The CP properties of the lightest Higgs boson with sbottom effects

In the framework of the recently proposed gluino-axion model, using the effective potential method and taking into account the top-stop as well as the bottom-sbottom effects, we discuss the CP--properties of the lightest Higgs boson, in particular its CP--odd composition, which can offer new opportunities at collider searches. It is found that although the CP-odd composition of the lightest Higgs increases slightly with the inclusion of the sbottom effects, it never exceeds %0.17 for all values of the renormalization scale Q ranging from top mass to TeV scaleComment: 24 pp, 12 eps fig

Clinical and radiographic evaluations of healing femoral fractures managed with conventional and novel allo-cadaveric bone plates in dogs

Femoral diaphyseal fractures are usually amenable to reduction with the use of orthodox fixation implants, which in most cases are expensive and cause intense stress to the patient, hence the need for safer, new biomaterials. This study assessed the use of allo-cadaveric bone plates (CBP-A) and conventional bone plates in managing femoral fractures in dogs. A total of four 8-12 kg Nigerian indigenous dogs were randomly divided into two groups, with each consisting of a male and female dog. Sterilized osteotome wire was employed to surgically create transverse mid-shaft femoral fractures in all the dogs. The fractures in Group I dogs were managed using Vitallium-alloy bone plates and served as control, while Group II fractures were reduced and fixed using CBP-A. Clinical and radiographic assessments for three months were carried out to compare the fracture healing between the groups. Results showed an early stabilization of vital parameters with a premature attempt to use the operated limb on days 4 and 5 post-reduction in groups I and II, respectively. The radiographs revealed good fracture reduction and fixation in all the dogs with the gradual disappearance of the fracture line, as well as progressive bone remodelling as the fracture healing advanced through the sixth week. At 12 weeks, there was distinct medullary and cortical continuity in all the dogs. Therefore, the novel CBP-A used in this study has effectively provided the needed fixation stability with minimal external immobilization for the repair of dog femoral fractures; hence, it should be recommended for use

Gut bacteria require neutrophils to promote mammary tumorigenesis

Recent studies suggest that gastrointestinal tract microbiota modulate cancer development in distant non-intestinal tissues. Here we tested mechanistic hypotheses using a targeted pathogenic gut microbial infection animal model with a predilection to breast cancer. FVB-Tg(C3-1-TAg)cJeg/JegJ female mice were infected by gastric gavage with Helicobacter hepaticus at three-months-of-age putting them at increased risk for mammary tumor development. Tumorigenesis was multifocal and characterized by extensive infiltrates of myeloperoxidase-positive neutrophils otherwise implicated in cancer progression in humans and animal models. To test whether neutrophils were important in etiopathogenesis in this bacteria-triggered model system, we next systemically depleted mice of neutrophils using thrice weekly intraperitoneal injections with anti-Ly-6G antibody. We found that antibody depletion entirely inhibited tumor development in this H. hepaticus-infected model. These data demonstrate that host neutrophil-associated immune responses to intestinal tract microbes significantly impact cancer progression in distal tissues such as mammary glands, and identify gut microbes as novel targets for extra-intestinal cancer therapy.National Institutes of Health (U.S.) (Grant U01 CA164337)National Institutes of Health (U.S.) (Grant T32 OD011141

A case of muscular bridge resulting in myocardial infraction following heavy effort: a case report

Muscular bridge (MB) is transient systolic coronary blockage occurring due to exposure of a portion of epicardial coronary arteries to compression during systole as a result of tunneling into the myocardium. Although rare, these patients may develop angina pectoris, severe arrhythmia and myocardial infraction (MI). A 30-year-old male patient presented to the emergency with severe pain with an onset at the front part of the chest followed by spreading to the back and arms, during a football match. The investigations performed revealed anterior wall infraction and thus thrombolytic treatment was administered. Patient's history was normal except for smoking. The patient was detected to play football occasionally since his childhood; however, we learnt that he had started playing without warm-up exercises at the last football match. Coronary angiography detected a lesion with an onset in the left anterior descending artery following the 1st diagonal and extending to the 2nd diagonal and exhibiting a significant contraction during systole. The patient was considered to have myocardial infraction secondary to myocardial bridge. Sudden deaths frequently occur in competitive sports requiring heavy effort

Ego defense mechanisms in Pakistani medical students: a cross sectional analysis

Background: Ego defense mechanisms (or factors), defined by Freud as unconscious resources used by the ego to reduce conflict between the id and superego, are a reflection of how an individual deals with conflict and stress. This study assesses the prevalence of various ego defense mechanisms employed by medical students of Karachi, which is a group with higher stress levels than the general population. Methods: A questionnaire based cross-sectional study was conducted on 682 students from five major medical colleges of Karachi over 4 weeks in November 2006. Ego defense mechanisms were assessed using the Defense Style Questionnaire (DSQ-40) individually and as grouped under Mature, Immature, and Neurotic factors. Results: Lower mean scores of Immature defense mechanisms (4.78) were identified than those for Neurotic (5.62) and Mature (5.60) mechanisms among medical students of Karachi. Immature mechanisms were more commonly employed by males whereas females employed more Neurotic mechanisms than males. Neurotic and Immature defenses were significantly more prevalent in first and second year students. Mature mechanisms were significantly higher in students enrolled in Government colleges than Private institutions (p \u3c 0.05). Conclusions: Immature defense mechanisms were less commonly employed than Neurotic and Mature mechanisms among medical students of Karachi. The greater employment of Neurotic defenses may reflect greater stress levels than the general population. Employment of these mechanisms was associated with female gender, enrollment in a private medical college, and students enrolled in the first 2 years of medical school

Clinical outcome of endonasal KTP laser assisted dacryocystorhinostomy

BACKGROUND: To evaluate the clinical outcome of primary endonasal laser assisted dacryocystorhinostomy (ENL-DCR) using the potassium-titanyl-phosphate laser. METHODS: We retrospectively reviewed all primary ENL-DCRs performed within a period of twelve months by the same combined Ophthalmology and Otorhinolaringology team in Freeman Hospital, Newcastle upon Tyne, UK. The main outcome measure for success was resolution or significant improvement of epiphora. Details of surgery, intraoperative and postoperative complications, as well as pathology associated with failure were also studied. Patients were followed up for at least 12 months. RESULTS: A total of 41 consecutive ENL-DCRs on 29 patients (22 females, 7 males, mean age 75 years) were analysed. All patients had bicanalicular silicone intubation for at least 4 months. The success rate at 12 months postoperatively was 78.1%. Pathology associated with failure included: intranasal pathology (12.2%), mucocele (7.3%), and systemic sarcoidosis (2.4%). No significant intra-operative complications were recorded. CONCLUSION: The ENL-DCR with potassium-titanyl-phosphate laser can be considered as a safe and efficient primary procedure for the treatment of nasolacrimal duct obstruction

Fuzzy logic based energy and throughput aware design space exploration for MPSoCs

Multicore architectures were introduced to mitigate the issue of increase in power dissipation with clock frequency. Introduction of deeper pipelines, speculative threading etc. for single core systems were not able to bring much increase in performance as compared to their associated power overhead. However for multicore architectures performance scaling with number of cores has always been a challenge. The Amdahl's law shows that the theoretical maximum speedup of a multicore architecture is not even close to the multiple of number of cores. With less amount of code in parallel having more number of cores for an application might just contribute in greater power dissipation instead of bringing some performance advantage. Therefore there is a need of an adaptive multicore architecture that can be tailored for the application in use for higher energy efficiency. In this paper a fuzzy logic based design space exploration technique is presented that is targeted to optimize a multicore architecture according to the workload requirements in order to achieve optimum balance between throughput and energy of the system

Extracellular Vesicles in Liver Diseases: Meeting Report from the International Liver Congress 2018

Extracellular vesicles (EVs) are small and heterogeneous membrane-bound structures released by cells and found in all biological fluids. They are effective intercellular communicators, acting on a number of close and/or distant target cells. EV cargo may reflect the cell of origin as well as the specific stress that induces their formation and release. They transport a variety of bioactive molecules, including messenger RNA, noncoding RNAs, proteins, lipids, and metabolites, that can be transferred among cells, regulating various cell responses. Alteration in the concentration and composition of EVs in biological fluids is a typical hallmark of pathologies in different liver diseases. Circulating EVs can serve as biomarkers or as messengers following uptake by other cells. This review is a meeting report from the International Liver Congress 2018 (European Association for the Study of the Liver) celebrated in Paris (Symposium: Extracellular vesicles and signal transmission) that discusses the role of EVs in several liver diseases, highlighting their potential value as disease biomarkers and therapeutic opportunities