The Subaru/XMM-Newton Deep Survey (SXDS) -VII. Clustering Segregation with Ultraviolet and Optical Luminosities of Lyman-Break Galaxies at z~3

We investigate clustering properties of Lyman-break galaxies (LBGs) at z~3 based on deep multi-waveband imaging data from optical to near-infrared wavelengths in the Subaru/XMM-Newton Deep Field. The LBGs are selected by U-V and V-z' colors in one contiguous area of 561 arcmin^2 down to z'=25.5. We study the dependence of the clustering strength on rest-frame UV and optical magnitudes, which can be indicators of star formation rate and stellar mass, respectively. The correlation length is found to be a strong function of both UV and optical magnitudes with brighter galaxies being more clustered than faint ones in both cases. Furthermore, the correlation length is dependent on a combination of UV and optical magnitudes in the sense that galaxies bright in optical magnitude have large correlation lengths irrespective of UV magnitude, while galaxies faint in optical magnitude have correlation lengths decreasing with decreasing UV brightness. These results suggest that galaxies with large stellar masses always belong to massive halos in which they can have various star formation rates, while galaxies with small stellar masses reside in less massive halos only if they have low star formation rates. There appears to be an upper limit to the stellar mass and the star formation rate which is determined by the mass of hosting dark halos.Comment: 16 pages, 15 figures, accepted for publication in Ap

Identification of the P-TEFb complex-interacting domain of Brd4 as an inhibitor of HIV-1 replication by functional cDNA library screening in MT-4 cells

AbstractWe conducted a phenotypic cDNA screening using a T cell line-based assay to identify human genes that render cells resistant to human immunodeficiency virus type 1 (HIV-1). We isolated potential HIV-1 resistance genes, including the carboxy terminal domain (CTD) of bromodomain-containing protein 4 (Brd4). Expression of GFP-Brd4-CTD was tolerated in MT-4 and Jurkat cells in which HIV-1 replication was markedly inhibited. We provide direct experimental data demonstrating that Brd4-CTD serves as a specific inhibitor of HIV-1 replication in T cells. Our method is a powerful tool for the identification of host factors that regulate HIV-1 replication in T cells

Star Formation Rates and Metallicities of K-selected Star Forming Galaxies at z~2

We present spectroscopy of 15 star-forming BzK galaxies (sBzKs) with K(AB)<23 in the Subaru Deep Field, for which Halpha and some other emission lines are detected in 0.9 to 2.3 micron spectra with a resolution of R=500. Using Halpha luminosities, we obtain star formation rates (SFRs), and then specific SFRs (SSFRs) dividing SFRs by stellar masses, which are derived from SED fitting to BVRi'z'K photometry. It is found that sBzKs with higher stellar masses have larger SFRs. A negative correlation is seen between stellar mass and SSFR, which is consistent with the previous results for z~2 galaxies. This implies that a larger growth of stellar mass occurs in less massive galaxies. In addition, gas-phase oxygen abundances, 12+log(O/H), are derived from the ratio of NII(lambda 6584) to Halpha using the N2 index method. We have found a correlation between stellar mass and oxygen abundance in the sense that more massive sBzKs tend to be more metal rich, which is qualitatively consistent with the relation for UV-selected z~2 galaxies. However, the metallicity of the sBzKs is ~0.2 dex higher than that of UV-selected galaxies with similar stellar masses, which is significant considering the small uncertainties. The sBzKs in our sample have redder R-K colors than the UV-selected galaxies. This galaxy color-dependence in the oxygen abundance may be caused by older or dustier galaxies having higher metallicities at z~2.Comment: 20 pages, 13 figures, 2 tables, accepted for publication in The Astrophysical Journa

Statistics of 207 Lya Emitters at a Redshift Near 7: Constraints on Reionization and Galaxy Formation Models

We present Lya luminosity function (LF), clustering measurements, and Lya line profiles based on the largest sample, to date, of 207 Lya emitters (LAEs) at z=6.6 on the 1-deg^2 sky of Subaru/XMM-Newton Deep Survey (SXDS) field. Our z=6.6 Lya LF including cosmic variance estimates yields the best-fit Schechter parameters of phi*=8.5 +3.0/-2.2 x10^(-4) Mpc^(-3) and L*(Lya)=4.4 +/-0.6 x10^42 erg s^(-1) with a fixed alpha=-1.5, and indicates a decrease from z=5.7 at the >~90% confidence level. However, this decrease is not large, only =~30% in Lya luminosity, which is too small to be identified in the previous studies. A clustering signal of z=6.6 LAEs is detected for the first time. We obtain the correlation length of r_0=2-5 h^(-1) Mpc and bias of b=3-6, and find no significant boost of clustering amplitude by reionization at z=6.6. The average hosting dark halo mass inferred from clustering is 10^10-10^11 Mo, and duty cycle of LAE population is roughly ~1% albeit with large uncertainties. The average of our high-quality Keck/DEIMOS spectra shows an FWHM velocity width of 251 +/-16 km s^(-1). We find no large evolution of Lya line profile from z=5.7 to 6.6, and no anti-correlation between Lya luminosity and line width at z=6.6. The combination of various reionization models and our observational results about the LF, clustering, and line profile indicates that there would exist a small decrease of IGM's Lya transmission owing to reionization, but that the hydrogen IGM is not highly neutral at z=6.6. Our neutral-hydrogen fraction constraint implies that the major reionization process took place at z>~7.Comment: 28 pages, 23 figures. Accepted for publication in Ap

Risk prediction models for dementia constructed by supervised principal component analysis using miRNA expression data

Alzheimer’s disease (AD) is the most common subtype of dementia, followed by Vascular Dementia (VaD), and Dementia with Lewy Bodies (DLB). Recently, microRNAs (miRNAs) have received a lot of attention as the novel biomarkers for dementia. Here, using serum miRNA expression of 1,601 Japanese individuals, we investigated potential miRNA biomarkers and constructed risk prediction models, based on a supervised principal component analysis (PCA) logistic regression method, according to the subtype of dementia. The final risk prediction model achieved a high accuracy of 0.873 on a validation cohort in AD, when using 78 miRNAs: Accuracy = 0.836 with 86 miRNAs in VaD; Accuracy = 0.825 with 110 miRNAs in DLB. To our knowledge, this is the first report applying miRNA-based risk prediction models to a dementia prospective cohort. Our study demonstrates our models to be effective in prospective disease risk prediction, and with further improvement may contribute to practical clinical use in dementia

Indices calculated by serum creatinine and cystatin C as predictors of liver damage, muscle strength and sarcopenia in liver disease

Serum creatinine (Cr)-based glomerular filtration rate (CrGFR) is overestimated in liver disease. The present study evaluated whether the difference in CrGFR and cystatin C (CysC) GFR (dGFR) is significant in liver disease. The Cr-to-CysC ratio and sarcopenia index (SI) have been reported to correlate with muscle volume. An estimated total body muscle mass with Cr, CysC and calculated body muscle mass (CBMM) has also been reported to correlate with muscle mass. The applicability of dGFR, SI and CBMM for liver disease were evaluated. A total of 313 patients with liver damage were evaluated for Child-Pugh score, albumin-bilirubin (ALBI) score, model for end-stage liver disease, fibrosis-4, Cr, CysC, Cr-based estimated GFR (CreGFR), CysCGFR and grip strength. Of the 313 patients, 199 were evaluated using cross-sectional computed tomography (CT) of the third lumbar vertebra to determine the skeletal muscle (SM) mass. dGFR, CBMM and SI were compared to liver damage, muscle strength and muscle mass. In the 313 patients, dGFR was correlated with age, ALBI and grip strength; CBMM was correlated with body mass index (BMI) and grip strength; and SI was correlated with BMI and grip strength. In patients evaluated with CT, the correlation coefficients for CBMM and SI with SM were 0.804 and 0.293, respectively. Thus, CBMM and SI were associated with sarcopenia. The relationship between dGFR and ALBI does not differ with different grades of CrGFR-based chronic kidney disease (CKD). dGFR is a marker of liver damage and muscle strength regardless of CKD. CBMM and SI are markers for sarcopenia in liver disease

高リン食投与がラットの腎臓カルシウム,マグネシウム量及び腎機能に及ぼす影響

We studied the alteration of kidney function with increased kidney contents of calcium and magnesium in rats fed a high-phosphorus diet. Five-week-old male SD rats were used. The rats were fed a diet with either a control (0.3%) or a high (1.5%) level of phosphorus for 21 days. Body weight gain and food intake were depressed, and kidney calcium and magnesium concentrations increased in rats fed a 1.5% phosphorus diet. The concentrations of magnesium and phosphorus in plasma decreased in rats fed a 1.5% phosphorus diet, but the concentration of calcium was not changed. As indicators of kidney function, plasma urea nitrogen concentration was higher and plasma uric acid concentration was lower than those of rats fed a control diet. TEARS in the kidney tissue of a high phosphorus diet rats was lower than that of rats fed a control diet. DHA was significantly low in fed a high phosphorus diet. These facts with high calcium and magnesium contents in kidney may have relation to reduction of kidney function

Study protocol for a multi-center, randomized controlled trial to develop Japanese denture adhesive guidelines for patients with complete dentures : the Denture Adhesive Guideline trial : study protocol for a randomized controlled trial

Background: Denture adhesives, characterized as medical products in 1935 by the American Dental Association, have been considered useful adjuncts for improving denture retention and stability. However, many dentists in Japan are hesitant to acknowledge denture adhesives in daily practice because of the stereotype that dentures should be inherently stable, without the aid of adhesives. The aim of this study is to verify the efficacy of denture adhesives to establish guidelines for Japanese users. The null hypothesis is that the application of denture adhesives, including the cream and powder types, or a control (isotonic sodium chloride solution) would not produce different outcomes nor would they differentially improve the set outcomes between baseline and day 4 post-application. Methods: This ten-center, randomized controlled trial with parallel groups is ongoing. Three hundred edentulous patients with complete dentures will be allocated to three groups (cream-type adhesive, powder-type adhesive, and control groups). The participants will wear their dentures with the denture adhesive for 4 days, including during eight meals (three breakfasts, two lunches, and three dinners). The baseline measurements and final measurements for the denture adhesives will be performed on the first day and after breakfast on the fourth day. The primary outcome is a general satisfaction rating for the denture. The secondary outcomes are denture satisfaction ratings for various denture functions, occlusal bite force, resistance to dislodgement, masticatory performance, perceived chewing ability, and oral health-related quality of life. Between-subjects comparisons among the three groups and within-subjects comparisons of the pre- and post-intervention measurements will be performed. Furthermore, a multiple regression analysis will be performed. The main analyses will be based on the intention-to-treat principle. A sample size of 100 subjects per group, including an assumed dropout rate of 10 %, will be required to achieve 80 % power with a 5 % alpha level. Discussion: This randomized clinical trial will provide information about denture adhesives to complete denture wearers, prosthodontic educators, and dentists in Japan. We believe this new evidence on denture adhesive use from Japan will aid dentists in their daily practice even in other countries

Lyman Break Galaxies at z~1.8-2.8: GALEX/NUV Imaging of the Subaru Deep Field

Abridged: A photometric sample of ~7100 V<25.3 Lyman break galaxies (LBGs) has been selected by combining Subaru/Suprime-Cam BVRci'z' data with deep GALEX/NUV imaging of the Subaru Deep Field. Follow-up spectroscopy confirmed 24 LBGs at 1.5<z<2.7. Among the optical spectra, 12 have Ly-alpha emission with rest-frame equivalent widths of ~5-60AA. The success rate for identifying LBGs as NUV-dropouts at 1.5<z<2.7 is 86%. The rest-frame UV (1700AA) luminosity function (LF) is constructed from the photometric sample with corrections for stellar contamination and z<1.5 interlopers. The LF is 1.7+/-0.1 times higher than those of z~2 BXs and z~3 LBGs. Three explanations were considered, and it is argued that significantly underestimating low-z contamination or effective comoving volume is unlikely: the former would be inconsistent with the spectroscopic sample at 93% confidence, and the second explanation would not resolve the discrepancy. The third scenario is that different photometric selection of the samples yields non-identical galaxy populations, such that some BX galaxies are LBGs and vice versa. This argument is supported by a higher surface density of LBGs at all magnitudes while the redshift distribution of the two populations is nearly identical. This study, when combined with other star-formation rate (SFR) density UV measurements from LBG surveys, indicates that there is a rise in the SFR density: a factor of 3-6 (3-10) increase from z~5 (z~6) to z~2, followed by a decrease to z~0. This result, along with past sub-mm studies that find a peak at z~2 in their redshift distribution, suggest that z~2 is the epoch of peak star-formation. Additional spectroscopy is required to characterize the complete shape of the z~2 LBG UV LF via measurements of contamination and accurate distances.Comment: 24 pages, 24 figures (color figures are included), 4 tables. Accepted for publication in the Astrophysical Journal. Latest version contains minor changes to Tables 1 and 2, and Figure 4 and 10. Conclusions remain unchange