2019
- Field of study
Modern theoretical physics has benefited from a rapid growth in mathematical
technology. In particular, technology developed in one field can be quickly
adapted for use in another. Two key techniques developed for simplifying
calculations of Feynman diagrams are spinor-helicity and the double copy. This
thesis will discuss how they can be applied to general relativity.
Spinor-helicity is used in particle physics to simplify expressions. In D > 4 this is
done by observing that the residual symmetry of the little group is non-trivial. We
adapt this technology to classify higher-dimensional spacetimes in the style of the
D = 4 Petrov classification. Focusing on D = 5, our scheme naturally reproduces
the full structure previously seen in both the CMPP and de Smet classifications,
and resolves long-standing questions concerning their relationship.
We review the exact classical double copy introduced for stationary Kerr-Schild
spacetimes. We consider a time-dependent generalisation: the accelerating,
radiating point particle. This Kerr-Schild solution has a non-trivial stress-energy
tensor which we interpret as the radiative part of the field and find the
corresponding single copy. Using Bremsstrahlung as an example, we determine
a scattering amplitude describing the radiation which is consistent with the
quantum double copy. This indicates a profound connection between exact
classical solutions and the double copy.
The double copy relates YM and gravity amplitudes through the observation
that numerators of Feynman diagrams can be made to obey a Jacobi relation
mirroring the colour charges. This additional structure can be adapted for use in
classical perturbative calculations. The double copy maps to N = 0 supergravity
requiring careful treatment of the dilaton. Using the Janis-Newman-Winicour
family of naked singularities as an example we demonstrate how to construct
spacetime metrics through a systematic perturbative expansion
Type D spacetimes and the Weyl double copy
- Author
- Publication venue
- 'IOP Publishing'
- Publication date
- 18/02/2019
- Field of study
We study the double-copy relation between classical solutions in gauge theory and gravity, focusing on four-dimensional vacuum metrics of algebraic type D, a class that includes several important solutions. We present a double copy of curvatures that applies to all spacetimes of this type—the Weyl double copy—relating the curvature of the spacetime to an electromagnetic field strength. We show that the Weyl double copy is consistent with the previously known Kerr–Schild double copy, and in fact resolves certain ambiguities of the latter. The most interesting new example of the classical double copy presented here is that of the C-metric. This well-known solution, which represents a pair of uniformly accelerated black holes, is mapped to the Liénard–Wiechert potential for a pair of uniformly accelerated charges. We also present a new double-copy interpretation of the Eguchi–Hanson instanton
Inelastic Black Hole Scattering from Charged Scalar Amplitudes
- Author
- A Anastasiou
- A Anastasiou
- A Anastasiou
- A Luna
- A Luna
- A Luna
- A Sabio Vera
- AI Janis
- Andrés Luna
- BR Holstein
- C Cheung
- C Cheung
- C Cheung
- C-H Fu
- C-H Fu
- C-H Fu
- CD White
- Chris D. White
- Donal O’Connell
- E Laenen
- F Bloch
- H Johansson
- H Johansson
- H Johansson
- H Kawai
- Isobel Nicholson
- L Borsten
- M Chiodaroli
- M Chiodaroli
- M Tolotti
- N Bahjat-Abbas
- NEJ Bjerrum-Bohr
- NEJ Bjerrum-Bohr
- NEJ Bjerrum-Bohr
- R Monteiro
- R Monteiro
- R Monteiro
- R Saotome
- RW Brown
- S Oxburgh
- T Adamo
- T Kinoshita
- TD Lee
- Y-J Du
- Y-J Du
- Z Bern
- Z Bern
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 10/11/2017
- Field of study
We explain how the lowest-order classical gravitational radiation produced
during the inelastic scattering of two Schwarzschild black holes in General
Relativity can be obtained from a tree scattering amplitude in gauge theory
coupled to scalar fields. The gauge calculation is related to gravity through
the double copy. We remove unwanted scalar forces which can occur in the double
copy by introducing a massless scalar in the gauge theory, which is treated as
a ghost in the link to gravity. We hope these methods are a step towards a
direct application of the double copy at higher orders in classical
perturbation theory, with the potential to greatly streamline gravity
calculations for phenomenological applications.Comment: 28 pages, 6 figure
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- Author
- Abbass Hakam
- Adhikari Neill
- Affleck Julia
- Agno Sathianathan Ronan
- Ahmad Norfaizan
- Ahmed Iram
- Ainscough Kate
- Al Qasim Eman
- Al Swaidan Lolowa
- Al-Bassam Wisam
- Al-Beidh Farah
- Al-Beidh Farah
- Albert Martin
- Alegria Ana
- Alexander Brian
- Alexander Peter
- Allan Angela
- Allan Elizabeth
- Allen Louise
- Allibone Suzanne
- Amaro dos Santos Catorze Teodoro
- Anderson Tom
- Andric Zdravko
- Angus Derek
- Angus Derek C
- Anjum Aisha
- Ankert Juliane
- Annane Djillali
- Annane Djillali
- Anstey Matthew
- Antcliffe David
- Aparicio Christelle
- Appelt Peter
- Arabi Yaseen
- Arabi Yaseen
- Arbane Gill
- Archer Simon
- Aref Noah
- Arias Ana-Marie
- Arishi Hatim
- Arnold Donald
- Asghar Adeeba
- Ashelford Angela
- Attwood Ben
- Austin Karen
- Aysel Florescu Simin
- Azaiz Amine
- Babel Jakša
- Babio-Galan Maite
- Badie Julio
- Bagshaw Sean
- Baillie Kenneth
- Baker Evelyn
- Bakthavatsalam Dhanalakshmi
- Bamford Peter
- Banach Dorota
- Bannard-Smith Jonathan
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- Barber Russell
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- Berry Scott
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- Venkatesh Balasubramanian
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- Verlander Mark
- Verrier Nathalie
- Victor Saji
- Vieillard-Baron Antoine
- Voicu Sebastian
- Vowell Emma
- Vujaklija Brajković Ana
- Vuylsteke Alain
- Wagh Atul
- Walden Andrew
- Walker Rachel
- Walsh Joanne
- Walsh Tim
- Walsham James
- Ward Kathryn
- Warnock Majella
- Waterson Sharon
- Watkins Claire
- Watpool Irene
- Watters Malcolm
- Waugh Victoria
- Webb Steve
- Webb Steven A
- Wedd Steve
- Weismann Dirk
- Weissman Alexandra
- Wells Colin
- Welters Ingeborg
- Wetherill Bill
- Whelan Ruth
- Whileman Amanda
- Whitbread Jennifer
- White Hayden
- White Ian
- White Katie
- Whitehead Christina
- Wibrow Bradley
- Wigbers J
- Wilby Elizabeth
- Wild Laura
- Wild Laura
- Wilding Laura
- Wiley Daisy
- Wilhelmsen Elva
- Wilkinson Dean
- Willams Felicity
- Williams Alexandra
- Williams Erin
- Williams Hannah
- Williams Karen
- Williams Patricia
- Williams Patricia
- Williams Penny
- Williams Tony
- Williams Virginie
- Williamson Dawn
- Williamson James
- Wilson Karen
- Wilson Maggie
- Wiseman Sophie
- Wong Helen
- Wood Erica
- Wood Hannah
- Wood Tracy
- Woods Jane
- Woods Lindsey
- Worner Ruth
- Wren Jess
- Wren Lynn
- Wrey Brown Caroline
- Writing Committee for the REMAP-CAP Investigators
- Xavier Kugan
- Xia Le Tai Charlotte
- Yarad Elizabeth
- Yates David
- Young Chelsea
- Young Ian
- Young Meredith
- Young Paul
- Yusuff Hakeem
- Zaharia Miahela Florentina
- Zaidi Abbas
- Zaki Ahmed
- Zaman Mohsin
- Zammit Claire
- Zapalac Marija
- Zarychanski Ryan
- Zarychanski Ryan
- Zhao Xiao Bei
- Zinzoni Vanessa
- Zitter Letizia
- Đimoti Renata
- Publication venue
- JAMA: Journal of the American Medical Association
- Publication date
- 06/10/2020
- Field of study
Importance: Evidence regarding corticosteroid use for severe coronavirus disease 2019 (COVID-19) is limited. Objective: To determine whether hydrocortisone improves outcome for patients with severe COVID-19. Design, Setting, and Participants: An ongoing adaptive platform trial testing multiple interventions within multiple therapeutic domains, for example, antiviral agents, corticosteroids, or immunoglobulin. Between March 9 and June 17, 2020, 614 adult patients with suspected or confirmed COVID-19 were enrolled and randomized within at least 1 domain following admission to an intensive care unit (ICU) for respiratory or cardiovascular organ support at 121 sites in 8 countries. Of these, 403 were randomized to open-label interventions within the corticosteroid domain. The domain was halted after results from another trial were released. Follow-up ended August 12, 2020. Interventions: The corticosteroid domain randomized participants to a fixed 7-day course of intravenous hydrocortisone (50 mg or 100 mg every 6 hours) (n = 143), a shock-dependent course (50 mg every 6 hours when shock was clinically evident) (n = 152), or no hydrocortisone (n = 108). Main Outcomes and Measures: The primary end point was organ support-free days (days alive and free of ICU-based respiratory or cardiovascular support) within 21 days, where patients who died were assigned -1 day. The primary analysis was a bayesian cumulative logistic model that included all patients enrolled with severe COVID-19, adjusting for age, sex, site, region, time, assignment to interventions within other domains, and domain and intervention eligibility. Superiority was defined as the posterior probability of an odds ratio greater than 1 (threshold for trial conclusion of superiority >99%). Results: After excluding 19 participants who withdrew consent, there were 384 patients (mean age, 60 years; 29% female) randomized to the fixed-dose (n = 137), shock-dependent (n = 146), and no (n = 101) hydrocortisone groups; 379 (99%) completed the study and were included in the analysis. The mean age for the 3 groups ranged between 59.5 and 60.4 years; most patients were male (range, 70.6%-71.5%); mean body mass index ranged between 29.7 and 30.9; and patients receiving mechanical ventilation ranged between 50.0% and 63.5%. For the fixed-dose, shock-dependent, and no hydrocortisone groups, respectively, the median organ support-free days were 0 (IQR, -1 to 15), 0 (IQR, -1 to 13), and 0 (-1 to 11) days (composed of 30%, 26%, and 33% mortality rates and 11.5, 9.5, and 6 median organ support-free days among survivors). The median adjusted odds ratio and bayesian probability of superiority were 1.43 (95% credible interval, 0.91-2.27) and 93% for fixed-dose hydrocortisone, respectively, and were 1.22 (95% credible interval, 0.76-1.94) and 80% for shock-dependent hydrocortisone compared with no hydrocortisone. Serious adverse events were reported in 4 (3%), 5 (3%), and 1 (1%) patients in the fixed-dose, shock-dependent, and no hydrocortisone groups, respectively. Conclusions and Relevance: Among patients with severe COVID-19, treatment with a 7-day fixed-dose course of hydrocortisone or shock-dependent dosing of hydrocortisone, compared with no hydrocortisone, resulted in 93% and 80% probabilities of superiority with regard to the odds of improvement in organ support-free days within 21 days. However, the trial was stopped early and no treatment strategy met prespecified criteria for statistical superiority, precluding definitive conclusions. Trial Registration: ClinicalTrials.gov Identifier: NCT02735707
Impact of opioid-free analgesia on pain severity and patient satisfaction after discharge from surgery: multispecialty, prospective cohort study in 25 countries
- Author
- Aamir Faiqa Binte
- Aamir Syed Roohan
- Ababneh Adnan
- Abbal Muhammad Anas
- Abbas Ahmed M
- Abbas Mostafa
- Abd-Albain Montasir A
- Abdalei Abdulwahab
- Abdalla Ahmed
- Abdalla Ahmed Yassir
- Abdalla Mohamed Galal Ali
- Abdalla Zainab
- Abdallah Mohamed M
- Abdalmahmoud Noon Ezzeldien
- Abdalsadeg Rowa
- Abdelaal Ahmed M
- Abdelbagi Alnazeer Y
- Abdelbaky Mostafa
- Abdelbaset Doaa
- AbdElbaset Esraa
- Abdelbast Menhag
- Abdelfatah Mohammed Abdelnasser
- Abdelgawad Samia
- Abdelhamid Mohamed M
- Abdeljaber Mahmoud
- Abdelkhalig Mubarak
- Abdelmaksoud Mohamed
- Abdelmeguid Rana
- Abdelmelek Dhia Errahmane
- Abdelnaeam Samah
- Abdelnasser Mohammad K
- Abdelrahim Najwa
- Abdelrahman Amira
- Abdelrahman Ayman
- Abdelsalam Hebatalla
- Abdelsamed Enas Abdelbaset
- Abdelwahab Khaled
- Abdoun Meriem
- Abdulali Fatima
- Abdulaziz Mohamed
- Abdulla Dheba Almukhtar
- Abdullah Bahiyah
- Abdullah Bahiyah
- Abdullah Walaa
- Abdullahi Habiba Ibrahim
- Abdulrahman Ahmed
- Abdulrasheed Lubabatu
- Abdulwahed Eman
- Abdulwahed Eman
- Abeysirigunawardana Dewmi
- Abidin Muhammad Fihmi Zainal
- Abiola Olukayode
- Abiyere Henry
- Abodina Ahmed Mohammed
- Aboelela Reham
- AboElfarh Hadeer Elsaeed
- Aboudlal Husein
- AbouHiekal Osama
- Aboulfotouh Ahmed
- Abozid Anwaar
- Abubaker Noora
- Abubaker Noora
- Abufanas Asma
- Abughanima Mahmoud
- Abuhashem Shehab
- Abulafia Daniel
- Abushaala Fatima
- Abushanab Khaled
- AbuShawareb Issa
- Abuuqteish Hamza
- Abuzaho Amany
- Achem Arome
- Adam Eithar
- Adam Mohammed
- Adam Mohammed A
- Addalla Mohamed
- Addley Jordan
- Adeleye Gbadebo
- Adeniyi Adebayo
- Adewole Nathaniel
- Adeyemo Olabisi
- Adeyeye Ademola
- Adeyeye Ademola
- Adly Michael
- Adnan Siti Nasyirah Nisya
- Ads Adel Mohamed
- Ads Alaa Mohamed
- Adze Joel Amwe
- Afeikhena Ehis
- Agida Teddy
- Agilla Hamza
- Agnew Emilie
- Agu Joy Onyekachi
- Ahmad Zatul Akmar
- Ahmed Abdalla
- Ahmed Ahmed
- Ahmed Ahmed
- Ahmed Alaaaldeen
- Ahmed Entisar
- Ahmed Habeeba
- Ahmed Hatem
- Ahmed Reem
- Ahmed Rehab
- Ahmed Rihab
- Ahmed Rogia Ahmed Abdalla
- Ahmed Ruaa
- Ahmed Sharwany
- Ahmed Uzair
- Ahmed Wahiba
- Ahmeed Sultan
- Airede Lydia Regina
- Aitchison Lori
- Ajredini Mirac
- Ajulo Adeshina A
- Akaba Godwin
- Akasha Mazin
- Akbar Maha Ghulam
- Akbuz Seyma Orcan
- Akdere Hakan
- Akın Bilge
- Akkaya Ege Nur
- Akpamgbo Chukwunonso Nnamdi
- Akwaisah Ayoub
- Al Hammoud Amr
- Al Rawashdeh Toka
- Al-Baw Mahmoud
- Al-Dahdouh Mosheer
- Al-Haek Safa’
- Al-Hazaimeh Mo'ath
- Al-issawi Dima
- Al-Issawi Subhi
- Al-jammal Maryam
- Al-Juaifari Maytham A
- Al-Mwajeh Tesneem
- Al-Omary Sohaib
- Al-Quossi Mohammed
- Al-Shambaty Yasir Babkir Ali
- Al-Shami Qotadah
- Al-Smirat Heba
- Al-Tahayneh Sief-Addeen
- Al-Touny Aiman
- Al-Touny Shimaa
- Al-zawaydeh Alia
- Alaa Ali
- Alabed Ebtihal
- Alagelli Fatma
- Alagoz Ahmet Can
- Alameen Hind
- Alameen Maram
- Alamlih Laith
- Alaqoubi Retaj
- Alarabi Rehab
- Alariby Fatima
- Alatefi Dawood
- Alathameen Nassar
- Albakosh Bashir Abobaker
- Albanopoulos Konstantinos
- Albarhomy Osama
- Albarki Aisha
- Albashaireh Alaa
- Albatni Safa Sasi
- Albayadi Eslam
- Alboon Mosab
- Alboridy Muneera
- Alboueishi Asraa Ali
- Aldeges Marwan
- Aldreawi Mohammed
- Alflite Asil Omar Saleh
- Alfrijat Tamam
- Alfrjani Tariq
- Algabbasi Salima
- Algatanesh Nassib
- Alhadad Qamrah
- Alhaddad Hoda Salem
- Alhaleem Ayah
- Alhaleeq Saif
- Alharam Abtisam
- Alhashimi Abdulhadi Mohammed Alhadi
- Alhassan Monzer
- Alhudhairy Sara
- Ali Ahmed
- Ali Aml
- Ali Doua
- Ali Eithar M
- Ali Iqra Fatima Munawar
- Ali Maab
- Ali Manal
- Ali Muhammad
- Ali Radwa
- Ali Rawan Alsheikh
- Ali Rzan Ali Hamedelneel
- Ali Shehroz
- Aliosin Oleg
- Aljamal Mohammad
- Aljamal Sarah
- Alkaraja Layth
- Alkaseek Akram
- Alkazali Mustafa
- Alkchr Hayat Ben Hasan Mohamed A A
- Alkhatib Abed Alazeez
- Allam Shereen
- Almahroush Marin
- Almakki Doha Mohammed Ahmed
- Alnajjar Lara
- Alnajjar Majjd
- Alnatsheh Wesam
- Alnour Ammar
- Alomar Rabiaa
- Alomari Yazan
- Alqaarh Aya
- Alragig Zahra
- Alrifae Ghaliya Mohamed H
- Alrosan Risan
- Alsagoff Sharifah Nor Amirah Syed Abdul Latiff
- Alsaid Hamza
- Alsaify Esmat
- Alsaih Sawsan
- Alsari Najah
- Alshareea Entisar
- Alshawadfy Abdelrhman
- Alshawesh Aisha
- Alsheik Ahmad
- Alsori Mohamed
- Alsoudani Ali
- Altabbaa Hashem
- Altahir Mohamed
- Altair Mawadda
- Altaweel Ahmad
- Altughar Bushra
- Alvarez Matias
- Alvarez-Lozada Luis Adrian
- Alvarez-Lozada Luis Adrian
- Alwahaib Anas
- Alwash Mohammed
- Alzarga Ali
- Alzarouq Ebtisam
- Alzarroug Amal
- Alzghoul Bader
- Alzyoud Osama
- Amarasekara Mishka
- Amary Marwa
- Ametov Amet
- Amin Mostafa K
- Aminu Bashiru
- Aminu Muhammad Baffah
- Ammar Ahmed Siddique
- Amro Dana
- Ananthapadmanabhan Shravankrishna
- Anderson Paul
- Andrew Paul Chimezie
- Andriani Adelaide
- Anestiadou Elissavet
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- Angeslis Fragkiskos
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- Atadag Yildiz Buyukdereli
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- Ather M Hammad
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- Atia Ahmed
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- Husein Abrar
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- Hussein Aisha
- Hussien Ahmed
- Hussien Aya
- Hussien Tarek A
- Ibiyemi Femi
- Ibraheem Gbadebo Hakeem
- Ibrahim Abdullahi
- Ibrahim Islam
- Ibrahim Reham
- Ibtisam Muhammad
- Ifoto Oghenekaro
- Iftikhar Hareem
- Imran Aliza
- Incoll Ian
- Innes Michael
- Ioannidis Orestis
- Ioannidis Orestis
- Ioannidis Orestis
- Isaac Hope
- Isah AliyuYabagi
- Isah Dennis Anthony
- Isahak Mohamed Izzad
- Isais Jorge Arath Rosales
- Ismail Samir
- Ismail Tiamiyu
- Isopi Claudio
- Isweesi Mohamed
- Iya Abdulkarim
- Izgis Aylin
- Jaarsma Emily
- Jabur Aiden
- Jabur Aiden
- Jabur Aiden
- Jaffry Kumail
- Jaffry Kumail
- Jakanovski Philip
- Jamal Sami
- Jamali Salma
- Jamieson Jodie
- Jamil Muhammad Badrul Hisyam Mohamad
- Jangam Aishwarya
- Jangra Muskan
- Javed Imran
- Jawa Timothy
- Jayatilleke Shenuka
- Jayyab Mustafa Abu
- Jeffery Fraser
- Jenkins Gregory
- Jeyamohan Ragavi
- Jeyarajan Deepak Rajan
- Jiang Vincent
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- Jin Rong
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- Kaabache Oumelaz
- Kache Stephen Akau
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- Kaiser Nicole
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- Kalogiannidis Ioannis
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- Kamath Aditi
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- Keramida Myrto D
- Keskin Abdil Yetkin
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- Qian Gemma
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- Rae Hamish
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- Rajesh Krishnankutty
- Raji Hadijat Olaide
- Ramadan Mohamed
- Ramadan Mohamed F
- Ramlee Afiq Aizat
- Ramphal Shanay
- Rashed Osama Fathy Ali Ali
- Rasheed Ayat
- Raslan Bassma
- Rasslan Esraa
- Rathnayake Athulya
- Ratnayake Milidu
- Ratnayake Milidu
- Raubenheimer Kyle
- Raubenheimer Kyle
- Raubenheimer Kyle
- Rauf Abdul
- Ravi Anjana
- Rawal Alisha
- Raza Muhammad
- Razmi Akeedh
- Reed Catherine
- Rehfisch Peter
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- Reinke Caroline
- Reis Murat Emre
- Ren Seifei
- Restini Enrico
- Reyes Bernardo Alfonso Fernández
- Rhuma Heba
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- Roshdy Mo'men
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- Rusli Siti Mayuha
- Russo Iris Shari
- Saad Mahmoud M
- Saada Hind
- Saber Mona
- Sabry Ahmed Abdelfatah
- Sabuncu Kubilay
- Sadauskas Tomas
- Sadek Mirna
- Saeed Abdallah
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- Safar Amna
- Saha Sushanth
- Sahin Berfin İlgaz
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- Sakr Ahmed
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- Salameh Alaa Eddin
- Salawu Adedayo
- Salawu Hafeez
- Saleh Ahmad
- Saleh Sara Ahmed
- Salem Ebrahim
- Salem Mohammed
- Saliaris Konstantinos
- Salih Alaa A
- Salihu Makama Baje
- Sallam Abdelaziz
- Samalavicius Narimantas
- Sami Wesam
- Sammour Tarik
- Sampatha-Waduge Tharushi
- Sanad Aly
- Sandhu Jaspreet Kaur
- Sanguesa Maria Jose
- Sani Samuel Ali
- Sanli Ahmet Necati
- Sanz-Romera Jorge
- Sara Rachel
- Saraçoğlu Ayten
- Sarafi Aikaterini
- Sarangadasa Pavatharane
- Sarhan Osama
- Sarı Ahmet Can
- Sarih Monira
- Sarwar Albash
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- Sawaftah Khaled
- Sayed Ahmed M
- Sayed Mohamed Al
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- Saylar Alparslan
- Saylar Alparslan
- Sánchez Luis Antonio Heredia
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- Segaran Sharrada
- Seldon Alexandra
- Selim Kamar
- Selim Osama
- Seneviratne Dharani
- Sengupta Shomik
- Senthilrajan Rahavi
- Seow Warren
- Shaaban Abdelrahman
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- Tariq
- Tarmidi Jazmina
- Tasi Zoya
- Taşcı Muhammed Enes
- Taufiq Maliha
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- Tsakiridis Ioannis
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- Tsourouflis Gerasimos
- Tsui Sonia Ching Ting
- Tu Hien
- Tun Than
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- Tuzuner Filiz
- Tynan Dominic
- Ugool Mahmoud
- Uğurlu Mustafa Ümit
- Ukrani Ronika Devi
- Ukwuoma Ohia Ernest
- Ulkucu Attila
- Uludag Server Sezgin
- Ulusahin Mehmet
- umar Abubakar
- Umar Gabi Ibrahim
- Uprak Tevfik Kıvılcım
- Ureña Violeta
- Usman Liman Haruna
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- Uzair Ahmad
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- Vadioaloo Dinesh Kumar
- Valaroutsou Olga Maria
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- Vance Lucille
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- Vanguardia Maria Kristina
- Vanzuylekom Katie
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- Velenciuc Natalia
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- Vidanagama Sasini
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- Vu Jennifer
- Vu Jennifer
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- Walsh Eamon
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- Wang Nicole Qiwen
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- Wang Qiwen
- Wang Shelley
- Wang Yantong
- Wang Zixuan
- Waqar Usama
- Waraich Abdullah
- Ward Jack
- Wardeh Salah Abu
- Wasim Tayyiba
- Watson David
- Watson David
- Wedatalla Mansour
- Weeda Lewis
- Wells Cameron
- Wells Cameron
- Wells Cameron
- Wells Oliver
- Werenski Hope
- Wijayaratne Rivindu
- Wijetunga Asanka
- Williams Brittany
- Williams Peter
- Wilson Thomas
- Windsor John
- Windsor John
- Winthrop Lily
- Withanage Indrajith
- Wong James
- Wong Jason
- Wong Kenneth
- Wong King Ho
- Wong Patrick
- Wong Samantha
- Woodbridge Christian
- Wright Deborah
- Wright Deborah
- Wright Deborah
- Wu Alan
- Wu Alan
- Wu Chun-Yen
- Wu Hongyi
- Wycliff Daniel
- Xiao Haotian
- Xie Maria
- Xu Cindy
- Xu William
- Xu William
- Xu William
- Yaghmour Jamal
- Yahya Bilal Shuaibu
- Yahya Rawad
- Yang Wah
- Yao Michelle
- Yao Sunny
- Yao Sunny
- Yasar Meltem
- Yasir Ruaa
- Yassin Mohamed
- Yavuz Dogancan
- Yavuz Ikranur
- Yaytokgil Muhammet
- Yazgan Yasemin
- Yee Su-Ann
- Yeung Justin
- Yeung Kar Long
- Yew Anthea
- Yi Kevin
- Yiannakopoulos Christos
- Yildirim Yasemin
- Yildiz Ahmet
- Yıldız Berkay
- Yilmaz Hakan
- Yin Chonghao
- Ying Geoffrey
- Yodkitydomying Chatnapa
- Yong Nathania
- Yoon Si Woo
- You Ha Seong
- Young Simon
- Young Stevie
- Younus Khadijah
- Yousif Fatima Imad
- Yousri Mohamed
- Youssef Ahmed A
- Youssef Arkan
- Yu Hoi Hang
- Yu Victor
- Yuan Grace
- Yue Bosco
- Yue Tiffany
- Yunos Mohamed Haseef Mohamed
- Yusuf Stephen
- Yuzgec Ayse Nilufer
- Zachomitros Fotios
- Zaed Moahmed
- Zafar Fatima
- Zaghloul Ahmed
- Zaheer Adil
- Zaidi Faseeh
- Zain Ahmad
- Zakaria Ahmed
- Zakaria Andee Dzulkarnaen
- Zakaria Mohd Zaim
- Zalloum Jihad
- Zamanbandhon Bushra
- Zambon Mattia
- Zapsalis Konstantinos
- Zargar Kamran
- Zarzour Mohamed A
- Zeng Raymond
- Zeng Raymond
- Zengin Kagan
- Zertuche Juventino Tadeo Guerrero
- Zhang Caitlin
- Zhang Edward
- Zhang Shane
- Zhang Yichi
- Zhao Hailin
- Zheng Helen
- Zhou Karen
- Zhou Yida
- Ziergiebel Felix
- Zou Peishan
- Zuylekom Kate Van
- Zuylekom Katie Van
- Zwain Yasir Adnan
- Zyul'korneeva Sof'ya
- Aladna Abdallah
- Aljoumaa Abdullah
- Nawfal Hamdi
- Niazi Ammar
- Publication venue
- Publication date
- 01/01/2024
- Field of study
Background: Balancing opioid stewardship and the need for adequate analgesia following discharge after surgery is challenging. This study aimed to compare the outcomes for patients discharged with opioid versus opioid-free analgesia after common surgical procedures.Methods: This international, multicentre, prospective cohort study collected data from patients undergoing common acute and elective general surgical, urological, gynaecological, and orthopaedic procedures. The primary outcomes were patient-reported time in severe pain measured on a numerical analogue scale from 0 to 100% and patient-reported satisfaction with pain relief during the first week following discharge. Data were collected by in-hospital chart review and patient telephone interview 1 week after discharge.Results: The study recruited 4273 patients from 144 centres in 25 countries; 1311 patients (30.7%) were prescribed opioid analgesia at discharge. Patients reported being in severe pain for 10 (i.q.r. 1-30)% of the first week after discharge and rated satisfaction with analgesia as 90 (i.q.r. 80-100) of 100. After adjustment for confounders, opioid analgesia on discharge was independently associated with increased pain severity (risk ratio 1.52, 95% c.i. 1.31 to 1.76; P < 0.001) and re-presentation to healthcare providers owing to side-effects of medication (OR 2.38, 95% c.i. 1.36 to 4.17; P = 0.004), but not with satisfaction with analgesia (beta coefficient 0.92, 95% c.i. -1.52 to 3.36; P = 0.468) compared with opioid-free analgesia. Although opioid prescribing varied greatly between high-income and low- and middle-income countries, patient-reported outcomes did not.Conclusion: Opioid analgesia prescription on surgical discharge is associated with a higher risk of re-presentation owing to side-effects of medication and increased patient-reported pain, but not with changes in patient-reported satisfaction. Opioid-free discharge analgesia should be adopted routinely
Perturbative spacetimes from Yang-Mills theory
- Author
- A Anastasiou
- A Anastasiou
- A Anastasiou
- A Bhadra
- A Luna
- A Luna
- AI Janis
- AK Ridgway
- Alexander Ochirov
- Andrés Luna
- B Feng
- C-H Fu
- C-H Fu
- C-H Fu
- CD White
- Chris D. White
- CR Mafra
- CR Mafra
- CR Mafra
- CR Mafra
- CR Mafra
- D Neill
- Donal O’Connell
- E Poisson
- F Cachazo
- F Cachazo
- G Mogull
- GL Cardoso
- H Johansson
- H Johansson
- H Johansson
- H Kawai
- HA Buchdahl
- Isobel Nicholson
- J Nohle
- JJ Carrasco
- JJM Carrasco
- JJM Carrasco
- KA Bronnikov
- L Borsten
- M Chiodaroli
- M Chiodaroli
- M Tolotti
- M Wyman
- MB Green
- MJ Duff
- NEJ Bjerrum-Bohr
- NEJ Bjerrum-Bohr
- NEJ Bjerrum-Bohr
- NEJ Bjerrum-Bohr
- NEJ Bjerrum-Bohr
- NEJ Bjerrum-Bohr
- NEJ Bjerrum-Bohr
- NEJ Bjerrum-Bohr
- Niclas Westerberg
- R Monteiro
- R Monteiro
- R Monteiro
- R Saotome
- RA Porto
- RH Boels
- Ricardo Monteiro
- RW Brown
- RW Brown
- S He
- S Lee
- S Litsey
- S Nagy
- S Oxburgh
- SG Naculich
- SG Naculich
- SG Naculich
- Z Bern
- Z Bern
- Z Bern
- Z Bern
- Z Bern
- Z Bern
- Z Bern
- Z Bern
- Z Bern
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- Field of study
Fludarabine, cytarabine, granulocyte colony-stimulating factor, and idarubicin with gemtuzumab ozogamicin improves event-free survival in younger patients with newly diagnosed aml and overall survival in patients with npm1 and flt3 mutations
- Author
- Ackroyd Sam
- Addada Juanah (Jo)
- Ademokun Debo
- Ahmed Alhassani Thubeena M.
- Ahmed Khalil
- Aitchison Robin
- Al-Ani Maryam
- Aldouri Maadh
- Alfred Arun
- Allford Sarah
- Alvares Caroline
- Andrews Vivienne
- Anjum Farahn
- Ardeshna Kirit
- Arnold Claire
- Arnold Claire
- Austen Belinda
- Bake Bart
- Barker Helen
- Basu Supratik
- Batten Leona M.
- Beier Ommen Hans
- Berkhan Leanne
- Betteridge Sophie
- Blombery Piers
- Bokhari Syed
- Bond Lee
- Borg Anton
- Borregaard Niels
- Bowen Angela
- Bowen David
- Bowett Peter
- Brearton Gillian
- Burgess Jordan
- Burns Sarah
- Butler Andrew
- Byrne Jenny
- Cahalin Paul
- Canham Joanna
- Carr Robert
- Cavenagh Jamie
- Chacko Joseph
- Chalmers Isobel
- Chandra Deepak
- Chapman Oliver
- Chapple Mary
- Chatterjee Poulami
- Chodhouri Senthil S.
- Chvuka Shingi
- Copplestone Adrian
- Corbett Gillian
- Corbett Timothy
- Corser Robert
- Craddock Charles
- Craig Jenny
- Craig Joanne
- Cranfield Tanya
- Crawley Charles
- Creach Desmond
- Crowe Josephine
- Culligan Dominic
- Cullis Jonathan
- Cuthbert Robert
- Cutting Robert
- Cutting Robert
- Dalley Chris
- Dang Ray
- Dasgupta Emma
- Dasgupta Ranjit
- David Marianna
- Davidson Kerri
- Davies Simon
- Dennis Mike
- Devanny Ian
- DeVos Johannes
- Dignum Helen
- Dillon Richard
- Doocey Richard
- Dungarwalla Moez
- Dyer Peter
- Eagleton Helen
- Eden Ayed
- Edwards David
- Edwards Hugh
- Ellis Lauren
- Emmett Shannon
- Eve Heather
- Evely Roger
- Everington Tamara
- Fail Tom
- Farrell Katrina
- Fenella Willis Neoh
- Ferguson Paul
- Fernandes Savio
- Fernyhough Liam
- Finnegan Damian
- Fletcher Andrew
- Fletcher Andrew
- Forsyth Peter
- Francis McMullin Mary
- Freeman Sylvie D.
- Friis Lone
- Ganczakowski Mary
- Gandhi Anna Cowley S.
- Ganly Peter
- Gelly Keith
- Gharib Maged
- Gibbons Steve
- Gibbs Simon
- Gilkes Amanda
- Gilles Julie
- Gomez Cesar
- Goodman Hugh
- Goodrick Margaret
- Grand Effie
- Grey-Davies Elisabeth
- Groch Henri
- Hada Sunil
- Hall Rachel
- Hamilton Malcolm
- Hanlon Katharine
- Harrison Beth
- Hasan Yasmin
- Haskins Lea
- Hatcliffe Faye
- Hawkins Timothy
- Heartin Earnest
- Hemmaway Claire
- Hemmaway Claire
- Hendry Louise
- Hervey Victoria
- Hinson Emily L.
- Hodson Andrew
- Holm Mette
- Horne Gillian
- Horne Gillian
- Houghton John
- Hoyle Christine
- Hunter Ann
- Hunter Hannah
- Islam Shahid
- Ismail Saad
- Jack Fergus
- Jackson Nicholas
- Jacob Abraham
- Janes Sarah
- Janmohamed Riaz
- Jenner Matthew
- Jobanputra Shailesh
- Johnson Peter
- Jones Christopher
- Joseph Joe
- Jowitt Simon
- Juul Nielsen Ove
- Kaczmarski Richard
- Kakalamudi Sudhakar
- Kallenbach Maria
- Kampmann Peter
- Kaul Stuti
- Kaur Harpreet
- Keat Sally
- Kell Jonathan
- Kelsey P.
- Kerr Paul
- Kerr Ron
- Khwaja Asim
- Kjeldsen Lars
- Knapper Steve
- Knapper Steven
- Knechtli Christopher
- Kottaridis Panagiotis
- Krishnamurthy Pramila
- Krishnamurthy Suchitra
- Krogh Jensen Morten
- Kwan Mark
- Laing Alison
- Laird Jane
- Lawes Matthew
- Linch David
- Lindsay Kathrine
- Lindsay-Holmes Srividhya Sarah
- Longmuir Karyn
- Lovell Richard
- Lush Chris
- Lush Richard
- Lykke Petersen Soeren
- Lyons Simon
- Maclean Peter
- MacWhonell Alan
- Maddams Rebecca
- Maddox Jamie
- Mamat Mohd
- Mangos Hilda
- Mannari Deepak
- Marcher Claus
- Marks David
- Marshall Scott
- Martin Murray
- Maughan Elizabeth
- Maxwell Norgaard Jan
- McCaig Alison
- McCloskey Kayleigh
- McIntyre Victoria
- McLintock Lorna
- Medd Patrick
- Mehta Priyanka
- Mehta Priyanka
- Meiklejohn David
- Micallef-Eynaud Paul
- Milligan Donald
- Mills Juliet
- Milne Alison
- Mitchell Lindsey
- Mohite Unmesh
- Moreton Paul
- Moss Paula
- Mucklow Stuart
- Munro Laura
- Murphy John
- Murray Jim
- Murrin Richard
- Narat Santosh
- Narayanan Mekkali
- Neilson Jeff
- Neylon Annette
- Ngu Loretta
- Nicholson Emma
- Nicholson Toby
- Nicolle Annette
- Niemann Carsten
- Nokes Tim
- O'Hea Anne-Marie
- Omran Asad
- Orchard Kim
- Othman Jad
- Oun Hajer
- Overgaard Ulrik Malthe
- Paneesha Shankara
- Patel Amit
- Paterson Pamela
- Patil Kavita
- Pattinson Jonathan
- Pattinson Jonathan
- Patton Nigel
- Pechey Victoria
- Pemberton Lucy
- Peniket Andy
- Peters Jayne
- Plews Diane
- Popat Rakesh
- Potter Mike
- Potter Nicola
- Pottinger Bryson
- Powell Matthew
- Pullon Humphrey
- Raafat Alaeddin
- Raj Kavita
- Reilly John
- Richardson Deborah
- Roberts Patrick
- Roddie P.H.
- Rogers Stephen
- Rose Peter
- Roy Ashok
- Rudin Claudius
- Ruell Jackie
- Rule Simon
- Russell Nigel
- Russell Nigel H.
- Rye Adam
- Rye Adam
- Rymes Nicholas
- Sadik Walid
- Sadullah Shala
- Salesh Sana
- Sampson Rebecca
- Saravanamuttu Kandeepan
- Sati Hamdi
- Severinsen Marianne
- Shafeek Salim
- Sidra Gamal
- Simpson Sylwia
- Smith Jeffery
- Smith Mark
- Smith Steve
- Snowden John
- Somerfield Sven
- Somervaille Tim
- Sorour Youssef
- Spearing Ruth
- Stanchev Atanas
- Stokley Simone
- Sud Amit
- Sugai Taku
- Tauro Sudhir
- Tholouli Eleni
- Thomas Wayne
- Thomas-Dewing Rowena
- Tighe Jane
- Tomlins Jo
- Tuegar Salah
- Udby Peter Møller Lene
- Vavyla Maria
- Virchis Andres
- Walewska Renata
- Wandoo Farooq
- Wei Bjerrum Ole
- Welch Emma
- Went Richard
- Wexler Sarah
- White Denise
- Wilhelm-Benartzi Charlotte
- Wiliams Adrian
- Williams Mark
- Williamson Peter
- Wilson-Morkeh Isaac
- Wodzinski Mark
- Wright David
- Xu Chin Kate
- Yong Kwee
- Zaman Sonya
- Zhao New Oo Rui
- Publication venue
- American Society of Clinical Oncology
- Publication date
- 30/04/2024
- Field of study
Purpose
To determine the optimal induction chemotherapy regimen for younger adults with newly diagnosed AML without known adverse risk cytogenetics.
Patients and Methods
One thousand thirty-three patients were randomly assigned to intensified (fludarabine, cytarabine, granulocyte colony-stimulating factor, and idarubicin [FLAG-Ida]) or standard (daunorubicin and Ara-C [DA]) induction chemotherapy, with one or two doses of gemtuzumab ozogamicin (GO). The primary end point was overall survival (OS).
Results
There was no difference in remission rate after two courses between FLAG-Ida + GO and DA + GO (complete remission [CR] + CR with incomplete hematologic recovery 93% v 91%) or in day 60 mortality (4.3% v 4.6%). There was no difference in OS (66% v 63%; P = .41); however, the risk of relapse was lower with FLAG-Ida + GO (24% v 41%; P < .001) and 3-year event-free survival was higher (57% v 45%; P < .001). In patients with an NPM1 mutation (30%), 3-year OS was significantly higher with FLAG-Ida + GO (82% v 64%; P = .005). NPM1 measurable residual disease (MRD) clearance was also greater, with 88% versus 77% becoming MRD-negative in peripheral blood after cycle 2 (P = .02). Three-year OS was also higher in patients with a FLT3 mutation (64% v 54%; P = .047). Fewer transplants were performed in patients receiving FLAG-Ida + GO (238 v 278; P = .02). There was no difference in outcome according to the number of GO doses, although NPM1 MRD clearance was higher with two doses in the DA arm. Patients with core binding factor AML treated with DA and one dose of GO had a 3-year OS of 96% with no survival benefit from FLAG-Ida + GO.
Conclusion
Overall, FLAG-Ida + GO significantly reduced relapse without improving OS. However, exploratory analyses show that patients with NPM1 and FLT3 mutations had substantial improvements in OS. By contrast, in patients with core binding factor AML, outcomes were excellent with DA + GO with no FLAG-Ida benefit
Effect of remote ischaemic conditioning on clinical outcomes in patients with acute myocardial infarction (CONDI-2/ERIC-PPCI): a single-blind randomised controlled trial.
- Author
- Aarøe Jens
- Abbass Hakam
- Abella-Ovalle Luis
- Adam Zul
- Agyemang Michael
- Ahlehof Ole
- Ahlehoff Ole
- Ahmad Yousif
- Al-Lamee Rasha
- Alberdi Lucía
- Aleti Shilpa
- Ali Danish
- Allen Kezia
- Alvares Wilson
- Alzuhairi Karam
- Amed Nadifa
- Anantharam Brijesh
- Andersen Grethe
- Andersen Henning Rud
- Anderson Michelle
- Andiapen Mervyn
- Andrews Michelle
- Ankersen Jens Peter
- Ansell Valerie
- Arango Amalia
- Armstrong Elissa
- Astarci Josenir
- Atkinson Emma
- Austin Rosalynn
- Avanzas Pablo
- Aziz Ahmed
- Azkhalil Mohammed
- Bales Emily
- Banerjee Prithwish
- Barclay Justin
- Barker Deborah
- Barker Joann
- Barmby David
- Bates Rachel
- Baucutt Karen
- Been Martin
- Beirnes Charmaine
- Bell Sheila
- Bennett Amy
- Bennett Lorraine
- Bernardo-Alba Pablo
- Berry Alan
- Berry Colin
- Besana Rissa
- Bhatre Gurbir
- Bhatti Rishma
- Bidle Amanda
- Bijsterveld Petra
- Bose Tuhina
- Boyle Georgina
- Brady Rebecca
- Braybrook Christine
- Breeze Jonathan
- Brennan Oliver
- Brett Sarah
- Brogan Richard
- Brown Janette
- Bucciarelli-Ducci Chiara
- Buchanan Louise
- Buelga-Díaz Covadonga
- Bueno Hector
- Bulluck Heerajnarain
- Burd Amanda
- Burnett Gillian
- Burtonwood Natalie
- Burunsuzoglu Senem
- Butler Robert
- Butler Robert
- Byrne Jean
- Bøtker Hans Erik
- Capel Robert
- Cappelen Helle
- Carruthers Gayle
- Carstensen Steen
- Castro Rafael
- Champney Felicity
- Chant Nicholas
- Charles Thabitha
- Chester Emma
- Chong Jun
- Christensen Erika Frischknecht
- Christiansen Evald Høj
- Christiansen Martin Kirk
- Christmas Natasha
- Chu Rebecca
- Chung Alan
- Cimas Teodorna
- Clapp Brian
- Clare Thomas
- Clarke Millie
- Clayton Tim
- Clifford Piers
- Cockayne Laura
- Colicchia Martina
- Collier Lucy
- Cooper Theresa
- Copas Andrew
- Copestick Jane
- Corps Ellie
- Corrigan Julie
- Cottam Victoria
- Cotton James
- Coward Paul
- Cox Emily
- Crause Jacolene
- Cruden Nick
- Cunliffe Denise
- Cunnington Michael
- Cuxton Josephine
- Dana Ali
- Dana Ali
- Darby Damaris
- Davies John
- Davies Justin
- Davies Nina
- de Cima Sara
- de la Hera Galarza Jesus Maria
- de la Roz Manuel
- De Mance Gianluigi
- De Sousa Phillipa
- Deen Zakhira
- del Valle Raquel
- Delaney Jane
- Denman Joanne
- Dias Priyanthi
- Dillon Angela
- Dimond Kirsty
- Din J.
- Dockerty Francesca
- Dodd Matthew
- Douglas James
- Douthwaite Rebecca
- Drew Martin
- Díaz-González Eloy
- East Clare
- Eaton Michelle
- Ellert Julia
- Elliott Rebecca
- Ellis Howard
- Elshiekh Dr Mohamed
- Elston Ruth
- Emery Lisa
- Engstrom Thomas
- Erntgaard Dennis
- Evans Richard
- Fahrai Gregor
- Farag Mohamed
- Fath-Orboubadi DR Fazin
- Fati Pene
- Fayed Hossam
- Fente Ana I.
- Fernandez Olga
- Fernández Elena
- Fernández-Carral Marcos Fernández-Carral
- Fernández-Gonzalo David
- Fernández-Mallo Francisco J.
- Finch Amanda
- Fleming Catherine
- Fofie Joyce
- Foundun Aboo
- Francis Rohin
- Francis Rohin
- Frank Emma
- Freeman Philip
- Freestone Beth
- Fuentes María D.
- Gale Joanne
- Gale Joanne
- Gallagher Ian
- Galván-Núñez Pablo
- Gamma Reto
- Garcia-Ruiz José Manuel
- García-Alonso María
- García-Castro Alfonso
- Gaughran Lisa
- Germon Rachel
- Gibson Kirsty
- Giebner Matthias
- Gill Abby
- Gill Simrat
- Giuffrida Gaia
- Given Rachel
- Glen James
- Goitia-Martín Javier
- Gomes Sara
- Gorog Diana
- Gorog Diana A
- Gowing Anne
- Gracey Jay
- Grech Ever
- Greenwood John
- Greenwood John P
- Gregory Sally
- Gregson Lisa
- Griffiths Huw
- Grosser Konrad
- Gue Ying
- Guinea Rocío
- Gunn Julian
- Guyatt Samantha
- Hall Charlotte
- Hall Ian
- Hall Lorna
- Hamid Mahmood
- Hansen Henrik Steen
- Hansen Knud Nørregård
- Hansen Poul Anders
- Hansen Troels Martin Hansen
- Harfield Scott
- Harkins Ruth
- Harland Charlotte
- Hartley Amy
- Hausenloy Derek J
- Haworth Peter
- Hayes Michelle
- Hedegaard Kim Witting
- Hedrera Segundo A.
- Helqvist Steffen
- Henderson Rob
- Hendry Cara
- Heppell Richard
- Hermosa Francisco J.
- Hernández Ernesto
- Hetherington Daniel
- Hetherington Simon
- Hildick-Smith David
- Hindle Julia
- Hjort Jakob
- Hoare Amy
- Hobson Alex
- Hodgson Adrian
- Hodierne Jeremy
- Hogrefe Kai
- Holloway Rachael
- Holmvang Lene
- Hoole Stephen
- Hopper Oliver
- Horler Stephanie
- Horner Victoria
- Horwood Carol
- Houghton Richard F
- Housley Kay
- Howe Serena
- Hudson Karen
- Hussein Jodie
- Hyndman Samantha
- Ibanez Borja
- Iglesias-Llaca Fernando
- Ilsley Mary
- Ingoldby Fiona
- Iqbal , Javid
- Iversen Allan
- Jack Pearse
- Jackson-Lawrence Karen
- Jakobsen Lars
- Jamal Zahra
- Jamieson-Leadbitter Caroline
- Jennison Alan
- Jensen Lisette Okkels
- Jensen Svend Eggert
- Johnstone Donna
- Jones Leslie
- Jones Sophie
- Joshi Francis
- Joyce Joan
- Junker Anders
- Jørgensen Erik
- Kaeng Lee
- Kaltoft Anne
- Kanji Rahim
- Kaur Ramandeep
- Kaur-Babooa Priya
- Kaus Henning
- Keate Kirstie
- Kelbæk Henning
- Kelly Julie
- Kelsall Nicci
- Kempel John
- Kennard Sarah
- Khan Arif
- Kharbanda Rajesh
- Kharbanda Rajesh K
- Khawaja Muhammed Zeeshan
- Knight Rosemary
- Knighton Abigail
- Kobson Barbara
- Kodoth Vivek
- Kolakaluri Laurel
- Koothoor Raiji
- Korsgaard Mette Tidemand
- Kotecha Tushar
- Krishnamoorthy Suresh
- Krishnamurthy Arvindra
- Kristensen Steen Dalby
- Laca Sonia I.
- Lakeman Nicki
- Langrish Jeremy
- Lasica Ratko
- Lassen Jens Flensted
- Laurence Julia
- Lazar Nicoleta
- Leathers Chris
- Lee Dr Kaeng
- Lee Kelvin
- Lee Sandra
- Lenzi Valentina
- Leonard Gerry
- Lippert Freddy K
- Llorente-Álvarez Susana
- Lloyd Steph
- Loder Chris
- Longbottom Colin
- Longman Kristel
- Lozano Iñigo
- Lucking Andrew
- Ludman Andrew
- Lønborg Jacob T
- Maart Clint
- Mackenzie Ailie
- Mackie Sarah
- Madsen Morten
- Maeng Michael
- Malik Iqbal
- Marber Michael
- Mark Bettina Løjmand
- Markham-Jones Helene
- Martin Katherine
- Martinez-González Eugenio
- Martins Joe
- Martínez-Bastida Ginés
- Martínez-Fernández César M.
- Martínez-Pérez Polácido J.
- Martínez-Valle Marta
- Massey Ian
- Mathur Anthony
- Matic Dragan
- Mcarthy Rachel
- McCormick Louise
- McFarlane-Henry Eleanor
- McGregor Andrew
- McLeod Jane
- McSkeane Anna
- Meade Tom
- Meadows Deborah
- Medina-Cameán Ana B.
- Mehmedbegovic Zlatko
- Merrick Angela
- Metherell Stella
- Middle Janet
- Milasinovic Dejan
- Milgate Sarah
- Mohiddin Saidi
- Mojela Idah
- Moon Angela
- Moore Donna
- Moore Roger
- More Ranjit
- More Ranjit
- Moreby Berni
- Moreira Silvia
- Morgan Maureen
- Morris Steve
- Morís César
- Mota Paula
- Mudd Alexandra
- Munir Shahzad
- Muriel-Velasco Ana
- Musa Anntoniette
- Musselwhite Janine
- Møller Ulla Kristine
- Nair Sunil
- Naves María C.
- Neal Debbie
- Nelthorpe Faye
- Neubauer Stephen
- Newman Hannah
- Nicholas Jennifer M
- Nicholson Anne
- Nicholson Susan
- Nonide Marta
- Norfolk Derek
- O'Connor John
- O'Donnell Joshua
- O'Kane Peter
- O'Neill James
- Oakes Trevor
- Ocampo Madelaine
- Odedra Toral
- Oliveira Joana
- Oliver Victoria
- Oommen Anu
- Orr Sarah
- Paddy Loveth
- Padrón Remigio
- Panicker Abeesh Sadasiva
- Parsons Georgina
- Pascual Isaac
- Pascual Susana
- Patale Sheetal
- Pavlidis Antonis
- Pedersen Danny Mejsner
- Pedersen Frants
- Pedersen Karin Møller
- Pedersen Knud Erik
- Pedley Lauren
- Pejic Marijana
- Peláez María C.
- Pemberton Chris
- Pengelley Clare
- Penney Lucy
- Pepper Stacey
- Perara Divaka
- Perkins Alexander
- Phillips Hannah
- Phuyal Urmila
- Pine Amy
- Pitcher Louise
- Pitt Mike
- Polokova Karin
- Polwarth Gary
- Pomar-Amillo Ángeles
- Pozo-López Mónica
- Prendergast Bernard
- prentice Scott
- Preston Stephen
- Prodanovic Maja
- Prossora Mary
- Pulikal George
- Quintana Rosa B.
- Radford Elizabeth
- Radosavljevic-Radovanovic Mina
- Radovanovic Nebojsa
- Rai Amrit
- Raju Prashanth
- Rakhit Roby
- Rakhit Roby D
- Ramlall Manish
- Ramos Angelo
- Ratcliffe Amanda
- Raungaard Bent
- Ravkilde Jan
- Redington Andrew
- Redman Emily
- Redwood Simon
- Redwood Simon
- Reed Helen
- Reeve Christy
- Relph Chris
- Richardson James
- Riches Joanne
- Riddervold Ingunn Skogstad
- Riedel Ella
- Roberts Josh
- Robertson Steven
- Rodil-Díaz Juan A.
- Rondán Juan
- Ross David
- Roy Liby
- Roza César L.
- Rozado José
- Ryan Tony
- Ryding Alisdair
- Ryding Alisdair D
- Saclot Louie
- Samaniego Beatriz
- Sanchez-Vidal Ruth
- Sandhu Kully
- Sarti Charlotte
- Saunamäki Kari
- Saunders Heidi
- Savic Lidija
- Schmidt Michael R
- Schumacher Natasha
- Scott Kerry
- Sebastian Deepa
- Sebastian Deepti
- Segovia Eduardo
- Sevillano Annaliza
- Shaw Caroline
- Shelton Rhidian
- Shepherd Lucy
- Sherwood Martin
- Sidgwick Sian
- Simpson Holly
- Skipper Nicola
- Skov Charlotte Schmidt
- Smallwood Andrew
- Smee Joanna
- Smit Angelique
- Smith Bethany
- Smith Clare
- Smith Ian
- Smith Jan
- Smith Megan
- Smith Trevor
- Snow Tom
- Solieri Ashley
- Somers Kathryn
- Spence Sharon
- Spickett Helen
- Spinthakis Nicholas
- Stables Rod
- Staines Jocasta
- Stankovic Goran
- Stimson Leah
- Storey Robert F.
- Strike Philip
- Subotic Ida
- Suttling Anne
- Suárez Alfonso
- Suárez-Coto Raquel
- Suárez-Noriega Raquel
- Sørensen Henrik Toft
- Sørensen Rikke
- Tapp Luke
- Tawiah Cecilia
- Taylor Rebecca
- Terkelsen Christian Juhl
- Thambi Sunil
- Theodorou Nana
- Thim Troels
- Thomas Isobel
- Thompson Rebecca
- Thornborough Lauren
- Thornton Emma
- Thuesen Leif
- Thygesen Kristian
- Tilsted Hans Henrik
- Tipping Aoife
- Tomlinson Lucy
- Tomlinson Sharon
- Topic Dragan
- Tresguerres Jose M.
- Turner Charlotte
- Turner Jenny
- Turney Sharon
- Upton Robert
- Uscumlic Ana
- Van Dyck Laura
- Varma Madhusudhan
- Varma Madhusudhan
- Veerapen Jessry
- Vega-Fernández José L.
- Vegas-Valle Jose M.
- Veien Karsten
- Venugopal Vinod
- Vertue Mark
- Victor Saji
- Villadsen Anton Boel
- Villanueva María J.
- Villar-Fernández Lara
- Vinagrero María S.
- Viribay Fernando M.
- Vlad Ionela
- von Weitzel-Mudersbach Paul
- Vukcevic Vladan
- Vázquez-Suárez María
- Waddington Natalia
- Wain Jill
- Waitrak Paulina
- Waldron Molly
- Wallace Lauren
- Walshe Siobhan
- Walvin Tom
- Warner Karen
- Watkins Richard
- Watkinson Oliver
- Weatherlley Louise
- Webb Ian
- Webb Ian
- Wells Nicki
- Westwood Mark
- Wheeldon Nigel
- Whitehead Helena
- Whiteside Charlene
- Wilkinson Conor
- Wilson Karen
- Wittrock Daniel
- Wolyrum Mathias
- Woods Sarah
- Wragg Christopher
- Yellon Derek M
- Publication venue
- 'Elsevier BV'
- Publication date
- 01/01/2019
- Field of study
BACKGROUND: Remote ischaemic conditioning with transient ischaemia and reperfusion applied to the arm has been shown to reduce myocardial infarct size in patients with ST-elevation myocardial infarction (STEMI) undergoing primary percutaneous coronary intervention (PPCI). We investigated whether remote ischaemic conditioning could reduce the incidence of cardiac death and hospitalisation for heart failure at 12 months. METHODS: We did an international investigator-initiated, prospective, single-blind, randomised controlled trial (CONDI-2/ERIC-PPCI) at 33 centres across the UK, Denmark, Spain, and Serbia. Patients (age >18 years) with suspected STEMI and who were eligible for PPCI were randomly allocated (1:1, stratified by centre with a permuted block method) to receive standard treatment (including a sham simulated remote ischaemic conditioning intervention at UK sites only) or remote ischaemic conditioning treatment (intermittent ischaemia and reperfusion applied to the arm through four cycles of 5-min inflation and 5-min deflation of an automated cuff device) before PPCI. Investigators responsible for data collection and outcome assessment were masked to treatment allocation. The primary combined endpoint was cardiac death or hospitalisation for heart failure at 12 months in the intention-to-treat population. This trial is registered with ClinicalTrials.gov (NCT02342522) and is completed. FINDINGS: Between Nov 6, 2013, and March 31, 2018, 5401 patients were randomly allocated to either the control group (n=2701) or the remote ischaemic conditioning group (n=2700). After exclusion of patients upon hospital arrival or loss to follow-up, 2569 patients in the control group and 2546 in the intervention group were included in the intention-to-treat analysis. At 12 months post-PPCI, the Kaplan-Meier-estimated frequencies of cardiac death or hospitalisation for heart failure (the primary endpoint) were 220 (8·6%) patients in the control group and 239 (9·4%) in the remote ischaemic conditioning group (hazard ratio 1·10 [95% CI 0·91-1·32], p=0·32 for intervention versus control). No important unexpected adverse events or side effects of remote ischaemic conditioning were observed. INTERPRETATION: Remote ischaemic conditioning does not improve clinical outcomes (cardiac death or hospitalisation for heart failure) at 12 months in patients with STEMI undergoing PPCI. FUNDING: British Heart Foundation, University College London Hospitals/University College London Biomedical Research Centre, Danish Innovation Foundation, Novo Nordisk Foundation, TrygFonden
Effect of angiotensin-converting enzyme inhibitor and angiotensin receptor blocker initiation on organ support-free days in patients hospitalized with COVID-19
- Author
- ?ivko Iris
- Abbass Hakam
- Abdeladim Lilia
- Abdelhady Hesham
- Abdelkharim Hussam
- Abdelrazik Marwa
- Abdi Zakee
- Abdukahil Sheryl Ann
- Abel Lynn
- Abraham Jacinta
- Abrahamson Gail
- Abusamra Yousuf
- Aceto Romina
- Adams Nick
- Adams Peter
- Adebambo Olumide
- Adhikari Neill
- Adhikari Sheetal
- Affleck Julia
- Agha Gloria
- Aghemo Alessio
- Agno Ronan
- Ahmad Norfaizan
- Ain Quratul
- Ainscough Kate
- Ainsworth James
- Aitken Lindianne
- Akamp Ceren
- Al Enezi Farhan
- Al-Bassam Wisam
- Al-Beidh Farah
- Albert Martin
- Albrett Jonathan
- Alderman Meera
- Aldo Bonizzoni Matteo
- Alegria Ana
- Alessandro Carà Gianmarco
- Alexander Brian
- Alexander Peter
- Alfonso Jordan
- Ali Maryam
- Ali Murtaza
- Allam Hayat
- Allen Barbara
- Allen Louise
- Allibone Suzanne
- Almeshhedani Hasham
- AlQahtani Samah
- Alswaidan Lolowa
- Altomy Mohammed
- Al Amri Ali
- Al Qasim Eman
- Amatya Sameena
- Ambrosino Richard
- Anderson Thomas
- Andreae Mark
- Aneman Anders
- Angus Derek C.
- Anjum Aisha
- Ankert Juliane
- Annane Djillali
- Anne-Laure Fedou
- Anstey Matthew
- Antcliffe David
- Anthony Alpha
- Antoine Marchalot
- Antoine Pierre
- Antoine Studer
- Anumakonda Vikram
- Aparicio Christelle
- Aquino Maia
- Arabi Yaseen M.
- Arachchige Malka
- Aravindan Latha
- Arbane Gill
- Archambault Patrick
- Archer Simon
- Aref Noah
- Arias Ana-Marie
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- Zouita Louisa
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- 'American Medical Association (AMA)'
- Publication date
- 11/04/2023
- Field of study
IMPORTANCE Overactivation of the renin-angiotensin system (RAS) may contribute to poor clinical outcomes in patients with COVID-19.
Objective To determine whether angiotensin-converting enzyme (ACE) inhibitor or angiotensin receptor blocker (ARB) initiation improves outcomes in patients hospitalized for COVID-19.
DESIGN, SETTING, AND PARTICIPANTS In an ongoing, adaptive platform randomized clinical trial, 721 critically ill and 58 non–critically ill hospitalized adults were randomized to receive an RAS inhibitor or control between March 16, 2021, and February 25, 2022, at 69 sites in 7 countries (final follow-up on June 1, 2022).
INTERVENTIONS Patients were randomized to receive open-label initiation of an ACE inhibitor (n = 257), ARB (n = 248), ARB in combination with DMX-200 (a chemokine receptor-2 inhibitor; n = 10), or no RAS inhibitor (control; n = 264) for up to 10 days.
MAIN OUTCOMES AND MEASURES The primary outcome was organ support–free days, a composite of hospital survival and days alive without cardiovascular or respiratory organ support through 21 days. The primary analysis was a bayesian cumulative logistic model. Odds ratios (ORs) greater than 1 represent improved outcomes.
RESULTS On February 25, 2022, enrollment was discontinued due to safety concerns. Among 679 critically ill patients with available primary outcome data, the median age was 56 years and 239 participants (35.2%) were women. Median (IQR) organ support–free days among critically ill patients was 10 (–1 to 16) in the ACE inhibitor group (n = 231), 8 (–1 to 17) in the ARB group (n = 217), and 12 (0 to 17) in the control group (n = 231) (median adjusted odds ratios of 0.77 [95% bayesian credible interval, 0.58-1.06] for improvement for ACE inhibitor and 0.76 [95% credible interval, 0.56-1.05] for ARB compared with control). The posterior probabilities that ACE inhibitors and ARBs worsened organ support–free days compared with control were 94.9% and 95.4%, respectively. Hospital survival occurred in 166 of 231 critically ill participants (71.9%) in the ACE inhibitor group, 152 of 217 (70.0%) in the ARB group, and 182 of 231 (78.8%) in the control group (posterior probabilities that ACE inhibitor and ARB worsened hospital survival compared with control were 95.3% and 98.1%, respectively).
CONCLUSIONS AND RELEVANCE In this trial, among critically ill adults with COVID-19, initiation of an ACE inhibitor or ARB did not improve, and likely worsened, clinical outcomes.
TRIAL REGISTRATION ClinicalTrials.gov Identifier: NCT0273570
Reducing the environmental impact of surgery on a global scale: systematic review and co-prioritization with healthcare workers in 132 countries
- Author
- Abad-Motos Ane
- Abbas Ahmed M.
- Abbas Mostafa
- Abbasi Mujeeb
- Abbott Tom
- Abd Karim Muhammad Fairuz Shah
- Abdalaal Ibrahim
- Abdel-Galil Khalid
- Abdelemam Rania
- Abdelgawad Abdalrahman
- Abdelkarim Maryam
- Abdelkhalek Mohamed
- Abdelmageed Abdelfatah
- Abdelmawgoud Sherif
- Abdelmohsen Sarah
- Abdelrahman Ahmed Saber
- Abdelrahman Mostafa
- Abdelwahab Khaled
- Abdou Hossam
- Abdulai Darling Ramatu
- Abdulkhaleq Marwa
- Abdullah Bahiyah
- Abdulsalam Khalifa
- Abdulsalam Shuaib
- Abdur-Rahman Lukman
- Abdus-Salam Rukiyat
- Abdussalam Hameedat Opeyemi
- Abebrese John Tabiri
- Abeldaño Ariel
- Abou-Khalil Jad
- Abou-Taleb Hisham
- Abozid Anwaar
- Abozied Hesham
- Abrate Alberto
- Abu-Zaid Ahmed
- Abubakar Mohammed Kabir
- Abud Burçin
- Abuzaid Mohammed
- Adam Albushra Altayeb
- Adamina Michel
- Adamou Harissou
- Adamu Auwal
- Adamu Kabir Musa
- Adanu Kekeli
- Adebara Idowu
- Adebola Oluwaseyi
- Ademuyiwa Adesoji
- Adeniran Abiodun
- Adepiti Akinfolarin
- Aderogba Adeleke Akeem
- Adesunkanmi Abdulhafiz
- Adeyeye Ademola
- Adisa Adewale
- Adjeso Theophilus Justus Kofi
- Ads Adel Mohamed
- Ads Alaa Mohamed
- Adu-Aryee Nii Armah
- Adumah Collins
- Afzal Irrum
- Agapov Mikhail
- Agarwal Gaurav
- Agarwal Ravi
- Agbeko Anita Eseenam
- Agbeno Evans Kofi
- Agbonrofo Peter
- Agboola Oluseyi
- Aggarwal Gaurav
- Aghadi Ifeanyi
- Aghtarafi Natasha
- Agrawal Amit
- Agresta Ferdinando
- Aguado Héctor J.
- Aguilera-Arevalo Maria-Lorena
- Aherne Thomas
- Ahmad Aline
- Ahmad Maleeha
- Ahmad Misbahu
- Ahmad Sarwat
- Ahmad Shahzaib
- Ahmad Shoaib
- Ahmed Hayat Tarig Abdelhafiz
- Ahmed Khalid
- Ahmed Sharwany
- Ahmed Shima
- Ahmed Usama
- Aisuodionoe-Shadrach Oseremen
- Aitken Sarah
- Ajenifuja Kayode
- Ajiya Abdulrazak
- Akeel Nouf
- Akin Emrah
- Akinajo Opeyemi
- Akinyemi Tosin
- Akrida Ioanna
- Aktokmakyan Talar Vartanoglu
- Akwaisah Ayoub
- Al Bettar Osama
- Al-Badawi Ismail A.
- Al-Juaifari Maytham
- Al-Khyatt Waleed
- Al-Mallah Abdullah
- Al-Nusairi Ahmed
- Al-Saadi Nina
- Al-Sayaghi Khaled
- Al-Shaiji Tariq
- Al-Shehari Mohammed
- Al-Touny Aiman
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- Meead Adullah
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- Watson Matthew
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- Williams Shekinah
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- Wittmann Maria
- Wolde Amanuel
- Wolfenden John W. D.
- Wong Benjamin Ngie Xiong
- Wong Enoch
- Wong Evan G.
- Wong George Kwok Chu
- Wong Ho Ying Flora
- Wong Kai Yuen
- Wormald Justin
- Wright Deborah
- Wright Joshua
- Wu Fiona
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- Yakubu Mustapha
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- Yanowsky-Reyes Guillermo
- Yassin Abubaker
- Yates Elizabeth
- Yebes Alvaro
- Yenli Edwin Mwintiereh Ta-Ang
- Yeoh Tien
- Yeung Justin
- Yiallourou Anneza
- Yigit Banu
- Yildirim Asif
- Yim Guang
- Yiu Andrew
- Yonekura Hiroshi
- Yotsov Tsanko
- Younis Muhammad Umar
- Yunus Alif
- Yusefi Hossein
- Zabaleta Jon
- Zabkiewicz Catheriner
- Zaccaria Giulia
- Zacharia Bincy
- Zafar Syed Nabeel
- Zago Mauro
- Zaheen Zakia
- Zahid Zahra
- Zaimis Tilemachos
- Zakaria Andee Dzulkarnaen
- Zambon Martina
- Zamora Lindsey
- Zampogna Biagio
- Zancana Giuseppa
- Zani Augusto
- Zanin Luca
- Zanini Nicola
- Zapardiel Ignacio
- Zapata Carlos Shiraishi
- Zarif Pierre
- Zaránd Attila
- Zehnder Philipp
- Zenger Serkan
- Zenha Horácio
- Zhu Michael Z. L.
- Ziemann Sebastian
- Zimak Danijela Mrazovac
- Zimak Zoran
- Zivkovic Dragana
- Zizzo Maurizio
- Zucker Benjamin
- Zwain Yasir
- Zyskowski Michael
- Ávila Clara Castro
- Älgå Andreas
- Çakici Mehmet Çaǧlar
- Çelik Enes
- Çelik Meryem Nur
- Özçay Necdet
- Şevik Hüsnü
- Šantak Goran
- Šimko Kristián
- Žatecký Jan
- Publication venue
- 'Oxford University Press (OUP)'
- Publication date
- 01/01/2023
- Field of study
Abstract
Background
Healthcare cannot achieve net-zero carbon without addressing operating theatres. The aim of this study was to prioritize feasible interventions to reduce the environmental impact of operating theatres.
Methods
This study adopted a four-phase Delphi consensus co-prioritization methodology. In phase 1, a systematic review of published interventions and global consultation of perioperative healthcare professionals were used to longlist interventions. In phase 2, iterative thematic analysis consolidated comparable interventions into a shortlist. In phase 3, the shortlist was co-prioritized based on patient and clinician views on acceptability, feasibility, and safety. In phase 4, ranked lists of interventions were presented by their relevance to high-income countries and low–middle-income countries.
Results
In phase 1, 43 interventions were identified, which had low uptake in practice according to 3042 professionals globally. In phase 2, a shortlist of 15 intervention domains was generated. In phase 3, interventions were deemed acceptable for more than 90 per cent of patients except for reducing general anaesthesia (84 per cent) and re-sterilization of ‘single-use’ consumables (86 per cent). In phase 4, the top three shortlisted interventions for high-income countries were: introducing recycling; reducing use of anaesthetic gases; and appropriate clinical waste processing. In phase 4, the top three shortlisted interventions for low–middle-income countries were: introducing reusable surgical devices; reducing use of consumables; and reducing the use of general anaesthesia.
Conclusion
This is a step toward environmentally sustainable operating environments with actionable interventions applicable to both high– and low–middle–income countries