Presence and Effects of Pituitary Adenylate Cyclase Activating Polypeptide Under Physiological and Pathological Conditions in the Stomach

Pituitary adenylate cyclase activating polypeptide (PACAP) is a multifunctional neuropeptide with widespread occurrence throughout the body including the gastrointestinal system. In the small and large intestine, effects of PACAP on cell proliferation, secretion, motility, gut immunology and blood flow, as well as its importance in bowel inflammatory reactions and cancer development have been shown and reviewed earlier. However, no current review is available on the actions of PACAP in the stomach in spite of numerous data published on the gastric presence and actions of the peptide. Therefore, the aim of the present review is to summarize currently available data on the distribution and effects of PACAP in the stomach. We review data on the localization of PACAP and its receptors in the stomach wall of various mammalian and non-mammalian species, we then give an overview on PACAP's effects on secretion of gastric acid and various hormones. Effects on cell proliferation, differentiation, blood flow and gastric motility are also reviewed. Finally, we outline PACAP's involvement and changes in various human pathological conditions

Wetting of Different Lead Free Solder Alloys During Vapour Phase Soldering

In this paper the wetting properties of lead free solder alloys were investigated on different printed circuit boards (PCB) during Vapour Phase Soldering (VPS), which is an alternative reflow method with non-conventional heat-transfer mechanism. Our motivation was to investigate the phenomenon on PCBs with different thermal capacities, with different heating power and with different solder alloys. The aim of the research is to clear the relations between the thermal capacities of the) PCBs and the spreading of the solder on it, and to investigate the effect of the change of heating power on the solder spreading during VPS. In addition, the impact of the VPS on different solder alloys and the performance of the VPS machine in the wake of the contact angle quality was investigated. Findings show that the thickness of the PCB is not affecting significantly the spread and the wetting. The composition of the alloy, the paste, and the heating power points to observable differences in the final result

Communicating results in post-Belmont era biomonitoring studies: Lessons from genetics and neuroimaging research

BACKGROUND: Biomonitoring is a critical tool to assess the effects of chemicals on health, as scientists seek to better characterize life-course exposures from diverse environments. This trend, coupled with increased institutional support for community-engaged environmental health research, challenge established ethical norms related to biomonitoring results communication and data sharing between scientists, study participants, and their wider communities. METHODS: Through a literature review, participant observation at workshops, and interviews, we examine ethical tensions related to reporting individual data from chemical biomonitoring studies by drawing relevant lessons from the genetics and neuroimaging fields. RESULTS: In all three fields ethical debates about whether/how to report-back results to study participants are precipitated by two trends. First, changes in analytical methods have made more data accessible to stakeholders. For biomonitoring, improved techniques enable detection of more chemicals at lower levels, and diverse groups of scientists and health advocates now conduct exposure studies. Similarly, innovations in genetics have catalyzed large-scale projects and broadened the scope of who has access to genetic information. Second, increasing public interest in personal medical information has compelled imaging researchers to address demands by participants to know their personal data, despite uncertainties about their clinical significance. Four ethical arenas relevant to biomonitoring results communication emerged from our review: Tensions between participants’ right-to-know their personal results versus their ability or right-to-act to protect their health; whether and how to report incidental findings; informed consent in biobanking; and open-access data sharing. CONCLUSION: Ethically engaging participants in biomonitoring studies requires consideration of several issues, including scientific uncertainty about health implications and exposure sources, the ability of participants to follow up on potentially problematic results, tensions between individual and community research protections, governance and consent regarding secondary use of tissue samples, and privacy challenges in open access data sharing

ENGINEERING FOR RURAL DEVELOPMENT CLUSTERS AND CONCENTRATION OF BUSINESSES IN REGIONS OF SOME EUROPEAN COUNTRIES AS TOOLS FOR ECONOMIC DEVELOPMENT

Abstract. In our paper we made an overview on the literature about the creation and role of clusters and concentration of economic activities in the development of regions in Europe. Based on data available, we tried to find the correlation between the welfare, the quality of life and the clusters (especially in the knowledgeintensive sectors). In our research we assumed that the concentration of a sector in a region can have influence on the quality of life and that higher knowledge-intensive sectors of manufacturing and services have greater contribution to welfare. During research two main questions may arise: After how many years can we see beneficial effects on quality of life if a region starts to specialize. And: Can quality of life react flexibly to the changes in economy? After our research we got to the conclusion that there is a time shift in this phenomenon, the correlation is not linear and the changes are not elastic. We assumed that knowledge-driven economy has greater effect on quality of life than traditional economy but this cannot be proven generally. Moreover, regional specialties in labor market and industrial traditions seem to have great impact. We collected the data from the Eurostat database. The sample data give the opportunity to calculate the labor based location quotient (LQ), Herfindahl index and Dissimilarity index as well. All the three indices can show us the same effects that we are interested, but we have chosen LQ for our research. Eurostat has a so called high-tech industry and knowledgeintensive service database, which was used and filtered to the employment data in order to calculate the labor based LQ. The database lasts from 1994 to 2008 and shows the employment in the different knowledge intensive sectors on regional levels in 33 countries. The aim of our research was to find out how much the clusters/economic concentrations affect the development of regions and to try to define possible development ways for the future. Keywords: specialization of industries, location quotient, quality of life, labor market change. Introduction The goal of the paper is to measure the impact of the actions of economic policy on the quality of life, especially the relationship between regional specialization and welfare. The contribution of these factors to quality of life is difficult for several reasons, as observed in our parallel studies about quality of life. Therefore, we compared the most common index of welfare the per capita GDP with the index of regional and sectoral specialization measured by the labor based location quotient. We can easily accept that among scarce resources not every initiative can be supported, which can elevate welfare, so we should define the sectors with the greatest contribution to the quality of life. Through our investigation we examined which sector's concentration brings the greatest effect on local per capita GDP. The literature specifies those branches and sectors (traded, basic, export branches) [1] that can lead a region into success. Porter If we accept the theory of innovation driven development and the statements of Porter [2] about traded cluster, then we should only focus on the impact of these branches on the quality of life. Ketels and Sölvell [3] have made already these kinds of studies about the regional economic performance and clusters. In a broader perspective it is conceivable that small local clusters with non-traded activities (such as craftsmanship or culinary products) can connect local suppliers and producers and these clusters can have impact on their surrounding region as it was observed by tourism by Szanyi et a

L-arginine pathway in COPD patients with acute exacerbation: a new potential biomarker

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