Metástasis gingival de adenocarcinoma de colon

La cavidad oral es lugar de asiento de tumores metastásicos, sobre todo con origen en mama y pulmón. La mayoría de los casos afectan por este orden a los huesos mandibular y maxilar, aunque en ocasiones se desarrollan sobre las partes blandas intraorales. Presentamos el caso de un paciente de 62 años diagnosticado de adenocarcinoma de colon sigmoide con metástasis ganglionares y hepáticas, que 6 meses después presenta una lesión vegetante en la encía, interpretada inicialmente como neoplasia primaria de encía, que tras ser biopsiada fue diagnosticada como adenocarcinoma intestinal metastásico. El estudio histológico es obligatorio para diferenciar un adenocarcinoma de los carcinomas de células escamosas, habituales en la zona, y las técnicas inmunohistoquímicas permiten diferenciar entre un tumor metastásico, sea intestinal o de otro origen, y un adenocarcinoma primario originado en glándulas salivares menores de la zona. La presencia de un tumor diseminado con extensión intraoral acarrea un pronóstico ominoso, aunque si se trata de una metástasis única es posible un tratamiento quirúrgico radical con una supervivencia mayor.Metastatic tumors involve the oral cavity, and the most common primary sites are the breast and lung. Most cases affect the mandible and maxilla in that order, although some of them can be located in the soft perioral tissues. We report the case of a 62-year-old male who had been diagnosed with sigmoid adenocarcinoma with nodal and liver metastasis, who presented 6 months later with a gingival polypoid tumor, at first considered as a primary neoplasm of gingiva, that was diagnosed in a biopsy as metastatic intestinal adenocarcinoma. The histological evaluation is essential to separate adenocarcinoma from the commoner in this site squamous cell carcinoma, and the immunohistochemical techniques are useful to distinguish metastatic tumor versus primary adenocarcinoma from the minor salivary glands of the area. The intraoral spread of a disseminated neoplasm is generally a sign of bad prognosis, although a longer survival can be expected if a radical surgical treatment of a solitary metastasis is carried out

Colon adenocarcinoma with metastasis to the gingiva

La cavidad oral es lugar de asiento de tumores metastásicos, sobre todo con origen en mama y pulmón. La mayoría de los casos afectan por este orden a los huesos mandibular y maxilar, aunque en ocasiones se desarrollan sobre las partes blandas intraorales. Presentamos el caso de un paciente de 62 años diagnosticado de adenocarcinoma de colon sigmoide con metástasis ganglionares y hepáticas, que 6 meses después presenta una lesión vegetante en la encía, interpretada inicialmente como neoplasia primaria de encía, que tras ser biopsiada fue diagnosticada como adenocarcinoma intestinal metastásico. El estudio histológico es obligatorio para diferenciar un adenocarcinoma de los carcinomas de células escamosas, habituales en la zona, y las técnicas inmunohistoquímicas permiten diferenciar entre un tumor metastásico, sea intestinal o de otro origen, y un adenocarcinoma primario originado en glándulas salivares menores de la zona. La presencia de un tumor diseminado con extensión intraoral acarrea un pronóstico ominoso, aunque si se trata de una metástasis única es posible un tratamiento quirúrgico radical con una supervivencia mayor

Impact of HCV infection in a HIV cohort followed over18 years: past and present

Pôster abstrac

Evidence of random magnetic anisotropy in ferrihydrite nanoparticles based on analysis of statistical distributions

We show that the magnetic anisotropy energy of antiferromagnetic ferrihydrite depends on the square root of the nanoparticles volume, using a method based on the analysis of statistical distributions. The size distribution was obtained by transmission electron microscopy, and the anisotropy energy distributions were obtained from ac magnetic susceptibility and magnetic relaxation. The square root dependence corresponds to random local anisotropy, whose average is given by its variance, and can be understood in terms of the recently proposed single phase homogeneous structure of ferrihydrite.Comment: 6 pages, 2 figure

The planetary system host HR\,8799: On its λ\lambda Bootis nature

HR\,8799 is a $\lambda$ Bootis, $\gamma$ Doradus star hosting a planetary system and a debris disk with two rings. This makes this system a very interesting target for asteroseismic studies. This work is devoted to the determination of the internal metallicity of this star, linked with its $\lambda$ Bootis nature (i.e., solar surface abundances of light elements, and subsolar surface abundances of heavy elements), taking advantage of its $\gamma$ Doradus pulsations. This is the most accurate way to obtain this information, and this is the first time such a study is performed for a planetary-system-host star. We have used the equilibrium code CESAM and the non-adiabatic pulsational code GraCo. We have applied the Frequency Ratio Method (FRM) and the Time Dependent Convection theory (TDC) to estimate the mode identification, the Brunt-Va\"is\"al\"a frequency integral and the mode instability, making the selection of the possible models. When the non-seismological constraints (i.e its position in the HR diagram) are used, the solar abundance models are discarded. This result contradicts one of the main hypothesis for explaining the $\lambda$ Bootis nature, namely the accretion/diffusion of gas by a star with solar abundance. Therefore, according to these results, a revision of this hypothesis is needed. The inclusion of accurate internal chemical mixing processes seems to be necessary to explain the peculiar abundances observed in the surface of stars with internal subsolar metallicities. The use of the asteroseismological constraints, like those provided by the FRM or the instability analysis, provides a very accurate determination of the physical characteristics of HR 8799. However, a dependence of the results on the inclination angle $i$ still remains. The determination of this angle, more accurate multicolour photometric observations, and high resolution spectroscopy can definitively fix the mass and metallicity of this star.Comment: 11 pages, 10 figures. Accepted for publication in MNRA

TEMPORAL AND SPATIAL VARIABILITY OF ATMOSPHERIC PARTICLE NUMBER SIZE DISTRIBUTIONS ACROSS SPAIN

This study synthesizes for the first time results from simultaneous aerosol measurements performed at seven diverse locations distributed all over the Spanish geography. The observations were carried out during two field campaigns in 2012–2013, one-month each and during different seasons. These field campaigns were performed in the framework of the Spanish Network of DMAs (REDMAAS) activities. Measurement sites were grouped as polluted sites (urban background) and clean sites (rural background and high-altitude sites). Seasonal differences were more important at polluted sites, mainly related to meteorology and aerosol sources. Higher total particle concentrations were found during the cold period, driven mainly by Aitken-mode particles (traffic-related aerosol particles).This work has been financed by the Ministry of Science and Innovation (CGL2011-15008-E, CGL2010-1777, CGL2011-27020, CGL2014-52877-R, CGL2010-11095-E, CGL2012-39623-C02-01, CGL2014-55230-R & PI15/0051

Experiences of water immersion during childbirth: a qualitative thematic synthesis

Background The increasing demand for childbirth care based on physiological principles has led official bodies to encourage health centers to provide evidence‑based care aimed at promoting women’s participation in informed decision‑making and avoiding excessive medical intervention during childbirth. One of the goals is to reduce pain and find alternative measures to epidural anesthesia to enhance women’s autonomy and well‑being during child‑ birth. Currently, water immersion is used as a non‑pharmacological method for pain relief. This review aimed to identify and synthesize evidence on women’s and midwives’ experiences, values, and prefer‑ ences regarding water immersion during childbirth. Methods A systematic review and thematic synthesis of qualitative evidence were conducted. Databases were searched and references were checked according to specific criteria. Studies that used qualitative data collection and analysis methods to examine the opinions of women or midwives in the hospital setting were included. Non‑qualita‑ tive studies, mixed‑methods studies that did not separately report qualitative results, and studies in languages other than English or Spanish were excluded. The Critical Appraisal Skills Program Qualitative Research Checklist was used to assess study quality, and results were synthesized using thematic synthesis. Results Thirteen studies met the inclusion criteria and were included in this review. The qualitative studies yielded three key themes: 1) reasons identified by women and midwives for choosing a water birth, 2) benefits experienced in water births, and 3) barriers and facilitators of water immersion during childbirth. Conclusions The evidence from qualitative studies indicates that women report benefits associated with water birth. From the perspective of midwives, ensuring safe water births requires adequate resources, midwives training, and rig‑ orous standardized protocols to ensure that all pregnant women can safely opt for water immersion during childbirth with satisfactory results

TEAD and YAP regulate the enhancer network of human embryonic pancreatic progenitors.

The genomic regulatory programmes that underlie human organogenesis are poorly understood. Pancreas development, in particular, has pivotal implications for pancreatic regeneration, cancer and diabetes. We have now characterized the regulatory landscape of embryonic multipotent progenitor cells that give rise to all pancreatic epithelial lineages. Using human embryonic pancreas and embryonic-stem-cell-derived progenitors we identify stage-specific transcripts and associated enhancers, many of which are co-occupied by transcription factors that are essential for pancreas development. We further show that TEAD1, a Hippo signalling effector, is an integral component of the transcription factor combinatorial code of pancreatic progenitor enhancers. TEAD and its coactivator YAP activate key pancreatic signalling mediators and transcription factors, and regulate the expansion of pancreatic progenitors. This work therefore uncovers a central role for TEAD and YAP as signal-responsive regulators of multipotent pancreatic progenitors, and provides a resource for the study of embryonic development of the human pancreas