501 research outputs found
Ad- and desorption of Rb atoms on a gold nanofilm measured by surface plasmon polaritons
Hybrid quantum systems made of cold atoms near nanostructured surfaces are
expected to open up new opportunities for the construction of quantum sensors
and for quantum information. For the design of such tailored quantum systems
the interaction of alkali atoms with dielectric and metallic surfaces is
crucial and required to be understood in detail. Here, we present real-time
measurements of the adsorption and desorption of Rubidium atoms on gold
nanofilms. Surface plasmon polaritons (SPP) are excited at the gold surface and
detected in a phase sensitive way. From the temporal change of the SPP phase
the Rubidium coverage of the gold film is deduced with a sensitivity of better
than 0.3 % of a monolayer. By comparing the experimental data with a Langmuir
type adsorption model we obtain the thermal desorption rate and the sticking
probability. In addition, also laser-induced desorption is observed and
quantified.Comment: 9 pages, 6 figure
Towards improving the accuracy of aortic transvalvular pressure gradients: rethinking Bernoulli
The transvalvular pressure gradient (TPG) is commonly estimated using the Bernoulli equation. However, the method is known to be inaccurate. Therefore, an adjusted Bernoulli model for accurate TPG assessment was developed and evaluated. Numerical simulations were used to calculate TPGCFD in patient-specific geometries of aortic stenosis as ground truth. Geometries, aortic valve areas (AVA), and flow rates were derived from computed tomography scans. Simulations were divided in a training data set (135 cases) and a test data set (36 cases). The training data was used to fit an adjusted Bernoulli model as a function of AVA and flow rate. The model-predicted TPGModel was evaluated using the test data set and also compared against the common Bernoulli equation (TPGB). TPGB and TPGModel both correlated well with TPGCFD (r > 0.94), but significantly overestimated it. The average difference between TPGModel and TPGCFD was much lower: 3.3 mmHg vs. 17.3 mmHg between TPGB and TPGCFD. Also, the standard error of estimate was lower for the adjusted model: SEEModel = 5.3 mmHg vs. SEEB = 22.3 mmHg. The adjusted model's performance was more accurate than that of the conventional Bernoulli equation. The model might help to improve non-invasive assessment of TPG. Graphical abstract Processing pipeline for the definition of an adjusted Bernoulli model for the assessment of transvalvular pressure gradient. Using CT image data, the patient specific geometry of the stenosed AVs were reconstructed. Using this segmentation, the AVA as well as the volume flow rate was calculated and used for model definition. This novel model was compared against classical approaches on a test data set, which was not used for the model definition
Myeloid-derived suppressor cells are implicated in regulating permissiveness for tumor metastasis during mouse gestation.
Metastasis depends on the ability of tumor cells to establish a relationship with the newly seeded tissue that is conducive to their survival and proliferation. However, the factors that render tissues permissive for metastatic tumor growth have yet to be fully elucidated. Breast tumors arising during pregnancy display early metastatic proclivity, raising the possibility that pregnancy may constitute a physiological condition of permissiveness for tumor dissemination. Here we have shown that during murine gestation, metastasis is enhanced regardless of tumor type, and that decreased NK cell activity is responsible for the observed increase in experimental metastasis. Gene expression changes in pregnant mouse lung and liver were shown to be similar to those detected in premetastatic sites and indicative of myeloid cell infiltration. Indeed, myeloid-derived suppressor cells (MDSCs) accumulated in pregnant mice and exerted an inhibitory effect on NK cell activity, providing a candidate mechanism for the enhanced metastatic tumor growth observed in gestant mice. Although the functions of MDSCs are not yet understood in the context of pregnancy, our observations suggest that they may represent a shared mechanism of immune suppression occurring during gestation and tumor growth
Estimation of valvular resistance of segmented aortic valves using computational fluid dynamics
Aortic valve stenosis is associated with an elevated left ventricular pressure and transaortic pressure drop. Clinicians routinely use Doppler ultrasound to quantify aortic valve stenosis severity by estimating this pressure drop from blood velocity. However, this method approximates the peak pressure drop, and is unable to quantify the partial pressure recovery distal to the valve. As pressure drops are flow dependent, it remains difficult to assess the true significance of a stenosis for low-flow low-gradient patients. Recent advances in segmentation techniques enable patient-specific Computational Fluid Dynamics (CFD) simulations of flow through the aortic valve. In this work a simulation framework is presented and used to analyze data of 18 patients. The ventricle and valve are reconstructed from 4D Computed Tomography imaging data. Ventricular motion is extracted from the medical images and used to model ventricular contraction and corresponding blood flow through the valve. Simplifications of the framework are assessed by introducing two simplified CFD models: a truncated time-dependent and a steady-state model. Model simplifications are justified for cases where the simulated pressure drop is above 10 mmHg. Furthermore, we propose a valve resistance index to quantify stenosis severity from simulation results. This index is compared to established metrics for clinical decision making, i.e. blood velocity and valve area. It is found that velocity measurements alone do not adequately reflect stenosis severity. This work demonstrates that combining 4D imaging data and CFD has the potential to provide a physiologically relevant diagnostic metric to quantify aortic valve stenosis severity
The channel-activating protease CAP1/Prss8 is required for placental labyrinth maturation.
The serine protease CAP1/Prss8 is crucial for skin barrier function, lung alveolar fluid clearance and has been unveiled as diagnostic marker for specific cancer types. Here, we show that a constitutive knockout of CAP1/Prss8 leads to embryonic lethality. These embryos presented no specific defects, but it is during this period, and in particular at E13.5, that wildtype placentas show an increased expression of CAP1/Prss8, thus suggesting a placental defect in the knockout situation. The placentas of knockout embryos exhibited significantly reduced vascular development and incomplete cellular maturation. In contrary, epiblast-specific deletion of CAP1/Prss8 allowed development until birth. These CAP1/Prss8-deficient newborns presented abnormal epidermis, and died soon after birth due to impaired skin function. We thus conclude that a late placental insufficiency might be the primary cause of embryonic lethality in CAP1/Prss8 knockouts. This study highlights a novel and crucial role for CAP1/Prss8 in placental development and function
Tidally distorted accretion discs in binary stars
The non-axisymmetric features observed in the discs of dwarf novae in
outburst are usually considered to be spiral shocks, which are the non-linear
relatives of tidally excited waves. This interpretation suffers from a number
of problems. For example, the natural site of wave excitation lies outside the
Roche lobe, the disc must be especially hot, and most treatments of wave
propagation do not take into account the vertical structure of the disc.
In this paper I construct a detailed semi-analytical model of the non-linear
tidal distortion of a thin, three-dimensional accretion disc by a binary
companion on a circular orbit. The analysis presented here allows for vertical
motion and radiative energy transport, and introduces a simple model for the
turbulent magnetic stress. The m=2 inner vertical resonance has an important
influence on the amplitude and phase of the tidal distortion. I show that the
observed patterns find a natural explanation if the emission is associated with
the tidally thickened sectors of the outer disc, which may be irradiated from
the centre. According to this hypothesis, it may be possible to constrain the
physical parameters of the disc through future observations.Comment: 13 pages, 3 figures, to be published in MNRA
Brown Dwarfs and the Cataclysmic Variable Period Minimum
Using improved, up-to-date stellar input physics tested against observations
of low-mass stars and brown dwarfs we calculate the secular evolution of
low-mass donor cataclysmic variables (CVs), including those which form with a
brown dwarf donor. Our models confirm the mismatch between the calculated
minimum period (Pmin ~ 70 min) and the observed short-period cut-off (~ 80 min)
in the CV period histogram. We find that tidal and rotational corrections
applied to the one-dimensional stellar structure equations have no significant
effect on the period minimum. Theoretical period distributions synthesized from
our model sequences always show an accumulation of systems at the minimum
period, a feature absent from the observed distribution. We suggest that
non-magnetic CVs become unobservable as they are effectively trapped in
permanent quiescence before they reach Pmin, and that small-number statistics
may hide the period spike for magnetic CVs.Comment: 10 pages; accepted for publication in MNRA
First measurement of Mg isotope abundances at high redshifts and accurate estimate of Delta alpha/alpha
(Abridged) We use a high-resolution spectrum of the quasar HE0001-2340
observed with the UVES/VLT to measure Mg isotope abundances in the intervening
absorption-line systems at high redshifts. Line profiles are prepared
accounting for possible shifts between the individual exposures. Due to unique
composition of the selected systems - the presence of several transitions of
the same ion - we can test the local accuracy of the wavelength scale
calibration which is the main source of errors in the sub-pixel line position
measurements. In the system at zabs = 0.45 which is probably a fragment of the
outflow caused by SN Ia explosion of high-metallicity white dwarf(s) we
measured velocity shifts of MgII and MgI lines relative to other lines (FeI,
FeII, CaI, CaII): Delta V(MgII) = -0.44 +/- 0.05 km/s and Delta V(MgI) = -0.17
+/- 0.17$ km/s. This translates into the isotopic ratio 24Mg:25Mg:26Mg = (19
+/- 11):(22 +/- 13):(59 +/- 6) with a strong relative overabundance of heavy Mg
isotopes, (25Mg+26Mg)/24Mg = 4, as compared to the solar ratio 24Mg:25Mg:26Mg =
79:10:11, and (25Mg+26Mg)/24Mg = 0.3. At zabs = 1.58, we put a strong
constraint on a putative variation of alpha: Delta alpha/alpha = (-1.5 +/-
2.6)x10^{-6} which is one of the most stringent limits obtained from optical
spectra of QSOs. We reveal that the wavelength calibration in the range above
7500 A is subject to systematic wavelength-dependent drifts.Comment: 20 pages, 13 figures, 7 tables. Accepted for publication in Astronomy
and Astrophysic
On the late spectral types of cataclysmic variable secondaries
We investigate why the spectral type of most cataclysmic variable (CV)
secondaries is significantly later than that of a ZAMS star with the same mean
density. Using improved stellar input physics, tested against observations of
low-mass stars at the bottom of the main sequence, we calculate the secular
evolution of CVs with low-mass donors. We consider sequences with different
mass transfer rates and with a different degree of nuclear evolution of the
donor prior to mass transfer. Systems near the upper edge of the gap ( h) can be reproduced by models with a wide range of mass transfer rates
from 1.5 \times 10^{-9} \msolyr to 10^{-8} \msolyr. Evolutionary sequences
with a small transfer rate and donors that are substantially evolved off the
ZAMS (central hydrogen content ) reproduce CVs with late spectral
types above P \simgr 6 h. Systems with the most discrepant (late) spectral
type should have the smallest donor mass at any given . Consistency with the
period gap suggests that the mass transfer rate increases with decreasing donor
mass for evolved sequences above the period gap. In this case, a
single-parameter family of sequences with varying \xc and increasing mass
transfer rate reproduces the full range of observed spectral types. This would
imply that CVs with such evolved secondaries dominate the CV population.Comment: 9 pages, Latex file, uses mn.sty, accepted for publication in MNRA
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