Relevancia clínica y tratamiento de la insuficiencia pancreática exocrina en pancreatitis crónica

La pancreatitis crónica es un proceso fibroinflamatorio progresivo del páncreas que da como resultado la destrucción del parénquima pancreático y el desarrollo de fibrosis. Esto causa la pérdida irreversible de la función pancreática exocrina y endocrina. La pérdida de la función exocrina da lugar al desarrollo de déficits nutricionales que se asocian a un incremento de la mortalidad y del riesgo cardiovascular en pacientes con pancreatitis crónica. El tratamiento enzimático sustitutivo es efectivo, incrementando la absorción de grasa y de nitrógeno y mejorando el estado nutricional y calidad de vida de estos pacientes. Se debe optimizar el tratamiento enzimático sustitutivo para la normalización del estado nutricional

Endoscopic ultrasonography: Enhancing diagnostic accuracy

Endoscopic ultrasound (EUS) is an essential technique for the management of several diseases. Over the years, new technologies have been developed because to improve and overcome certain limitations related to EUS guided tissue acquisition. Among these new methods, EUS guided elastography and contrast enhanced EUS has arisen as the most widely recognized and available. We will review in this manuscript the different techniques of elastography and contrast enhancement. Nowadays, there are well establish indications for advance imaging, mainly for supporting the management of pancreatic diseases (diagnosis of chronic pancreatitis and differential diagnosis of solid and cystic pancreatic tumors) and characterization of lymph nodes. However, there are more data on new potential indications for the near futureS

Diseño de una Planta Piloto de Refinación Electrolítica de un Bullion de Oro y Plata

Fil: García, Juan Antonio. Universidad Nacional de San Juan. Instituto de Investigaciones Mineras; Argentina (San Juan)Fil: Parra, Ricardo. Servicio Geológico Minero Argentino. Centro SEGEMAR Salta; Argentina.Fil: Montenegro, Carlos Alberto. Universidad Nacional de San Juan. Instituto de Investigaciones Mineras; Argentina (San Juan)Fil: Gómez Agustín Alberto. Universidad Nacional de San Juan. Instituto de Investigaciones Mineras; Argentina (San Juan)Fil: Núñez, Enrique Antonio. Universidad Nacional de San Juan. Instituto de Investigaciones Mineras; Argentina (San Juan)Fil: De la Iglesia, Daniel. Universidad Nacional de San Juan. Instituto de Investigaciones Mineras; Argentina (San juan)Fil: Matar, José Agustín. Universidad Nacional de San Juan. Instituto de Investigaciones Mineras; Argentina (San Juan)Fil: Villas Boas, Roberto. Centro de Tecnología Mineral CETEM; Brasil (Río de Janeiro)El presente trabajo de investigación fue realizado en el Instituto de Investigaciones Mineras (UNSJ) por los autores. Tuvo como objetivo el diseño, construcción y puesta en marcha de una planta refinadora de oro y plata a partir de un bullion impuro obtenido en la Mina Farallón Negro, provincia de Catamarca. Con los resultados obtenidos en esta etapa, se diseñó y construyó la planta comercial de refinación de oro y plata de la empresa Yacimientos Mineros Aguas de Dionisio (YMAD) en la ciudad de Catamarca. Este trabajo se presentó oportunamente en las Jornadas de Metalurgia extractiva realizadas en La Serena, Chile (CONAMET-SAM 2004

Implementation of a mindfulness-based crisis intervention for frontline healthcare workers during the COVID-19 outbreak in a public general hospital in Madrid, Spain

Introduction: The COVID-19 outbreak is having an impact on the well-being of healthcare workers. Mindfulness-based interventions have shown effectiveness in reducing stress and fostering resilience and recovery in healthcare workers. There are no studies examining the feasibility of brief mindfulness-based interventions during the COVID-19 outbreak. Materials and Methods: This is an exploratory study with a post intervention assessment. We describe an on-site brief mindfulness intervention and evaluate its helpfulness, safety, and feasibility. Results: One thousand out of 7,000 (14%) healthcare workers from La Paz University Hospital in Madrid (Spain) participated in at least one session. One hundred and fifty out of 1,000 (15%) participants filled out a self-report questionnaire evaluating the helpfulness of the intervention for on-site stress reduction. Ninety two subjects (61%) participated in more than one session. Most of the participants were women (80%) with a mean age of 38.6 years. Almost half of the sample were nurses (46%). Sessions were perceived as being helpful with a mean rating of 8.4 on a scale from 0 to 10. Only 3 people (2%) reported a minor adverse effect (increased anxiety or dizziness). Discussion: Our data supports the utility, safety and feasibility of an on-site, brief mindfulness-based intervention designed to reduce stress for frontline health workers during a crisis. There is a need to continue testing this type of interventions, and to integrate emotion regulation strategies as an essential part of health workers' general training. Clinical Trial Registration number: NCT04555005

Hacking ético para profundizar en la implementación de sistemas informáticos seguros

Memoria ID-052 Ayudas de la Universidad de Salamanca para la innovación docente, curso 2020-2021

Minecraft para diseños HDL: flujo de síntesis de Verilog para circuitos de redstone

Memoria ID-076. Ayudas de la Universidad de Salamanca para la innovación docente, curso 2019-2020.[ES]El objetivo de este proyecto es crear un espacio virtual mediante la utilización de tecnología Minecraft que permita al estudiante aumentar el contenido académico relacionado con los conocimientos impartidos en las distintas ramas de las asignaturas de electrónica-física de la Universidad de Salamanca

Sistema inmersivo para la tutorización virtual con Oculus Go

Memoria ID-080. Ayudas de la Universidad de Salamanca para la innovación docente, curso 2018-2019

Tarteso. Nuevas Fronteras (II)

El presente volumen recoge las contribuciones presentadas al II Congreso Internacional sobre Tarteso, Nuevas Fronteras, que tuvo lugar en Mérida entre los días 17 y 19 de noviembre de 2021. Su lectura permite un viaje desde el extremo oriental del Mediterráneo hasta el suroeste de la península ibérica, mostrando las diversas realidades históricas acontecidas en este territorio durante la I Edad del Hierro. El objetivo de esta publicación es mostrar la situación que atravesaba el Mediterráneo durante los años de surgimiento y desarrollo de la cultura tartésica para así comprender mejor la formación y evolución de dicha cultura. El conocimiento de Tarteso ha evolucionado sensiblemente en la última década, desde la celebración y publicación de las actas del I Congreso Internacional, Tarteso. El emporio del metal (Almuzara, 2013). La incorporación de nuevas voces y visiones enfocadas al conocimiento de la protohistoria peninsular, así como de algunos temas nunca antes abordados en el conocimiento de Tarteso, permiten presentar en este volumen una visión renovada, donde destaca la incorporación de unos nuevos límites territoriales para esta cultura.Esta publicación se ha beneficiado de las siguientes ayudas para su financiación: Proyecto de Investigación del Plan Nacional I+D+i: “Construyendo Tarteso 2.0: análisis constructivo, espacial y territorial de un modelo arquitectónico en el valle medio del Guadiana” (PID2019-108180GBI00), financiado por MCIN (AEI/10.13039/501100011033). Subvención global de la Secretaría General de Ciencia, Tecnología, Innovación y Universidad de la Junta de Extremadura al Instituto de Arqueología.Peer reviewe

Global phylogeography and ancient evolution of the widespread human gut virus crAssphage

Microbiomes are vast communities of microorganisms and viruses that populate all natural ecosystems. Viruses have been considered to be the most variable component of microbiomes, as supported by virome surveys and examples of high genomic mosaicism. However, recent evidence suggests that the human gut virome is remarkably stable compared with that of other environments. Here, we investigate the origin, evolution and epidemiology of crAssphage, a widespread human gut virus. Through a global collaboration, we obtained DNA sequences of crAssphage from more than one-third of the world's countries and showed that the phylogeography of crAssphage is locally clustered within countries, cities and individuals. We also found fully colinear crAssphage-like genomes in both Old-World and New-World primates, suggesting that the association of crAssphage with primates may be millions of years old. Finally, by exploiting a large cohort of more than 1,000 individuals, we tested whether crAssphage is associated with bacterial taxonomic groups of the gut microbiome, diverse human health parameters and a wide range of dietary factors. We identified strong correlations with different clades of bacteria that are related to Bacteroidetes and weak associations with several diet categories, but no significant association with health or disease. We conclude that crAssphage is a benign cosmopolitan virus that may have coevolved with the human lineage and is an integral part of the normal human gut virome

RICORS2040 : The need for collaborative research in chronic kidney disease

Chronic kidney disease (CKD) is a silent and poorly known killer. The current concept of CKD is relatively young and uptake by the public, physicians and health authorities is not widespread. Physicians still confuse CKD with chronic kidney insufficiency or failure. For the wider public and health authorities, CKD evokes kidney replacement therapy (KRT). In Spain, the prevalence of KRT is 0.13%. Thus health authorities may consider CKD a non-issue: very few persons eventually need KRT and, for those in whom kidneys fail, the problem is 'solved' by dialysis or kidney transplantation. However, KRT is the tip of the iceberg in the burden of CKD. The main burden of CKD is accelerated ageing and premature death. The cut-off points for kidney function and kidney damage indexes that define CKD also mark an increased risk for all-cause premature death. CKD is the most prevalent risk factor for lethal coronavirus disease 2019 (COVID-19) and the factor that most increases the risk of death in COVID-19, after old age. Men and women undergoing KRT still have an annual mortality that is 10- to 100-fold higher than similar-age peers, and life expectancy is shortened by ~40 years for young persons on dialysis and by 15 years for young persons with a functioning kidney graft. CKD is expected to become the fifth greatest global cause of death by 2040 and the second greatest cause of death in Spain before the end of the century, a time when one in four Spaniards will have CKD. However, by 2022, CKD will become the only top-15 global predicted cause of death that is not supported by a dedicated well-funded Centres for Biomedical Research (CIBER) network structure in Spain. Realizing the underestimation of the CKD burden of disease by health authorities, the Decade of the Kidney initiative for 2020-2030 was launched by the American Association of Kidney Patients and the European Kidney Health Alliance. Leading Spanish kidney researchers grouped in the kidney collaborative research network Red de Investigación Renal have now applied for the Redes de Investigación Cooperativa Orientadas a Resultados en Salud (RICORS) call for collaborative research in Spain with the support of the Spanish Society of Nephrology, Federación Nacional de Asociaciones para la Lucha Contra las Enfermedades del Riñón and ONT: RICORS2040 aims to prevent the dire predictions for the global 2040 burden of CKD from becoming true